Origin and role of aneuploidy in cancer;Entstehung und bedeutung von numerischen chromosomenveränderungen bei bösartigen tumorerkrankungen

Deutsche Medizinische Wochenschrift

Volumn 131, Issue 31-32, 2006, Pages 1747-1753

  Schnerch, D ^a   Hasskarl, J ^a   Engelhardt, M ^a   Wäsch, Ralph ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Aneuploidy; Cancer

Indexed keywords

CYCLIN A; CYCLIN E;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOCYTIC LEUKEMIA; ANEUPLOIDY; BREAST CANCER; CANCER; CELL CYCLE PROGRESSION; CHRONIC LYMPHATIC LEUKEMIA; CHRONIC MYELOID LEUKEMIA; COLORECTAL CARCINOMA; DIPLOIDY; DNA REPAIR; GENE MUTATION; GENE SEQUENCE; GENETIC RECOMBINATION; HUMAN; KARYOTYPE; LUNG CANCER; MITOSIS SPINDLE; MULTIPLE MYELOMA; NONHODGKIN LYMPHOMA; OVARY CARCINOMA; PROSTATE CARCINOMA; REVIEW; TELOMERE; TETRAPLOIDY; ARTICLE; CENTROSOME; CHROMOSOME ABERRATION; GENETICS; NEOPLASM; PATHOLOGY;

ANEUPLOIDY; CENTROSOME; CHROMOSOME ABERRATIONS; HUMANS; NEOPLASMS;

EID: 33748662416     PISSN: 00120472     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2006-947828     Document Type: Review

References (49)

