Intestinal microvascular endothelium and innate immunity in inflammatory bowel disease: A second line of defense?

Infection and Immunity

Volumn 74, Issue 10, 2006, Pages 5425-5432

  Heidemann, Jan ^a   Domschke, Wolfram ^a   Kucharzik, Torsten ^a   Maaser, Christian ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 10; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 6; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9;

CROHN DISEASE; ENDOTHELIUM CELL; ENTERITIS; IMMUNE RESPONSE; INFLAMMATION; INNATE IMMUNITY; INTESTINE MUCOSA; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SHORT SURVEY; ULCERATIVE COLITIS;

CAPILLARIES; ENDOTHELIUM, VASCULAR; ESCHERICHIA COLI; HUMANS; IMMUNITY, INNATE; IMMUNITY, NATURAL; INFLAMMATORY BOWEL DISEASES; INTESTINAL MUCOSA; TOLL-LIKE RECEPTORS; VIRUSES;

EID: 33749265507     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.00248-06     Document Type: Short Survey

References (87)

1. Abreu, M. T., M. Fukata, and M. Arditi. 2005. TLR signaling in the gut in health and disease. J. Immunol. 174:4453-4460.
2. Abreu, M. T., K. D. Taylor, Y. C. Lin, T. Hang, J. Gaiennie, C. J. Landers, E. A. Vasiliauskas, L. Y. Kam, M. Rojany, K. A. Papadakis, J. I. Rotter, S. R. Targan, and H. Yang. 2002. Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease. Gastroenterology 123:679-688.
3. Akhtar, M., J. L. Watson, A. Nazli, and D. M. McKay. 2003. Bacterial DNA evokes epithelial IL-8 production by a MAPK-dependent, NF-KB-independent pathway. FASEB J. 17:1319-1321.
4. Akira, S., and H. Henimi. 2003. Recognition of pathogen-associated molecular patterns by TLR family. Immunol. Lett. 85:85-95.
5. Alexopoulou, L., A. C. Holt, R. Medzhitov, and R. A. Flavell. 2001. Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3. Nature 413:732-738.
6. Alvarez-Lobos, M., J. I. Arostegui, M. Sans, D. Tassies, S. Plaza, S. Delgado, A. M. Lacy, J. M. Pique, J. Vague, and J. Panes. 2005. Crohn's disease patients carrying Nod2/CARD15 gene variants have an increased and early need for first surgery due to stricturing disease and higher rate of surgical recurrence. Ann. Surg. 242:693-700.
7. Baumgart, D. C., D. Metzke, J. Schmitz, A. Scheffold, A. Sturm, B. Wiedenmann, and A. U. Dignass. 2005. Patients with active inflammatory bowel disease lack immature peripheral blood plasmacytoid and myeloid dendritic cells. Gut 54:228-236.
8. Beck, G. C., B. A. Yard, A. J. Breedyk, K. Van Ackern, and F. J. Van Der Woude. 1999. Release of CXC-chemokines by human lung microvascular endothelial cells (LMVEC) compared with macrovascular umbilical vein endothelial cells. Clin. Exp. Immunol. 118:298-303.
9. Berg, E. L., A. T. Mullowney, D. P. Andrew, J. E. Goldberg, and E. C. Butcher. 1998. Complexity and differential expression of carbohydrate epitopes associated with L-selectin recognition of high endothelial venules. Am. J. Pathol. 152:469-477.
10. Bevilacqua, M. P., R. R. Schleef, M. A. Gimbrone, Jr., and D. J. Loskutoff. 1986. Regulation of the fibrinolytic system of cultured human vascular endothelium by interleukin 1. J. Clin. Investig. 78:587-591.
11. Binion, D. G., P. Rafiee, K. S. Ramanujam, S. Fu, P. J. Fisher, M. T. Rivera, C. P. Johnson, M. F. Otterson, G. L. Telford, and K. T. Wilson. 2000. Deficient iNOS in inflammatory bowel disease intestinal microvascular endothelial cells results in increased leukocyte adhesion. Free Radic. Biol. Med. 29:881-888.
12. Binion, D. G., G. A. West, K. Ina, N. P. Ziats, S. N. Emancipator, and C. Fiocchi. 1997. Enhanced leukocyte binding by intestinal microvascular endothelial cells in inflammatory bowel disease. Gastroenterology 112:1895-1907.
