메뉴 건너뛰기




Volumn 296, Issue 6, 2006, Pages 421-434

cDNA microarray analysis of differential gene expression and regulation in clinically drug-resistant isolates of Candida albicans from bone marrow transplanted patients

Author keywords

Bone marrow transplant; Candida albicans; Differential gene expression; Drug resistance; Microarray

Indexed keywords

ABC TRANSPORTER; ANTIFUNGAL AGENT; CARRIER PROTEIN; COMPLEMENTARY DNA; FLUCONAZOLE; MESSENGER RNA;

EID: 33748466564     PISSN: 14384221     EISSN: 16180607     Source Type: Journal    
DOI: 10.1016/j.ijmm.2006.03.004     Document Type: Article
Times cited : (25)

References (51)
  • 1
    • 0037399053 scopus 로고    scopus 로고
    • Mode of selection and experimental evolution of antifungal drug resistance in Saccharomyces cerevisiae
    • Anderson J.B., Sirjusingh C., Parsons A.B., Boone C., Wickens C., Cowen L.E., and Kohn L.M. Mode of selection and experimental evolution of antifungal drug resistance in Saccharomyces cerevisiae. Genetics 163 (2003) 1287-1298
    • (2003) Genetics , vol.163 , pp. 1287-1298
    • Anderson, J.B.1    Sirjusingh, C.2    Parsons, A.B.3    Boone, C.4    Wickens, C.5    Cowen, L.E.6    Kohn, L.M.7
  • 2
    • 4444231806 scopus 로고    scopus 로고
    • Genome-wide expression profiling reveals genes associated with amphotericin B and fluconazole resistance in experimentally induced antifungal resistant isolates of Candida albicans
    • Barker K.S., Crisp S., Wiederhold N., Lewis R.E., Bareither B., Eckstein J., Barbuch R., Bard M., and Rogers P.D. Genome-wide expression profiling reveals genes associated with amphotericin B and fluconazole resistance in experimentally induced antifungal resistant isolates of Candida albicans. J. Antimicrob. Chemother. 54 (2004) 376-385
    • (2004) J. Antimicrob. Chemother. , vol.54 , pp. 376-385
    • Barker, K.S.1    Crisp, S.2    Wiederhold, N.3    Lewis, R.E.4    Bareither, B.5    Eckstein, J.6    Barbuch, R.7    Bard, M.8    Rogers, P.D.9
  • 3
    • 0031038192 scopus 로고    scopus 로고
    • Reversible fluconazole resistance in Candida albicans: a potential in vitro model
    • Calvet H.M., Yeaman M.R., and Filler S.G. Reversible fluconazole resistance in Candida albicans: a potential in vitro model. Antimicrob. Agents Chemother. 41 (1997) 535-539
    • (1997) Antimicrob. Agents Chemother. , vol.41 , pp. 535-539
    • Calvet, H.M.1    Yeaman, M.R.2    Filler, S.G.3
  • 5
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • Chomczynski P., and Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162 (1987) 156-159
    • (1987) Anal. Biochem. , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 6
    • 11144270183 scopus 로고    scopus 로고
    • TAC1, transcriptional activator of CDR genes, is a new transcription factor involved in the regulation of Candida albicans ABC transporters CDR1 and CDR2
    • Coste A.T., Karababa M., Ischer F., Bille J., and Sanglard D. TAC1, transcriptional activator of CDR genes, is a new transcription factor involved in the regulation of Candida albicans ABC transporters CDR1 and CDR2. Eukaryot. Cell 3 (2004) 1639-1652
    • (2004) Eukaryot. Cell , vol.3 , pp. 1639-1652
    • Coste, A.T.1    Karababa, M.2    Ischer, F.3    Bille, J.4    Sanglard, D.5
  • 8
    • 0242413149 scopus 로고    scopus 로고
    • Inhibition of heme biosynthesis prevents transcription of iron uptake genes in yeast
    • Crisp R.J., Pollington A., Galea C., Jaron S., Yamaguchi-Iwai Y., and Kaplan J. Inhibition of heme biosynthesis prevents transcription of iron uptake genes in yeast. J. Biol. Chem. 278 (2003) 45499-45506
    • (2003) J. Biol. Chem. , vol.278 , pp. 45499-45506
