Mechanism of inhibition of TREK-2 (K2P10.1) by the G q-coupled M3 muscarinic receptor

American Journal of Physiology - Cell Physiology

Volumn 291, Issue 4, 2006, Pages

  Kang, Dawon ^a,b   Han, Jaehee ^b   Kim, Donghee ^a  

^a ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

^b Gyeongsang National University School of Medicine   (South Korea)

Author keywords

Background potassium conductance; Gq protein; Phosphatidylinositol 4,5 bisphosphate; Protein kinase C; Two pore domain potassium channel

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; ACETYLCHOLINE; BISINDOLYLMALEIMIDE; CALCIUM; DIACYLGLYCEROL; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); MUSCARINIC M3 RECEPTOR; PHOSPHATIDIC ACID; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; POTASSIUM CHANNEL; PROTEIN TREK 2; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL CELL; ARTICLE; CELL ADHESION; CONTROLLED STUDY; DRUG INHIBITION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN PHOSPHORYLATION; WHOLE CELL;

ACETYLCHOLINE; ANIMALS; CALCIUM; CERCOPITHECUS AETHIOPS; COS CELLS; DIGLYCERIDES; ENZYME INHIBITORS; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; INDOLES; MALEIMIDES; MUTATION; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; PHOSPHOLIPASE C; POTASSIUM CHANNELS, TANDEM PORE DOMAIN; PROTEIN KINASE C; RATS; RECEPTOR, MUSCARINIC M3; TRANSFECTION;

EID: 33749350486     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00047.2006     Document Type: Article

References (41)

1. + channel family. J Biol Chem 275: 17412-17419, 2000.
2. 2+ current and M current in rat sympathetic neurons. Proc Natl Acad Sci USA 89: 9544-9548, 1992.
3. Bofill-Cardona E, Vartian N, Nanoff C, Freissmuth M, and Boehm S. Two different signaling mechanisms involved in the excitation of rat sympathetic neurons by uridine nucleotides. Mol Pharmacol 57: 1165-1172, 2000.
4. + channels. EMBO J 22: 5403-5411, 2003.
5. + channels in a receptor-specific manner. Proc Natl Acad Sci USA 102: 4643-4648, 2005.
6. Czirjak G, Petheo GL, Spat A, and Enyedi P. Inhibition of TASK-1 potassium channel by phospholipase C. Am J Physiol Cell Physiol 281: C700-C708, 2001.
7. Delmas P, Abogadie FC, Dayrell M, Haley JE, Milligan G, Caulfield MP, Brown DA, and Buckley NJ. G-proteins and G-protein subunits mediating cholinergic inhibition of N-type calcium currents in sympathetic neurons. Eur J Neurosci 10: 1654-1666, 1998.
8. 3 pathways in neurons. Neuron 34: 209-220, 2002.
9. Du X, Zhang H, Lopes C, Mirshahi T, Rohacs T, and Logothetis DE. Characteristic interactions with phosphatidylinositol 4,5-bisphosphate determine regulation of Kir channels by diverse modulators. J Biol Chem 279: 37271-37281, 2004.
10. 2+- and ATP hydrolysis-dependent mechanisms. J Biol Chem 280: 30814-30828, 2005.
11. + channels. J Gen Physiol 122: 17-31, 2003.
12. + channel in cultured rat brain astrocytes. Brain Res 931: 56-67, 2002.
13. Goldstein SA, Bockenhauer D, O'Kelly I, and Zilberberg N. Potassium leak channels and the KCNK family of two-P-domain subunits. Nat Rev Neurosci 2: 175-184, 2001.
14. Gu W, Schlichthörl G, Hirsch JR, Engels H, Karschin C, Karschin A, Derst C, Steinlein OK, and Daut J. Expression pattern and functional characteristics of two novel splice variants of the two-pore-domain potassium channel TREK-2. J Physiol 539: 657-668, 2002.
15. Han J, Truell J, Gnatenco C, and Kim D. Characterization of four types of background potassium channels in rat cerebellar granule neurons. J Physiol 542: 431-444, 2002.
16. 2+ requirement, and regulation of M current. J Gen Physiol 126: 243-262, 2005.
17. 2 and its stabilization by Gβγ. Nature 391: 803-806, 1998.
18. Kang D, Choe C, and Kim D. Functional expression of TREK-2 in insulin-secreting MIN6 cells. Biochem Biophys Res Commun 323: 323-331, 2004.
19. + channels TREK-2 and TRAAK. J Physiol 564: 103-116, 2005.
20. + channel in heart cells: activation by arachidonic acid. J Gen Physiol 100: 1-20, 1992.
21. Kim D. Physiology and pharmacology of two-pore domain potassium channels. Curr Pharm Des 11: 2717-2736, 2005.
22. Kim D and Clapham DE. Potassium channels in cardiac cells activated by arachidonic acid and phospholipids. Science 244: 1174-1176, 1989.
23. + channels in cultured rat neuronal cells. J Physiol 484: 643-660, 1995.
24. + channel family. J Biol Chem 275: 9340-9347, 2000.
25. i. Pflügers Arch 442: 952-960, 2001.
26. +-current desensitization. Nat Cell Biol 2: 507-514, 2000.
27. Lesage F and Lazdunski M. Molecular and functional properties of two-pore-domain potassium channels. Am J Physiol Renal Physiol 279: F793-F801, 2000.
28. q protein-coupled receptors. J Biol Chem 275: 28398-28405, 2000.
29. + channel open probability by phosphatidylinositol 4,5-bisphosphate. J Neurosci 25: 9825-9835, 2005.
30. + channels. J Physiol 564: 117-129, 2005.
31. 2+ channels through phosphatidylinositol 3-kinase. J Biol Chem 280: 40347-40354, 2005.
32. Medhurst AD, Rennie G, Chapman CG, Meadows H, Duckworth MD, Kelsell RE, Gloger II, and Pangalos MN. Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery. Brain Res Mol Brain Res 86: 101-114, 2001.
33. Murbartian J, Lei Q, Sando JJ, and Bayliss DA. Sequential phosphorylation mediates receptor- and kinase-induced inhibition of TREK-1 background potassium channels. J Biol Chem 280: 30175-30184, 2005.
34. Ordway RW, Walsh JV Jr, and Singer JJ. Arachidonic acid and other fatty acids directly activate potassium channels in smooth muscle cells. Science 244: 1176-1179, 1989.
35. + channels. Trends Neurosci 24: 339-346, 2001.
36. + channel. EMBO J 17: 4283-4290, 1998.
37. Sorensen SD, Linseman DA, McEwen EL, Heacock AM, and Fisher SK. A role for a wortmannin-sensitive phosphatidylinositol-4-kinase in the endocytosis of muscarinic cholinergic receptors. Mol Pharmacol 53: 827-836, 1998.
38. Suh BC and Hille B. Recovery from muscarinic modulation of M current channels requires phosphatidylinositol 4,5-bisphosphate synthesis. Neuron 35: 507-520, 2002.
39. Talley EM, Solorzano G, Lei Q, Kim D, and Bayliss DA. CNS distribution of members of the two-pore-domain (KCNK) potassium channel family. J Neurosci 21: 7491-7505, 2001.
40. Winks JS, Hughes S, Filippov AK, Tatulian L, Abogadie FC, Brown DA, and Marsh SJ. Relationship between membrane phosphatidylinositol-4,5-bisphosphate and receptor-mediated inhibition of native neuronal M channels. J Neurosci 25: 3400-3413, 2005.
41. 2 activates KCNQ channels, and its hydrolysis underlies receptor-mediated inhibition of M currents. Neuron 37: 963-975, 2003.