DNA vaccination favours memory rather than effector B cell responses

Clinical and Experimental Immunology

Volumn 117, Issue 1, 1999, Pages 106-112

  Laylor, R ^a   Porakishvili, N ^a   De Souza, J B ^a   Playfair, J H L ^a   Delves, P J ^a   Lund, T ^a,b  

^a Windeyer Institute of Medical Sciences   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

DNA immunization; hCG; Immunological memory; Vaccine

Indexed keywords

DNA VACCINE; GAMMA INTERFERON; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G2B; INTERLEUKIN 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; FEMALE; IMMUNIZATION; IMMUNOLOGICAL MEMORY; IMMUNOMODULATION; IMMUNOREACTIVITY; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; B-LYMPHOCYTE SUBSETS; CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN; FEMALE; GENETIC VECTORS; HUMANS; IMMUNIZATION; IMMUNIZATION, SECONDARY; IMMUNOLOGIC MEMORY; INTERFERON TYPE II; INTERLEUKIN-4; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; SPLEEN; TH1 CELLS; TH2 CELLS; VACCINES, DNA;

EID: 0032972512     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1999.00941.x     Document Type: Article

References (28)

1. Wolff JA, Marlone RW, Williams P et al. Direct gene transfer into mouse muscle in vivo. Science 1990; 257: 1465-8.
2. Wolff JA, Williams P, Acsadi G et al. Conditions affecting direct gene transfer into rodent muscle in vivo. Biotechniques 1991; 11: 474 85.
3. Tang DC, Devit M, Johnston SA. Genetic immunization is a simple method for eliciting an immune response. Nature 1992; 356: 152-4.
4. Ulmer JB, Donnelly JJ, Parker SE et al. Heterulogous protection against influenza by injection of DNA encoding a viral protein. Science 1993; 269: 1745-9.
5. Torres CA, Iwasaki A, Barber BH et al. Differential dependence on target site tissue for gene gun and intramuscular DNA immunizations. J Immunol 1997; 158: 4529-32.
6. Fu TM, Ulmer JB, Caulfied MJ et al. Priming of cytotoxic T lymphocytes by DNA vaccines: Requirement for professional antigen presenting cells and evidence for antigen transfer from myocytes. Mol Med 1997; 3: 361-71.
7. Condon C, Watkins SC, Celluzzi CM et al. DNA-based immunization by in vivo transfection of dendritic cells. Nat Med 1996; 2:1122-8.
8. Ulmer JB, Deck RR, DeWitt CM et al. Expression of a viral protein by muscle cells in vivo induces protective cell-mediated immunity. Vaccine 1997; 15: 839-41.
9. Donnelly JJ, Ulmer JB, Liu MA. Immunization with DNA. J Immunol Methods 1994; 176: 145-52.
10. Chu RS, Targoni OS, Krieg AM et al. CpG oligodeonynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity. J Exp Med 1997; 186: 1625-31.
11. Carson DA, Raz E. Oligonucleotidc adjuvants for T helper 1 (Th1)-specific vaccination. J Exp Med 1997; 186: 1621-2.
12. Klinman DM, Yi AK, Beaucage SL et al. CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma. Proc Natl Acad Sci USA 1996; 93: 2879-83.
13. Krieg AM, Yi AK, Matson S et al. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 1995; 374: 546-9.
14. Sato Y, Roman M, Tighe H et al. Immunostimulatory DNA sequences necessary for effective intradermal gene immunization. Science 1996; 283: 352-4.
15. Stephens PE, Cockett MI. The construction of a highly efficient and versatile set mammalian expression vectors. Nucleic Acids Res 1989; 17: 7110.
16. Jackson AM, Klonisch T, Lapthorn AJ et al. Identification and selective destruction of shared epitopes in human chorionic gonadotrophin beta subunit. J Reprod Immunol 1996; 31: 21-36.
17. Gregoriadis G, Saffie R, DeSouza JB. Liposome-mediated DNA vaccination. FEBS Letters 1997; 402: 107-10.
18. Jackson AM, PhD thesis, University College London, London, UK 1996.
19. Porakishvili N, Jackson AM, DeSouza JB et al. Epitopes of human chorionic gonadotrophin (hCG) and their relationship to immunogenicity and cross-reactivity of beta chain mutants. Am J Reprod Immunol 1998; 40: 210-4.
20. Peet N, Delves PJ, DeSouza JB et al. The immune response to HIV gp12O induced by nucleic acid immunization (NAI). Ann NY Acad Sci 1995; 772: 267-70.
21. Peet NM, McKeating JA, Ramos B et al. Comparison of nucleic acid and protein immunization for induction of antibodies specific for HIV-1 gp120. Clin Exp Immunol 1997; 109: 259-66.
22. Boyle JS, Silva A, Brady JL et al. DNA immunization: Induction of higher avidity antibody and effect of route on T cell cytoxicity. Proc Natl Acad Sci USA 1997; 94: 14627-31.
23. Talwar GP, Singh O, Pal R et al. A vaccine that prevents pregnancy in women. Proc Natl Acad Sci USA 1994; 91: 8532-6.
24. Boyle JS, Brady JI, Lew AM. Enhanced responses to a DNA vaccine encoding a fusion antigen that is directed to sites of immune induction. Nature 1998; 392: 408-11.
25. Geissler M, Wand G, Gesien A et al. Genetic immunization with free human chorionic gonadotrophin beta subunit elicits cytotoxic T lymphocyte responses and protects against tumor formation in mice. Lab Invest 1997; 76: 859-71.
26. Emtage JS, Angal S, Doel MT et al. Synthesis of calf prochymosin (prorennin) in Escherichia coli. Proc Natl Acad Sci USA 1980; 80: 3671-5.
27. Lusky M, Botchan M. Inhibition of SV40 replication in simian cells by specific pBR322 DNA sequences. Nature 1981; 293: 79-81.
28. Sulitzeanu D, Axelrad M. Enrichment of memory cells carrying receptor for a protein antigen (HSA). Immunol 1973; 25: 803-11.