    • Crisp, R.J.1    Pollington, A.2    Galea, C.3    Jaron, S.4    Yamaguchi-Iwai, Y.5    Kaplan, J.6
  • 9
    • 3042670682 scopus 로고    scopus 로고
    • Constitutive activation of the PDR16 promoter in a Candida albicans azole-resistant clinical isolate overexpressing CDR1 and CDR2
    • de Deken X., and Raymond M. Constitutive activation of the PDR16 promoter in a Candida albicans azole-resistant clinical isolate overexpressing CDR1 and CDR2. Antimicrob. Agents Chemother. 48 (2004) 2700-2703
    • (2004) Antimicrob. Agents Chemother. , vol.48 , pp. 2700-2703
    • de Deken, X.1    Raymond, M.2
  • 11
    • 0036223414 scopus 로고    scopus 로고
    • A common drug-responsive element mediates the upregulation of the Candida albicans ABC transporters CDR1 and CDR2, two genes involved in antifungal drug resistance
    • de Micheli M., Bille J., Schueller C., and Sanglard D. A common drug-responsive element mediates the upregulation of the Candida albicans ABC transporters CDR1 and CDR2, two genes involved in antifungal drug resistance. Mol. Microbiol. 43 (2002) 1197-1214
    • (2002) Mol. Microbiol. , vol.43 , pp. 1197-1214
    • de Micheli, M.1    Bille, J.2    Schueller, C.3    Sanglard, D.4
  • 12
    • 0034708797 scopus 로고    scopus 로고
    • Genome microarray analysis of transcriptional activation in multidrug resistance yeast mutants
    • DeRisi J., van den Hazel B., Marc P., Balzi E., Brown P., Jacq C., and Goffeau A. Genome microarray analysis of transcriptional activation in multidrug resistance yeast mutants. FEBS Lett. 470 (2000) 156-160
    • (2000) FEBS Lett. , vol.470 , pp. 156-160
    • DeRisi, J.1    van den Hazel, B.2    Marc, P.3    Balzi, E.4    Brown, P.5    Jacq, C.6    Goffeau, A.7
  • 13
    • 0031759244 scopus 로고    scopus 로고
    • Multiple molecular mechanisms contribute to a stepwise development of fluconazole resistance in clinical Candida albicans strains
    • Franz R., Kelly S.L., Lamb D.C., Kelly D.E., Ruhnke M., and Morschhäuser J. Multiple molecular mechanisms contribute to a stepwise development of fluconazole resistance in clinical Candida albicans strains. Antimicrob. Agents Chemother. 42 (1998) 3065-3072
    • (1998) Antimicrob. Agents Chemother. , vol.42 , pp. 3065-3072
    • Franz, R.1    Kelly, S.L.2    Lamb, D.C.3    Kelly, D.E.4    Ruhnke, M.5    Morschhäuser, J.6
  • 14
    • 0034534975 scopus 로고    scopus 로고
    • Multiple signals from dysfunctional mitochondria activate the pleiotropic drug resistance pathway in Saccharomyces cerevisiae
    • Hallstrom T.C., and Moye-Rowley W.S. Multiple signals from dysfunctional mitochondria activate the pleiotropic drug resistance pathway in Saccharomyces cerevisiae. J. Biol. Chem. 275 (2000) 37347-37356
    • (2000) J. Biol. Chem. , vol.275 , pp. 37347-37356
    • Hallstrom, T.C.1    Moye-Rowley, W.S.2
  • 16
    • 0036854503 scopus 로고    scopus 로고
    • Copper- and zinc-containing superoxide dismutase (Cu/Zn SOD) is required for the protection of Candida albicans against oxidative stresses and the expression of its full virulence
    • Hwang C.S., Rhie G.E., Oh J.H., Huh W.K., Yim H.S., and Kang S.O. Copper- and zinc-containing superoxide dismutase (Cu/Zn SOD) is required for the protection of Candida albicans against oxidative stresses and the expression of its full virulence. Microbiology 148 (2002) 3705-3713
    • (2002) Microbiology , vol.148 , pp. 3705-3713
    • Hwang, C.S.1    Rhie, G.E.2    Oh, J.H.3    Huh, W.K.4    Yim, H.S.5    Kang, S.O.6
  • 18
    • 3342996550 scopus 로고    scopus 로고
