In vivo 1H NMR spectroscopy of individual human brain metabolites at moderate field strengths

Magnetic Resonance Imaging

Volumn 21, Issue 10, 2003, Pages 1295-1302

  Trabesinger, Andreas H ^a   Meier, Dieter ^a   Boesiger, Peter ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

1H MRS; Human brain; Spectral editing; Strong coupling

Indexed keywords

BRAIN METABOLISM; BRAIN TISSUE; HUMAN; IN VIVO STUDY; METABOLITE; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; REVIEW; THEORY; BRAIN; BRAIN LEVEL; HISTOLOGY; METABOLISM; METHODOLOGY;

DIAGNOSTIC AGENT;

BRAIN; BRAIN CHEMISTRY; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY;

EID: 1042277841     PISSN: 0730725X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mri.2003.08.029     Document Type: Article

References (68)

1. Lauterbur P.C. Image formation by induced local interactions - examples employing nuclear magnetic resonance. Nature. 242:1973;190-191.
2. Hoult D.I., Busby S.J.W., Gadian D.G., Radda G.K., Richards R.E., Seeley P.J. Observation of tissue metabolites using P-31 nuclear magnetic resonance. Nature. 252:1974;285-287.
3. Govindaraju V., Young K., Maudsley A.A. Proton NMR chemical shifts and coupling constants for brain metabolites. NMR Biomed. 13:2000;129-153.
4. Le Belle J.E., Harris N.G., Williams S.R., Bhakoo K.K. A comparison of cell and tissue extraction techniques using high-resolution H-1-NMR spectroscopy. NMR Biomed. 15:2002;37-44.
5. Gruetter R., Weisdorf S.A., Rajanayagan V., Terpstra M., Merkle H., Truwit C.L., Garwood M., Nyberg S.L., Ugurbil K. Resolution improvements in in vivo H-1 NMR spectra with increased magnetic field strength. J Magn Reson. 135:1998;260-264.
6. Bottomley P.A., Edelstein W.A., Foster T.H., Adams W.A. Invivo solvent-suppressed localized hydrogen nuclear magnetic resonance spectroscopy - a window to metabolism. Proc Natl Acad Sci USA. 82:1985;2148-2152.
7. Burtscher I.M., Holtas S. Proton MR spectroscopy in clinical routine. J Magn Reson Imaging. 13:(4):2001;560-567.
8. Thomas M.A., Ryner L.N., Mehta M.P., Turski P.A., Sorenson J.A. Localized 2D J-resolved H-1 MR spectroscopy of human brain tumors in vivo. J Magn Reson Imaging. 6:1996;453-459.
9. Thomas M.A., Yue K., Binesh N., Davanzo P., Kumar A., Siegel B., Frye M., Curran J., Lufkin R., Martin P., et al. Localized two-dimensional shift correlated MR spectroscopy of human brain. Magn Reson Med. 46:2001;58-67.
10. Provencher S.W. Estimation of metabolite concentrations from localized in-vivo proton NMR spectra. Magn Reson Med. 30:1993;672-679.
11. Behar K.L., Rothman D.L., Spencer D.D., Petroff O.A.C. Analysis of macromolecule resonances in H-1-NMR spectra of human brain. Magn Reson Med. 32:1994;294-302.
12. Seeger U., Mader I., Nagele T., Grodd W., Lutz O., Klose U. Reliable detection of macromolecules in single-volume H-1 NMR spectra of the human brain. Magn Reson Med. 45:2001;948-954.
13. Hofmann L., Slotboom J., Boesch C., Kreis R. Characterization of the macromolecule baseline in localized H- 1-MR spectra of human brain. Magn Reson Med. 46:2001;855-863.
14. Mader I., Seeger U., Karitzky J., Erb M., Schick F., Klose U. Proton magnetic resonance spectroscopy with metabolite nulling reveals regional differences of macromolecules in normal human brain. J Magn Reson Imaging. 16:2002;538-546.
15. Ernst R.R., Bodenhausen G., Wokaun A. Principles of nuclear magnetic resonance in one and two dimensions. 1987;Oxford University Press, Oxford.
16. Bottomly P.A. Spatial localization in NMR spectroscopy in vivo. Ann NY Acad Sci. 508:1987;333-348.
17. Frahm J., Merboldt K.D., Hanicke W. Localized proton spectroscopy using stimulated echoes. J Magn Reson. 72:1987;502.
18. Thompson R.B., Allen P.S. Sources of variability in the response of coupled spins to the PRESS sequence and their potential impact on metabolite quantification. Magn Reson Med. 41:1999;1162-1169.
19. Ordidge R.J., Connelly A., Lohman J.A.B. Image-selected in vivo spectroscopy (ISIS) - a new technique for spatially selective NMR-spectroscopy. J Magn Reson. 66:1986;283-294.
