p38 MAP kinase inhibitors. Part 6: 2-Arylpyridazin-3-ones as templates for inhibitor design

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 22, 2006, Pages 5809-5813

  Natarajan, Swaminathan R ^a   Heller, Stephen T ^a   Nam, Kiyean ^a   Singh, Suresh B ^a   Scapin, Giovanna ^a   Patel, Sangita ^a   Thompson, James E ^a   Fitzgerald, Catherine E ^a   O'Keefe, Stephen J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

MAP Kinase; p38 Inhibitors

Indexed keywords

3,4 DIHYDROPYRIDO[4,3 D]PYRIMIDAZIN 2 ONE; 5 (2,6 DICHLOROPHENYL) 2 (2,4 DIFLUOROPHENYLTHIO)PYRIMIDO[1,6 B]PYRIDAZIN 6 ONE; GLYCINE; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; PYRIDAZINE DERIVATIVE; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION;

BINDING SITES; DRUG DESIGN; ENZYME INHIBITORS; GLYCINE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRIDAZINES; STRUCTURE-ACTIVITY RELATIONSHIP; TYROSINE;

EID: 33749268005     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.08.074     Document Type: Article

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24. Coordinates for the X-ray crystal structure have been deposited. Accession codes are rscb038982 and PDB ID is 2I0H.