    • Comparison of gene expression profiles of Candida albicans azole-resistant clinical isolates and laboratory strains exposed to drugs inducing multidrug transporters
    • Karababa M., Coste A.T., Rognon B., Bille J., and Sanglard D. Comparison of gene expression profiles of Candida albicans azole-resistant clinical isolates and laboratory strains exposed to drugs inducing multidrug transporters. Antimicrob. Agents Chemother. 48 (2004) 3064-3079
    • (2004) Antimicrob. Agents Chemother. , vol.48 , pp. 3064-3079
    • Karababa, M.1    Coste, A.T.2    Rognon, B.3    Bille, J.4    Sanglard, D.5
  • 19
    • 0037119462 scopus 로고    scopus 로고
    • Identification and characterization of a Saccharomyces cerevisiae gene, RSB1, involved in sphingoid long-chain base release
    • Kihara A., and Igarashi Y. Identification and characterization of a Saccharomyces cerevisiae gene, RSB1, involved in sphingoid long-chain base release. J. Biol. Chem. 277 (2002) 30048-30054
    • (2002) J. Biol. Chem. , vol.277 , pp. 30048-30054
    • Kihara, A.1    Igarashi, Y.2
  • 20
    • 0032709222 scopus 로고    scopus 로고
    • Involvement of mitochondrial aldehyde dehydrogenase ALD5 in maintenance of the mitochondrial electron transport chain in Saccharomyces cerevisiae
    • Kurita O., and Nishida Y. Involvement of mitochondrial aldehyde dehydrogenase ALD5 in maintenance of the mitochondrial electron transport chain in Saccharomyces cerevisiae. FEMS. Microbiol. Lett. 181 (1999) 281-287
    • (1999) FEMS. Microbiol. Lett. , vol.181 , pp. 281-287
    • Kurita, O.1    Nishida, Y.2
  • 22
    • 0030941339 scopus 로고    scopus 로고
    • Copper-specific transcriptional repression of yeast genes encoding critical components in the copper transport pathway
    • Labbe S., Zhu Z., and Thiele D.J. Copper-specific transcriptional repression of yeast genes encoding critical components in the copper transport pathway. J. Biol. Chem. 272 (1997) 15951-15958
    • (1997) J. Biol. Chem. , vol.272 , pp. 15951-15958
    • Labbe, S.1    Zhu, Z.2    Thiele, D.J.3
  • 24
    • 18844393429 scopus 로고    scopus 로고
    • Genome-wide expression profiling of the response to azole, polyene, echinocandin, and pyrimidine antifungal agents in Candida albicans
    • Liu T.T., Lee R.E., Barker K.S., Lee R.E., Wei L., Homayouni R., and Rogers P.D. Genome-wide expression profiling of the response to azole, polyene, echinocandin, and pyrimidine antifungal agents in Candida albicans. Antimicrob. Agents Chemother. 49 (2005) 2226-2236
    • (2005) Antimicrob. Agents Chemother. , vol.49 , pp. 2226-2236
    • Liu, T.T.1    Lee, R.E.2    Barker, K.S.3    Lee, R.E.4    Wei, L.5    Homayouni, R.6    Rogers, P.D.7
  • 25
    • 0030761555 scopus 로고    scopus 로고
    • Development of fluconazole resistance in Candida albicans causing disseminated infection in a patient undergoing marrow transplantation
    • Marr K.A., White T.C., vanBurik J.A.H., and Bowden R.A. Development of fluconazole resistance in Candida albicans causing disseminated infection in a patient undergoing marrow transplantation. Clin. Infect. Dis. 25 (1997) 908-910
    • (1997) Clin. Infect. Dis. , vol.25 , pp. 908-910
    • Marr, K.A.1    White, T.C.2    vanBurik, J.A.H.3    Bowden, R.A.4
  • 26
    • 0031687814 scopus 로고    scopus 로고
    • Rapid, transient fluconazole resistance in Candida albicans is associated with increased mRNA levels of CDR
    • Marr K.A., Lyons C.N., Rustad T.R., Bowden R.A., and White T.C. Rapid, transient fluconazole resistance in Candida albicans is associated with increased mRNA levels of CDR. Antimicrob. Agents Chemother. 42 (1998) 2584-2589
    • (1998) Antimicrob. Agents Chemother. , vol.42 , pp. 2584-2589
