Bone marrow cells have a potent anti-ischemic effect against myocardial cell death in humans

Journal of Thoracic and Cardiovascular Surgery

Volumn 132, Issue 5, 2006, Pages 1112-1118

  Kubal, Chandrashekhar ^a   Sheth, Kamlesh ^a   Nadal Ginard, Bernardo ^b   Galiñanes, Manuel ^a  

^a GLENFIELD HOSPITAL   (United Kingdom)

^b MOUNT SINAI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; BIOTIN; CHELERYTHRINE; CREATINE KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; PROPIDIUM IODIDE; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR;

APOPTOSIS; ARTICLE; BODY TEMPERATURE; BONE MARROW CELL; BONE MARROW TRANSPLANTATION; CELL DEATH; CELL FUNCTION; CONTROLLED STUDY; ENZYME ACTIVATION; HEART ATRIUM APPENDAGE; HEART MUSCLE; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HEART RIGHT ATRIUM; HUMAN; HUMAN CELL; HUMAN TISSUE; INCUBATION TIME; ISCHEMIA; NECROSIS; NICK END LABELING; PRIORITY JOURNAL; REOXYGENATION; STATISTICAL SIGNIFICANCE; TREATMENT OUTCOME;

ALKALOIDS; APOPTOSIS; BENZOPHENANTHRIDINES; BONE MARROW CELLS; CELL DEATH; HEART; HEART ATRIA; HUMANS; IMIDAZOLES; MODELS, CARDIOVASCULAR; MYOCARDIAL ISCHEMIA; MYOCARDIUM; NECROSIS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHOTRANSFERASES; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; PYRIDINES;

EID: 33748755240     PISSN: 00225223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jtcvs.2006.06.028     Document Type: Article

References (37)

