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Volumn 19, Issue 6, 2006, Pages 655-668

Evaluation of treatment effects in Alzheimer's and other neurodegenerative diseases by MRI and MRS

Author keywords

Diffusion tensor imaging; Functional magnetic resonance imaging; Magnetic resonance imaging; Neurodegeneration; Outcome measure; Spectroscopy; Treatment; Volumetry

Indexed keywords

ALZHEIMER'S DISEASE; DIFFUSION TENSOR IMAGING; FUNCTIONAL MAGNETIC RESONANCE IMAGING; NEURODEGENERATION; NEURODEGENERATIVE DISEASES;

EID: 33749504441     PISSN: 09523480     EISSN: 10991492     Source Type: Journal    
DOI: 10.1002/nbm.1062     Document Type: Review
Times cited : (60)

References (111)
  • 2
    • 0002004673 scopus 로고    scopus 로고
    • The world-wide impact of dementia. Projections of prevalence and costs
    • In Mayeaux R, Christen Y (eds). Springer-Verlag: Berlin
    • Katzman R, Fox P. The world-wide impact of dementia. Projections of prevalence and costs. In Epidemiology of Alzheimer's Disease: from Gene to Prevention, Mayeaux R, Christen Y (eds). Springer-Verlag: Berlin, 1999; 1-17.
    • (1999) Epidemiology of Alzheimer's Disease: From Gene to Prevention , pp. 1-17
    • Katzman, R.1    Fox, P.2
  • 3
    • 12244314012 scopus 로고    scopus 로고
    • Therapeutic approaches to age-associated neurocognitive disorders. Dialogues in clinical neuroscience
    • O'Hara R, Yesavage JA, Derouesne C. Therapeutic approaches to age-associated neurocognitive disorders. Dialogues in clinical neuroscience. Cerebral Aging Concepts Assess. 2001; 3: 191-213.
    • (2001) Cerebral Aging Concepts Assess. , vol.3 , pp. 191-213
    • O'Hara, R.1    Yesavage, J.A.2    Derouesne, C.3
  • 4
    • 0033604631 scopus 로고    scopus 로고
    • Treatment of Alzheimer's disease
    • Mayeux R, Sano M. Treatment of Alzheimer's disease. N. Engl. J. Med. 1999; 341: 1670-1679.
    • (1999) N. Engl. J. Med. , vol.341 , pp. 1670-1679
    • Mayeux, R.1    Sano, M.2
  • 5
    • 0030865454 scopus 로고    scopus 로고
    • Slowing the progression of Alzheimer's disease: Methodological issues
    • Leber P. Slowing the progression of Alzheimer's disease: methodological issues. Alzheimer Dis. Assoc. Disord. 1997; 11 (Suppl 5): S10-S21.
    • (1997) Alzheimer Dis. Assoc. Disord. , vol.11 , Issue.SUPPL. 5
    • Leber, P.1
  • 6
    • 0347093537 scopus 로고    scopus 로고
    • The evaluation of disease modifying therapies in Alzheimer's disease: A regulatory review
    • Mani R. The evaluation of disease modifying therapies in Alzheimer's disease: a regulatory review. Stat. Med. 2004; 23: 305-314.
    • (2004) Stat. Med. , vol.23 , pp. 305-314
    • Mani, R.1
  • 11
    • 0037996766 scopus 로고    scopus 로고
    • Longitudinal magnetic resonance imaging studies of older adults: A shrinking brain
    • Resnick SM, Pham DL, Kraut MA, Zondrmann AB, Davatzikos C. Longitudinal magnetic resonance imaging studies of older adults: a shrinking brain. J. Neurosci. 2003; 23: 3295-3301.
    • (2003) J. Neurosci. , vol.23 , pp. 3295-3301
    • Resnick, S.M.1    Pham, D.L.2    Kraut, M.A.3    Zondrmann, A.B.4    Davatzikos, C.5
  • 12
    • 0842283229 scopus 로고    scopus 로고
    • Imaging cerebral atrophy: Normal ageing to Alzheimer's disease
    • Fox NC, Schrott JM. Imaging cerebral atrophy: normal ageing to Alzheimer's disease. Lancet 2004; 363: 392-394.