20. de Graaf R.A., Rothman D.L. In vivo detection and quantification of scalar coupled H-1 NMR resonances. Concepts Magn Reson. 13:2001;32-76.
21. Allen P.S., Thompson R.B., Wilman A.H. Metabolite-specific NMR spectroscopy in vivo. NMR Biomed. 10:1997;435-444.
22. Sørensen O.W., Eich G.W., Levitt M.H., Bodenhausen G., Ernst R.R. Product operator formalism for the description of NMR pulse experiments. Prog NMR Spectrosc. 63:1983;92.
23. Pecker K.J., Wright K.M. The use of a single-spin operator basis set in the NMR spectroscopy of scalar-coupled spin systems. Mol Phys. 50:1983;797-813.
24. Van DeVen F.J.M., Hilbers C.W. A simple formalism for the description of multiple-pulse experiments. Application to a weakly coupled two-spin (I = 1/2) system. J Magn Reson. 54:1983;512-520.
25. Warren W.S., Richter W., Andreotti A.H., Farmer B.T. Generation of impossible cross-peaks between bulk water and biomolecules in solution NMR. Science. 262:1993;2005-2009.
26. Lee S., Richter W., Vathyam S., Warren W.S. Quantum treatment of the effects of dipole-dipole interactions in liquid nuclear magnetic resonance. J Chem Phys. 105:1996;874-900.
27. Wilman A.H., Allen P.S. Observing N-acetyl aspartate via both its N-acetyl and its strongly coupled aspartate groups in in vivo proton magnetic resonance spectroscopy. J Magn Reson. B113:1996;203-213.
28. Hanstock C.C., Coupland N.J., Allen P.S. GABA X-2 multiplet measured pre- and post administration of vigabatrin in human brain. Magn Reson Med. 48:2002;617-623.
29. Hennig J., Thiel T., Speck O. Improved sensitivity to overlapping multiplet signals in in vivo proton spectroscopy using a multiecho volume selective (CPRESS) experiment. Magn Reson Med. 37:1997;816-820.
30. Allerhand A. Analysis of Carr-Purcell spin-echo NMR experiments on multiple-spin systems. I. The effect of homonuclear coupling. J Chem Phys. 44:1966;1-9.
31. Garwood M., DelaBarre L. The return of the frequency sweep designing adiabatic pulses for contemporary NMR . J Magn Reson. 153:2001;155-177.
32. 1H NMR measurements of γ-aminobutyric acid in human brain in vivo. Proc Natl Acad Sci USA 1993;90:5662-6.
33. 1H spectroscopic measurements of γ-aminobutyric acid, glutamate and glutamine in human brain. Epilepsia. 36:1995;457-464.
34. Petroff O.A.C., Rothman D.L., Behar K.L., Lamoureux D., Mattson R.H. The effect of gabapentin on brain GABA in patients with epilepsy. Ann Neurol. 39:1996;95-99.
35. Bunse M., Jung W.I., Schick F., Dietze G.J., Lutz O. HOPE, a new lactate editing method. J Magn Reson. B109:1995;270-274.
36. Keltner J.R., Wald L.L., Christensen J.D., Maas L.C., Moore C.M., Cohen B.M., Renshaw P.F. A technique for detecting GABA in the human brain with PRESS localization and optimized refocusing spectral editing radiofrequency pulses. Magn Reson Med. 36:1996;458-461.
37. Henry P.G., Dautry C., Hantraye P., Bloch G. Brain GABA editing without macromolecule contamination. Magn Reson Med. 45:2001;517-520.
38. Terpstra M., Ugurbil K., Gruetter R. Direct in vivo measurement of human cerebral GABA concentration using MEGA-editing at 7 Tesla. Magn Reson Med. 47:2002;1009-1012.
39. Takegoshi K., Ogura K., Hikichi K. A perfect spin echo in a weak homonuclear J-coupled two spin-1/2 system. J Magn Reson. 84:1989;611-615.
40. van Zijl P.C.M., Moonen C.T.W., von Kienlin M. Homonuclear J refocussing in echo spectroscopy. J Magn Reson. 89:1990;28-37.
41. Trabesinger A.H., Mueller D.C., Boesiger P. Single-quantum coherence filter for strongly coupled spin systems for localized H-1 NMR spectroscopy. J Magn Reson. 145:2000;237-245.
42. Wang Z.Y.J., Bergqvist C., Hunter J.V., Jin D.Z., Wang D.J.Y., Wehrli S., Zimmerman R.A. In vivo measurement of brain metabolites using two-dimensional double-quantum MR spectroscopy - exploration of GABA levels in a ketogenic diet. Magn Reson Med. 49:2003;615-619.
43. Bax A., De Jong P.G., Mehlkopf A.F., Smidt J. Separation of the different orders of NMR multiple-quantum transitions by the use of pulsed field gradients. Chem Phys Lett. 69:1980;567-570.
