Persistent sodium currents and repetitive firing in motoneurons of the sacrocaudal spinal cord of adult rats

Journal of Neurophysiology

Volumn 96, Issue 3, 2006, Pages 1141-1157

  Harvey, P J ^a   Li, Y ^a   Li, X ^a   Bennett, D J ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; NIMODIPINE; RILUZOLE; SODIUM ION; TETRODOTOXIN;

ANIMAL TISSUE; ARTICLE; CALCIUM CURRENT; CONTROLLED STUDY; EVOKED RESPONSE; FEMALE; HYPERPOLARIZATION; MEMBRANE STEADY POTENTIAL; MOTOR NERVE CONDUCTION; NONHUMAN; PRIORITY JOURNAL; RAT; SACRUM; SODIUM CURRENT; SPIKE WAVE; SPINAL CORD MOTONEURON; SPINAL CORD POTENTIAL;

ANIMALS; CALCIUM CHANNELS; FEMALE; MEMBRANE POTENTIALS; MOTOR NEURONS; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; SODIUM CHANNELS; SPINAL CORD; SPINAL CORD INJURIES; TETRODOTOXIN;

EID: 33748580668     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.00335.2005     Document Type: Article

References (55)

1. Alaburda A and Hounsgaard J. Metabotropic modulation of motoneurons by scratch-like spinal network activity. J Neurosci 23: 8625-8629, 2003.
2. Alvarez FJ, Pearson JC, Harrington D, Dewey D, Torbeck L, and Fyffe RE. Distribution of 5-hydroxytryptamine-immunoreactive boutons on alpha-motoneurons in the lumbar spinal cord of adult cats. J Comp Neurol 393: 69-83, 1998.
3. + current in pyramidal neurons from rat and cat sensorimotor cortex. J Neurosci 13: 660-673, 1993.
4. Bennett DJ, Gorassini M, Fouad K, Sanelli L, Han Y, and Cheng J. Spasticity in rats with sacral spinal cord injury. J Neurotrauma 16: 69-84, 1999.
5. Bennett DJ, Li Y, and Siu M. Plateau potentials in sacrocaudal motoneurons of chronic spinal rats, recorded in vitro. J Neurophysiol 86: 1955-1971, 2001.
6. Bennett DJ, Sanelli L, Cooke C, Harvey PJ, and Gorassini MA. Spastic long-lasting reflexes in the awake rat after sacral spinal cord injury. J Neurophysiol 91: 2247-2258, 2004.
7. Cassam AK, Llewellyn-Smith IJ, and Weaver LC. Catecholamine enzymes and neuropeptides are expressed in fibres and somata in the intermediate gray matter in chronic spinal rats. Neuroscience 78: 829-841, 1997.
8. Conway BA, Hultborn H, Kiehn O, and Mintz I. Plateau potentials in alpha-motoneurones induced by intravenous injection of L-dopa and clonidine in the spinal cat. J Physiol 405: 369-384, 1988.
9. Coraboeuf E. Ionic basis of excitation mechanism in cardiac muscle. Recent Adv Stud Card Struct Metab 11: 11-18, 1976.
10. Crill WE. Persistent sodium current in mammalian central neurons. Annu Rev Physiol 58: 349-362, 1996.
11. Deisz RA, Fortin G, and Zieglgansberger W. Voltage dependence of excitatory postsynaptic potentials of rat neocortical neurons. J Neurophysiol 65: 371-382, 1991.
12. Delgado-Lezama R, Perrier JF, Nedergaard S, Svirskis G, and Hounsgaard J. Metabotropic synaptic regulation of intrinsic response properties of turtle spinal motoneurones. J Physiol 504: 97-102, 1997.
13. Eken T, Hultborn H, and Kiehn O. Possible functions of transmitter-controlled plateau potentials in alpha motoneurones. Prog Brain Res 80: 257-267, 1989.
14. Fedirchuk B and Dai Y. Monoamines increase the excitability of spinal neurones in the neonatal rat by hyperpolarizing the threshold for action potential production. J Physiol 557: 355-361, 2004.
15. French CR, Sah P, Buckett KJ, and Gage PW. A voltage-dependent persistent sodium current in mammalian hippocampal neurons. J Gen Physiol 95: 1139-1157, 1990.