    • (2004) Lancet , vol.363 , pp. 392-394
    • Fox, N.C.1    Schrott, J.M.2
  • 16
    • 0031240181 scopus 로고    scopus 로고
    • The boundary shift integral: An accurate and robust measure of cerebral volume changes from registered repeat MRI
    • Freebourogh PA, Foc NC. The boundary shift integral: an accurate and robust measure of cerebral volume changes from registered repeat MRI. IEEE Trans. Med. Imag. 1997; 15: 623-629.
    • (1997) IEEE Trans. Med. Imag. , vol.15 , pp. 623-629
    • Freebourogh, P.A.1    Foc, N.C.2
  • 18
    • 0041422641 scopus 로고    scopus 로고
    • An intensity consistent filtering approach to the analysis of deformation tenser derived maps of brain shape
    • Studholme C, Cardenas V, Maudsley A, Weiner MW. An intensity consistent filtering approach to the analysis of deformation tenser derived maps of brain shape. Neuroimage 2003; 19: 1638-1649.
    • (2003) Neuroimage , vol.19 , pp. 1638-1649
    • Studholme, C.1    Cardenas, V.2    Maudsley, A.3    Weiner, M.W.4
  • 19
    • 0038538234 scopus 로고    scopus 로고
    • Imaging methods for evaluating brain function in man
    • Kessler RM. Imaging methods for evaluating brain function in man. Neurobiol. Aging 2003; Suppl. 1: S21-S35.
    • (2003) Neurobiol. Aging , Issue.SUPPL. 1
    • Kessler, R.M.1
  • 21
    • 0030859038 scopus 로고    scopus 로고
    • Dynamic NMR studies of perfusion and oxidative metabolism during focal brain activation
    • Frahm J, Krueger G, Merboldt KD, Kleinschmidt A. Dynamic NMR studies of perfusion and oxidative metabolism during focal brain activation. Adv. Exp. Med. Biol. 1997; 413: 195-203.
    • (1997) Adv. Exp. Med. Biol. , vol.413 , pp. 195-203
    • Frahm, J.1    Krueger, G.2    Merboldt, K.D.3    Kleinschmidt, A.4
  • 22
    • 2342628596 scopus 로고    scopus 로고
    • Differential expression of oxidative phophorylation genes in patients with Alzheimer's disease: Implication for early mitochondrial dysfunction and oxidative damage
    • Manczak M, Park BS, Jung Y, Reddy PH. Differential expression of oxidative phophorylation genes in patients with Alzheimer's disease: implication for early mitochondrial dysfunction and oxidative damage. Neuromol. Med. 2004; 5: 147-162.
    • (2004) Neuromol. Med. , vol.5 , pp. 147-162
    • Manczak, M.1    Park, B.S.2    Jung, Y.3    Reddy, P.H.4
  • 24
    • 0141483384 scopus 로고    scopus 로고
    • High resolution MRI: A promising approach for diagnosing Alzheimer's disease and mapping its course
    • Small SA. High resolution MRI: a promising approach for diagnosing Alzheimer's disease and mapping its course. Alzheimer Dis. Assoc. Disord. 2003; 17: 154-161.
    • (2003) Alzheimer Dis. Assoc. Disord. , vol.17 , pp. 154-161
    • Small, S.A.1
  • 25
    • 0037409849 scopus 로고    scopus 로고
    • N-Acetylaspartate in the vertebrate brain: Metabolism and function
    • Baslow MH. N-Acetylaspartate in the vertebrate brain:metabolism and function. Neurochem. Res. 2003; 28: 941-953.
    • (2003) Neurochem. Res. , vol.28 , pp. 941-953
    • Baslow, M.H.1
  • 26
    • 0034643639 scopus 로고    scopus 로고
    • Longitudinal decline of the neuronal marker N-acteylaspartate in Alzheimer's disease
    • Adalsteinsson E, Sullivan EV, Kleinhans N, Spielman DM, Pfefferbaum A. Longitudinal decline of the neuronal marker N-acteylaspartate in Alzheimer's disease. Lancet 2000; 355: 1696-1697.
    • (2000) Lancet , vol.355 , pp. 1696-1697
    • Adalsteinsson, E.1    Sullivan, E.V.2    Kleinhans, N.3    Spielman, D.M.4    Pfefferbaum, A.5
  • 27
    • 1042277841 scopus 로고    scopus 로고
    • 1H NMR spectroscopy of individual human brain metabolites at moderate field strengths
    • 1H NMR spectroscopy of individual human brain metabolites at moderate field strengths. Magn. Reson. Imaging 2003; 21: 1295-1302.
