The change of the scFv into the Fab format improves the stability and in vivo toxin neutralization capacity of recombinant antibodies

Molecular Immunology

Volumn 44, Issue 6, 2007, Pages 1307-1315

  Quintero Hernández, Veronica ^a   Juárez González, Victor R ^a   Ortíz León, Mauricio ^a   Sánchez, Rosalba ^a   Possani, Lourival D ^a   Becerril, Baltazar ^a  

^a INSTITUTO DE BIOTECNOLOGÍA   (Mexico)

Author keywords

Functional stability; Recombinant Fab; scFv; Scorpion toxin; Toxin neutralization

Indexed keywords

GUANIDINE; IMMUNOGLOBULIN F(AB) FRAGMENT; NEUTRALIZING ANTIBODY; RECOMBINANT ANTIBODY; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; TOXIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FEMALE; INTOXICATION; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCORPION; SYMPTOM; TREATMENT OUTCOME;

ANIMALS; ANTIBODIES; FEMALE; IMMUNOGLOBULIN FAB FRAGMENTS; MICE; NEUTRALIZATION TESTS; RECOMBINANT PROTEINS; SCORPION VENOMS;

SCORPIONES;

EID: 33748809530     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2006.05.009     Document Type: Article

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