Neurine, an acetylcholine autolysis product, elevates secreted amyloid-β protein precursor and amyloid-β peptide levels, and lowers neuronal cell viability in culture: A role in Alzheimer's disease?

Journal of Alzheimer's Disease

Volumn 10, Issue 1, 2006, Pages 9-16

  Tweedie, David ^a   Brossi, Arnold ^b   Chen, DeMoa ^c   Ge, Yuan Wen ^c   Bailey, Jason ^c   Yu, Qian Sheng ^a   Kamal, Mohammad A ^d   Sambamurti, Kumar ^e   Lahiri, Debomoy K ^c   Greig, Nigel H ^a,f  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Enzymoics   (Australia)

^e MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^f NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Acetylcholine; Alzheimer's disease; Amyloid peptide; Amyloid protein precursor; Neurine; Ptomaine

Indexed keywords

ACETYLCHOLINE; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID PRECURSOR PROTEIN; LACTATE DEHYDROGENASE; NEURINE; TETRAZOLIUM; UNCLASSIFIED DRUG; VINYL DERIVATIVE;

ALZHEIMER DISEASE; ARTICLE; AUTOLYSIS; CELL CULTURE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; NERVE CELL; NEUROBLASTOMA CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; QUANTITATIVE ANALYSIS; WESTERN BLOTTING;

EID: 33748742887     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2006-10102     Document Type: Article

References (38)

