Perturbation of glucose flux in the liver by decreasing F26P2 levels causes hepatic insulin resistance and hyperglycemia

American Journal of Physiology - Endocrinology and Metabolism

Volumn 291, Issue 3, 2006, Pages

  Wu, Chaodong ^a   Khan, Salmaan A ^a   Peng, Li Jen ^a   Li, Honggui ^a   Carmella, Steven G ^a   Lange, Alex J ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

Diabetes; Fructose 2,6 bisphosphate; Gluconeogenesis; Glycolysis; Hepatic glucose production

Indexed keywords

6 PHOSPHOFRUCTO 2 KINASE; FRUCTOSE 2,6 BISPHOSPHATASE; INSULIN; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP);

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME PHOSPHORYLATION; GENE OVEREXPRESSION; GLUCONEOGENESIS; GLUCOSE METABOLISM; GLYCOGENOLYSIS; HYPERGLYCEMIA; HYPERINSULINEMIA; IN VIVO STUDY; INSULIN RESISTANCE; LIVER FUNCTION; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RAT;

ADENOVIRIDAE; ANIMALS; BLOOD GLUCOSE; FRUCTOSEDIPHOSPHATES; GENE EXPRESSION; GLUCONEOGENESIS; GLUCOSE; GLUCOSE INTOLERANCE; GLUCOSE-6-PHOSPHATASE; GLYCOGENOLYSIS; HYPERGLYCEMIA; INSULIN; INSULIN RESISTANCE; LIVER; MALE; MICE; MICE, INBRED STRAINS; MUTATION; ONCOGENE PROTEIN V-AKT; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PHOSPHOFRUCTOKINASE-2; TRANS-ACTIVATORS; TRANSFECTION;

EID: 33748451150     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00126.2006     Document Type: Article

References (35)

