Multibranch and pseudopeptide approach for design of novel inhibitors of subtilisin kexin isozyme-1

Protein and Peptide Letters

Volumn 13, Issue 9, 2006, Pages 863-876

  Basak, Sarmistha ^a   Mohottalage, Dayani ^a   Basak, Ajoy ^a  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

Author keywords

Circular dichroism; Enzyme inhibitors; Inhibition constant; Isostere; Mass spectrometry; Multibranch peptide; Pseudopeptide; Secondary structure; Site 1 Protease (S1P); Subtilisin Kexin Isozyme 1 (SKI 1)

Indexed keywords

ISOENZYME; MEMBRANE BOUND TRANSCRIPTION FACTOR PEPTIDASE, SITE 1; MEMBRANE-BOUND TRANSCRIPTION FACTOR PEPTIDASE, SITE 1; PEPTIDE; RECOMBINANT PROTEIN; SERINE PROTEINASE; SITE 1 PROTEASE; SITE-1 PROTEASE;

AMINO ACID SEQUENCE; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; CIRCULAR DICHROISM; DRUG ANTAGONISM; ENZYME ACTIVE SITE; GENETICS; HUMAN; HYDROGEN BOND; METABOLISM; MOLECULAR GENETICS; PROTEIN CONFORMATION; SYNTHESIS;

AMINO ACID SEQUENCE; CATALYTIC DOMAIN; CIRCULAR DICHROISM; HUMANS; HYDROGEN BONDING; ISOENZYMES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; PEPTIDES; PROPROTEIN CONVERTASES; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SERINE ENDOPEPTIDASES;

EID: 33748634622     PISSN: 09298665     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986606778256199     Document Type: Article

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