The long and short of it: Somite formation in mice

Developmental Dynamics

Volumn 235, Issue 9, 2006, Pages 2330-2336

  Gridley, Thomas ^a  

^a JACKSON LABORATORY   (United States)

Author keywords

Inherited disease; Molecular oscillators; Notch signaling; Paraxial mesoderm; Somite clock; Spondylocostal dysostosis; Wnt signaling

Indexed keywords

FIBROBLAST GROWTH FACTOR 8; NOTCH RECEPTOR; NOTCH1 RECEPTOR; NOTCH2 RECEPTOR; RETINOIC ACID; TRANSCRIPTION FACTOR; WNT3A PROTEIN;

EMBRYO SEGMENTATION; GENE CONTROL; GENE FUNCTION; GENE MUTATION; INHERITANCE; JARCHO LEVIN SYNDROME; MESODERM; MORPHOGENESIS; MOUSE; MOUSE MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION; SOMITE; VERTEBRA MALFORMATION; VERTEBRATE;

ANIMALS; BIOLOGICAL CLOCKS; BODY PATTERNING; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, HOMEOBOX; HUMANS; MESODERM; MICE; MUTATION; PREGNANCY; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; SOMITES; SPINE;

VERTEBRATA;

EID: 33748300903     PISSN: 10588388     EISSN: 10970177     Source Type: Journal    
DOI: 10.1002/dvdy.20850     Document Type: Review

References (64)