13. Bozic, C. R., N. P. Gerard, C. von Uexkull-Guldenband, L. F. Kolakowski, Jr., M. J. Conklyn, R. Breslow, H. J. Showell, and C. Gerard. 1994. The murine interleukin 8 type B receptor homologue and its ligands. Expression and biological characterization. J. Biol. Chem. 269:29355-29358.
14. Briskin, M., D. Winsor-Hines, A. Shyjan, N. Cochran, S. Bloom, J. Wilson, L. M. McEvoy, E. C. Butcher, N. Kassam, C. R. Mackay, W. Newman, and D. J. Ringler. 1997. Human mucosal addressin cell adhesion molecule-1 is preferentially expressed in intestinal tract and associated lymphoid tissue. Am. J. Pathol. 151:97-110.
15. Bruewer, M., A. Luegering, T. Kucharzik, C. A. Parkos, J. L. Madara, A. M. Hopkins, and A. Nusrat. 2003. Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms. J. Immunol. 171:6164-6172.
16. Bulut, Y., E. Faure, L. Thomas, O. Equils, and M. Arditi. 2001. Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling. J. Immunol. 167:987-994.
17. Cario, E. 2005. Bacterial interactions with cells of the intestinal mucosa: Toll-like receptors and NOD2. Gut 54:1182-1193.
18. Chuang, T., and R. J. Ulevitch. 2001. Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells. Biochim. Biophys. Acta 1518:157-161.
19. Da Costa, C. U., N. Wantia, C. J. Kirschning, D. H. Busch, N. Rodriguez, H. Wagner, and T. Miethke. 2004. Heat shock protein 60 from Chlamydia pneumoniae elicits an unusual set of inflammatory responses via Toll-like receptor 2 and 4 in vivo. Eur. J. Immunol. 34:2874-2884.
20. Darfeuille-Michaud, A., J. Boudeau, P. Bulois, C. Neut, A. L. Classer, N. Barnich, M. A. Bringer, A. Swidsinski, L. Beaugerie, and J. F. Colombel. 2004. High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn's disease. Gastroenterology 127:412-421.
21. Desreumaux, P., and J. F. Colombel. 2003. Intestinal flora and Crohn's disease. Ann. Pharm. Fr. 61:276-281. (In French.)
22. Diebold, S. S., T. Kaisho, H. Hemmi, S. Akira, and C. Reis e Sousa. 2004. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 303:1529-1531.
23. Dunzendorfer, S., H. K. Lee, and P. S. Tobias. 2004. Flow-dependent regulation of endothelial Toll-like receptor 2 expression through inhibition of SP1 activity. Circ. Res. 95:684-691.
24. Edfeldt, K., J. Swedenborg, G. K. Hansson, and Z. Q. Yan. 2002. Expression of toll-like receptors in human atherosclerotic lesions: a possible pathway for plaque activation. Circulation 105:1158-1161.
25. Faure, E., L. Thomas, H. Xu, A. Medvedev, O. Equils, and M. Arditi. 2001. Bacterial lipopolysaccharide and IFN-γ induce Toll-like receptor 2 and Toll-like receptor 4 expression in human endothelial cells: role of NF-κB activation. J. Immunol. 166:2018-2024.
26. Fichorova, R. N., A. O. Cronin, E. Lien, D. J. Anderson, and R. R. Ingalls. 2002. Response to Neisseria gonorrhoeae by cervicovaginal epithelial cells occurs in the absence of toll-like receptor 4-mediated signaling. J. Immunol. 168:2424-2432.
27. Garlanda, C., and E. Dejana. 1997. Heterogeneity of endothelial cells. Specific markers. Arterioscler. Thromb. Vasc. Biol. 17:1193-1202.
28. Gehlert, T., O. Devergne, and G. Niedobitek. 2004. Epstein-Barr virus (EBV) infection and expression of the interleukin-12 family member EBV-induced gene 3 (EBI3) in chronic inflammatory bowel disease. J. Med. Virol. 73:432-438.
29. Gewirtz, A. T., T. A. Navas, S. Lyons, P. J. Godowski, and J. L. Madara. 2001. Bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression. J. Immunol. 167:1882-1885.