    • (2003) Magn. Reson. Imaging , vol.21 , pp. 1295-1302
    • Trabesinger, A.H.1    Meier, D.2    Boesiger, P.3
  • 30
    • 0034975272 scopus 로고    scopus 로고
    • Frontotemporal dementia (Pick's disease): Clinical features and assessment
    • Hodges JR. Frontotemporal dementia (Pick's disease): clinical features and assessment. Neurology 2001: 56 (Suppl. 4): S6-S10.
    • (2001) Neurology , vol.56 , Issue.SUPPL. 4
    • Hodges, J.R.1
  • 31
    • 3943092621 scopus 로고    scopus 로고
    • Pathways towards and away from Alzheimer's disease
    • Mattson MP. Pathways towards and away from Alzheimer's disease. Nature 2004; 430: 631-639.
    • (2004) Nature , vol.430 , pp. 631-639
    • Mattson, M.P.1
  • 32
    • 3042857903 scopus 로고    scopus 로고
    • Alzheimer's disease
    • Cummings JL. Alzheimer's disease. N. Engl. J. Med. 2004; 351: 56-67.
    • (2004) N. Engl. J. Med. , vol.351 , pp. 56-67
    • Cummings, J.L.1
  • 34
    • 11344251308 scopus 로고    scopus 로고
    • Effects of A-beta immunotherapy (AN1792) on MRI measures of brain, ventricle and hippocampal volumes in Alzheimer's disase
    • Fox NC, Black RS, Gilman S, Rossor MN, Griffith SG, Jenkins L, Koller M. Effects of A-beta immunotherapy (AN1792) on MRI measures of brain, ventricle and hippocampal volumes in Alzheimer's disase. Neurobiol. Aging 2004; 25 (Suppl. 2): 84.
    • (2004) Neurobiol. Aging , vol.25 , Issue.SUPPL. 2 , pp. 84
    • Fox, N.C.1    Black, R.S.2    Gilman, S.3    Rossor, M.N.4    Griffith, S.G.5    Jenkins, L.6    Koller, M.7
  • 35
    • 0029686696 scopus 로고    scopus 로고
    • Evolution of the neuropathology of Alzheimer's disease
    • Braak H, Braak E. Evolution of the neuropathology of Alzheimer's disease. Acta Neurol. Scand. 1996; Suppl. 165: 3-12.
    • (1996) Acta Neurol. Scand. , Issue.SUPPL. 165 , pp. 3-12
    • Braak, H.1    Braak, E.2
  • 37
    • 4544335597 scopus 로고    scopus 로고
    • Mild cognitive impairment a diagnostic entity
    • Petersen RC. Mild cognitive impairment a diagnostic entity. J. Intern. Med. 2004; 256: 183-194.
    • (2004) J. Intern. Med. , vol.256 , pp. 183-194
    • Petersen, R.C.1
  • 45
    • 0142074701 scopus 로고    scopus 로고
    • Changes in hippocampal volume and shape across time distinguish dementia of the Alzheimer type from healthy aging
    • Wang L, Swank JS, Glick IE, Gado HM, Miller MI, Morris JC, Csernansky JG. Changes in hippocampal volume and shape across time distinguish dementia of the Alzheimer type from healthy aging. Neuroimage 2003; 20: 667-682.
    • (2003) Neuroimage , vol.20 , pp. 667-682
    • Wang, L.1    Swank, J.S.2    Glick, I.E.3    Gado, H.M.4    Miller, M.I.5    Morris, J.C.6    Csernansky, J.G.7
  • 46
    • 0141751616 scopus 로고    scopus 로고
    • Change in rates of cerebral atrophy over time in early-onset Alzheimer's disease: Longitudinal MRI study
    • Chan D, Janssen JC, Withwell JL, Watts HC, Jenkins R, Frost C, Rossor MN, Fox NC. Change in rates of cerebral atrophy over time in early-onset Alzheimer's disease: longitudinal MRI study. Lancet 2003; 362: 1121-1122.
