Constitutive activation of the PDR16 promoter in a Candida albicans azole-resistant clinical isolate overexpressing CDR1 and CDR2

Antimicrobial Agents and Chemotherapy

Volumn 48, Issue 7, 2004, Pages 2700-2703

  De Deken, Xavier ^a   Raymond, Martine ^a  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; CIS ACTING ELEMENT; FLUCONAZOLE; GLYCOPROTEIN P; ITRACONAZOLE; KETOCONAZOLE; PHOSPHATIDYLINOSITOL TRANSFER PROTEIN; PYRROLE; TRANS ACTING FACTOR; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; CANDIDA ALBICANS; CDR1 GENE; CDR2 GENE; CONTROLLED STUDY; CROSS RESISTANCE; FUNGAL GENE; FUNGAL STRAIN; FUNGUS ISOLATION; GENE ACTIVATION; GENE CONTROL; GENE FUNCTION; GENE MUTATION; GENE OVEREXPRESSION; GENE SEQUENCE; MOLECULAR CLONING; NONHUMAN; PDR16 GENE; PRIORITY JOURNAL; PROMOTER REGION; SEQUENCE ALIGNMENT; TRANSCRIPTION INITIATION; UPREGULATION;

ANTIFUNGAL AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; AZOLES; BASE SEQUENCE; CANDIDA ALBICANS; CARRIER PROTEINS; DATABASES, GENETIC; DNA PRIMERS; DNA, FUNGAL; FLOW CYTOMETRY; FUNGAL PROTEINS; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; MOLECULAR SEQUENCE DATA; MUTATION; PHOSPHOLIPID TRANSFER PROTEINS; PROMOTER REGIONS (GENETICS); UP-REGULATION;

EID: 3042670682     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.48.7.2700-2703.2004     Document Type: Article

References (12)

1. Akache, B., and B. Turcotte. 2002. New regulators of drug sensitivity in the family of yeast zinc cluster proteins. J. Biol. Chem. 277:21254-21260.
2. de Micheli, M., J. Bille, C. Schueller, and D. Sanglard. 2002. A common drug-responsive element mediates the upregulation of the Candida albicans ABC transporters CDR1 and CDR2, two genes involved in antifungal drug resistance. Mol. Microbiol. 43:1197-1214.
3. Gietz, R. D., R. H. Schiestl, A. R. Willems, and R. A. Woods. 1995. Studies on the transformation of intact yeast cells by the LiAc/SS-DNA/PEG procedure. Yeast 11:355-360.
4. Hellauer, K., M.-H. Rochon, and B. Turcotte. 1996. A novel DNA binding motif for yeast zinc cluster proteins: the Leu3p and Pdr3p transcriptional activators recognize everted repeats. Mol. Cell. Biol. 16:6096-6102.
5. Kolaczkowska, A., and A. Goffeau. 1999. Regulation of pleiotropic drug resistance in yeast. Drug Resist. Updates 2:403-414.
6. Le Crom, S., F. Devaux, P. Marc, X. Zhang, W. S. Moye-Rowley, and C. Jacq. 2002. New insights into the pleiotropic drug resistance network from genome-wide characterization of the YRR1 transcription factor regulation system. Mol. Cell. Biol. 22:2642-2649.
7. Li, X., S. M. Routt, Z. Xie, X. Cui, M. Fang, M. A. Kearns, M. Bard, D. R. Kirsch, and V. A. Bankaitis. 2000. Identification of a novel family of non-classic yeast phosphatidylinositol transfer proteins whose function modulates phospholipase D activity and Sec14p-independent cell growth. Mol. Biol. Cell 11:1989-2005.
8. van den Hazel, H. B., H. Pichler, M. A. do Valle Matta, E. Leitner, A. Goffeau, and G. Daum. 1999. PDR16 and PDR17, two homologous genes of Saccharomyces cerevisiae, affect lipid biosynthesis and resistance to multiple drugs. J. Biol. Chem. 274:1934-1941.
9. van Helden, J., B. Andre, and J. Collado-Vides. 2000. A web site for the computational analysis of yeast regulatory sequences. Yeast 16:177-187.
10. White, T. C., K. A. Marr, and R. A. Bowden. 1998. Clinical, cellular, and molecular factors that contribute to antifungal drug resistance. Clin. Microbiol. Rev. 11:382-402.
11. Wingender, E., X. Chen, E. Fricke, R. Geffers, R. Hehl, I. Liebich, M. Krull, V. Matys, H. Michael, R. Ohnhauser, M. Pruss, F. Schacherer, S. Thiele, and S. Urbach. 2001. The TRANSFAC system on gene expression regulation. Nucleic Acids Res. 29:281-283.
12. Wirsching, S., S. Michel, G. Köhler, and J. Morschhäuser. 2000. Activation of the multiple drug resistance gene MDR1 in fluconazole-resistant, clinical Candida albicans strains is caused by mutations in a trans-regulatory factor. J. Bacteriol. 182:400-404.