Exploring novel bioactive compounds from marine microbes

Current Opinion in Microbiology

Volumn 8, Issue 3, 2005, Pages 276-281

  Zhang, Lixin ^a,b,c   An, Rong ^a,d   Wang, Jinping ^d   Sun, Nuo ^a,d   Zhang, Si ^b   Hu, Jiangchun ^e   Kuai, Jun ^f  

^a GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH   (China)

^b SOUTH CHINA SEA INSTITUTE OF OCEANOLOGY   (China)

^c SynerZ Pharmaceuticals Inc   (United States)

^d SHANDONG UNIVERSITY   (China)

^e INSTITUTE OF APPLIED ECOLOGY   (China)

^f PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALOID; AMPHILACTAM; ANTIFUNGAL AGENT; ANTINEMATODAL AGENT; ANTINEOPLASTIC AGENT; ANTIPARASITIC AGENT; AURANTOSIDE B; AVARONE; AXISONITRILE 3; BENGAZOLE A; BROMOSPHAERONE; BRYOSTATIN; CRIBROSTATIN 3; DIHYDROXYTETRAHYDROFURAN; FASCAPLYSIN; GYMNOCHROME D; HALISHIGAMMIDE; HENNOXAZOLE A; JORUMYCIN; LITOSTEROL; MACROCYCLIC COMPOUND; MACROLIDE; MANZAMINE A; MERIDINE; MICROSPINOSAMIDE; MITHRAMYCIN; NATURAL PRODUCT; OMEGA CONOTOXIN MVIIA; PAPUAMIDE A; PEROXIDE; PESTALONE; PHORBOXAZOLE A; PLAKORTIDE; POLYKETIDE; PROTEASOME INHIBITOR; PTILOMYCALIN A; PUUPEHENONE; SALINOSPORAMIDE A; SIGMOSCEPTRELLIN B; SOLENOLIDE A; SPONGIADIOL; SQUALAMINE; TETRAHYDROFURAN DERIVATIVE; THYRSIFEROL; TRABECTEDIN; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ANTHELMINTIC ACTIVITY; ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIPROTOZOAL ACTIVITY; ANTIVIRAL ACTIVITY; BACTERIAL STRAIN; BIOTECHNOLOGY; CLINICAL TRIAL; DRUG ACTIVITY; ECOSYSTEM; HUMAN; INTRACTABLE PAIN; MARINE ENVIRONMENT; METABOLITE; MICROORGANISM; MOLECULAR MECHANICS; NONHUMAN; REVIEW; SOFT TISSUE SARCOMA;

ANTI-INFECTIVE AGENTS; BACTERIA; DRUG INDUSTRY; INDUSTRIAL MICROBIOLOGY; MARINE BIOLOGY; OCEANS AND SEAS;

EID: 20444440335     PISSN: 13695274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mib.2005.04.008     Document Type: Review

References (29)