    • (2003) Lancet , vol.362 , pp. 1121-1122
    • Chan, D.1    Janssen, J.C.2    Withwell, J.L.3    Watts, H.C.4    Jenkins, R.5    Frost, C.6    Rossor, M.N.7    Fox, N.C.8
  • 50
    • 0034099077 scopus 로고    scopus 로고
    • Using serial registered brain magnetic resonance imaging to measure disease progression in Alzheimer's disease. Power calculations and estimates of sample size to detect treatment effects
    • Fox NC, Cousens S, Scahill R, Harvey RJ, Rossor N. Using serial registered brain magnetic resonance imaging to measure disease progression in Alzheimer's disease. Power calculations and estimates of sample size to detect treatment effects. Arch. Neurol. 2000; 57: 339-344.
    • (2000) Arch. Neurol. , vol.57 , pp. 339-344
    • Fox, N.C.1    Cousens, S.2    Scahill, R.3    Harvey, R.J.4    Rossor, N.5
  • 54
    • 0036901184 scopus 로고    scopus 로고
    • Alteration in brain activation during cholinergic enhancement with rivastigmine in Alzheimer's disease
    • Rombouts SARB, Barkhof F, van Meel CS, Scheltens P. Alteration in brain activation during cholinergic enhancement with rivastigmine in Alzheimer's disease. J. Neurol. Neurosurg. Psychiatry 2002; 73: 665-671.
    • (2002) J. Neurol. Neurosurg. Psychiatry , vol.73 , pp. 665-671
    • Rombouts, S.A.R.B.1    Barkhof, F.2    van Meel, C.S.3    Scheltens, P.4
  • 56
    • 0030910311 scopus 로고    scopus 로고
    • Measurement of acetylcholinesterase by positron emisson tomography in the brains of healthy controls and patients with Alzheimer's disease
    • Iyo M, Namba H, Fukushi K, Shinotoh H, Nagatsuka S, Suhara T, Sudo Y, Suzuki K, Irie T. Measurement of acetylcholinesterase by positron emisson tomography in the brains of healthy controls and patients with Alzheimer's disease. Lancet 1997; 349: 1805-1809.
    • (1997) Lancet , vol.349 , pp. 1805-1809
    • Iyo, M.1    Namba, H.2    Fukushi, K.3    Shinotoh, H.4    Nagatsuka, S.5    Suhara, T.6    Sudo, Y.7    Suzuki, K.8    Irie, T.9
  • 58
    • 0033867948 scopus 로고    scopus 로고
    • Progressive loss of cortical acetylcholinesterase activity in association with cognitive decline in Alzheimer's disase: A positron emission tomography study
    • Shinotoh H, Namba H, Fukushi K, Nagatsuka S, Tanaka N, Aotsuka A, Ota T, Tanada S, Irie T. Progressive loss of cortical acetylcholinesterase activity in association with cognitive decline in Alzheimer's disase: a positron emission tomography study. Ann. Neurol. 2000; 48: 194-200.
    • (2000) Ann. Neurol. , vol.48 , pp. 194-200
    • Shinotoh, H.1    Namba, H.2    Fukushi, K.3    Nagatsuka, S.4    Tanaka, N.5    Aotsuka, A.6    Ota, T.7    Tanada, S.8    Irie, T.9
  • 60
    • 0033844518 scopus 로고    scopus 로고
    • Limited donepezil inhibition of acetylcholinesterase measured with positron emission tomography in living Alzheimer cerebral cortex
    • Kuhl DE, Minoshima S, Frey KA, Foster NL, Kilbourn MR, Koeppe RA. Limited donepezil inhibition of acetylcholinesterase measured with positron emission tomography in living Alzheimer cerebral cortex. Ann. Neurol. 2000; 48: 391-395.
    • (2000) Ann. Neurol. , vol.48 , pp. 391-395
    • Kuhl, D.E.1    Minoshima, S.2    Frey, K.A.3    Foster, N.L.4    Kilbourn, M.R.5    Koeppe, R.A.6
  • 65
    • 0034796786 scopus 로고    scopus 로고
    • Donepezil hydrochloride preserves regional cerebral blood flow in patients with Alzheimer's disease
    • Nakano S, Asada T, Matsuda H, Uno M, Takasaki M. Donepezil hydrochloride preserves regional cerebral blood flow in patients with Alzheimer's disease. J. Nucl. Med. 2001; 42: 1441-1445.