    • Marr, K.A.1    Lyons, C.N.2    Rustad, T.R.3    Bowden, R.A.4    White, T.C.5
  • 27
    • 0035173979 scopus 로고    scopus 로고
    • Inducible azole resistance associated with a heterogeneous phenotype in Candida albicans
    • Marr K.A., Lyons C.N., Ha K., Rustad T.R., and White T.C. Inducible azole resistance associated with a heterogeneous phenotype in Candida albicans. Antimicrob. Agents Chemother. 45 (2001) 52-59
    • (2001) Antimicrob. Agents Chemother. , vol.45 , pp. 52-59
    • Marr, K.A.1    Lyons, C.N.2    Ha, K.3    Rustad, T.R.4    White, T.C.5
  • 28
    • 0742288065 scopus 로고    scopus 로고
    • Superoxide dismutases in Candida albicans: transcriptional regulation and functional characterization of the hyphal-induced SOD5 gene
    • Martchenko M., Alarco A.M., Harcus D., and Whiteway M. Superoxide dismutases in Candida albicans: transcriptional regulation and functional characterization of the hyphal-induced SOD5 gene. Mol. Biol. Cell 15 (2004) 456-467
    • (2004) Mol. Biol. Cell , vol.15 , pp. 456-467
    • Martchenko, M.1    Alarco, A.M.2    Harcus, D.3    Whiteway, M.4
  • 29
    • 0038818593 scopus 로고    scopus 로고
    • The Candida albicans CTR1 gene encodes a functional copper transporter
    • Marvin M.E., Williams P.H., and Cashmore A.M. The Candida albicans CTR1 gene encodes a functional copper transporter. Microbiology 149 (2003) 1461-1474
    • (2003) Microbiology , vol.149 , pp. 1461-1474
    • Marvin, M.E.1    Williams, P.H.2    Cashmore, A.M.3
  • 30
    • 4344617803 scopus 로고    scopus 로고
    • The CaCTR1 gene is required for high-affinity iron uptake and is transcriptionally controlled by a copper-sensing transactivator encoded by CaMAC1
    • Marvin M.E., Mason R.P., and Cashmore A.M. The CaCTR1 gene is required for high-affinity iron uptake and is transcriptionally controlled by a copper-sensing transactivator encoded by CaMAC1. Microbiology 150 (2004) 2197-2208
    • (2004) Microbiology , vol.150 , pp. 2197-2208
    • Marvin, M.E.1    Mason, R.P.2    Cashmore, A.M.3
  • 31
    • 0037130284 scopus 로고    scopus 로고
    • The genetic basis of fluconazole resistance development in Candida albicans
    • Morschhäuser J. The genetic basis of fluconazole resistance development in Candida albicans. Biochim. Biophys. Acta 1587 (2002) 240-248
    • (2002) Biochim. Biophys. Acta , vol.1587 , pp. 240-248
    • Morschhäuser, J.1
  • 32
    • 0035430918 scopus 로고    scopus 로고
    • The effects of transcription regulating genes PDR1, pdr1-3 and PDR3 in pleiotropic drug resistance
    • Nawrocki A., Fey S.J., Goffeau A., Roepstorff P., and Larsen P.M. The effects of transcription regulating genes PDR1, pdr1-3 and PDR3 in pleiotropic drug resistance. Proteomics 1 (2001) 1022-1032
    • (2001) Proteomics , vol.1 , pp. 1022-1032
    • Nawrocki, A.1    Fey, S.J.2    Goffeau, A.3    Roepstorff, P.4    Larsen, P.M.5
  • 34
    • 0032555204 scopus 로고    scopus 로고
    • The elusive function of metallothioneins
    • Palmiter R.D. The elusive function of metallothioneins. Proc. Natl. Acad. Sci. USA 95 (1998) 8428-8430
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 8428-8430
    • Palmiter, R.D.1
  • 35
    • 0141704206 scopus 로고    scopus 로고
    • Regulation of intracellular heme levels by HMX1, a homologue of heme oxygenase, in Saccharomyces cerevisiae
    • Protchenko O., and Philpott C.C. Regulation of intracellular heme levels by HMX1, a homologue of heme oxygenase, in Saccharomyces cerevisiae. J. Biol. Chem. 278 (2003) 36582-36587
    • (2003) J. Biol. Chem. , vol.278 , pp. 36582-36587
    • Protchenko, O.1    Philpott, C.C.2
  • 36
    • 33644650719 scopus 로고    scopus 로고