30. Girardin, S. E., I. G. Boneca, L. A. Carneiro, A. Antignac, M. Jehanno, J. Viala, K. Tedin, M. K. Taha, A. Labigne, U. Zahringer, A. J. Coyle, P. S. DiStefano, J. Bertin, P. J. Sansonetti, and D. J. Philpott. 2003. Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan. Science 300:1584-1587.
31. Gunzer, M., H. Riemann, Y. Basoglu, A. Hillmer, C. Weishaupt, S. Balkow, B. Benninghoff, B. Ernst, M. Steinert, T. Scholzen, C. Sunderkotter, and S. Grabbe. 2005. Systemic administration of a TLR7 ligand leads to transient immune incompetence due to peripheral-blood leukocyte depletion. Blood 106:2424-2432.
32. Hampe, J., A. Cuthbert, P. J. Croucher, M. M. Mirza, S. Mascheretti, S. Fisher, H. Frenzel, K. King, A. Hasselmeyer, A. J. MacPherson, S. Bridger, S. van Deventer, A. Forbes, S. Nikolaus, J. E. Lennard-Jones, U. R. Foelsch, M. Krawczak, C. Lewis, S. Schreiber, and C. G. Mathew. 2001. Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations. Lancet 357:1925-1928.
33. Haraldsen, G., J. Rugtveit, D. Kvale, T. Scholz, W. A. Muller, T. Hovig, and P. Brandtzaeg. 1995. Isolation and longterm culture of human intestinal microvascular endothelial cells. Gut 37:225-234.
34. Haraldsen, G., L. M. Sollid, O. Bakke, I. N. Farstad, D. Kvale, Molberg, J. Norstein, E. Stang, and P. Brandtzaeg. 1998. Major histocompatibility complex class II-dependent antigen presentation by human intestinal endothelial cells. Gastroenterology 114:649-656.
35. Hasan, U., C. Chaffois, C. Gaillard, V. Saulnier, E. Merck, S. Tancredi, C. Guiet, F. Briere, J. Vlach, S. Lebecque, G. Trinchieri, and E. E. Bates. 2005. Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88. J. Immunol. 174:2942-2950.
36. Hatoum, O. A., D. G. Binion, and D. D. Gutterman. 2005. Paradox of simultaneous intestinal ischaemia and hyperaemia in inflammatory bowel disease. Eur. J. Clin. Investig. 35:599-609.
37. Heidemann, J., H. Ogawa, P. Rafiee, N. Lugering, C. Maaser, W. Domschke, D. G. Binion, and M. B. Dwinell. 2004. Mucosal angiogenesis regulation by CXCR4 and its ligand CXCL12 expressed by human intestinal microvascular endothelial cells. Am. J. Physiol. Gastrointest. Liver Physiol. 286:G1059-G1068.
38. Heil, F., H. Hemmi, H. Hochrein, F. Ampenberger, C. Kirschning, S. Akira, G. Lipford, H. Wagner, and S. Bauer. 2004. Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science 303:1526-1529.
39. Hemmi, H., T. Kaisho, O. Takeuchi, S. Sato, H. Sanjo, K. Hoshino, T. Horiuchi, H. Tomizawa, K. Takeda, and S. Akira. 2002. Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat. Immunol. 3:196-200.
40. Hijiya, N., K. Miyake, S. Akashi, K. Matsuura, Y. Higuchi, and S. Yamamoto. 2002. Possible involvement of toll-like receptor 4 in endothelial cell activation of larger vessels in response to lipopolysaccharide. Pathobiology 70:18-25.
41. Hisamatsu, T., M. Suzuki, H. C. Reinecker, W. J. Nadeau, B. A. McCormick, and D. K. Podolsky. 2003. CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells. Gastroenterology 124:993-1000.
42. Hollander, D. 1992. The intestinal permeability barrier. A hypothesis as to its regulation and involvement in Crohn's disease. Scand. J. Gastroenterol. 27:721-726.
43. Hornung, V., S. Rothenfusser, S. Britsch, A. Krug, B. Jahrsdorfer, T. Giese, S. Endres, and G. Hartmann. 2002. Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J. Immunol. 168:4531-4537.
44. Hugot, J. P., M. Chamaillard, H. Zouali, S. Lesage, J. P. Cezard, J. Belaiche, S. Almer, C. Tysk, C. A. O'Morain, M. Gassull, V. Binder, Y. Finkel, A. Cortot, R. Modigliani, P. Laurent-Puig, C. Gower-Rousseau, J. Macry, J. F. Colombel, M. Sahbatou, and G. Thomas. 2001. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411:599-603.
