Cardiac expression of kinase-deficient 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase inhibits glycolysis, promotes hypertrophy, impairs myocyte function, and reduces insulin sensitivity

Journal of Biological Chemistry

Volumn 279, Issue 46, 2004, Pages 48085-48090

  Donthi, Rajakumar V ^a   Ye, Gang ^a   Wu, Chaodong ^b   McClain, Donald A ^c   Lange, Alex J ^b   Epstein, Paul N ^a  

^a University of Louisville School of Medicine   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; DISEASE CONTROL; FRUCTOSE; INSULIN; LIVING SYSTEMS STUDIES; METABOLISM; REDUCTION;

CARDIAC EXPRESSIONS; CARDIOMYOPATHY; DIABETES; GLYCOLYSIS;

ENZYMES;

6 PHOSPHOFRUCTO 2 KINASE; COLLAGEN; FRUCTOSE 1,6 BISPHOSPHATE; FRUCTOSE 2,6 BISPHOSPHATASE; FRUCTOSE 6 PHOSPHATE; GLUCOSE 6 PHOSPHATE; GLYCOGEN; INSULIN; PROTEIN KINASE B; URIDINE DIPHOSPHATE N ACETYLGALACTOSAMINE;

ANIMAL CELL; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME INHIBITION; ENZYME REGULATION; FEMALE; FIBROSIS; GLYCOLYSIS; HEART MUSCLE CELL; HEART PERFUSION; HEART WEIGHT; HYPERTROPHY; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TRANSGENE; TRANSGENIC MOUSE;

ANIMALS; CARDIOMEGALY; COLLAGEN; DIABETES MELLITUS; GLUCOSE; GLYCOLYSIS; HEART; INSULIN; INSULIN RESISTANCE; MICE; MICE, TRANSGENIC; MYOCARDIAL CONTRACTION; MYOCARDIUM; MYOCYTES, CARDIAC; PHOSPHOFRUCTOKINASE-2; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT;

ANIMALIA; MUS MUSCULUS;

EID: 9144271769     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M405510200     Document Type: Article

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