16. Geijo-Barrientos E and Pastore C. The effects of dopamine on the subthreshold electrophysiological responses of rat prefrontal cortex neurons in vitro. Eur J Neurosci 7: 358-366, 1995.
17. Gorassini MA, Bennett DJ, and Yang JF. Self-sustained firing of human motor units. Neurosci Lett 247: 13-16, 1998.
18. Granit R, Henatsch HD, and Steg G. Tonic and phasic ventral horn cells differentiated by post-tetanic potentiation in cat extensors. Acta Physiol Scand 37: 114-126, 1956.
19. Guertin PA and Hounsgaard J. Non-volatile general anaesthetics reduce spinal activity by suppressing plateau potentials. Neuroscience 88: 353-358, 1999.
20. 2 receptor activation facilitates a persistent sodium current and repetitive firing in spinal motoneurons of rats with and without chronic spinal cord injury. J Neurophysiol 96: 1158-1170, 2006a.
21. Harvey PJ, Li X, Li Y, and Bennett DJ. Endogenous monoamine receptor activation is essential for enabling persistent sodium currents and repetitive firing in rat spinal motoneurons. J Neurophysiol 96: 1171-1186, 2006b.
22. Hounsgaard J, Hultborn H, Jespersen B, and Kiehn O. Bistability of alpha-motoneurones in the decerebrate cat and in the acute spinal cat after intravenous 5-hydroxytryptophan. J Physiol 405: 345-367, 1988a.
23. Hounsgaard J and Kiehn O. Serotonin-induced bistability of turtle motoneurones caused by a nifedipine-sensitive calcium plateau potential. J Physiol 414: 265-282, 1989.
24. Hounsgaard J, Kiehn O, and Mintz I. Response properties of motoneurones in a slice preparation of the turtle spinal cord. J Physiol 398: 575-589, 1988b.
25. Hsiao CF, Del Negro CA, Trueblood PR, and Chandler SH. Ionic basis for serotonin-induced bistable membrane properties in guinea pig trigeminal motoneurons. J Neurophysiol 79: 2847-2856, 1998.
26. Hultborn H and Kiehn O. Neuromodulation of vertebrate motor neuron membrane properties. Curr Opin Neurobiol 2: 770-775, 1992.
27. Kiehn O and Eken T. Prolonged firing in motor units: evidence of plateau potentials in human motoneurons? J Neurophysiol 78: 3061-3068, 1997.
28. Kiehn O and Harris-Warrick RM. Serotonergic stretch receptors induce plateau properties in a crustacean motor neuron by a dual-conductance mechanism. J Neurophysiol 68: 485-495, 1992.
29. Kitzman P. Alteration in axial motoneuronal morphology in the spinal cord injured spastic rat. Exp Neurol 192: 100-108, 2005.
30. Kuo JJ, Schonewille M, Siddique T, Schults AN, Fu R, Bar PR, Anelli R, Heckman CJ, and Kroese AB. Hyperexcitability of cultured spinal motoneurons from presymptomatic ALS mice. J Neurophysiol 91: 571-575, 2004.
31. Lee RH and Heckman CJ. Bistability in spinal motoneurons in vivo: systematic variations in persistent inward currents. J Neurophysiol 80: 583-593, 1998a.
32. Lee RH and Heckman CJ. Bistability in spinal motoneurons in vivo: systematic variations in rhythmic firing patterns. J Neurophysiol 80: 572-582, 1998b.
33. Lee RH and Heckman CJ. Enhancement of bistability in spinal motoneurons in vivo by the noradrenergic alpha1 agonist methoxamine. J Neurophysiol 81: 2164-2174, 1999.
34. Lee RH and Heckman CJ. Essential role of a fast persistent inward current in action potential initiation and control of rhythmic firing. J Neurophysiol 85: 472-475, 2001.
35. Li Y and Bennett DJ. Persistent sodium and calcium currents cause plateau potentials in motoneurons of chronic spinal rats. J Neurophysiol 90: 857-869, 2003.