    • (2001) J. Nucl. Med. , vol.42 , pp. 1441-1445
    • Nakano, S.1    Asada, T.2    Matsuda, H.3    Uno, M.4    Takasaki, M.5
  • 68
    • 0037371058 scopus 로고    scopus 로고
    • Donepezil HCl (E2020) maintains functional brain activity in patients with Alzheimer disease: Results of a 24-week, double-blind, placebo-controlled study
    • Tune L, Tiseo PJ, Ieni J, Perdomo C, Pratt RD, Votaw JR, Jewart RD, Hoffman JM. Donepezil HCl (E2020) maintains functional brain activity in patients with Alzheimer disease: results of a 24-week, double-blind, placebo-controlled study. Am. J. Geriatr. Psychiatry 2003; 11: 169-177.
    • (2003) Am. J. Geriatr. Psychiatry , vol.11 , pp. 169-177
    • Tune, L.1    Tiseo, P.J.2    Ieni, J.3    Perdomo, C.4    Pratt, R.D.5    Votaw, J.R.6    Jewart, R.D.7    Hoffman, J.M.8
  • 70
    • 0037111135 scopus 로고    scopus 로고
    • The pathology of ischemic-vascular dementia: An update
    • Jellinger KA. The pathology of ischemic-vascular dementia: an update. J. Neurol. Sci. 2002; 203-204: 153-157.
    • (2002) J. Neurol. Sci. , vol.203-204 , pp. 153-157
    • Jellinger, K.A.1
  • 72
    • 1842418653 scopus 로고    scopus 로고
    • Emerging therapies for vascular dementia and vascular cognitive impairment
    • Erkinjuntti T, Roman G, Gauthier S, Feldman H, Rockwood K. Emerging therapies for vascular dementia and vascular cognitive impairment. Stroke 2004; 35: 1010-1017.
    • (2004) Stroke , vol.35 , pp. 1010-1017
    • Erkinjuntti, T.1    Roman, G.2    Gauthier, S.3    Feldman, H.4    Rockwood, K.5
  • 78
    • 8644260834 scopus 로고    scopus 로고
    • Treatment of vascular dementia: Evidence from trials with non-cholinergic drugs
    • Pantoni L. Treatment of vascular dementia: evidence from trials with non-cholinergic drugs. J. Neurosci. 2004; 226: 67-70.
    • (2004) J. Neurosci. , vol.226 , pp. 67-70
    • Pantoni, L.1
  • 79
    • 0035122853 scopus 로고    scopus 로고
    • Temoral changes in brain volume and cognition in a randomized treatment trial of vascular dementia
    • Broderick JP, Gaskill M, Dhawan A, Khoury JC. Temoral changes in brain volume and cognition in a randomized treatment trial of vascular dementia. J. Neuroimaging 2001; 11: 6-12.
    • (2001) J. Neuroimaging , vol.11 , pp. 6-12
    • Broderick, J.P.1    Gaskill, M.2    Dhawan, A.3    Khoury, J.C.4
  • 81
    • 0344197596 scopus 로고    scopus 로고
    • Propentophylline in treatment of vascular dementia and Alzheimer-type dementia: Overview of phase I and phase II clinical trials
    • Mielke R, Moller HJ, Erkinjuntti T, Rosenkranz B, Rother M, Kittner B. Propentophylline in treatment of vascular dementia and Alzheimer-type dementia: overview of phase I and phase II clinical trials. Alzheimer Dis. Assoc. Disord. 1998; 12 (Suppl. 2): S29-S35.
    • (1998) Alzheimer Dis. Assoc. Disord. , vol.12 , Issue.SUPPL. 2
    • Mielke, R.1    Moller, H.J.2    Erkinjuntti, T.3    Rosenkranz, B.4    Rother, M.5    Kittner, B.6
  • 82
    • 0242523117 scopus 로고    scopus 로고
    • The effect of cholinesterase inhibitors on the regional blood flow in patients with Alzheimer's disease and vascular dementia
    • Lojkowska W, Ryglewicz D, Jedrzejczak T, Mine S, Jakubowska T, Jarosz H, Bochnyska A. The effect of cholinesterase inhibitors on the regional blood flow in patients with Alzheimer's disease and vascular dementia. J. Neurol. Sci. 2003; 216: 119-126.
