Spatiotemporal regulation of the p42/p44 MAPK pathway

Biology of the Cell

Volumn 93, Issue 1-2, 2001, Pages 71-79

  Volmat, Véronique ^a   Pouysségur, Jacques ^a  

^a CENTRE ANTOINE LACASSAGNE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN P42; PROTEIN P44;

CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; REGULATORY MECHANISM; REVIEW;

EID: 0034765383     PISSN: 02484900     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0248-4900(01)01129-7     Document Type: Review

References (44)

1. Two co-existing mechanisms for nuclear import of MAP kinase: Passive diffusion of a monomer and active transport of a dimer
2. Nuclear export of MAP kinase (ERK) involves a MAP kinase kinase (MEK)-dependent active transport mechanism
3. Stress-induced map kinase Hog1 is part of transcription activation complexes
4. Inactivation of p42 MAP kinase by protein phosphatase 2A and a protein tyrosine phosphatase, but not CL100, in various cell lines
5. Repression of yeast Ste12 transcription factor by direct binding of unphosphorylated Kss1 MAPK and its regulation by the Ste7 MEK
6. Differential regulation of transcription: Repression by unactivated mitogen-activated protein kinase Kss1 requires the Dig1 and Dig2 proteins
7. Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2
8. The dual specificity mitogen-activated protein kinase phosphatase-1 and -2 are induced by the p42/p44MAPK cascade
9. Constitutive MAP kinase phosphatase (MKP-1) expression blocks G1 specific gene transcription and S-phase entry in fibroblasts
10. Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation
11. Growth factor-stimulated MAP kinase induces rapid retrophosphorylation and inhibition of MAP kinase kinase (MEK1)
12. Identification of MAP kinase domains by redirecting stress signals into growth factor responses
13. Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry
14. Dual specificity phosphatases: A gene family for control of MAP kinase function
15. Catalytic activation of the phosphatase MKP-3 by ERK2 mitogen-activated protein kinase
16. Nuclear localization and regulation of erk- and rsk-encoded protein kinases
17. Inhibitory and activating functions for MAPK Kss1 in the S. cerevisiae filamentous-growth signalling pathway
18. Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells
19. Regulation of nuclear localization during signaling
20. Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation
21. Docking sites on substrate proteins direct extracellular signal-regulated kinase to phosphorylate specific residues
22. A novel regulatory mechanism in the mitogen-activated protein (MAP) kinase cascade. Role of nuclear export signal of MAP kinase kinase
23. Interaction of MAP kinase with MAP kinase kinase: Its possible role in the control of nucleocytoplasmic transport of MAP kinase
24. Phosphorylation and association with the transcription factor Atf1 regulate localization of Spc1/Sty1 stress-activated kinase in fission yeast
25. Two protein-tyrosine phosphatases inactivate the osmotic stress response pathway in yeast by targeting the mitogen-activated protein kinase, Hog1
26. Protein phosphatases and the regulation of mitogen-activated protein kinase signalling
27. Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation
28. The p42/p44 MAP kinase pathway prevents apoptosis induced by anchorage and serum removal
29. Growth factor-induced p42/p44 MAPK nuclear translocation and retention requires both MAPK activation and neosynthesis of nuclear anchoring proteins
30. Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts
31. MAP kinases with distinct inhibitory functions impart signaling specificity during yeast differentiation
32. Two protein tyrosine phosphatases, Ptp2 and Ptp3, modulate the subcellular localization of the Hog1 MAP kinase in yeast
33. Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation
34. PTP-SL and STEP protein tyrosine phosphatases regulate the activation of the extracellular signal-regulated kinases ERK1 and ERK2 by association through a kinase interaction motif
35. Kinase activity-dependent nuclear export opposes stress-induced nuclear accumulation and retention of Hog1 mitogen-activated protein kinase in the budding yeast Saccharomyces cerevisiae
36. Docking domains and substrate-specificity determination for MAP kinases
37. Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo
38. A conserved docking motif in MAP kinases common to substrates, activators and regulators
39. Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions
40. The nucleus, a site for signal termination by sequestration and inactivation of p42/p44 MAP Kinases
41. Mitogen-activated protein kinase: Conservation of a three-kinase module from yeast to human
42. Involvement of the activation loop of erk in the detachment from cytosolic anchoring
43. Hydrophobic as well as charged residues in both mek1 and erk2 are important for their proper docking
44. Interaction of mitogen-activated protein kinases with the kinase interaction motif of the tyrosine phosphatase PTP-SL provides substrate specificity and retains ERK2 in the cytoplasm