36. Li Y, Gorassini MA, and Bennett DJ. Role of persistent sodium and calcium currents in motoneuron firing and spasticity in chronic spinal rats. J Neurophysiol 91: 767-783, 2004a.
37. Li Y, Harvey PJ, Li X, and Bennett DJ. Spastic long-lasting reflexes in the chronic spinal rat, studied in vitro. J Neurophysiol 91: 2236-2246, 2004b.
38. Li Y, Li X, Harvey PJ, and Bennett DJ. Effects of baclofen on spinal reflexes and persistent inward currents in motoneurons of chronic spinal rats with spasticity. J Neurophysiol 92: 2694-2703, 2004c.
39. Newton BW and Hamill RW. The morphology and distribution of rat serotoninergic intraspinal neurons: an immunohistochemical study. Brain Res Bull 20: 349-360, 1988.
40. Nishimura Y, Schwindt PC, and Crill WE. Electrical properties of facial motoneurons in brainstem slices from guinea pig. Brain Res 502: 127-142, 1989.
41. Perrier JF and Hounsgaard J. 5-HT2 receptors promote plateau potentials in turtle spinal motoneurons by facilitating an L-type calcium current. J Neurophysiol 89: 954-959, 2003.
42. Perrier JF, Mejia-Gervacio S, and Hounsgaard J. Facilitation of plateau potentials in turtle motoneurones by a pathway dependent on calcium and calmodulin. J Physiol 528: 107-113, 2000.
43. Powers RK and Binder MD. Effective synaptic current and motoneuron firing rate modulation. J Neurophysiol 74: 793-801, 1995.
44. Powers RK and Binder MD. Persistent sodium and calcium currents in rat hypoglossal motoneurons. J Neurophysiol 89: 615-624, 2003.
45. Prather JF, Powers RK, and Cope TC. Amplification and linear summation of synaptic effects on motoneuron firing rate. J Neurophysiol 85: 43-53, 2001.
46. Schlue WR, Richter DW, Mauritz KH, and Nacimiento AC. Responses of cat spinal motoneuron somata and axons to linearly rising currents. J Neurophysiol 37: 303-309, 1974.
47. Schmidt BJ and Jordan LM. The role of serotonin in reflex modulation and locomotor rhythm production in the mammalian spinal cord. Brain Res Bull 53: 689-710, 2000.
48. Schroder HD and Skagerberg G. Catecholamine innervation of the caudal spinal cord in the rat. J Comp Neurol 242: 358-368, 1985.
49. Schwindt PC and Crill WE. Factors influencing motoneuron rhythmic firing: results from a voltage-clamp study. J Neurophysiol 48: 875-890, 1982.
50. Stafstrom CE, Schwindt PC, Chubb MC, and Crill WE. Properties of persistent sodium conductance and calcium conductance of layer V neurons from cat sensorimotor cortex in vitro. J Neurophysiol 53: 153-170, 1985.
51. Taddese A and Bean BP. Subthreshold sodium current from rapidly inactivating sodium channels drives spontaneous firing of tuberomammillary neurons. Neuron 33: 587-600, 2002.
52. Urbani A and Belluzzi O. Riluzole inhibits the persistent sodium current in mammalian CNS neurons. Eur J Neurosci 12: 3567-3574, 2000.
53. White SR and Fung SJ. Serotonin depolarizes cat spinal motoneurons in situ and decreases motoneuron afterhyperpolarizing potentials. Brain Res 502: 205-213, 1989.
54. Xu W and Lipscombe D. Neuronal Ca(V)1.3alpha(1) L-type channels activate at relatively hyperpolarized membrane potentials and are incompletely inhibited by dihydropyridines. J Neurosci 21: 5944-5951, 2001.
55. Zeng J, Powers RK, Newkirk G, Yonkers M, and Binder MD. Contribution of persistent sodium currents to spike-frequency adaptation in rat hypoglossal motoneurons. J Neurophysiol 93: 1035-1041, 2005.