1. Fox K.F., Cowie M.R., Wood D.A., Coats A.J., Gibbs J.S., Underwood S.R., et al. Coronary artery disease as the cause of incident heart failure in the population. Eur Heart J 22 (2001) 228-236
2. American Heart Association. Heart disease and stroke-update 2005 (2005), American Heart Association, Dallas, Tex
3. Swedberg K., Cleland J., Dargie H., Drexler H., Follath F., Komajda M., et al. Guidelines for the diagnosis and treatment of chronic heart failure: executive summary (update 2005): the Task Force for the Diagnosis and Treatment of Chronic Heart Failure of the European Society of Cardiology. Eur Heart J 26 (2005) 1115-1140
4. Kamalesh M., and Nair G. Disproportionate increase in prevalence of diabetes among patients with congestive heart failure due to systolic dysfunction. Int J Cardiol 99 (2005) 125-127
5. Hamano K., Nishida M., Hirata K., Mikamo A., Li T.S., Harada M., et al. Local implantation of autologous bone marrow cells for therapeutic angiogenesis in patients with ischemic heart disease: clinical trial and preliminary results. Jpn Circ J 65 (2001) 845-847
6. Strauer B.E., Brehm M., Zeus T., Kostering M., Hernandez A., Sorg R.V., et al. Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans. Circulation 106 (2002) 1913-1918
7. Assmus B., Schachinger V., Teupe C., Britten M., Lehman R., Dobert N., et al. Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI). Circulation 106 (2002) 3009-3017
8. Stamm C., Westphal B., Kleine H.D., Petzsch M., Kittner C., Klinge H., et al. Autologous bone-marrow stem-cell transplantation for myocardial regeneration. Lancet 361 (2003) 45-46
9. Galiñanes M., Loubani M., Davies J., Chin D., Pasi J., and Bell P.R. Safety and efficacy of transplantation of autologous bone marrow into scarred myocardium for the enhancement of cardiac function in man. Cell Transpl 13 (2004) 7-13
10. Tomita S., Li R.K., Weisel R.D., Mickle D.A., Kim E.J., Sakai T., et al. Autologous transplantation of bone marrow cells improves damaged heart function. Circulation 100 suppl (1999) II247-II256
11. Orlic D., Kajstura J., Chimenti S., Jakoniuk I., Anderson S.M., Li B., et al. Bone marrow cells regenerate infarcted myocardium. Nature 410 (2001) 701-705
12. Fernandez-Aviles F., San Roman J.A., Garcia-Frade J., Fernandez M.E., Penarrubia M.J., de la Fuente L., et al. Experimental and clinical regenerative capability of human bone marrow cells after myocardial infarction. Circ Res 95 (2004) 742-748
13. Murry C.E., Soonpaa M.H., Reinecke H., Nakajima H., Nakajima H.O., Rubart M., et al. Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts. Nature 428 (2004) 664-668
14. Balsam L.B., Wagers A.J., Christensen J.L., Kofidis T., Weissman I.L., and Robbins R.C. Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium. Nature 428 (2004) 668-673
15. Terada N., Hamazaki T., Oka M., Hoki M., Mastalerz D.M., Nakano Y., et al. Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion. Nature 416 (2002) 542-545
16. Alvarez-Dolado M., Pardal R., Garcia-Verdugo J.M., Fike J.R., Lee H.O., Pfeffer K., et al. Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes. Nature 425 (2003) 968-973
17. Nygren J.M., Jovinge S., Breitbach M., Sawen P., Roll W., Hescheler J., et al. Bone marrow-derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation. Nat Med 10 (2004) 494-501
18. Kajstura J., Rota M., Whang B., Cascapera S., Hosoda T., Bearzi C., et al. Bone marrow cells differentiate in cardiac cell lineages after infarction independently of cell fusion. Circ Res 96 (2005) 127-137
19. Beltrami A.P., Barlucchi L., Torella D., Baker M., Limana F., Chimenti S., et al. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell 114 (2003) 763-776
20. Shenje L.T., Matata B.M., and Galiñanes M. Uncovering human cardiac myocyte progenitor cells for myocardial regeneration [abstract]. J Am Coll Cardiol 43 suppl A (2004) 263A
21. Oh H., Bradfute S.B., Gallardo T.D., Nakamura T., Gaussin V., Mishina Y., et al. Cardiac progenitor cells from adult myocardium: homing, differentiation, and fusion after infarction. Proc Natl Acad Sci U S A 100 (2003) 12313-12318
22. Matsuura K., Nagain T., Nishigaki N., Oyama T., Nishi J., Wada H., et al. Adult cardiac Sca-1-positive cells differentiate into beating cardiomyocytes. J Biol Chem 279 (2004) 11384-11391
23. Yoon Y.S., Wecker A., Heyd L., Park J.S., Tkebuchava T., Kusano K., et al. Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium after myocardial infarction. J Clin Invest 115 (2005) 326-338
24. Tang Y.L., Zhao Q., Qin X., Shen L., Cheng L., Ge J., et al. Paracrine action enhances the effects of autologous mesenchymal stem cell transplantation on vascular regeneration in rat model of myocardial infarction. Ann Thorac Surg 80 (2005) 229-237
25. Gnecchi M., He H., Liang O.D., Melo L.G., Morello F., Mu H., et al. Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells. Nat Med 11 (2005) 367-368
26. Fuchs S., Baffour R., Zhou Y.F., Shou M., Pierre A., Tio F.O., et al. Transendocardial delivery of autologous bone marrow enhances collateral perfusion and regional function in pigs with chronic experimental myocardial ischemia. J Am Coll Cardiol 37 (2001) 1726-1732
27. Lotem J., and Sachs L. Cytokines as suppressors of apoptosis. Apoptosis 4 (1999) 187-196
28. Tehranchi R., Fadeel B., Schmidt-Mende J., Forsblom A.M., Emanuelsson E., Jadersten M., et al. Antiapoptotic role of growth factors in the myelodysplastic syndromes: concordance between in vitro and in vivo observations. Clin Cancer Res 11 (2005) 6291-6299
29. Zhang J.G., Ghosh S., Ockelford C., and Galiñanes M. Characterization of an in vitro model for the study of the short and prolonged effects of myocardial ischaemia and reperfusion in man. Clin Sci 99 (2000) 443-453
30. Makino S., Fukuda K., Miyoshi S., Konishi F., Kodama H., Pan J., et al. Cardiomyocytes can be generated from marrow stromal cells in vitro. J Clin Invest 103 (1999) 697-705
31. Misao Y., Takemura G., Arai M., Sato S., Suzuki K., Miyata S., et al. Bone marrow-derived myocyte-like cells and regulation of repair-related cytokines after bone marrow cell transplantation. Cardiovasc Res 69 (2006) 476-490
32. Hofmann M., Wollert K.C., Meyer G.P., Menke A., Arseniev L., Hertenstein B., et al. Monitoring of bone marrow cell homing into the infarcted human myocardium. Circulation 111 (2005) 2198-2202
33. Loubani M., and Galiñanes M. Pharmacological and ischemic preconditioning of the human myocardium: mitoKatp channels are upstream and p38 MAPK is downstream of PKC. BMC Physiol 2 (2002) 10
34. Hassouna A., Matata B.M., and Galiñanes M. PKC-epsilon is upstream and PKC-alpha is downstream of mitoKATP channels in the signal transduction pathway of ischemic preconditioning of human myocardium. Am J Physiol Cell Physiol 287 (2004) C1418-C1425
35. Ii M., Nishimura H., Iwakura A., Wecker A., Eaton E., Asahara T., et al. Endothelial progenitor cells are rapidly recruited to myocardium and mediate protective effect of ischemic preconditioning via "imported" nitric oxide synthase activity. Circulation 111 (2005) 1114-1120
36. Vohra H.A., and Galiñanes M. Effect of the degree of ischaemic injury and reoxygenation time on the type of myocardial cell death in man: role of caspases. BMC Physiol 5 (2005) 14
37. Frangogiannis N.G., Smith C.W., and Entman M.L. The inflammatory response in myocardial infarction. Cardiovasc Res 53 (2002) 31-47