Dynamic NMR studies of perfusion and oxidative metabolism during focal brain activation

Advances in Experimental Medicine and Biology

Volumn 413, Issue , 1997, Pages 195-203

  Frahm, J ^a   Krueger, G ^a   Merboldt, K D ^a   Kleinschmidt, A ^a  

^a Biomedizinische NMR Forschungs GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; LACTIC ACID;

AEROBIC METABOLISM; ARTICLE; BLOOD FLOW VELOCITY; BRAIN BLOOD FLOW; BRAIN FUNCTION; BRAIN METABOLISM; BRAIN OXYGEN CONSUMPTION; GLYCOLYSIS; HUMAN; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL;

EID: 0030859038     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4899-0056-2_21     Document Type: Article

References (21)

1. Bandettini, P.A., Wong, E.C., Hinks, R.S, Tikofsky, R.S., and Hyde, J.S., 1992, Time course EPI of human brain function during task activation, Magn. Reson. Med. 25:390-397.
2. Bandettini, P.A., Jesmanowicz, A., Wong, E.C., Hyde, J.S., 1993, Processing strategies for time-course data sets in functional MRI of the human brain, Magn. Reson. Med. 30:161-173.
3. Blamire, A.M., Ogawa, S., Ugurbil, K., Rothman, D., McCarthy, G., Ellermann, J.M., Hyder, F., Rattner, Z., and Shulman, R.G., 1992, Dynamic mapping of the human visual cortex by high-speed magnetic resonance imaging, Proc. Natl. Acad. Sci. USA. 89:11069-11073.
4. Chen, W., Novotny, E., Zhu, X.H., Rothman, D., and Shulman, R.G., 1993, Localized 1H NMR measurement of glucose consumption in human brain during visual stimulation, Proc. Natl. Acad. Sci. USA 90:9896-9900.
5. Fox, P.T., and Raichle, M.E., 1986, Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects, Proc. Natl. Acad. Sci. USA 83:1140-1144.
6. Fox, P.T., Raichle, M.E., Mintun, M.A., and Dence, C., 1988. Nonoxidative glucose consumption during focal physiologic neural activity. Science 241:462-464.
7. Frahm, J., Michaelis, T., Merboldt, K.D., Bruhn, H., Gyngell, M.L., and Haenicke, W., 1990, Improvements in localized 1H-NMR spectroscopy of human brain. Water suppression, short echo times, and 1 mL resolution, J. Magn. Reson. 90:464-73.
8. Frahm, J., Bruhn, H., Merboldt, K.D., and Haenicke, W., 1992. Dynamic MRI of human brain oxygenation during rest and photic stimulation, J. Magn. Reson. Imag. 2:501-505.
9. Frahm, J., Merboldt, K.D., and Haenicke, W., 1993, Functional MRI of human brain activation at high spatial resolution, Magn. Reson. Med. 29:139-144.
10. Frahm, J., Merboldt, K.D., Haenicke, W., Kleinschmidt, A., and Boecker, H., 1994, Brain or vein - oxygenation or flow? On signal physiology in functional MRI of human brain activation, NMR Biomed. 7:45-53.
11. Frahm, J., Krueger, G., Merboldt, K.D., and Kleinschmidt, A., 1995, Dynamic uncoupling and recoupling of perfusion and oxidative metabolism during focal brain activation in man, Magn. Reson. Med. , in press.
12. Hathout, G.M., Kirlew, K.A.T., So, G.J.K., Hamilton, D.R., Zhang, J.X., Sinha, U., Sinha, S., Sayre, J., Gozal, D., Harper, R.M., and Lufkin, R.B., 1994. MR imaging signal response to sustained stimulation in human visual cortex, J. Magn. Reson. Imag. 4:537-543.
13. Kleinschmidt, A., Requardt, M., Merboldt, K.D., and Frahm, J., 1995, On the use of temporal correlation coefficients for magnetic resonance mapping of functional brain activation. Individualized thresholds and spatial response delineation, Intern. J. Imag. Sci. Technol., in press.
14. Krueger, G., 1995, Entwicklung und Anwendung der funktioneilen NMR-Tomografie und Spektroskopie zur Untersuchung des menschlichen Hirns in vivo, Diploma Thesis, Braunschweig.
15. Kwong, K.K., Belliveau, J.W., Chester, D.A., Goldberg, I.E., Weisskoff, R.M., Poncelet, B.P., Kennedy, D.N., Hoppel, B.E., Cohen, M.S., Turner, R., Cheng, H.M., Brady, T.J., and Rosen, B.R., 1992, Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation, Proc. Natl. Acad. Sci. USA 89:5675-5679.
16. Merboldt, K.D., Bruhn, H., Haenicke, W., Michaelis, T., and Frahm, J., 1992, Decrease of glucose in the human visual cortex during photic stimulation, Magn. Reson. Med. 25:187-194.
17. Michaelis, T., Merboldt, K.D., Bruhn, H., Haenicke, W., and Frahm, J., 1993, Absolute concentrations of metabolites in the adult human brain in vivo: quantification of localized proton MR spectra. Radiology 187:219-27.
18. Ogawa, S., Tank, D.W., Menon, R., Ellermann, J.M., Kim, S.G., Merkle, H., and Ugurbil, K., 1992. Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging, Proc. Natl. Acad. Sci. USA 89:5951-5955.
19. Pellerin, L., and Magistretti, P.J., 1994, Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization, Proc. Natl. Acad. Sci. USA 91:10625-10629.
20. Prichard, J., Rothman, D., Novotny, E., Petroff, O., Kuwabara, T., Avison, M., Howseman, A., Hanstock, C., and Shulman, R.G., 1992, Lactate rise detected by 1H NMR in human visual cortex during physiologic stimulation, Proc. Natl. Acad. Sci. USA 88:5829-5831.
21. Provencher, S.W., 1993, Estimation of metabolite concentrations from localized in vivo NMR spectra, Magn. Reson. Med. 30:672-679.