1. Argaud D, Kirby TL, Newgard CB, and Lange AJ. Stimulation of glucose-6-phosphatase gene expression by glucose and fructose-2,6-bisphosphate. J Biol Chem 272: 12854-12861, 1997.
2. Bell PM, Firth RG, and Rizza RA. Assessment of insulin action in insulin-dependent diabetes mellitus using [6(14)C]glucose, [3(3)H]glucose, and [2(3)H]glucose. Differences in the apparent pattern of insulin resistance depending on the isotope used. J Clin Invest 78: 1479-1486, 1986.
3. Collier JJ and Scott DK. Sweet changes: glucose homeostasis can be altered by manipulating genes controlling hepatic glucose metabolism. Mol Endocrinol 18: 1051-1063, 2004.
4. DeFronzo RA. Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM. Diabetes 37: 667-687, 1988.
5. Donthi RV, Ye G, Wu C, McClain DA, Lange AJ, and Epstein PN. Cardiac expression of kinase-deficient 6-phosphofructo-2-kinase/fructose-2,6- bisphosphatase inhibits glycolysis, promotes hypertrophy, impairs myocyte function, and reduces insulin sensitivity. J Biol Chem 279: 48085-48090, 2004.
6. El-Maghrabi MR, Pate TM, Murray KJ, and Pilkis SJ. Differential effects of proteolysis and protein modification on the activities of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. J Biol Chem 259: 13096-13103, 1984.
7. Giaccari A and Rossetti L. Predominant role of gluconeogenesis in the hepatic glycogen repletion of diabetic rats. J Clin Invest 89: 36-45, 1992.
8. Jin ES, Uyeda K, Kawaguchi T, Burgess SC, Malloy CR, and Sherry AD. Increased hepatic fructose 2,6 bisphosphate after an oral glucose load does not affect gluconeogenesis. J Biol Chem 278: 28427-28433, 2003.
9. Lam TK, van de Werve G, and Giacca A. Free fatty acids increase basal hepatic glucose production and induce hepatic insulin resistance at different sites. Am J Physiol Endocrinol Metab 284: E281-E290, 2003.
10. Massillon D, Chen W, Hawkins M, Liu R, Barzilai N, and Rossetti L. Quantitation of hepatic glucose fluxes and pathways of hepatic glycogen synthesis in conscious mice. Am J Physiol Endocrinol Metab 269: E1037-E1043, 1995.
11. Meyer C, Stumvoll M, Nadkarni V, Dostou J, Mitrakou A, and Gerich J. Abnormal renal and hepatic glucose metabolism in type 2 diabetes mellitus. J Clin Invest 102: 619-624, 1998.
12. Michael MD, Kulkarni RN, Postic C, Previs SF, Shulman GI, Magnuson MA, and Kahn CR. Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol Cell 6: 87-97, 2000.
13. Muse ED, Obici S, Bhanot S, Monia BP, McKay RA, Rajala MW, Scherer PE, and Rossetti L. Role of resistin in diet-induced hepatic insulin resistance. J Clin Invest 114: 232-239, 2004.
14. Nordlie RC, Foster JD, and Lange AJ. Regulation of glucose production by the liver. Annu Rev Nutr 19: 379-406, 1999.
15. Okar DA, Manzano A, Navarro-Sabate A, Riera L, Bartrons R, and Lange AJ. PFK-2/FBPase-2: maker and breaker of the essential biofactor fructose-2,6-bisphosphate. Trends Biochem Sci 26: 30-35, 2001.
16. Okar DA, Wu C, and Lange AJ. Regulation of the regulatory enzyme, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphate. Adv Enzyme Regul 44: 123-154, 2004.
17. Payne VA, Arden C, Wu C, Lange AJ, and Agius L. Dual role of phosphofructokinase-2/fructose bisphosphatase-2 in regulating the compartmentation and expression of glucokinase in hepatocytes. Diabetes 54: 1949-1957, 2005.
18. Pilkis SJ, Claus TH, Kurland IJ, and Lange AJ. 6-Phosphofructo-2-kinase/ fructose-2,6-bisphosphatase: a metabolic signaling enzyme. Annu Rev Biochem 64: 799-835, 1995.
19. Pilkis SJ, El-Maghrabi MR, and Claus TH. Hormonal regulation of hepatic gluconeogenesis and glycolysis. Annu Rev Biochem 57: 755-783, 1988.
20. Pilkis SJ, El-Maghrabi MR, McGrane MM, Pilkis J, and Claus TH. The role of fructose 2,6-bisphosphate in regulation of fructose-1,6-bisphosphatase. J Biol Chem 256: 11489-11495, 1981.
21. Pocai A, Obici S, Schwartz GJ, and Rossetti L. A brain-liver circuit regulates glucose homeostasis. Cell Metab 1: 53-61, 2005.
22. Puigserver P, Rhee J, Donovan J, Walkey CJ, Yoon JC, Oriente F, Kitamura Y, Altomonte J, Dong H, Accili D, and Spiegelman BM. Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. Nature 423: 550-555, 2003.
23. Rossetti L, Barzilai N, Chen W, Harris T, Yang D, and Rogler CE. Hepatic overexpression of insulin-like growth factor-II in adulthood increases basal and insulin-stimulated glucose disposal in conscious mice. J Biol Chem 271: 203-208, 1996.
24. Rossetti L and Giaccari A. Relative contribution of glycogen synthesis and glycolysis to insulin-mediated glucose uptake. A dose-response euglycemic clamp study in normal and diabetic rats. J Clin Invest 85: 1785-1792, 1990.
25. Rossetti L, Giaccari A, Barzilai N, Howard K, Sebel G, and Hu M. Mechanism by which hyperglycemia inhibits hepatic glucose production in conscious rats. Implications for the pathophysiology of fasting hyperglycemia in diabetes. J Clin Invest 92: 1126-1134, 1993.
26. Rossetti L, Massillon D, Barzilai N, Vuguin P, Chen W, Hawkins M., Wu J, and Wang J. Short term effects of leptin on hepatic gluconeogenesis and in vivo insulin resistance. J Biol Chem 272: 27758-27763, 1997.
27. Rossetti L, Stenbit AE, Wei C, Hu M, Barzilai N, Katz EB, and Charron MJ. Peripheral but not hepatic insulin resistance in mice with one disrupted allele of the glucose transporter type 4 (GLUT4) gene. J Clin Invest 100: 1831-1839, 1997.
28. Sun Y, Liu S, Ferguson S, Wang L, Klepcyk P, Yun JS, and Friedman JE. Phosphoenolpyruvate carboxykinase overexpression selectively attenuates insulin signaling and hepatic insulin sensitivity in transgenic mice. J Biol Chem 277: 23301-23307, 2002.
29. Taniguchi CM, Ueki K, and Kahn CR. Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism. J Clin Invest 115: 718-727, 2005. Erratum: J Clin Invest 115: 1388, 2005.
30. Trinh KY, O'Doherty RM, Anderson P, Lange AJ, and Newgard CB. Perturbation of fuel homeostasis caused by overexpression of the glucose-6-phosphatase catalytic subunit in liver of normal rats. J Biol Chem 273: 31615-31620, 1998.
31. Van schaftingen E, Lederer B, Bartrons R, and Hers HG. A kinetic study of pyrophosphate: fructose-6-phosphate phosphotransferase from potato tubers. Application to a microassay of fructose-2,6-bisphosphate. Eur J Biochem 129: 191-195, 1982.
32. Wu C, Kang JE, Peng L, Li H, Khan SA, Hillard CJ, Okar DA, and Lange AJ. Enhancing hepatic glycolysis reduces obesity: Differential effects on lipogenesis depend on site of glycolytic modulation. Cell Metab 2: 131-140, 2005.
33. Wu C, Okar DA, Newgard CB, and Lange AJ. Increasing fructose 2,6-bisphosphate overcomes hepatic insulin resistance of type 2 diabetes. Am J Physiol Endocrinol Metab 282: E38-E45, 2002.
34. Wu C, Okar DA, Newgard CB, and Lange AJ. Overexpression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in mouse liver lowers blood glucose by suppression of hepatic glucose production. J Clin Invest 107: 91-98, 2001.
35. Wu C, Okar DA, Stoeckman AK, Peng L, Herrera AH, Herrera JE, Towle HC, and Lange AJ. A potential role for fructose-2,6-bisphosphate in the stimulation of hepatic glucokinase gene expression. Endocrinology 145: 650-658, 2004.