Persistent sodium and calcium currents in rat hypoglossal motoneurons

Journal of Neurophysiology

Volumn 89, Issue 1, 2003, Pages 615-624

  Powers, Randall K ^a   Binder, Marc D ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOPYRIDINE; CALCIUM CHANNEL; CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL N TYPE; CALCIUM CHANNEL P TYPE; CESIUM; POTASSIUM CHANNEL BLOCKING AGENT; SODIUM CHANNEL; TETRODOTOXIN; TETRYLAMMONIUM;

ALPHA NERVE FIBER; ANIMAL TISSUE; ARTICLE; CALCIUM CURRENT; CONTROLLED STUDY; DENDRITIC CELL; HYPOGLOSSAL NERVE; HYSTERESIS; MOTONEURON; NONHUMAN; PRIORITY JOURNAL; RAT; SODIUM CURRENT; VOLTAGE CLAMP;

EID: 0037247477     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.00241.2002     Document Type: Article

References (46)

1. Bayliss DA, Viana F, Talley EM, and Berger AJ. Neuromodulation of hypoglossal motoneurons: cellular and developmental mechanisms. Respir Physiol 110: 139-150, 1997.
2. Bean BP. Neurotransmitter inhibition of neuronal calcium currents by changes in channel voltage dependence. Nature 340: 153-156, 1989.
3. Bennett DJ, Hultborn H, Fedirchuk B, and Gorassini M. Synaptic activation of plateaus in hindlimb motoneurons of decerebrate cats. J Neurophysiol 80: 2023-2037, 1998.
4. Bernander O, Koch C, and Douglas RJ. Amplification and linearization of distal synaptic input to cortical pyramidal cells. J Neurophysiol 72: 2743-2753, 1994.
5. Binder MD. Integration of synaptic and intrinsic dendritic currents in cat spinal motoneurons. Brain Res Rev In press.
6. Binder MD, Heckman CJ, and Powers RK. The physiological control of motoneuron activity. In: Handbook of Physiology. Exercise: Regulation and Integration of Multiple Systems, edited by L. B. Rowell and J. T. Shepherd, New York: Oxford, 1996, sect. 12, pp. 3-53.
7. Binder MD, Zeng JS, Yonkers M, and Powers RK. Effects of active conductances on the transfer of synaptic currents from dendrites to soma in motoneurons. Soc. Neurosci. Abstr. 31: 856.8, 2002.
8. 2+-dependent spiking and plateau potentials under pharmacological treatment. J Neurophysiol 78: 3371-3385, 1997.
9. Burke RE. Motor units: anatomy, physiology, and functional organization. In: Handbook of Physiology, The Nervous System, Motor Control, edited by V. B. Brooks. Bethesda, MD: Am. Physiol. Soc., 1981, sect. 1, vol. II, p. 345-422.
10. Carlin KP, Jiang Z, and Brownstone RM. Characterization of calcium currents in functionally mature mouse spinal motoneurons. Eur J Neurosci 12: 1624-1634, 2000a.
11. Carlin KP, Jones, KE, Jiang Z, Jordan LM, and Brownstone RM. Dendritic L-type calcium currents in mouse spinal motoneurons: implications for bistability. Eur J Neurosci 12: 1635-1646, 2000b.
12. Delgado-Lezama R and Hounsgaard J. Adapting motoneurons for motor behavior. Prog Brain Res 123: 57-63, 1999.
13. Henneman E and Mendell LM. Functional organization of motoneuron pool and its inputs. In: Handbook of Physiology, The Nervous System, Motor Control, edited by V. B. Brooks. Bethesda, MD: Am. Physiol. Soc., 1981, sect. 1, vol. II, p. 423-507.
14. 2+ channels by G proteins, voltage-dependent facilitation, protein kinase C, and Ca(v)beta subunits. Proc Natl Acad Sci USA 98: 4699-4704, 2001.
15. Hounsgaard J, Hultborn H, Jespersen B, and Kiehn O. Intrinsic membrane properties causing a bistable behavior of α-motoneurones. Exp Brain Res 55: 391-394, 1984.
16. Hounsgaard J, Hultborn H, Jespersen B, and Kiehn O. Bistability of alpha-motoneurones in the decerebrate cat and in the acute spinal cat after intravenous 5-hydroxytryptophan, J Physiol (Lond) 405: 345-367, 1988.
17. Hounsgaard J and Kiehn O. Serotonin-induced bistability of turtle motoneurones caused by a nifedipine-sensitive calcium plateau potential. J Physiol (Lond) 414: 265-282, 1989.
18. Hounsgaard J and Kiehn O. Calcium spikes and calcium plateaux evoked by differential polarization in dendrites of turtle motoneurones in vitro. J Physiol (Lond) 468: 245-259, 1993.
19. Hounsgaard J and Mintz I. Calcium conductance and firing properties of spinal motoneurones in the turtle. J Physiol (Lond) 398: 591-603, 1988.