    • Potent in vitro synergism of fluconazole and berberine chloride against clinical isolates of Candida albicans resistant to fluconazole
    • Quan H., Cao Y.Y., Xu Z., Zhao J.X., Gao P.H., Qin X.F., and Jiang Y.Y. Potent in vitro synergism of fluconazole and berberine chloride against clinical isolates of Candida albicans resistant to fluconazole. Antimicrob. Agents Chemother. 50 (2006) 1096-1099
    • (2006) Antimicrob. Agents Chemother. , vol.50 , pp. 1096-1099
    • Quan, H.1    Cao, Y.Y.2    Xu, Z.3    Zhao, J.X.4    Gao, P.H.5    Qin, X.F.6    Jiang, Y.Y.7
  • 37
    • 0034640466 scopus 로고    scopus 로고
    • A high-affinity iron permease essential for Candida albicans virulence
    • Ramanan N., and Wang Y. A high-affinity iron permease essential for Candida albicans virulence. Science 288 (2000) 1062-1064
    • (2000) Science , vol.288 , pp. 1062-1064
    • Ramanan, N.1    Wang, Y.2
  • 38
    • 11144247945 scopus 로고    scopus 로고
    • Mobilization of intracellular copper stores by the ctr2 vacuolar copper transporter
    • Rees E.M., Lee J., and Thiele D.J. Mobilization of intracellular copper stores by the ctr2 vacuolar copper transporter. J. Biol. Chem. 279 (2004) 54221-54229
    • (2004) J. Biol. Chem. , vol.279 , pp. 54221-54229
    • Rees, E.M.1    Lee, J.2    Thiele, D.J.3
  • 40
    • 0033901460 scopus 로고    scopus 로고
    • Role of a Candida albicans P1-type ATPase in resistance to copper and silver ion toxicity
    • Riggle P.J., and Kumamoto C.A. Role of a Candida albicans P1-type ATPase in resistance to copper and silver ion toxicity. J. Bacteriol. 182 (2000) 4899-4905
    • (2000) J. Bacteriol. , vol.182 , pp. 4899-4905
    • Riggle, P.J.1    Kumamoto, C.A.2
  • 41
    • 0036839691 scopus 로고    scopus 로고
    • Evaluation of differential gene expression in fluconazole-susceptible and -resistant isolates of Candida albicans by cDNA microarray analysis
    • Rogers P.D., and Barker K.S. Evaluation of differential gene expression in fluconazole-susceptible and -resistant isolates of Candida albicans by cDNA microarray analysis. Antimicrob. Agents Chemother. 46 (2002) 3412-3417
    • (2002) Antimicrob. Agents Chemother. , vol.46 , pp. 3412-3417
    • Rogers, P.D.1    Barker, K.S.2
  • 42
    • 0037378017 scopus 로고    scopus 로고
    • Genome-wide expression profile analysis reveals coordinately regulated genes associated with stepwise acquisition of azole resistance in Candida albicans clinical isolates
    • Rogers P.D., and Barker K.S. Genome-wide expression profile analysis reveals coordinately regulated genes associated with stepwise acquisition of azole resistance in Candida albicans clinical isolates. Antimicrob. Agents Chemother. 47 (2003) 1220-1227
    • (2003) Antimicrob. Agents Chemother. , vol.47 , pp. 1220-1227
    • Rogers, P.D.1    Barker, K.S.2
  • 43
    • 0027169905 scopus 로고
    • Yeast and mammalian metallothioneins functionally substitute for yeast copper-zinc superoxide dismutase
    • Tamai K.T., Gralla E.B., Ellerby L.M., Valentine J.S., and Thiele D.J. Yeast and mammalian metallothioneins functionally substitute for yeast copper-zinc superoxide dismutase. Proc. Natl. Acad. Sci. USA 90 (1993) 8013-8017
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 8013-8017
    • Tamai, K.T.1    Gralla, E.B.2    Ellerby, L.M.3    Valentine, J.S.4    Thiele, D.J.5
  • 44
    • 0000942202 scopus 로고    scopus 로고
    • PDR16 and PDR17, two homologous genes of Saccharomyces cerevisiae, affect lipid biosynthesis and resistance to multiple drugs
