p38 MAP kinase inhibitors. Part 3: SAR on 3,4-dihydropyrimido[4,5-d]pyrimidin-2-ones and 3,4-dihydropyrido[4,3-d]pyrimidin-2-ones

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 16, 2006, Pages 4400-4404

  Natarajan, Swaminathan R ^a   Wisnoski, David D ^a   Thompson, James E ^a   O'Neill, Edward A ^a   O'Keefe, Stephen J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Cellular and functional activity; Pyrimido pyrimidone; VX 745

Indexed keywords

3,4 DIHYDROPYRIDO[4,3 D]PYRIMIDIN 2 ONE; 3,4 DIHYDROPYRIMIDO [4,5 D]PYRIMIDIN 2 ONE; ION CHANNEL; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; PIPERIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; PYRIMIDINONE DERIVATIVE; QUINAZOLINONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; ENZYME INHIBITION; HUMAN; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRIDAZINES; PYRIDINES; PYRIMIDINES; PYRIMIDINONES; QUINAZOLINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33745699212     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.05.045     Document Type: Article

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6. 50s are means from three measurements.