20. Hsiao CF, DelNegro CA, Trueblood PR, and Chandler SH. Ionic basis for serotonin-induced bistable membrane properties in guinea pig trigeminal motoneurons. J Neurophysiol 79: 2847-2856, 1998.
21. Jiang Z, Rempel J, Li J, Sawchuk MA, Carlin KP, and Brownstone RM. Development of L-type calcium channels and a nifedipine-sensitive motor activity in the postnatal mouse spinal cord. Eur J Neurosci 11: 3481-3487, 1999.
22. Kammermeier PJ and Jones SW. Facilitation of L-type calcium current in thalamic neurons. J Neurophysiol 79: 410-417, 1998.
23. Kernell D. Functional properties of spinal motoneurons and gradation of muscle force. Adv Neurol 39: 213-226, 1983.
24. Lee RH and Heckman CJ. Bistability in spinal motoneurons in vivo: systematic variations in rhythmic firing patterns. J Neurophysiol 80: 572-582, 1998a.
25. Lee RH and Heckman CJ. Bistability in spinal motoneurons in vivo: systematic variations in persistent inward currents. J Neurophysiol 80: 583-593, 1998b.
26. Lee RH and Heckman CJ. Adjustable amplification of synaptic input in the dendrites of spinal motoneurons in vivo. J Neurosci 20: 6734-6740, 2000.
27. Lee RH and Heckman CJ. Essential role of a fast persistent inward current in action potential initiation and control of rhythmic firing. J Neurophysiol 85: 472-475, 2001.
28. Mintz IM, Venema VJ, Swiderek KM, Lee TD, Bean BP, and Adams ME. P-type calcium channels blocked by the spider toxin omega-Aga-IVA. Nature 355: 827-829, 1992.
29. Muller W and Lux HD. Analysis of voltage-dependent membrane currents in spatially extended neurons from point-clamp data. J Neurophysiol 69: 241-247, 1993.
30. Nishimura Y, Schwindt PC, and Crill WE. Electrical properties of facial motoneurons in brainstem slices from guinea pig. Brain Res 502: 127-142, 1989.
31. Nunez-Abades PA, He F, Barrionuevo G, and Cameron WE. Morphology of developing rat genioglossal motoneurons studied in vitro: changes in length, branching pattern, and spatial distribution of dendrites. J Comp Neurol 339: 401-420, 1994.
32. CAN) in turtle motoneurons. J Neurophysiol 82: 730-735, 1999.
33. Perrier JF and Hounsgaard J. Development and regulation of response properties in spinal cord motoneurons. Brain Res Bull 53: 529-535, 2000.
34. Perrier JF, Noraberg J, Simon M, and Hounsgaard J. Dedifferentiation of intrinsic response properties of motoneurons in organotypic cultures of the spinal cord of the adult turtle. Eur J Neurosci 12: 2397-2404, 2000.
35. 2+ channels in motoneurons of the rat facial nucleus. J Neurosci 18: 9573-9584, 1998.
36. Powers RK and Binder MD. Summation of effective synaptic currents and firing rate modulation in cat spinal motoneurons, J Neurophysiol 83: 483-500, 2000.
37. Powers RK and Binder MD. Input-output functions of mammalian motoneurons. Rev Physiol Biochem Pharmacol 143: 137-263, 2001.
38. Powers RK, Musick JR, and Binder MD. Calcium and sodium currents in rat hypoglossal motoneurons. Soc Neurosci Abstr 27: 934.7, 2001.
39. Prather JF, Powers RK, and Cope TC. Amplification and linear summation of synaptic effects on motoneuron firing rate. J Neurophysiol 85: 43-53, 2001.
40. Reynolds IJ, Wagner JA, Snyder SH, Thayer SA, Olivera BM, and Miller RJ. Brain voltage sensitive calcium channel subtypes differentiated by omega-conotoxin fraction GVIA. Proc Natl Acad Sci USA 83: 8804-8807, 1986.
41. Sawczuk A, Powers RK, and Binder MD. Spike frequency adaptation studied in hypoglossal motoneurons of the rat. J Neurophysiol 73: 1799-1810, 1995.
42. Schwindt PC and Crill WE. Factors influencing motoneuron rhythmic firing: results from a voltage-clamp study. J Neurophysiol 48: 875-890, 1982.
43. Song W and Surmeir DJ. Voltage-dependent facilitation of calcium channels in rat neostriatal neurons. J Neurophysiol 76: 2290-2306, 1996.
44. Svirskis G and Hounsgaard J. Depolarization-induced facilitation of a plateau-generating current in ventral horn neurons in the turtle spinal cord. J Neurophysiol 78: 1740-1742, 1997.
45. 2+ channels in hypoglossal motoneurons. J Neurosci 14: 5652-5660, 1994.
46. 2+-buffering in avian sensory neurons. Cell Calcium 28: 233-246, 2000.