메뉴 건너뛰기




Volumn 86, Issue 4, 2006, Pages 961-971

Aberrant expression of apoptosis proteins and ultrastructural aberrations in uterine leiomyomas from patients with hereditary leiomyomatosis and renal cell carcinoma

Author keywords

apoptosis; HLRCC; mitochondria; ultrastructure; uterine leiomyoma

Indexed keywords

CYCLINE; PROTEIN BAK; PROTEIN BCL 2; PROTEIN BCL XL;

EID: 33749250917     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2006.02.106     Document Type: Article
Times cited : (7)

References (38)
  • 1
    • 18544365990 scopus 로고    scopus 로고
    • Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer
    • Tomlinson I.P., Alam N.A., Rowan A.J., Barclay E., Jaeger E.E., Kelsell D., et al. Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer. Nat Genet 30 (2002) 406-410
    • (2002) Nat Genet , vol.30 , pp. 406-410
    • Tomlinson, I.P.1    Alam, N.A.2    Rowan, A.J.3    Barclay, E.4    Jaeger, E.E.5    Kelsell, D.6
  • 2
    • 12444259659 scopus 로고    scopus 로고
    • Genetic and functional analyses of FH mutations in multiple cutaneous and uterine leiomyomatosis, hereditary leiomyomatosis and renal cancer, and fumarate hydratase deficiency
    • Alam N.A., Rowan A.J., Wortham N.C., Pollard P.J., Mitchell M., Tyrer J.P., et al. Genetic and functional analyses of FH mutations in multiple cutaneous and uterine leiomyomatosis, hereditary leiomyomatosis and renal cancer, and fumarate hydratase deficiency. Hum Mol Genet 12 (2003) 1241-1252
    • (2003) Hum Mol Genet , vol.12 , pp. 1241-1252
    • Alam, N.A.1    Rowan, A.J.2    Wortham, N.C.3    Pollard, P.J.4    Mitchell, M.5    Tyrer, J.P.6
  • 3
    • 0348107409 scopus 로고    scopus 로고
    • The TCA cycle and tumorigenesis: the examples of fumarate hydratase and succinate dehydrogenase
    • Pollard P.J., Wortham N.C., and Tomlinson I.P. The TCA cycle and tumorigenesis: the examples of fumarate hydratase and succinate dehydrogenase. Ann Med 35 (2003) 632-639
    • (2003) Ann Med , vol.35 , pp. 632-639
    • Pollard, P.J.1    Wortham, N.C.2    Tomlinson, I.P.3
  • 4
    • 11144284227 scopus 로고    scopus 로고
    • Evidence of increased microvessel density and activation of the hypoxia pathway in tumours from the hereditary leiomyomatosis and renal cell cancer syndrome
    • Pollard P., Wortham N., Barclay E., Alam A., Elia G., Manek S., et al. Evidence of increased microvessel density and activation of the hypoxia pathway in tumours from the hereditary leiomyomatosis and renal cell cancer syndrome. J Pathol 205 (2005) 41-49
    • (2005) J Pathol , vol.205 , pp. 41-49
    • Pollard, P.1    Wortham, N.2    Barclay, E.3    Alam, A.4    Elia, G.5    Manek, S.6
  • 5
  • 6
    • 26444570010 scopus 로고    scopus 로고
    • Accumulation of Krebs cycle intermediates and over-expression of HIF1{alpha} in tumours which result from germline FH and SDH mutations
    • Pollard P.J., Briere J.J., Alam N.A., Barwell J., Barclay E., Wortham N.C., et al. Accumulation of Krebs cycle intermediates and over-expression of HIF1{alpha} in tumours which result from germline FH and SDH mutations. Hum Mol Genet 14 (2005) 2231-2239
    • (2005) Hum Mol Genet , vol.14 , pp. 2231-2239
    • Pollard, P.J.1    Briere, J.J.2    Alam, N.A.3    Barwell, J.4    Barclay, E.5    Wortham, N.C.6
  • 7
    • 23644448721 scopus 로고    scopus 로고
    • HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability
    • Isaacs J.S., Jung Y.J., Mole D.R., Lee S., Torres-Cabala C., Chung Y.L., et al. HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability. Cancer Cell 8 (2005) 143-153