45. Jurk, M., F. Heil, J. Vollmer, C. Schetter, A. M. Krieg, H. Wagner, G. Lipford, and S. Bauer. 2002. Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848. Nat. Immunol. 3:499.
46. Kucharzik, T., S. V. Walsh, J. Chen, C. A. Parkos, and A. Nusrat. 2001. Neutrophil transmigration in inflammatory bowel disease is associated with differential expression of epithelial intercellular junction proteins. Am. J. Pathol. 159:2001-2009.
47. Larousserie, F., S. Pflanz, A. Coulomb-L'Hermine, N. Brousse, R. Kastelein, and O. Devergne. 2004. Expression of IL-27 in human Th1-associated granulomatous diseases. J. Pathol. 202:164-171.
48. Li, J., Z. Ma, Z. L. Tang, T. Stevens, B. Pitt, and S. Li. 2004. CpG DNA-mediated immune response in pulmonary endothelial cells. Am. J. Physiol. Lung Cell Mol. Physiol. 287:L552-L558.
49. Linskens, R. K., X. W. Huijsdens, P. H. Savelkoul, C. M. Vandenbroucke-Grauls, and S. G. Meuwissen. 2001. The bacterial flora in inflammatory bowel disease: current insights in pathogenesis and the influence of antibiotics and probiotics. Scand. J. Gastroenterol. Suppl. 2001:29-40.
50. Lodes, M. J., Y. Cong, C. O. Elson, R. Mohamath, C. J. Landers, S. R. Targan, M. Fort, and R. M. Hershberg. 2004. Bacterial flagellin is a dominant antigen in Crohn disease. J. Clin. Investig. 113:1296-1306.
51. Louis, E., A. Collard, A. F. Oger, E. Degroote, F. A. Aboul Nasr El Yafi, and J. Belaiche. 2001. Behaviour of Crohn's disease according to the Vienna classification: changing pattern over the course of the disease. Gut 49:777-782.
52. Maaser, C., J. Heidemann, C. von Eiff, A. Lugering, T. W. Spahn, D. G. Binion, W. Domschke, N. Lugering, and T. Kucharzik. 2004. Human intestinal microvascular endothelial cells express Toll-like receptor 5: a binding partner for bacterial flagellin. J. Immunol. 172:5056-5062.
53. Miettinen, M., T. Sareneva, I. Julkunen, and S. Matikainen. 2001. IFNs activate toll-like receptor gene expression in viral infections. Genes Immun. 2:349-355.
54. Nakao, Y., K. Funami, S. Kikkawa, M. Taniguchi, M. Nishignchi, Y. Fukumori, T. Seya, and M. Matsumoto. 2005. Surface-expressed TLR6 participates in the recognition of diacylated lipopeptide and peptidoglycan in human cells. J. Immunol. 174:1566-1573.
55. Obermeier, F., N. Dunger, U. G. Strauch, C. Hofmann, A. Bleich, N. Grunwald, H. J. Hedrich, E. Aschenbrenner, B. Schlegelberger, G. Regler, J. Scholmerich, and W. Falk. 2005. CpG motifs of bacterial DNA essentially contribute to the perpetuation of chronic intestinal inflammation. Gastroenterology 129:913-927.
56. Ogawa, H., D. G. Binion, J. Heidemann, M. Theriot, P. J. Fisher, N. A. Johnson, M. F. Otterson, and P. Rafiee. 2005. Mechanisms of MAdCAM-1 gene expression in human intestinal microvascular endothelial cells. Am. J. Physiol. Cell Physiol. 288:C272-C281.
57. Ogawa, H., P. Rafiee, J. Heidemann, P. J. Fisher, N. A. Johnson, M. F. Otterson, B. Kalyanaraman, K. A. Pritchard, Jr., and D. G. Binion. 2003. Mechanisms of endotoxin tolerance in human intestinal microvascular endothelial cells. J. Immunol. 170:5956-5964.