1. A.L. Demain, and L. Zhang Natural products and drug discovery L. Zhang A. Demain Natural Products: Drug Discovery and Therapeutics Medicines 2005 Humana Press 3 32 This is a historical review of the great contribution that microbial natural products have made to drug discovery.
2. L. Zhang Integrated approaches for discovering novel drugs from microbial natural products L. Zhang A. Demain Natural Products: Drug Discovery and Therapeutics Medicines 2005 Humana Press 33 56
3. D.J. Gochfeld, K.A. El Sayed, M. Yousaf, J.F. Hu, P. Bartyzel, D.C. Dunbar, S.P. Wilkins, J.K. Zjawiony, R.F. Schinazi, and S. Schlueter Wirtz Marine natural products as lead anti-HIV agents Mini Rev Med Chem 3 2003 401 424
4. D.J. Newman, and G.M. Cragg The discovery of anticancer drugs from natural sources L. Zhang A. Demain Natural Products: Drug Discovery and Therapeutics Medicines 2005 Humana Press 275 294 This includes numerous, very interesting, molecules that have come from marine sources, or that have been synthesized as a result of knowledge gained from prototypical compounds. Many are either in or approaching Phase II or III clinical trials for cancer, analgesia, allergy and cognitive disease. A substantial number of other potential agents is also provided.
5. B. Haefner Drugs from the deep: marine natural products as drug candidates Drug Discov Today 8 2003 536 544 This work is very interesting because it reviews a variety of marine natural products as drug candidates that have been discovered over a long period of time in the angle of drug efficacy and specificity for the treatment of many human diseases.
6. J.C. Venter, K. Remington, J.F. Heidelberg, A.L. Halpern, D. Rusch, J.A. Eisen, D. Wu, I. Paulsen, K.E. Nelson, and W. Nelson Environmental genome shotgun sequencing of the Sargasso Sea Science 304 2004 66 74 This publication is remarkable because of the large number of novel genes detected within the enormous number of DNA sequences generated.
7. J.W. Blunt, B.R. Copp, M.H. Munro, P.T. Northcote, and M.R. Prinsep Marine natural products Nat Prod Rep 21 2004 1 49 This review covers the literature published in 2003 regarding marine natural products. It contains 619 citations.
8. J. Berdy Bioactive microbial metabolites J Antibiot (Tokyo) 58 2005 1 26
9. D.D. Baker, and K.A. Alvi Small-molecule natural products: new structures, new activities Curr Opin Biotechnol 15 2004 576 583 This is a good review article that summarizes the trends in natural product discovery and that highlights some of the recent discoveries of novel structures and interesting activities published from 2002 to 2004.
10. M. Donia, and M.T. Hamann Marine natural products and their potential applications as anti-infective agents Lancet Infect Dis 3 2003 338 348 This review focuses on the pharmacologically tested marine leads that have shown in vivo efficacy or potent in vitro activity against infectious and parasitic diseases.
11. E.L. Cooper Commentary on 'Traditional and modern biomedical prospecting: part II - the benefits' by Müller WEG, Schröder HC, Wiens M, Ottstadt SP, Batel R and Müller IM. Anti-protozoa and antiviral activities of non-cytotoxic truncated and variant analogues of mussel defensin by Roch P Beschin A and Bernard E eCAM 1 2004 207 209 This focuses on the cited papers and comments on the application, the resource and the efficacy of marine natural products as drug candidates.
12. B.G. Livett, K.R. Gayler, and Z. Khalil Drugs from the sea: conopeptides as potential therapeutics Curr Med Chem 11 2004 1715 1723 This review describes the progress made by several research groups to characterize the properties of conopeptides and to use them as drug leads for the development of novel therapeutics for the treatment of a range of neurological conditions.
13. H. Belarbi El, A.C. Gomez, and Y. Chisti Producing drugs from marine sponges Biotechnol Adv 21 2003 585 598
14. V. Knight, J.J. Sanglier, D. DiTullio, S. Braccili, P. Bonner, J. Waters, D. Hughes, and L. Zhang Diversifying microbial natural products for drug discovery Appl Microbiol Biotechnol 62 2003 446 458
15. T.J. Mincer, P.R. Jensen, C.A. Kauffman, and W. Fenical Widespread and persistent populations of a major new marine actinomycete taxon in ocean sediments Appl Environ Microbiol 68 2002 5005 5011
16. P.R. Jensen, and W. Fenical New natural-product diversity from marine actinomycetes L. Zhang A. Demain Natural Products: Drug Discovery and Therapeutics Medicines 2005 Humana Press 315 328
17. A. Bruns, H. Cypionka, and J. Overmann Cyclic AMP and acyl homoserine lactones increase the cultivation efficiency of heterotrophic bacteria from the central Baltic Sea Appl Environ Microbiol 68 2002 3978 3987
18. S.A. Connon, and S.J. Giovannoni High-throughput methods for culturing microorganisms in very-low-nutrient media yield diverse new marine isolates Appl Environ Microbiol 68 2002 3878 3885
19. J.C. Cho, and S.J. Giovannoni Parvularcula bermudensis gen. nov., sp. nov., a marine bacterium that forms a deep branch in the a-Proteobacteria Int J Syst Evol Microbiol 53 2003 1031 1036
20. T. Kaeberlein, K. Lewis, and S.S. Epstein Isolating 'uncultivable' microorganisms in pure culture in a simulated natural environment Science 296 2002 1127 1129
21. M. Keller, and K. Zengler Tapping into microbial diversity Nat Rev Microbiol 2 2004 141 150 This excellent review tapped into the recombinant DNA technology and a large number of new enzymes by cloning genes directly from the environment using environmental clone libraries, thereby accessing the tremendous microbial diversity of uncultivated microorganisms.
22. K. Zengler, G. Toldeo, M. Rappe, J. Elkins, E.J. Mathur, J.M. Short, and M. Keller Cultivating the uncultured Proc Natl Acad Sci USA 99 2002 15681 15686
23. K. Zengler, A. Paradkar, and M. Keller New methods to access microbial diversity for small molecule discovery L. Zhang A. Demain Natural Products: Drug Discovery and Therapeutics Medicines 2005 Humana Press 275 294
24. G.W. Tyson, J. Chapman, P. Hugenholtz, E.E. Allen, R.J. Ram, P.M. Richardson, V.V. Solovyev, E.M. Rubin, D.S. Rokhsar, and J.F. Banfield Community structure and metabolism through reconstruction of microbial genomes from the environment Nature 428 2004 37 43 This is one of the first publications to present a near-complete set of metagenomic sequences from a mixed but low-diversity microbial community.
25. M. Kruger, A. Meyerdierks, F.O. Glockner, R. Amann, F. Widdel, M. Kube, R. Reinhardt, J. Kahnt, R. Bocher, and R.K. Thauer A conspicuous nickel protein in microbial mats that oxidize methane anaerobically Nature 426 2003 878 881 This publication is remarkable as it identifies the functional role of a novel protein involved in the global carbon (methane) cycle and it subsequently identifies its DNA sequence.
26. A. Martinez, J. Hopke, I.A. MacNeil, and M.S. Osburne Accessing the genomes of uncultivated microbes for novel natural products L. Zhang A. Demain Natural Products: Drug Discovery and Therapeutics Medicines 2005 Humana Press 295 314
27. W.R. Streit, and R.A. Schmitz Metagenomics - the key to the uncultured microbes Curr Opin Microbiol 7 2004 492 498 This paper is a remarkable overview of the recent progress in metagenome technology.
28. E. Zazopoulos, K. Huang, A. Staffa, W. Liu, B.O. Bachmann, K. Nonaka, J. Ahlert, J.S. Thorson, B. Shen, and C.M. Farnet A genomics-guided approach for discovering and expressing cryptic metabolic pathways Nat Biotechnol 21 2003 187 190
29. C.M. Farnet, and E. Zazopoulos Improving drug discovery from microorganisms L. Zhang A. Demain Natural Products: Drug Discovery and Therapeutics Medicines 2005 Humana Press 95 106