    • (2005) Cancer Cell , vol.8 , pp. 143-153
    • Isaacs, J.S.1    Jung, Y.J.2    Mole, D.R.3    Lee, S.4    Torres-Cabala, C.5    Chung, Y.L.6
  • 8
    • 10744228261 scopus 로고    scopus 로고
    • c-Myc sensitization to oxygen deprivation-induced cell death is dependent on Bax/Bak, but is independent of p53 and hypoxia-inducible factor-1
    • Brunelle J.K., Santore M.T., Budinger G.R., Tang Y., Barrett T.A., Zong W.X., et al. c-Myc sensitization to oxygen deprivation-induced cell death is dependent on Bax/Bak, but is independent of p53 and hypoxia-inducible factor-1. J Biol Chem 279 (2004) 4305-4312
    • (2004) J Biol Chem , vol.279 , pp. 4305-4312
    • Brunelle, J.K.1    Santore, M.T.2    Budinger, G.R.3    Tang, Y.4    Barrett, T.A.5    Zong, W.X.6
  • 9
    • 0032725625 scopus 로고    scopus 로고
    • Molecular bases for the actions of ovarian sex steroids in the regulation of proliferation and apoptosis of human uterine leiomyoma
    • Matsuo H., Kurachi O., Shimomura Y., Samoto T., and Maruo T. Molecular bases for the actions of ovarian sex steroids in the regulation of proliferation and apoptosis of human uterine leiomyoma. Oncology 57 Suppl 2 (1999) 49-58
    • (1999) Oncology , vol.57 , Issue.SUPPL. 2 , pp. 49-58
    • Matsuo, H.1    Kurachi, O.2    Shimomura, Y.3    Samoto, T.4    Maruo, T.5
  • 10
    • 0031027688 scopus 로고    scopus 로고
    • Increased expression of Bcl-2 protein in human uterine leiomyoma and its up-regulation by progesterone
    • Matsuo H., Maruo T., and Samoto T. Increased expression of Bcl-2 protein in human uterine leiomyoma and its up-regulation by progesterone. J Clin Endocrinol Metab 82 (1997) 293-299
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 293-299
    • Matsuo, H.1    Maruo, T.2    Samoto, T.3
  • 11
    • 17744405954 scopus 로고    scopus 로고
    • Differential expression of Akt/protein kinase B, Bcl-2 and Bax proteins in human leiomyoma and myometrium
    • Kovacs K.A., Lengyel F., Kornyei J.L., Vertes Z., Szabo I., Sumegi B., et al. Differential expression of Akt/protein kinase B, Bcl-2 and Bax proteins in human leiomyoma and myometrium. J Steroid Biochem Mol Biol 87 (2003) 233-240
    • (2003) J Steroid Biochem Mol Biol , vol.87 , pp. 233-240
    • Kovacs, K.A.1    Lengyel, F.2    Kornyei, J.L.3    Vertes, Z.4    Szabo, I.5    Sumegi, B.6
  • 12
    • 1642568803 scopus 로고    scopus 로고
    • Bcl-2 receptor expression in patients with uterine smooth muscle tumors: an immunohistochemical analysis comparing leiomyoma, uterine smooth muscle tumor of uncertain malignant potential, and leiomyosarcoma
    • Bodner K., Bodner-Adler B., Kimberger O., Czerwenka K., and Mayerhofer K. Bcl-2 receptor expression in patients with uterine smooth muscle tumors: an immunohistochemical analysis comparing leiomyoma, uterine smooth muscle tumor of uncertain malignant potential, and leiomyosarcoma. J Soc Gynecol Investig 11 (2004) 187-191
    • (2004) J Soc Gynecol Investig , vol.11 , pp. 187-191
    • Bodner, K.1    Bodner-Adler, B.2    Kimberger, O.3    Czerwenka, K.4    Mayerhofer, K.5
  • 13
    • 0036176018 scopus 로고    scopus 로고
    • Expression of Bcl-2, Bcl-x, Mcl-1, Bax and Bak in human uterine leiomyomas and myometrium during the menstrual cycle and after menopause
    • Wu X., Blanck A., Olovsson M., Henriksen R., and Lindblom B. Expression of Bcl-2, Bcl-x, Mcl-1, Bax and Bak in human uterine leiomyomas and myometrium during the menstrual cycle and after menopause. J Steroid Biochem Mol Biol 80 (2002) 77-83