    • (2003) J. Neurol. Sci. , vol.216 , pp. 119-126
    • Lojkowska, W.1    Ryglewicz, D.2    Jedrzejczak, T.3    Mine, S.4    Jakubowska, T.5    Jarosz, H.6    Bochnyska, A.7
  • 85
    • 0035886436 scopus 로고    scopus 로고
    • Imaging and neurochemical markers for diagnosis and disease progression in ALS
    • Karitzky J, Ludolph AC. Imaging and neurochemical markers for diagnosis and disease progression in ALS. J. Neurol. Sci. 2001; 191: 35-41.
    • (2001) J. Neurol. Sci. , vol.191 , pp. 35-41
    • Karitzky, J.1    Ludolph, A.C.2
  • 86
    • 0028924742 scopus 로고
    • Amyotrophic lateral sclerosis: Correlation of clinical and MR imaging findings
    • Cheung G, Gawel MJ, Cooper PW, Farb RI, Ang LC, Gawel MJ. Amyotrophic lateral sclerosis: correlation of clinical and MR imaging findings. Radiology 1995; 194: 263-270.
    • (1995) Radiology , vol.194 , pp. 263-270
    • Cheung, G.1    Gawel, M.J.2    Cooper, P.W.3    Farb, R.I.4    Ang, L.C.5    Gawel, M.J.6
  • 87
    • 0027397903 scopus 로고
    • Signal loss in the motor cortex on magnetic resonance images in amyotrophic lateral sclerosis
    • Ishikawa T, Nagura H, Yokota T, Yamanouchi H. Signal loss in the motor cortex on magnetic resonance images in amyotrophic lateral sclerosis. Ann. Neurol. 1993; 33: 218-222.
    • (1993) Ann. Neurol. , vol.33 , pp. 218-222
    • Ishikawa, T.1    Nagura, H.2    Yokota, T.3    Yamanouchi, H.4
  • 88
    • 0030714187 scopus 로고    scopus 로고
    • MRI and clinical features in amyotrophic lateral sclerosis
    • Waragai M. MRI and clinical features in amyotrophic lateral sclerosis. Neuroradiology 1997; 39: 847-851.
    • (1997) Neuroradiology , vol.39 , pp. 847-851
    • Waragai, M.1
  • 99
    • 0032102114 scopus 로고    scopus 로고
    • Recovery of N-acetylaspartate in corticomotor neurons of patients with ALS after riluzole therapy
    • Kalra S, Cashman NR, Genge A, Arnold DL. Recovery of N-acetylaspartate in corticomotor neurons of patients with ALS after riluzole therapy. Neuroreport 1998; 9: 1757-1761.
    • (1998) Neuroreport , vol.9 , pp. 1757-1761
    • Kalra, S.1    Cashman, N.R.2    Genge, A.3    Arnold, D.L.4
  • 100
    • 0038147334 scopus 로고    scopus 로고
    • A prospective, randomized, placebo-controlled evaluation of corticoneuronal response to intrathecal BDNF therapy in ALS using magnetic resonance spectroscopy: Feasibility and results
    • Kalra S, Genge A, Arnold DL. A prospective, randomized, placebo-controlled evaluation of corticoneuronal response to intrathecal BDNF therapy in ALS using magnetic resonance spectroscopy: feasibility and results. Amyotroph. Lateral Scler. Other Motor Neuron Disord. 2003; 4: 22-26.
    • (2003) Amyotroph. Lateral Scler. Other Motor Neuron Disord. , vol.4 , pp. 22-26
    • Kalra, S.1    Genge, A.2    Arnold, D.L.3
  • 101
    • 0345700290 scopus 로고    scopus 로고
    • Gabapentin therapy for amyotrophic lateral sclerosis: Lack of improvement in neuronal integrity shown by MR spectroscopy
    • Kalra S, Cashman NR, Caramanos Z, Genge A, Arnold DL. Gabapentin therapy for amyotrophic lateral sclerosis: lack of improvement in neuronal integrity shown by MR spectroscopy. Am. J. Neuroradiol. 2003; 24: 476-480.
