Major histocompatibility complex class I restricted T-cell autoreactivity in human peripheral blood mononuclear cells

Cellular Immunology

Volumn 240, Issue 1, 2006, Pages 62-67

  Eleftheriadis, Theodoros ^a   Voyatzi, Soultana ^a   Antoniadi, Georgia ^a   Kartsios, Charalambos ^a   Liakopoulos, Vassilios ^a   Paraskevopoulos, Panagiotis ^a   Galaktidou, Grammatiki ^a  

^a THEAGENIO CANCER HOSPITAL   (Greece)

Author keywords

chain; Antigen processing; Interferon ; Proteasome; Self tolerance

Indexed keywords

AMMONIUM CHLORIDE; CHLOROQUINE; EPOXOMICIN; GAMMA INTERFERON; LOW MOLECULAR PROTEIN 2; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; N [N (3 CARBOXYOXIRANE 2 CARBONYL)LEUCYL]AGMATINE; PROTEASOME; PROTEIN; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ANTIGEN PRESENTATION; ARTICLE; AUTOIMMUNITY; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL PROLIFERATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOLOGICAL TOLERANCE; LYSOSOME; MAJOR HISTOCOMPATIBILITY COMPLEX; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

AUTOIMMUNITY; CELL PROLIFERATION; CELL SEPARATION; CELLS, CULTURED; CYSTEINE ENDOPEPTIDASES; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; INTERFERON TYPE II; INTERLEUKIN-2; LYSOSOMES; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; SUBCELLULAR FRACTIONS; T-LYMPHOCYTES;

EID: 33748621205     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2006.06.006     Document Type: Article

References (27)

