Aminoethyl benzenesulfonyl fluoride and its hexapeptide (Ac-VFRSLK) conjugate are both in vitro inhibitors of subtilisin kexin isozyme-1

FEBS Letters

Volumn 573, Issue 1-3, 2004, Pages 186-194

  Basak, Sarmistha ^a   Stewart, Nicolas A ^a   Chrétien, Michel ^a   Basak, Ajoy ^a  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

Author keywords

aa, amino acid(s); h, human; m, mouse; MALDI TOF, matrix assisted laser desorption ionization time of flight; PC, proprotein convertase; r, rat; SKI 1, subtilisin kexin isozyme 1, S1P, site 1 protease; vv, vaccinia virus

Indexed keywords

AMINOETHYLBENZENESULFONYL FLUORIDE; ETHANOLAMINE DERIVATIVE; FLUORIDE; HEXAPEPTIDE; ISOENZYME; KEXIN; LEUCINE; LYSINE; SUBTILISIN; UNCLASSIFIED DRUG; VALYLPHENYLALANYLARGINYLSERYLLEUCYLLYSINE; VIRUS GLYCOPROTEIN;

AMINO ACID SEQUENCE; ARTICLE; CONSENSUS SEQUENCE; ENZYME SUBSTRATE; HYDROPHOBICITY; IC 50; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION;

AMINO ACID SEQUENCE; CATALYSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; ISOENZYMES; MOLECULAR SEQUENCE DATA; PEPTIDES; PROPROTEIN CONVERTASES; SERINE ENDOPEPTIDASES; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SUBTILISIN; SULFONES;

VACCINIA VIRUS;

EID: 4344685947     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2004.07.069     Document Type: Article

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