New insights from the structure-function analysis of the catalytic region of human platelet phosphodiesterase 3A: A role for the unique 44-amino acid insert

Journal of Biological Chemistry

Volumn 281, Issue 39, 2006, Pages 29236-29244

  Hung, Su Hwi ^a   Zhang, Wei ^a   Pixley, Robin A ^a   Jameson, Bradford A ^b   Yu, Chu Huang ^c   Colman, Roberta F ^c   Colman, Robert W ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF DELAWARE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONAL CHANGE; HUMAN PHOSPHODIESTERASE 3A (PDE3A); PLATELET FUNCTION; SUBSTRATE-BINDING SITE;

AMINO ACIDS; BINDING ENERGY; BIOCATALYSTS; BIOCHEMISTRY; CARBON; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MUTAGENESIS;

ENZYMES;

AMINO ACID; CYCLIC AMP; CYSTEINE; MUTANT PROTEIN; PHOSPHODIESTERASE III; TYROSINE;

AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; CELL ISOLATION; CONTROLLED STUDY; ENZYME ACTIVITY; GENE INSERTION; GENE MUTATION; HUMAN; HUMAN CELL; KINETICS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; STRUCTURAL HOMOLOGY; THROMBOCYTE FUNCTION;

3',5'-CYCLIC-AMP PHOSPHODIESTERASES; 3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; AMINO ACID SEQUENCE; CATALYSIS; CATALYTIC DOMAIN; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 3; HUMANS; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPSIN; TYROSINE;

EID: 33749375162     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M606558200     Document Type: Article

References (32)

1. Meijer, A., Verheugt, F. W., Werter, C. J., Lie, K. I., van der Pol, J. M., and van Eenige, M. J. (1993) Circulation 87, 1524-1530
2. Jarvis, B., and Simpson, K. (2000) Drugs 60, 347-377
3. Gum, P. A., Kottke-Marchant, K., Welsh, P. A., White, J., and Topol, E. J. (2003) J. Am. Coll. Cardiol. 41, 961-965
4. Matetzky, S., Shenkman, B., Guetta, V., Shechter, M., Bienart, R., Goldenberg, I., Novikov, I., Pres, H., Savion, N., Varon, D., and Hod, H. (2004) Circulation 109, 3171-3175
5. Movsesian, M. A. (2003) J. Card. Fail. 9, 475-480
6. Levy, J. H., Bailey, J. M., and Deeb, G. M. (2002) Ann. Thorac. Surg. 73, 325-330
7. Beebe, H. G., Dawson, D. L., Cutler, B. S., Herd, J. A., Strandness, D. E., Jr., Bortey, E. B., and Forbes, W. P. (1999) Arch. Intern. Med. 159, 2041-2050
8. Xu, R. X., Hassell, A. M., Vanderwall, D., Lambert, M. H., Holmes, W. D., Luther, M. A., Rocque, W. J., Milburn, M. V., Zhao, Y., Ke, H., and Nolte, R. T. (2000) Science 288, 1822-1825
9. Lee, M. E., Markowitz, J., Lee, J. O., and Lee, H. (2002) FEBS Lett. 530, 53-58
10. Huai, Q., Liu, Y., Francis, S. H., Corbin, J. D., and Ke, H. (2004) J. Biol. Chem. 279, 13095-13101
11. Huai, Q., Wang, H., Zhang, W., Colman, R. W., Robinson, H., and Ke, H. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 9624-9629
12. Zhang, K. Y., Card, G. L., Suzuki, Y., Artis, D. R., Fong, D., Gillette, S., Hsieh, D., Neiman, J., West, B. L., Zhang, C., Milburn, M. V., Kim, S. H., Schlessinger, J., and Bollag, G. (2004) Mol. Cell 15, 279-286
13. Scapin, G., Patel, S. B., Chung, C., Varnerin, J. P., Edmondson, S. D., Mastracchio, A., Parmee, E. R., Singh, S. B., Becker, J. W., Van der Ploeg, L. H., and Tota, M. R. (2004) Biochemistry 43, 6091-6100
14. Tang, K. M., Jang, E. K., and Haslam, R. J. (1997) Biochem. J. 323, 217-224
15. Hung, S. H., Madhusoodanan, K. S., Beres, J. A., Boyd, R. L., Baldwin, J. L., Zhang, W., Colman, R. W., and Colman, R. F. (2002) Bioorg. Chem. 30, 16-31
16. Cheung, P. P., Xu, H., McLaughlin, M. M., Ghazaleh, F. A., Livi, G. P., and Colman, R. W. (1996) Blood 88, 1321-1329
17. Zhang, W., and Colman, R. W. (2000) Blood 95, 3380-3386
18. Zhang, W., Ke, H., Tretiakova, A. P., Jameson, B., and Colman, R. W. (2001) Protein Sci. 10, 1481-1489
19. Grant, P. G., and Colman, R. W. (1984) Biochemistry 23, 1801-1807
20. Varnerin, J. P., Chung, C. C., Patel, S. B., Scapin, G., Parmee, E. R., Morin, N. R., MacNeil, D. J., Cully, D. F., Van der Ploeg, L. H., and Tota, M. R. (2004) Protein Expression Purif. 35, 225-236
21. Cheung, P. P., Yu, L., Zhang, H., and Colman, R. W. (1998) Arch. Biochem. Biophys. 360, 99-104
22. Lee, T. T., Worby, C., Dixon, J. E., and Colman, R. F. (1997) J. Biol. Chem. 272, 458-465
23. Lee, T. T., Worby, C., Bao, Z. Q., Dixon, J. E., and Colman, R. F. (1998) Biochemistry 37, 8481-8489
24. Hung, S. H., Madhusoodanan, K. S., Boyd, R. L., Baldwin, J. L., Colman, R. F., and Colman, R. W. (2002) Biochemistry 41, 2962-2969
25. Mseeh, F., Colman, R. F., and Colman, R. W. (2000) Thromb. Res. 98, 395-401
26. Grant, P. G., DeCamp, D. L., Bailey, J. M., Colman, R. W., and Colman, R. F. (1990) Biochemistry 29, 887-894
27. Omburo, G. A., Torphy, T. J., Scott, G., Jacobitz, S., Colman, R. F., and Colman, R. W. (1997) Blood 89, 1019-1026
28. Huntington, J. A., Read, R. J., and Carrell, R. W. (2000) Nature 407, 923-926
29. Ye, S., Cech, A. L., Belmares, R., Bergstrom, R. C., Tong, Y., Corey, D. R., Kanost, M. R., and Goldsmith, E. J. (2001) Nat. Struct. Biol. 8, 979-983
30. Baldwin, E. T., Bhat, T. N., Gulnik, S., Hosur, M. V., Sowder, R. C., 2nd, Cachau, R. E., Collins, J., Silva, A. M., and Erickson, J. W. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 6796-6800
31. Bott, R., Subramanian, E., and Davies, D. R. (1982) Biochemistry 21, 6956-6962
32. James, M. N., Sielecki, A., Salituro, F., Rich, D. H., and Hofmann, T. (1982) Proc. Natl. Acad. Sci. U. S. A. 79, 6137-6141