44. McKinnon G.C., Boesiger P. Localized double-quantum filter and correlation spectroscopy experiments. Magn Reson Med. 6:1988;334-343.
45. Sotak H., Freeman D.M., Hurd R.E. The unequivocal determination of in vivo lactic acid using two-dimensional double-quantum-coherence-transfers spectroscopy. J Magn Reson. 78:1988;355-361.
46. Knüttel A., Kimmich R. Double-quantum filtered volume-selective NMR spectroscopy. Magn Reson Med. 10:1989;404-410.
47. Crozier S., Brereton I.M., Rose S.E., Field J., Shannon G.F., Doddrell D.M. Application of volume-selected, two-dimensional multiple-quantum editing in vivo to observe cerebral metabolites. Magn Reson Med. 16:1990;496-502.
48. 1H NMR spectroscopy. J Magn Reson. 93:1991;485-496.
49. de Graaf R.A., Luo Y., Terpstra M., Garwood M. Spectral editing with adiabatic pulses. J Magn Reson Series B. 109:1995;184-193.
50. Thompson R.B., Allen P.S. A new multiple quantum filter design procedure for use on strongly coupled spin systems found in vivo its application to glutamate . Magn Reson Med. 39:1998;762-771.
51. Lei H., Peeling J. Off-resonance effects of the radiofrequency pulses used in spectral editing with double-quantum coherence transfer. J Magn Reson. 144:2000;89-95.
52. Jouvensal L., Carlier P.G., Bloch G. Practical implementation of single-voxel double-quantum editing on a whole-body NMR spectrometer localized monitoring of lactate in the human leg during and after exercise . Magn Reson Med. 36:1996;487-490.
53. Keltner J.R., Wald L.L., Frederick BdB, Renshaw P.F. In vivo detection of GABA in human brain using a localized double-quantum filter technique. Magn Reson Med. 37:1997;366-371.
54. Trabesinger A.H., Weber O.M., Duc C.O., Boesiger P. Detection of glutathione in the human brain in vivo by means of double quantum coherence filtering. Magn Reson Med. 42:1999;283-289.
55. + measurement at 1.5T using a PRESS-localized double quantum filter. Magn Reson Med. 48:2002;233-241.
56. Lei H., Dunn J. The effects of slice-selective excitation/refocusing in localized spectral editing with gradient-selected double- quantum coherence transfer. J Magn Reson. 150:2001;17-25.
57. Wilman A.H., Allen P.S. In vivo NMR detection for γ-aminobutyric acid, utilizing proton spectroscopy and coherence-pathway filtering with gradients. J Magn Reson. B101:1993;165-171.
58. Wilman A.H., Allen P.S. Yield enhance of a double-quantum filter sequence designed for the edited detection of GABA. J Magn Reson. B109:1995;169-174.
59. Trimble L.A., Shen J.F., Wilman A.H., Allen P.S. Lactate editing by means of selective-pulse filtering of both zero- and double-quantum coherence signals. J Magn Reson. 86:1990;191-198.
60. Shen J.F., Allen P.S. Reduced length for double-quantum filtering sequences. J Magn Reson. 92:1991;398-403.
61. van Dijk J.E., Mehlkopf A.F., Boveé W.M.M.J. Comparison of double and zero quantum NMR editing techniques for in vivo use. NMR Biomed. 5:1992;75-86.
62. Shen J., Rothman D.L., Brown P. In vivo GABA editing using a novel doubly selective multiple quantum filter. Magn Reson Med. 47:2002;447-454.
63. Trabesinger A.H., Boesiger P. Improved selectivity of double quantum coherence filtering for the detection of glutathione in the human brain in vivo. Magn Reson Med. 45:2001;708-710.
64. Keltner J.R., Wald L.L., Ledden P.J., Chen Y.C.I., Matthews R.T., Kuestermann E., Baker J.R., Rosen B.R., Jenkins B.G. Localized double-quantum filter for the in vivo detection of brain glucose. Magn Reson Med. 39:1998;651-656.
65. de Graaf R.A., Dijkhuizen R.M., Biessels G.J., Braun K.P.J., Nicolay K. In vivo glucose detection by homonuclear spectral editing. Magn Reson Med. 43:2000;621-626.
66. Hardy D.L., Norwood T.J. Spectral editing technique for the in vitro and in vivo detection of taurine. J Magn Reson. 133:1998;70-78.
67. Lei H., Peeling J. A localized double-quantum filter for in vivo detection of taurine. Magn Reson Med. 42:1999;454-460.
68. Lei H., Peeling J. Simultaneous spectral editing for γ- aminobutyric acid and taurine using double quantum coherence transfer. J Magn Reson. 143:2000;95-100.