Selective excision of chain-terminating nucleotides by HIV-1 reverse transcriptase with phosphonoformate as substrate

Journal of Biological Chemistry

Volumn 281, Issue 38, 2006, Pages 27744-27752

  Cruchaga, Carlos ^a   Ansó, Elena ^a   Rouzaut, Ana ^a   Martínez Irujo, Juan J ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; CHEMOTHERAPY; ENZYMES; REACTION KINETICS; VIRUSES;

CHAIN-TERMINATING NUCLEOTIDES; NUCLEOSIDIC INHIBITORS; PHOSPHONOFORMATE; PHOSPHOROLYSIS;

NUCLEIC ACIDS;

BISPHOSPHONIC ACID DERIVATIVE; CLODRONIC ACID; EFAVIRENZ; ETIDRONIC ACID; FOSCARNET; MEDRONIC ACID; NUCLEOTIDE DERIVATIVE; ORTHOVANADIC ACID; PAMIDRONIC ACID; PHOSPHATE; PHOSPHONOACETIC ACID; PYROPHOSPHORIC ACID DERIVATIVE; RNA DIRECTED DNA POLYMERASE; SODIUM DISULFIDE; ZIDOVUDINE;

ARTICLE; DRUG ACTIVITY; DRUG BINDING; DRUG POTENTIATION; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME MECHANISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ANTIVIRAL AGENTS; BINDING SITES; CATALYSIS; FOSCARNET; HIV-1 REVERSE TRANSCRIPTASE; REVERSE TRANSCRIPTASE INHIBITORS; THYMINE NUCLEOTIDES; ZIDOVUDINE;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 33748767908     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M603360200     Document Type: Article

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