1. J.D. Buxbaum, A.A. Ruefli, C.A. Parker, A.M. Cypess and P. Greengard, Calcium regulates processing of the Alzheimer amyloid protein precursor in a protein kinase C-independent manner, Proc Natl Acad Sci USA 91 (1994), 4489-4493.
2. S. Efthimiopoulos, D. Vassilacopoulou, J.A. Ripellino, N. Tezapsidis and N.K. Robakis, Cholinergic agonists stimulate secretion of soluble full-length amyloid precursor protein in neuroendocrine cells, Proc Natl Acad Sci USA 93 (1996), 8046-8050.
3. A. Fleckenstein and F. Richter, Further studies on neutralization of the contraction effect of acetlycholine, neurine, nicotine, coniine, veratrine, potassium chloride and rubidium chloride by the anelectronic state, Pflugers Archiv 257 (1953), 1-11.
4. E. Giacobini, Cholinergic function and Alzheimer's disease, Int J Geriatr Psychiatry 18 (2003), S1-S5.
5. Y. Gong, L. Chang, K.L. Viola, P.N. Lacor, M.P. Lambert, C.E. Finch, G.A. Krafft and W.L. Klein, Alzheimer's disease-affected brain: Presence of oligomeric Aβ ligands (ADDLs) suggests a molecular basis for reversible memory loss, PNAS 100 (2003), 10417-10422.
6. J. Hardy, Has the amyloid cascade hypothesis for Alzheimer's disease been proved? Curr Alz Res 3 (2006), 71-74.
7. F. Kamenetz, T. Tomita, H. Hsieh, G. Seabrook, D. Borchelt, T. Iwatsubo, S.S. Sisodia and R. Malinow, APP processing and synaptic function, Neuron 37 (2003), 925-937.
8. S. Kar, S.P. Slowikowski, D. Westaway and H.T. Mount, Interactions between beta-amyloid and central cholinergic neurons: implications for Alzheimer's disease, J Psychiatry Neurosci 29 (2004), 427-441.
9. S. Kar and R. Quirion, Amyloid beta peptides and central cholinergic neurons: functional interrelationship and relevance to Alzheimer's disease pathology, Prog Brain Res 145 (2004), 261-274.
10. J.Y. Koh, L.L. Yang and C.W. Cotman, β-Amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage, Brain Res 533 (1990), 315-320.
11. P.N. Lacor, M.C. Buniel, L. Chang, S.J. Fernandez, Y. Gong, K.L. Viola, M.P. Lambert, P.T. Velasco, E.H. Bigio, C.E. Finch, G.A. Krafft and W.L. Klein, Synaptic targeting by Alzheimer's-related amyloid-β oligomers, J Neurosci 24 (2004), 10191-10200.
12. D.K. Lahiri, D. Chen, Y.-W. Ge, S.C. Bondy and E.H. Sharman, Dietary supplementation with melatonin reduces levels of amyloid beta-peptides in the murine cerebral cortex, J Pineal Res 36 (2004), 224-231.
13. D.K. Lahiri, D. Chen, D. Vivien, Y.-W. Ge, N.H. Grieg and J.T. Rogers, Role of cytokines in the gene expression of amyloid β-protein precursor: Identification of a 5′-UTR-Binding nuclear factor and its implications in Alzheimer's disease, J Alzheimers Dis 5 (2003), 81-90.
14. D.K. Lahiri, M.R. Farlow, K. Sambamurti, N.H. Greig, E, Giacobini and L.S. Schneider, A critical analysis of new molecular targets and strategies for drug developments in Alzheimer's disease, Curr Drug Targets 4 (2003), 97-112.
15. D.K. Lahiri and Y.W. Ge, Role of the APP promoter in Alzheimer's disease: cell type-specific expression of the beta-amyloid precursor protein, Ann N Y Acad Sci 1030 (2004), 310-316.
16. D.K. Lahiri and N.H. Greig, Lethal weapon: amyloid beta-peptide, role in the oxidative stress and neurodegeneration of Alzheimer's disease, Neurobiol Aging 25 (2004), 581-587.
17. H.-G. Lee, X. Zhu, A. Nunomura, G. Perry and M.A. Smith, Amyloid beta: the alternate hypothesis, Curr Alz Res 3 (2006), 75-80.
18. Y.-F. Liao , B.-J. Wang, H.-T. Cheng, L.-H. Kuo and M.S. Wolfe, Tumor necrosis factor-α, interleukin-1β, and interferon-γ stimulate γ-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway, J Biol Chem 47 (2004), 49523-49532.
19. M.P. Mattson, Excitotoxic and excitoprotective mechanisms: abundant targets for the prevention and treatment of neurodegenetarive disorders, Neuromolecular Med 3 (2003), 65-94.
20. M.P. Mattson, Pathways towards and away from Alzheimer's disease, Nature 430 (2004), 631-639.
21. S. Miranda, C. Opazo, L.F. Larrondo, F.J. Munoz, F. Ruiz, F. Leighton and N.C. Inestrosa, The role of oxidative stress in the toxicity induced by amyloid β-peptide in Alzheimer's disease, Prog Neurobiol 62 (2000), 633-648.
22. C. Morgan, M. Colombres, M.T. Nunez and N.C. Inestrosa, Structure and function of amyloidin Alzheimer's disease, Prog Neurobiol 74 (2004), 323-349.
23. R.M. Nitsch, B.E. Slack, R.J. Wurtman and J.H. Growdon, Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors, Science 258 (1992), 304-307.
24. L.D. Plant, J.P. Boyle, I.F. Smith, C. Peers and H.A. Pearson, The production of amyloid beta peptide is a critical requirement for the viability of central neurons, J Neurosci 23 (2003), 5531-5535.
25. L.D. Plant, N.J. Webster, J.P. Boyle, M. Ramsden, D.B. Freir, C. Peers and H.A. Pearson, Amyloid beta peptide as a physiological modulator of neuronal 'A'-type K(+) current, Neurobiol Aging, (3) (2005); [Epub ahead of print].
26. D.L. Price and S.S. Sisodia, Mutant genes in familial Alzheimer's disease and transgenic models, Annu Rev Neurosci 21 (1998), 479-505.
27. 2+ channel currents in primary cultures of rat cortical neurones by amyloid beta protein (1-40) is dependent on solubility status, Brain Res 956 (2002), 254-261.
28. C. Reinhard, S.S. Hebert and B. De Strooper, The amyloid-beta precursor protein: integrating structure with biological function, EMBO J 24 (2005), 3996-4006.
29. J.T. Rogers and D.K. Lahiri, Metal and inflammatory targets for Alzheimer's disease, Curr Drug Targets 5 (2004), 535-551.
30. K. Sambamurti, N.H. Greig and D.K. Lahiri, Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer's disease, Neuromolecular Med 1 (2002), 1-31.
31. K. Sambamurti, A. Suram, C. Venugopal, A. Prakasam, Y. Zhou, D.K. Lahiri and N.H. Greig, A partial failure of membrane protein turnover may cause Alzheimer's disease: a new hypothesis, Curr Alz Res 3 (2006), 81-90.
32. J. Seo, S. Kim, H. Kim, C.H. Park, S. Jeong, J. Lee, S.H. Choi, K. Chang, J. Rah, J. Koo, E. Kim and Y. Suh, Effects of nicotine on APP secretion and Abeta- or CT(105)-induced toxicity, Biol Psychiatry 49 (2001), 240-247.
33. T. Utsuki, M. Shoaib, H.W. Holloway, D.K. Ingram, W.C. Wallace, V. Haroutunian, K. Sambamurti, D.K. Lahiri and N.H. Greig, Nicotine lowers the secretion of the Alzheimer's amyloid beta-protein precursor that contains amyloid beta-peptide in rat, J Alzheimers Dis 4 (2002), 405-415.
34. W. Wallace, I. Lieberburg, D. Schenk, C. Vigo-Pelfrey, K. Davis and V. Haroutunian, Chronic elevation of secreted amyloid precursor protein in subcortically lesioned rats, and its exacerbation in aged rats, J Neurosci 15 (1995), 4896-4905.
35. D.M. Walsh, I. Klyubin, J.V. Fadeeva, W.K. Cullen, R. Anwyl, M.S. Wolfe, M.J. Rowan and D.J. Selkoe, Naturally secreted oligomers of amyloid [beta] protein potently inhibit hippocampal long-term potentiation in vivo, Nature 416 (2002), 535-539.
36. H.-W. Wang, J.F. Pasternak, H. Kuo, H. Ristic, M.P. Lambert, B. Chromy, K.L. Viola, W.L. Klein, W.B. Stine, G.A. Krafft and B.L. Trommer, Soluble oligomers of [beta] amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus, Brain Research 924 (2002), 133-140.
37. E.F. Williams, C.F. Hoffman and T.P. Nash, Stimulation of gastric secretion by neurine, Am J Physiol 139 (1943), 364-365.
38. T. Zuchner, J.R. Perez-Polo and R. Schliebs, Beta-secretase BACE1 is differentially controlled through muscarinic acetylcholine receptor signaling, J Neurosci Res 77 (2004), 250-257.