    • (2002) J Steroid Biochem Mol Biol , vol.80 , pp. 77-83
    • Wu, X.1    Blanck, A.2    Olovsson, M.3    Henriksen, R.4    Lindblom, B.5
  • 14
    • 0036716281 scopus 로고    scopus 로고
    • The Bcl2 family: regulators of the cellular life-or-death switch
    • Cory S., and Adams J.M. The Bcl2 family: regulators of the cellular life-or-death switch. Nat Rev Cancer 2 (2002) 647-656
    • (2002) Nat Rev Cancer , vol.2 , pp. 647-656
    • Cory, S.1    Adams, J.M.2
  • 15
    • 1442286330 scopus 로고    scopus 로고
    • The role of Bcl-2 family members in tumorigenesis
    • Kirkin V., Joos S., and Zornig M. The role of Bcl-2 family members in tumorigenesis. Biochim Biophys Acta 1644 (2004) 229-249
    • (2004) Biochim Biophys Acta , vol.1644 , pp. 229-249
    • Kirkin, V.1    Joos, S.2    Zornig, M.3
  • 16
    • 0038025230 scopus 로고    scopus 로고
    • Association of Bax and Bak homo-oligomers in mitochondria. Bax requirement for Bak reorganization and cytochrome c release
    • Mikhailov V., Mikhailova M., Degenhardt K., Venkatachalam M.A., White E., and Saikumar P. Association of Bax and Bak homo-oligomers in mitochondria. Bax requirement for Bak reorganization and cytochrome c release. J Biol Chem 278 (2003) 5367-5376
    • (2003) J Biol Chem , vol.278 , pp. 5367-5376
    • Mikhailov, V.1    Mikhailova, M.2    Degenhardt, K.3    Venkatachalam, M.A.4    White, E.5    Saikumar, P.6
  • 17
    • 0035891057 scopus 로고    scopus 로고
    • Cellular damage signals promote sequential changes at the N-terminus and BH-1 domain of the pro-apoptotic protein Bak
    • Griffiths G.J., Corfe B.M., Savory P., Leech S., Esposti M.D., Hickman J.A., et al. Cellular damage signals promote sequential changes at the N-terminus and BH-1 domain of the pro-apoptotic protein Bak. Oncogene 20 (2001) 7668-7676
    • (2001) Oncogene , vol.20 , pp. 7668-7676
    • Griffiths, G.J.1    Corfe, B.M.2    Savory, P.3    Leech, S.4    Esposti, M.D.5    Hickman, J.A.6
  • 18
    • 0033603847 scopus 로고    scopus 로고
    • Effects of differential overexpression of Bcl-2 on apoptosis, proliferation, and telomerase activity in Jurkat T cells
    • Johnson V.L., Cooper I.R., Jenkins J.R., and Chow S.C. Effects of differential overexpression of Bcl-2 on apoptosis, proliferation, and telomerase activity in Jurkat T cells. Exp Cell Res 251 (1999) 175-184
    • (1999) Exp Cell Res , vol.251 , pp. 175-184
    • Johnson, V.L.1    Cooper, I.R.2    Jenkins, J.R.3    Chow, S.C.4
  • 19
    • 0037134488 scopus 로고    scopus 로고
    • Bax and Bak independently promote cytochrome C release from mitochondria
    • Degenhardt K., Sundararajan R., Lindsten T., Thompson C., and White E. Bax and Bak independently promote cytochrome C release from mitochondria. J Biol Chem 277 (2002) 14127-14134
    • (2002) J Biol Chem , vol.277 , pp. 14127-14134
    • Degenhardt, K.1    Sundararajan, R.2    Lindsten, T.3    Thompson, C.4    White, E.5
  • 20
    • 0347627642 scopus 로고    scopus 로고
    • Effects of progesterone on growth factor expression in human uterine leiomyoma
    • Maruo T., Matsuo H., Shimomura Y., Kurachi O., Gao Z., Nakago S., et al. Effects of progesterone on growth factor expression in human uterine leiomyoma. Steroids 68 (2003) 817-824
    • (2003) Steroids , vol.68 , pp. 817-824
    • Maruo, T.1    Matsuo, H.2    Shimomura, Y.3    Kurachi, O.4    Gao, Z.5    Nakago, S.6