58. Ogura, Y., D. K. Bonen, N. Inohara, D. L. Nicolae, F. F. Chen, R. Ramos, H. Britton, T. Moran, R. Karaliuskas, R. H. Duerr, J. P. Achkar, S. R. Brant, T. M. Bayless, B. S. Kirschner, S. B. Hanauer, G. Nunez, and J. H. Cho. 2001. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 411:603-606.
59. Oh, H. M., H. J. Lee, G. S. Seo, E. Y. Choi, S. H. Kweon, C. H. Chun, W. C. Han, K. M. Lee, M. S. Lee, S. C. Choi, and C. D. Jun. 2005. Induction and localization of NOD2 protein in human endothelial cells. Cell. Immunol. 237:37-44.
60. Opitz, B., S. Forster, A. C. Hocke, M. Maass, B. Schmeck, S. Hippenstiel, N. Suttorp, and M. Krull. 2005. Nod1-mediated endothelial cell activation by Chlamydophila pneumoniae. Circ. Res. 96:319-326.
61. Opitz, B., A. Puschel, W. Beermann, A. C. Hocke, S. Forster, B. Schmeck, V. van Laak, T. Chakraborty, N. Suttorp, and S. Hippenstiel. 2006. Listeria monocytogenes activated p38 MAPK and induced IL-8 secretion in a nucleotide-binding oligomerization domain 1-dependent manner in endothelial cells. J. Immunol. 176:484-490.
62. Opitz, B., A. Puschel, B. Schmeck, A. C. Hocke, S. Rosseau, S. Hammerschmidt, R. R. Schumann, N. Suttorp, and S. Hippenstiel. 2004. Nucleotide-binding oligomerization domain proteins are innate immune receptors for internalized Streptococcus pneumoniae. J. Biol. Chem. 279:36426-36432.
63. Otte, J. M., I. M. Rosenberg, and D. K. Podolsky. 2003. Intestinal myofibroblasts in innate immune responses of the intestine. Gastroenterology 124:1866-1878.
64. Pedersen, G., L. Andresen, M. W. Matthiessen, J. Rask-Madsen, and J. Brynskov. 2005. Expression of Toll-like receptor 9 and response to bacterial CpG oligodeoxynucleotides in human intestinal epithelium. Clin. Exp. Immunol. 141:298-306.
65. + T cells. Immunity 16:779-790.
66. Pollet, I., C. J. Opina, C. Zimmerman, K. G. Leong, F. Wong, and A. Karsan. 2003. Bacterial lipopolysaccharide directly induces angiogenesis through TRAF6-mediated activation of NF-κB and c-Jun N-terminal kinase. Blood 102:1740-1742.
67. Rachmilewitz, D., F. Karmeli, K. Takabayashi, T. Hayashi, L. Leider-Trejo, J. Lee, L. M. Leoni, and E. Raz. 2002. Immunostimulatory DNA ameliorates experimental and spontaneous murine colitis. Gastroenterology 122:1428-1441.
68. Rachmilewitz, D., K. Katakura, F. Karmeli, T. Hayashi, C. Reinus, B. Rudensky, S. Akira, K. Takeda, J. Lee, K. Takabayashi, and E. Raz. 2004. Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis. Gastroenterology 126:520-528.
69. Ribatti, D., B. Nico, A. Vacca, L. Roncali, and F. Dammacco. 2002. Endothelial cell heterogeneity and organ specificity. J. Hematother. Stem Cell Res. 11:81-90.
70. Rosenstiel, P., M. Fantini, K. Brautigam, T. Kuhbacher, G. H. Waetzig, D. Seegert, and S. Schreiber. 2003. TNF-α and IFN-γ regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells. Gastroenterology 124:1001-1009.
71. Salcedo, R., J. H. Resau, D. Halverson, E. A. Hudson, M. Dambach, D. Powell, K. Wasserman, and J. J. Oppenheim. 2000. Differential expression and responsiveness of chemokine receptors (CXCR1-3) by human microvascular endothelial cells and umbilical vein endothelial cells. FASEB J. 14:2055-2064.
72. Sartor, R. B. 2003. Targeting enteric bacteria in treatment of inflammatory bowel diseases: why, how, and when. Curr. Opin. Gastroenterol. 19:358-365.
73. Schmitz, H., C. Barmeyer, M. Fromm, N. Runkel, H. D. Foss, C. J. Bentzel, E. O. Riecken, and J. D. Schulzke. 1999. Altered tight junction structure contributes to the impaired epithelial barrier function in ulcerative colitis. Gastroenterology 116:301-309.