    • (2003) Am. J. Neuroradiol. , vol.24 , pp. 476-480
    • Kalra, S.1    Cashman, N.R.2    Caramanos, Z.3    Genge, A.4    Arnold, D.L.5
  • 103
    • 2442570592 scopus 로고    scopus 로고
    • Disease modification in Parkinson's disease
    • Schapira AHV. Disease modification in Parkinson's disease. Lancet Neurol. 2004; 3: 362-368.
    • (2004) Lancet Neurol. , vol.3 , pp. 362-368
    • Schapira, A.H.V.1
  • 104
    • 0842286829 scopus 로고    scopus 로고
    • The sensitivity of 18-fluorodopa positron emisson tomography and magnetic resonance imaging in Parkinson's disease
    • Heiss WD, Hilker R. The sensitivity of 18-fluorodopa positron emisson tomography and magnetic resonance imaging in Parkinson's disease. Eur. J. Neurol. 2004; 11: 5-12.
    • (2004) Eur. J. Neurol. , vol.11 , pp. 5-12
    • Heiss, W.D.1    Hilker, R.2
  • 105
    • 0034078533 scopus 로고    scopus 로고
    • Structural changes of the substantia nigra in Parkinson's disease as revealed by MR imaging
    • Hutchinson M, Raff U. Structural changes of the substantia nigra in Parkinson's disease as revealed by MR imaging. Am. J. Neuroradiol. 2000; 21: 697-701.
    • (2000) Am. J. Neuroradiol. , vol.21 , pp. 697-701
    • Hutchinson, M.1    Raff, U.2
  • 106
    • 1542512004 scopus 로고    scopus 로고
    • Early pathological changes in the parkinsonian brain demonstrated by diffusion tensor MRI
    • Yoshikawa K, Nakata Y, Yamata K, Nakagawa M. Early pathological changes in the parkinsonian brain demonstrated by diffusion tensor MRI. J. Neurol. Neurosurg. Psychiatry 2004; 75: 481-484.
    • (2004) J. Neurol. Neurosurg. Psychiatry , vol.75 , pp. 481-484
    • Yoshikawa, K.1    Nakata, Y.2    Yamata, K.3    Nakagawa, M.4
  • 108
    • 0037012478 scopus 로고    scopus 로고
    • Dopamine transporter brain imaging to assess the effects of pramipexole vs levodopa in Parkinson disease progression
    • The Parkinson Study Group
    • The Parkinson Study Group. Dopamine transporter brain imaging to assess the effects of pramipexole vs levodopa in Parkinson disease progression. JAMA 2002; 287: 1653-1661.
    • (2002) JAMA , vol.287 , pp. 1653-1661
  • 109
    • 0042372649 scopus 로고    scopus 로고
    • Does levodopa slow or hasten the rat eof progression of Parkinson's disease? The results of the ELL-DOPA trial
    • The Parkinson Study Group
    • The Parkinson Study Group. Does levodopa slow or hasten the rat eof progression of Parkinson's disease? The results of the ELL-DOPA trial. Neurology 2003; Suppl. 1: A80-A81.
    • (2003) Neurology , Issue.SUPPL. 1
  • 110
    • 23844456320 scopus 로고    scopus 로고
    • Neuroimaging in Parkinson's disease
    • Brooks DJ. Neuroimaging in Parkinson's disease. Neuro Rx 2004; 1: 243-254.
    • (2004) Neuro Rx , vol.1 , pp. 243-254
    • Brooks, D.J.1
  • 111
    • 2442641602 scopus 로고    scopus 로고
    • Design and chemical synthesis of a magnetic resonance contrast agent with enhanced in vitro binding, high blood-brain barrier permeability and in vivo targeting to Alzheimer's disase amyloid plaques
    • Poduslo JF, Curran GL, Peterson JA, McCormick DJ, Fauq AH, Khan MA, Wengenack T. Design and chemical synthesis of a magnetic resonance contrast agent with enhanced in vitro binding, high blood-brain barrier permeability and in vivo targeting to Alzheimer's disase amyloid plaques. Biochemistry 2004; 43: 6064-6075.
    • (2004) Biochemistry , vol.43 , pp. 6064-6075
    • Poduslo, J.F.1    Curran, G.L.2    Peterson, J.A.3    McCormick, D.J.4    Fauq, A.H.5    Khan, M.A.6    Wengenack, T.7


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