  • 21
    • 2442419652 scopus 로고    scopus 로고
    • Case for the panel of ultrastructural pathology-uterine leiomyoma
    • Eyden B. Case for the panel of ultrastructural pathology-uterine leiomyoma. Ultrastruct Pathol 28 (2004) 115-117
    • (2004) Ultrastruct Pathol , vol.28 , pp. 115-117
    • Eyden, B.1
  • 22
    • 0026595480 scopus 로고
    • Cytoskeletal filaments in the smooth muscle cells of uterine leiomyomata and myometrium: an ultrastructural and immunohistochemical analysis
    • Eyden B.P., Hale R.J., Richmond I., and Buckley C.H. Cytoskeletal filaments in the smooth muscle cells of uterine leiomyomata and myometrium: an ultrastructural and immunohistochemical analysis. Virchows Arch A Pathol Anat Histopathol 420 (1992) 51-58
    • (1992) Virchows Arch A Pathol Anat Histopathol , vol.420 , pp. 51-58
    • Eyden, B.P.1    Hale, R.J.2    Richmond, I.3    Buckley, C.H.4
  • 23
    • 0032406406 scopus 로고    scopus 로고
    • The ultrastructure of fibromyomatous myometrium and its relationship to infertility
    • Richards P.A., Richards P.D., and Tiltman A.J. The ultrastructure of fibromyomatous myometrium and its relationship to infertility. Hum Reprod Update 4 (1998) 520-525
    • (1998) Hum Reprod Update , vol.4 , pp. 520-525
    • Richards, P.A.1    Richards, P.D.2    Tiltman, A.J.3
  • 25
    • 33749238439 scopus 로고    scopus 로고
    • Ylstra B. Available from: http://www.vumc.nl/microarrays/onderzoek/index.html?protocols.html∼hoofd. Accessed: March 2005.
  • 26
    • 11144222886 scopus 로고    scopus 로고
    • Mitochondrial DNA quantity increases with histopathologic grade in premalignant and malignant head and neck lesions
    • Kim M.M., Clinger J.D., Masayesva B.G., Ha P.K., Zahurak M.L., Westra W.H., et al. Mitochondrial DNA quantity increases with histopathologic grade in premalignant and malignant head and neck lesions. Clin Cancer Res 10 (2004) 8512-8515
    • (2004) Clin Cancer Res , vol.10 , pp. 8512-8515
    • Kim, M.M.1    Clinger, J.D.2    Masayesva, B.G.3    Ha, P.K.4    Zahurak, M.L.5    Westra, W.H.6
  • 27
    • 0023908539 scopus 로고
    • Uterine leiomyosarcomas and benign smooth muscle tumors: usefulness of nuclear DNA patterns studied by flow cytometry
    • Tsushima K., Stanhope C.R., Gaffey T.A., and Lieber M.M. Uterine leiomyosarcomas and benign smooth muscle tumors: usefulness of nuclear DNA patterns studied by flow cytometry. Mayo Clin Proc 63 (1988) 248-255
    • (1988) Mayo Clin Proc , vol.63 , pp. 248-255
    • Tsushima, K.1    Stanhope, C.R.2    Gaffey, T.A.3    Lieber, M.M.4
  • 28
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D., and Weinberg R.A. The hallmarks of cancer. Cell 100 (2000) 57-70
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 29
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia-a key regulatory factor in tumour growth
    • Harris A.L. Hypoxia-a key regulatory factor in tumour growth. Nat Rev Cancer 2 (2002) 38-47
    • (2002) Nat Rev Cancer , vol.2 , pp. 38-47
    • Harris, A.L.1
  • 30
    • 0032581277 scopus 로고    scopus 로고
    • Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
    • Carmeliet P., Dor Y., Herbert J.M., Fukumura D., Brusselmans K., Dewerchin M., et al. Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 394 (1998) 485-490
    • (1998) Nature , vol.394 , pp. 485-490
    • Carmeliet, P.1    Dor, Y.2    Herbert, J.M.3    Fukumura, D.4    Brusselmans, K.5    Dewerchin, M.6
  • 31
    • 23844540031 scopus 로고    scopus 로고