74. Shukaliak, J. A., and K. Dorovini-Zis. 2000. Expression of the beta-chemokines RANTES and MIP-1β by human brain microvessel endothelial cells in primary culture. J. Neuropathol. Exp. Neurol. 59:339-352.
75. Sitaraman, S. V., J. M. Klapproth, D. A. Moore III, C. Landers, S. Targan, I. R. Williams, and A. T. Gewirtz. 2005. Elevated flagellin-specific immunoglobulins in Crohn's disease. Am. J. Physiol. Gastrointest. Liver Physiol. 288:G403-G406.
76. Smith, P. L., G. Lombardi, and G. R. Foster. 2005. Type I interferons and the innate immune response-more than just antiviral cytokines. Mol. Immunol. 42:869-877.
77. Soderholm, J. D., G. Olaison, E. Lindberg, U. Hannestad, A. Vindels, C. Tysk, G. Jarnerot, and R. Sjodahl. 1999. Different intestinal permeability patterns in relatives and spouses of patients with Crohn's disease: an inherited defect in mucosal defence? Gut 44:96-100.
78. Spitzer, J. H., A. Visintin, A. Mazzoni, M. N. Kennedy, and D. M. Segal. 2002. Toll-like receptor 1 inhibits Toll-like receptor 4 signaling in endothelial cells. Eur. J. Immunol. 32:1182-1187.
79. Swidsinski, A., J. Weber, V. Loening-Baucke, L. P. Hale, and H. Lochs. 2005. Spatial organization and composition of the mucosal flora in patients with inflammatory bowel disease. J. Clin. Microbiol. 43:3380-3389.
80. Takeda, K., and S. Akira. 2005. Toll-like receptors in innate immunity. Int. Immunol. 17:1-14.
81. Takeda, K., T. Kaisho, and S. Akira. 2003. Toll-like receptors. Annu. Rev. Immunol. 21:335-376.
82. Targan, S. R., C. J. Landers, H. Yang, M. J. Lodes, Y. Cong, K. A. Papadakis, E. Vasiliauskas, C. O. Elson, and R. M. Hershberg. 2005. Antibodies to CBir1 flagellin define a unique response that is associated independently with complicated Crohn's disease. Gastroenterology 128:2020-2028.
83. Tissari, J., J. Siren, S. Meri, I. Julkunen, and S. Matikainen. 2005. IFN-α enhances TLR3-mediated antiviral cytokine expression in human endothelial and epithelial cells by up-regulating TLR3 expression. J. Immunol. 174:4289-4294.
84. Tlaskalova-Hogenova, H., R. Stepankova, T. Hudcovic, L. Tuckova, B. Cukrowska, R. Lodinova-Zadnikova, H. Kozakova, P. Rossmann, J. Bartova, D. Sokol, D. P. Funda, D. Borovska, Z. Rehakova, J. Sinkora, J. Hofman, P. Drastich, and A. Kokesova. 2004. Commensal bacteria (normal microflora), mucosal immunity and chronic inflammatory and autoimmune diseases. Immunol. Lett. 93:97-108.
85. Walton, K. A., A. L. Cole, M. Yen, G. Subbanagounder, S. R. Krulzik, R. L. Modlin, R. M. Lucas, J. Nakai, E. J. Smart, D. K. Vora, and J. A. Berliner. 2003. Specific phospholipid oxidation products inhibit ligand activation of toll-like receptors 4 and 2. Arterioscler. Thromb. Vasc. Biol. 23:1197-1203.
86. Wyllie, D. H., E. Kiss-Toth, A. Visintin, S. C. Smith, S. Boussouf, D. M. Segal, G. W. Duff, and S. K. Dower. 2000. Evidence for an accessory protein function for Toll-like receptor 1 in anti-bacterial responses. J. Immunol. 165:7125-7132.
87. Zhang, F. X., C. J. Kirschning, R. Mancinelli, X. P. Xu, Y. Jin, E. Faure, A. Mantovani, M. Rothe, M. Muzio, and M. Arditi. 1999. Bacterial lipopolysaccharide activates nuclear factor-κB through interleukin-1 signaling mediators in cultured human dermal endothelial cells and mononuclear phagocytes. J. Biol. Chem. 274:7611-7614.