1. Palmer E. Negative selection-clearing out the bad apples from the T-cell repertoire. Nat. Rev. Immunol. 3 5 (2003) 383-391
2. Kyewski B., and Derbinski J. Self-representation in the thymus: an extended view. Nat. Rev. Immunol. 4 9 (2004) 688-698
3. Watts C. Antigen processing in the endocytic compartment. Curr. Opin. Immunol. 13 1 (2001) 26-31
4. Hsing L.C., and Rudensky A.Y. The lysosomal cysteine proteases in MHC class II antigen presentation. Immunol. Rev. 207 (2005) 229-241
5. Cresswell P., Ackerman A.L., Giodini A., Peaper D.R., and Wearsch P.A. Mechanisms of MHC class I-restricted antigen processing and cross-presentation. Immunol. Rev. 207 (2005) 145-157
6. Kloetzel P.M. Generation of major histocompatibility complex class I antigens: functional interplay between proteasomes and TPPII. Nat. Immunol. 5 7 (2004) 661-669
7. Nakagawa T., Roth W., Wong P., Nelson A., Farr A., Deussing J., Villadangos J.A., Ploegh H., Peters C., and Rudensky A.Y. Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus. Science 280 5362 (1998) 450-453
8. Honey K., Nakagawa T., Peters C., and Rudensky A. Cathepsin L regulates CD4+ T cell selection independently of its effect on invariant chain: a role in the generation of positively selecting peptide ligands. J. Exp. Med. 195 10 (2002) 1349-1358
9. Beers C., Honey K., Fink S., Forbush K., and Rudensky A. Differential regulation of cathepsin S and cathepsin L in interferon gamma-treated macrophages. J. Exp. Med. 197 2 (2003) 169-179
10. Hsieh C.S., deRoos P., Honey K., Beers C., and Rudensky A.Y. A role for cathepsin L and cathepsin S in peptide generation for MHC class II presentation. J. Immunol. 168 6 (2002) 2618-2625
11. Bromme D., Li Z., Barnes M., and Mehler E. Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization. Biochemistry 38 (1999) 2377-2385
12. Aki M., Shimbara N., Takashina M., Akiyama K., Kagawa S., Tamura T., Tanahashi N., Yoshimura T., Tanaka K., and Ichihara A. Interferon-gamma induces different subunit organizations and functional diversity of proteasomes. J. Biochem. (Tokyo) 115 2 (1994) 257-269
13. Toes R.E., Nussbaum A.K., Degermann S., Schirle M., Emmerich N.P., Kraft M., Laplace C., Zwinderman A., Dick T.P., Muller J., Schonfisch B., Schmid C., Fehling H.J., Stevanovic S., Rammensee H.G., and Schild H. Discrete cleavage motifs of constitutive and immunoproteasomes revealed by quantitative analysis of cleavage products. J. Exp. Med. 194 1 (2001) 1-12
14. Nil A., Firat E., Sobek V., Eichmann K., and Niedermann G. Expression of housekeeping and immunoproteasome subunit genes is differentially regulated in positively and negatively selecting thymic stroma subsets. Eur. J. Immunol. 34 10 (2004) 2681-2689
15. Ziegler H.K., and Unanue E.R. Decrease in macrophage antigen catabolism caused by ammonia and chloroquine is associated with inhibition of antigen presentation to T cells. Proc. Natl. Acad. Sci. USA 79 1 (1982) 175-178
16. Barrett A.J., Kembhavi A.A., Brown M.A., Kirschke H., Knight C.G., Tamai M., and Hanada K. l-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L. Biochem. J. 201 1 (1982) 189-198
17. Meng L., Mohan R., Kwok B.H., Elofsson M., Sin N., and Crews C.M. Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity. Proc. Natl. Acad. Sci. USA 96 18 (1999) 10403-10408
18. Eleftheriadis T., Antoniadi G., Liakopoulos V., and Kortsaris A. T-Cell zeta chain expression, phosphorylation and degradation and their role in T-Cell signal transduction and immune response regulation in health and disease. Curr. Signal Transduct. Ther. 1 2 (2006) 191-208
19. Kersh E.N., Shaw A.S., and Allen P.M. Fidelity of T cell activation through multistep T cell receptor zeta phosphorylation. Science 281 5376 (1998) 572-575
20. Kersh G.J., Kersh E.N., Fremont D.H., and Allen P.M. High- and low-potency ligands with similar affinities for the TCR: the importance of kinetics in TCR signaling. Immunity 9 6 (1998) 817-826
21. Smith J.A., Tso J.Y., Clark M.R., Cole M.S., and Bluestone J.A. Nonmitogenic anti-CD3 monoclonal antibodies deliver a partial T cell receptor signal and induce clonal anergy. J. Exp. Med. 185 8 (1997) 1413-1422
22. Chae W.J., Lee H.K., Han J.H., Kim S.W., Bothwell A.L., Morio T., and Lee S.K. Qualitatively differential regulation of T cell activation and apoptosis by T cell receptor zeta chain ITAMs and their tyrosine residues. Int. Immunol. 16 9 (2004) 1225-1236
23. Pitcher L.A., Mathis M.A., Subramanian S., Young J.A., Wakeland E.K., Love P.E., and van Oers N.S. Selective expression of the 21-kilodalton tyrosine-phosphorylated form of TCR zeta promotes the emergence of T cells with autoreactive potential. J. Immunol. 174 10 (2005) 6071-6079
24. Smith K.A. IL-2. In: Oppenheim J.J., and Feldmann M. (Eds). Cytokine reference (2000), Academic Press, London 113-125
25. Opelz G., Kiuchi M., Takasugi M., and Terasaki P.I. Autologous stimulation of human lymphocyte subpopulations. J. Exp. Med. 142 (1975) 1327-1333
26. Medzhitov R., and Janeway Ch. Decoding the patterns of self and non-self by the innate immune system. Science 296 (2002) 298-300
27. Leblond J., Hubert-Buron A., Bole-Feysot C., Ducrotte P., Dechelotte P., and Coeffier M. Regulation of proteolysis by cytokines in the human intestinal epithelial cell line HCT-8: role of IFN-γ. Biochimie (2006) 10.1016/j.biochi.2006.01.003