    • Mechanism of HIF-1alpha-dependent suppression of hypoxia-induced apoptosis in squamous cell carcinoma cells
    • Sasabe E., Tatemoto Y., Li D., Yamamoto T., and Osaki T. Mechanism of HIF-1alpha-dependent suppression of hypoxia-induced apoptosis in squamous cell carcinoma cells. Cancer Sci 96 (2005) 394-402
    • (2005) Cancer Sci , vol.96 , pp. 394-402
    • Sasabe, E.1    Tatemoto, Y.2    Li, D.3    Yamamoto, T.4    Osaki, T.5
  • 32
    • 1542305379 scopus 로고    scopus 로고
    • Hypoxia selection of death-resistant cells. A role for Bcl-X(L)
    • Dong Z., and Wang J. Hypoxia selection of death-resistant cells. A role for Bcl-X(L). J Biol Chem 279 (2004) 9215-9221
    • (2004) J Biol Chem , vol.279 , pp. 9215-9221
    • Dong, Z.1    Wang, J.2
  • 33
    • 0019805180 scopus 로고
    • A comparative study of smooth muscle tumors utilizing light and electron microscopy, immunocytochemical staining and enzymatic assay
    • Bures J.C., Barnes L., and Mercer D. A comparative study of smooth muscle tumors utilizing light and electron microscopy, immunocytochemical staining and enzymatic assay. Cancer 48 (1981) 2420-2426
    • (1981) Cancer , vol.48 , pp. 2420-2426
    • Bures, J.C.1    Barnes, L.2    Mercer, D.3
  • 34
    • 0035174132 scopus 로고    scopus 로고
    • Ultrastructural comparison of uterine leiomyoma cells from the same myoma nodule before and after gonadotropin-releasing hormone agonist treatment
    • Ito F., Kawamura N., Ichimura T., Tsujimura A., Ishiko O., and Ogita S. Ultrastructural comparison of uterine leiomyoma cells from the same myoma nodule before and after gonadotropin-releasing hormone agonist treatment. Fertil Steril 75 (2001) 125-130
    • (2001) Fertil Steril , vol.75 , pp. 125-130
    • Ito, F.1    Kawamura, N.2    Ichimura, T.3    Tsujimura, A.4    Ishiko, O.5    Ogita, S.6
  • 35
    • 5044236959 scopus 로고    scopus 로고
    • Comparative ultrastructure of collagen fibrils in uterine leiomyomas and normal myometrium
    • Leppert P.C., Baginski T., Prupas C., Catherino W.H., Pletcher S., and Segars J.H. Comparative ultrastructure of collagen fibrils in uterine leiomyomas and normal myometrium. Fertil Steril 82 Suppl 3 (2004) 1182-1187
    • (2004) Fertil Steril , vol.82 , Issue.SUPPL. 3 , pp. 1182-1187
    • Leppert, P.C.1    Baginski, T.2    Prupas, C.3    Catherino, W.H.4    Pletcher, S.5    Segars, J.H.6
  • 37
    • 28544435485 scopus 로고    scopus 로고
    • Lysosomes and autophagy in cell death control
    • Kroemer G., and Jaattela M. Lysosomes and autophagy in cell death control. Nat Rev Cancer 5 (2005) 886-897
    • (2005) Nat Rev Cancer , vol.5 , pp. 886-897
    • Kroemer, G.1    Jaattela, M.2
  • 38
    • 0242391866 scopus 로고    scopus 로고
    • SDHD mutations in head and neck paragangliomas result in destabilization of complex II in the mitochondrial respiratory chain with loss of enzymatic activity and abnormal mitochondrial morphology
    • Douwes Dekker P.B., Hogendoorn P.C., Kuipers-Dijkshoorn N., Prins F.A., van Duinen S.G., Taschner P.E., et al. SDHD mutations in head and neck paragangliomas result in destabilization of complex II in the mitochondrial respiratory chain with loss of enzymatic activity and abnormal mitochondrial morphology. J Pathol 201 (2003) 480-486
    • (2003) J Pathol , vol.201 , pp. 480-486
    • Douwes Dekker, P.B.1    Hogendoorn, P.C.2    Kuipers-Dijkshoorn, N.3    Prins, F.A.4    van Duinen, S.G.5    Taschner, P.E.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.