    • van den Hazel H.B., Pichler H., do Valle Matta M.A., Leitner E., Goffeau A., and Daum G. PDR16 and PDR17, two homologous genes of Saccharomyces cerevisiae, affect lipid biosynthesis and resistance to multiple drugs. J. Biol. Chem. 274 (1999) 1934-1941
    • (1999) J. Biol. Chem. , vol.274 , pp. 1934-1941
    • van den Hazel, H.B.1    Pichler, H.2    do Valle Matta, M.A.3    Leitner, E.4    Goffeau, A.5    Daum, G.6
  • 45
    • 0035000072 scopus 로고    scopus 로고
    • A novel putative reductase (Cpd1p) and the multidrug exporter Snq2p are involved in resistance to cercosporin and other singlet oxygen-generating photosensitizers in Saccharomyces cerevisiae
    • Ververidis P., Davrazou F., Diallinas G., Georgakopoulos D., Kanellis A.K., and Panopoulos N. A novel putative reductase (Cpd1p) and the multidrug exporter Snq2p are involved in resistance to cercosporin and other singlet oxygen-generating photosensitizers in Saccharomyces cerevisiae. Curr. Genet. 39 (2001) 127-136
    • (2001) Curr. Genet. , vol.39 , pp. 127-136
    • Ververidis, P.1    Davrazou, F.2    Diallinas, G.3    Georgakopoulos, D.4    Kanellis, A.K.5    Panopoulos, N.6
  • 46
    • 0036016820 scopus 로고    scopus 로고
    • Deletion of the copper transporter CaCCC2 reveals two distinct pathways for iron acquisition in Candida albicans
    • Weissman Z., Shemer R., and Kornitzer D. Deletion of the copper transporter CaCCC2 reveals two distinct pathways for iron acquisition in Candida albicans. Mol. Microbiol. 44 (2002) 1551-1560
    • (2002) Mol. Microbiol. , vol.44 , pp. 1551-1560
    • Weissman, Z.1    Shemer, R.2    Kornitzer, D.3
  • 47
    • 0031969879 scopus 로고    scopus 로고
    • Clinical, cellular, and molecular factors that contribute to antifungal drug resistance
    • White T.C., Marr K.A., and Bowden R.A. Clinical, cellular, and molecular factors that contribute to antifungal drug resistance. Clin. Microbiol. Rev. 11 (1998) 382-402
    • (1998) Clin. Microbiol. Rev. , vol.11 , pp. 382-402
    • White, T.C.1    Marr, K.A.2    Bowden, R.A.3
  • 49
    • 24944544469 scopus 로고    scopus 로고
    • cDNA array analysis of the differential expression change in virulence-related genes during the development of resistance in Candida albicans
    • Xu Z., Cao Y.B., Zhang J.D., Cao Y.Y., Gao P.H., Wang D.J., Fu X.P., Ying K., Chen W.S., and Jiang Y.Y. cDNA array analysis of the differential expression change in virulence-related genes during the development of resistance in Candida albicans. Acta Biochim. Biophys. Sin. 37 (2005) 463-472
    • (2005) Acta Biochim. Biophys. Sin. , vol.37 , pp. 463-472
    • Xu, Z.1    Cao, Y.B.2    Zhang, J.D.3    Cao, Y.Y.4    Gao, P.H.5    Wang, D.J.6    Fu, X.P.7    Ying, K.8    Chen, W.S.9    Jiang, Y.Y.10
  • 50
    • 84892326679 scopus 로고    scopus 로고
    • Integrated approaches for discovering novel drugs from microbial natural products
    • Zhang L., and Demain A. (Eds), Humana Press, Totowa, NJ
    • Zhang L. Integrated approaches for discovering novel drugs from microbial natural products. In: Zhang L., and Demain A. (Eds). Natural Products: Drug Discovery and Therapeutics Medicines (2005), Humana Press, Totowa, NJ 33-56
    • (2005) Natural Products: Drug Discovery and Therapeutics Medicines , pp. 33-56
    • Zhang, L.1
  • 51
    • 20444440335 scopus 로고    scopus 로고
    • Isolation of novel bioactive compounds from marine microbes
    • Zhang L., An R., Wang J., Sun N., and Kuai J. Isolation of novel bioactive compounds from marine microbes. Curr. Opin. Microbiol. 8 (2005) 276-281
    • (2005) Curr. Opin. Microbiol. , vol.8 , pp. 276-281
    • Zhang, L.1    An, R.2    Wang, J.3    Sun, N.4    Kuai, J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.