Carbamoylphosphonate-based matrix metalloproteinase inhibitor metal complexes: Solution studies and stability constants. Towards a zinc-selective binding group

Journal of Biological Inorganic Chemistry

Volumn 9, Issue 3, 2004, Pages 307-315

  Farkas, Etelka ^b   Katz, Yiffat ^a   Bhusare, Sudhakar ^a   Reich, Reuven ^a   Röschenthaler, Gerd Volker ^c   Königsmann, Martin ^c   Breuer, Eli ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b UNIVERSITY OF DEBRECEN   (Hungary)

^c UNIVERSITY OF BREMEN   (Germany)

Author keywords

Carbamoylphosphonic acids; Matrix metalloproteinase inhibitors; Metal complexes; Zinc binding groups

Indexed keywords

2 (N,N DIMETHYLAMINO)CARBAMOYLPHOSPHONIC ACID; 2 CYCLOHEXYL 1,1 DIFLUOROETHYLPHOSPHONIC ACID; CALCIUM DERIVATIVE; COPPER COMPLEX; CYCLOPENTYLCARBAMOYLPHOSPHONIC ACID; LIGAND; MAGNESIUM DERIVATIVE; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE INHIBITOR; METAL COMPLEX; OXYGEN; PHOSPHONIC ACID DERIVATIVE; TRANSITION ELEMENT; UNCLASSIFIED DRUG; ZINC COMPLEX;

ARTICLE; BINDING AFFINITY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; METAL BINDING; MOLECULAR STABILITY; PH; PRECIPITATION; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

BINDING SITES; CARBOXYLIC ACIDS; ENZYME STABILITY; MATRIX METALLOPROTEINASES; PHOSPHONIC ACIDS; PROTEASE INHIBITORS; SOLUTIONS; ZINC;

EID: 2342624494     PISSN: 09498257     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00775-004-0524-5     Document Type: Article

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