1. Alani RM, Hasskarl J, Grace M et al. Immortalization of primary human keratinocytes by the helix-loop-helix protein, Id-1. Proc Natl Acad Sci U S A 1999; 96: 9637-9641
2. Albertson DC, Collins C, McCormick F, Gray JW. Chromosome aberrations in solid tumors. Nat Genet 2003; 34: 369-376
3. Artandi SE, Chang S et al. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature 2000; 406: 641-645
4. Baretton C, Vogt T, Valina C et al. Prostate cancers and potential precancerous conditions: DNA cytometric investigations and interphase cytogenetics. Verh Dtsch Ges Pathol 1993; 77: 86-92
5. Bharadwaj R, Yu H. The spindle checkpoint, aneuploidy, and cancer. Oncogene 2004; 23: 2016-2027
6. Boveri T. Zur Frage der Entstehung Maligner Tumoren. Jena: Fischer, 1914
7. Cahill DP, Lengauer C, Yu J et al. Mutations of mitotic checkpoint genes in human cancers. Nature 1998; 392: 300-303
8. D'Assoro AB, Lingle WL, Salisbury JL. Centrosome amplification and the development of cancer. Oncogene 2002; 21: 6146-6153
9. Dobles M, Liberal V, Scott ML, Benezra R, Sorger PK. Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2. Cell 2000; 101: 635-645
10. Doxsey SJ. Centrosomes as command centres for cellular control. Nat Cell Biol 2001; 3: E105-108
11. Duensing A, Duensing S. Guilt by association? p53 and the development of aneuploidy in cancer. Biochem Biophys Res Commun 2005; 331: 694-700
12. Duensing A, Liu Y, Tseng M et al. Cyclin-dependent kinase 2 is dispensable for normal centrosome duplication but required for oncogene-induced centrosome overduplication. Oncogene 2006; 25: 2943-2949
13. Duensing S. A tentative classification of centrosome abnormalities in cancer. Cell Biol Int 2005; 29: 352-359
14. Duensing S, Munger K. Human papillomaviruses and centrosome duplication errors: modeling the origins of genomic instability. Oncogene 2002; 21: 6241-6248
15. Duesberg P, Rausch C, Rasnick D, Hehlmann R. Genetic instability of cancer cells is proportional to their degree of aneuploidy. Proc Natl Acad Sci U S A 1998; 95: 13692-13697
16. Engelhardt M, Drullinsky P et al. Telomerase and telomere length in the development and progression of premalignant lesions to colorectal cancer. Clin Cancer Res 1997; 3: 1931-1941
17. Engelhardt M, Kumar R et al. Telomerase regulation, cell cycle, and telomere stability in primitive hematopoietic cells. Blood 1997; 90: 182-193
18. Engelhardt M, Mackenzie K, Drullinsky P, Silver KT, Moore MA. Telomerase activity and telomere length in acute and chronic leukemia, pre- and post-ex vivo culture. Cancer Res 2000; 60: 610-617
19. Engelhardt M, Ozkaynak MF, Drullinsky P et al. Telomerase activity and telomere length in pediatric patients with malignancies undergoing chemotherapy. Leukemia 1998; 12: 13-24
20. Fujiwara T, Bandi M, Nitta M et al. Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells. Nature 2005; 437: 1043-1047
21. Galipeau PC, Cowan DS, Sanchez CA et al. 17p (p53) allelic losses, 4N (G2/tetraploid) populations, and progression to aneuploidy in Barrett's esophagus. Proc Natl Acad Sci USA 1996; 93: 7081-7084
22. Gemma A, Hosoya Y, Seike M et al. Genomic structure of the human MAD2 gene and mutation analysis in human lung and breast cancers. Lung Cancer 2001; 32: 289-295
23. Giehl M, Fabarius A, Frank O et al. Centrosome aberrations in chronic myeloid leukemia correlate with stage of disease and chromosomal instability. Leukemia 2005; 19: 1192-1197
24. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100: 57-70
25. Hanks S, Coleman K, Reid S et al. Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B. Nat Genet 2004; 36: 1159-1161
26. Hasskarl J, Duensing S, Manuel E, Munger K. The helix-loop-helix protein ID1 localizes to centrosomes and rapidly induces abnormal centrosome numbers. Oncogene 2004; 23: 1930-1938
27. Hempen PM, Kurpad H, Calhoun ES et al. A double missense variation of the BUB1 gene and a defective mitotic spindle checkpoint in the pancreatic cancer cell line Hs766T. Hum Mutat 2003; 21: 445
28. Jaffrey RG, Pritchard SC, Clark C et al. Genomic instability at the BUB1 locus in colorectal cancer, but not in non-small cell lung cancer. Cancer Res 2000; 60: 4349-4352
29. Kalitsis P, Earle E, Fowler KJ, Choo KH. Bub3 gene disruption in mice reveals essential mitotic spindle checkpoint function during early embryogenesis. Genes Dev 2000; 14: 2277-2282
30. Kinzler KW, Vogelstein B. Lessons from hereditary colorectal cancer. Cell 1996; 87: 159-170
31. Kops GJ, Weaver BA, Cleveland DW. On the road to cancer: aneuploidy and the mitotic checkpoint. Nat Rev Cancer 2005; 5: 773-785
32. Lengauer C, Kinzler KW, Vogelstein B. Genetic instability in colorectal cancers. Nature 1997; 386: 623-627
33. Nigg EA. Centrosome aberrations: cause or consequence of cancer progression? Nat Rev Cancer 2002; 2: 815-825
34. O'Driscoll M, Jeggo PA. The role of double-strand break repair - insights from human genetics. Nat Rev Genet 2006; 7: 45-54
35. Ohshima K, Haraoka S et al. Mutation analysis of mitotic checkpoint genes (hBUB1 and hBUBR1) and microsatellite instability in adult T-cell leukemia/lymphoma. Cancer Lett 2000; 158: 141-150
36. Olaharski AJ, Sotelo R, Solorza-Luna G et al. Tetraploidy and chromosomal instability are early events during cervical carcinogenesis. Carcinogenesis 2006; 27: 337-343
37. Persons DL, Croughan WS et al. Interphase cytogenetics of esophageal adenocarcinoma and precursor lesions. Cancer Genet Cytogenet 1998; 106: 11-17
38. Pihan G, Doxsey SJ. Mutations and aneuploidy: co-conspirators in cancer? Cancer Cell 2003; 4: 89-94
39. Rajagopalan H, Lengauer C. Aneuploidy and cancer. Nature 2004; 432: 338-341
40. Ru HV, Chen RL, Lu WC, Cfien JH. hBUB1 defects in leukemia and lymphoma cells. Oncogene 2002; 21: 4673-4679
41. Rubin EM, DeRose PB, Cohen C. Comparative image cytometric DNA ploidy of liver cell dysplasia and hepatocellular carcinoma. Mod Pathol 1994; 7: 677-680
42. Shi Q, King RW. Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines. Nature 2005; 437: 1038-1042
43. Shichiri M, Yoshinaga K, Hisatomi H et al. Genetic and epigenetic inactivation of mitotic checkpoint genes hBUB1 and hBUBR1 and their relationship to survival. Cancer Res 2002; 62: 13-17
44. Shiloh Y. ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer 2003; 3: 155-168
45. Storchova Z, Pellman D. From polyploidy to aneuploidy, genome instability and cancer. Nat Rev Mol Cell Biol 2004; 5: 45-54
46. Takahashi T, Haruki N, Nomoto S et al. Identification of frequent impairment of the mitotic checkpoint and molecular analysis of the mitotic checkpoint genes, hsMAD2 and pSSCDC, in human lung cancers. Oncogene 1999; 18: 4295-300
47. Wäsch R, Cross FR. APC-dependent proteolysis of the mitotic cyclin Clb2 is essential for mitotic exit. Nature 2002; 418: 556-562
48. Wäsch R, Engelbert D. Anaphase-promoting complex-dependent proteolysis of cell cycle regulators and genomic instability of cancer cells. Oncogene 2005; 24: 1-10
49. Zhou H, Kuang J et al. Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. Nat Genet 1998; 20: 189-193