1. Aulehla A, Herrmann BG. 2004. Segmentation in vertebrates: clock and gradient finally joined. Genes Dev 18:2060-2067.
2. Aulehla A, Johnson RL. 1999. Dynamic expression of lunatic fringe suggests a link between notch signaling and an autonomous cellular oscillator driving somite segmentation. Dev Biol 207:49-61.
3. Aulehla A, Wehrle C, Brand-Saberi B, Kemler R, Gossler A, Kanzler B, Herrmann BG. 2003. Wnt3a plays a major role in the segmentation clock controlling somitogenesis. Dev Cell 4:395-406.
4. Beckers J, Schlautmann N, Gossler A. 2000. The mouse rib-vertebrae mutation disrupts anterior-posterior somite patterning and genetically interacts with a Deltal null allele. Mech Dev 95:35-46.
5. Bessho Y, Kageyama R. 2003. Oscillations, clocks and segmentation. Curr Opin Genet Dev 13:379-384.
6. Bessho Y, Sakata R, Komatsu S, Shiota K, Yamada S, Kageyama R. 2001. Dynamic expression and essential functions of Hes7 in somite segmentation. Genes Dev 15:2642-2647.
7. Bessho Y, Hirata H, Masamizu Y, Kageyama R. 2003. Periodic repression by the bHLH factor Hes7 is an essential mechanism for the somite segmentation clock. Genes Dev 17:1451-1456.
8. Bulman MP, Kusumi K, Frayling TM, McKeown C, Garrett C, Lander ES, Krumlauf R, Hattersley AT, Ellard S, Turnpenny PD. 2000. Mutations in the human delta homologue, DLL3, cause axial skeletal defects in spondylocostal dysostosis. Nature Genet. 24:438-441.
9. Burke AC. 2000. Hox genes and the global patterning of the somitic mesoderm. Curr Top Dev Biol 47:155-181.
10. Carapuco M, Novoa A, Bobola N, Mallo M. 2005. Hox genes specify vertebral types in the presomitic mesoderm. Genes Dev 19:2116-2121.
11. Chapman DL, Papaioannou VE. 1998. Three neural tubes in mouse embryos with mutations in the T-box gene Tbx6. Nature 391:695-697.
12. Cohen B, Bashirullah A, Dagnino L, Campbell C, Fisher WW, Leow CC, Whiting E, Ryan D, Zinyk D, Boulianne G, Hui CC, Gallie B, Phillips RA, Lipshitz HD, Egan SE. 1997. Fringe boundaries coincide with Notch-dependent patterning centres in mammals and alter Notch-dependent development in Drosophila. Nat Genet 16:283-288.
13. Conlon RA, Reaume AG, Rossant J. 1995. Notch 1 is required for the coordinate segmentation of somites. Development 121:1533-1545.
14. Cordes R, Schuster-Gossler K, Serth K, Gossler A. 2004. Specification of vertebral identity is coupled to Notch signaling and the segmentation clock. Development 131:1221-1233.
15. Delfini MC, Dubrulle J, Malapert P, Chal J, Pourquie O. 2005. Control of the segmentation process by graded MAPK/ERK activation in the chick embryo. Proc Natl Acad Sci U S A 102:11343-11348.
16. Diez del Corral R, Olivera-Martinez I, Goriely A, Gale E, Maden M, Storey K. 2003. Opposing FGF and retinoid pathways control ventral neural pattern, neuronal differentiation, and segmentation during body axis extension. Neuron 40:65-79.
17. Dubrulle J, Pourquie O. 2004. Coupling segmentation to axis formation. Development 131:5783-5793.
18. Dubrulle J, McGrew MJ, Pourquie O. 2001. FGF signaling controls somite boundary position and regulates segmentation clock control of spatiotemporal Hox gene activation. Cell 106:219-232.
19. Dunwoodie SL, Clements M, Sparrow DB, Sa X, Conlon RA, Beddington RS. 2002. Axial skeletal defects caused by mutation in the spondylocostal dysplasia/pudgy gene Dll3 are associated with disruption of the segmentation clock within the presomitic mesoderm. Development 129:1795-1806.
20. Evrard YA, Lun Y, Aulehla A, Gan L, Johnson RL. 1998. Lunatic fringe is an essential mediator of somite segmentation and patterning. Nature 394:377-381.
21. Forsberg H, Crozet F, Brown NA. 1998. Waves of mouse Lunatic fringe expression, in four-hour cycles at two-hour intervals, precede somite boundary formation. Curr Biol 8:1027-1030.
22. Freitas C, Rodrigues S, Saude L, Palmeirim I. 2005. Running after the clock. Int J Dev Biol 49:317-324.
23. Galceran J, Sustmann C, Hsu SC, Folberth S, Grosschedl R. 2004. LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis. Genes Dev 18:2718-2723.
24. Giudicelli F, Lewis J. 2004. The vertebrate segmentation clock. Curr Opin Genet Dev 14:407-414.
25. Gossler A, Tam PPL. 2002. Somitogenesis: segmentation of the paraxial mesoderm and the delineation of tissue compartments. In: Rossant J, Tam PPL, editors. Mouse development: patterning, morphogenesis, and organogenesis. San Diego: Academic Press.
26. Gridley T. 2003. Notch signaling and inherited disease syndromes. Hum Mol Genet 12 Spec No 1:R9-R13.
27. Haltiwanger RS, Lowe JB. 2004. Role of glycosylation in development. Annu Rev Biochem 73:491-537.
28. Hofmann M, Schuster-Gossler K, Watabe-Rudolph M, Aulehla A, Herrmann BG, Gossler A. 2004. WNT signaling, in synergy with T/TBX6, controls Notch signaling by regulating Dll1 expression in the presomitic mesoderm of mouse embryos. Genes Dev 18:2712-2717.
29. Hornstein E, Tabin CJ. 2005. Developmental biology: asymmetrical threat averted. Nature 435:155-156.
30. Hrabe de Angelis M, McIntyre II J, Gossler A. 1997. Maintenence of somite borders in mice requires the Delta homologue Dill. Nature 386:717-721.
31. Huppert SS, Ilagan MX, De Strooper B, Kopan R. 2005. Analysis of Notch function in presomitic mesoderm suggests a gamma-secretase-independent role for presenilins in somite differentiation. Dev Cell 8:677-688.
32. Ishikawa A, Kitajima S, Takahashi Y, Kokubo H, Kanno J, Inoue T, Saga Y. 2004. Mouse Nkd1, a Wnt antagonist, exhibits oscillatory gene expression in the PSM under the control of Notch signaling. Mech Dev 121:1443-1453.
33. Johnston SH, Rauskolb C, Wilson R, Prabhakaran B, Irvine KD, Vogt TF. 1997. A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway. Development 124:2245-2254.
34. Jouve C, Palmeirim I, Henrique D, Beckers J, Gossler A, Ish-Horowicz D, Pourquie O. 2000. Notch signalling is required for cyclic expression of the hairy-like gene HES1 in the presomitic mesoderm. Development 127:1421-1429.
35. Kawakami Y, Raya A, Raya RM, Rodriguez-Esteban C, Belmonte JC. 2005. Retinoic acid signalling links left-right asymmetric patterning and bilaterally symmetric somitogenesis in the zebrafish embryo. Nature 435:165-171.
36. Kusumi K, Sun E, Kerrebrock AW, Bronson RT, Chi D-C, Bulotsky MS, Spencer JB, Birren BW, Frankel WN, Lander ES. 1998. The mouse pudgy mutation disrupts Delta homologue Dll3 and initiation of early somite boundaries. Nat Genet 19:274-278.
37. Kusumi K, Mimoto MS, Covello KL, Beddington RS, Krumlauf R, Dunwoodie SL. 2004. Dll3 pudgy mutation differentially disrupts dynamic expression of somite genes. Genesis 39:115-121.
38. Levin M. 2005. Left-right asymmetry in embryonic development: a comprehensive review. Mech Dev 122:3-25.
39. Masamizu Y, Ohtsuka T, Takashima Y, Nagahara H, Takenaka Y, Yoshikawa K, Okamura H, Kageyama R. 2006. Real-time imaging of the somite segmentation clock: revelation of unstable oscillators in the individual presomitic mesoderm cells. Proc Natl Acad Sci U S A 103:1313-1318.
40. Moreno TA, Kintner C. 2004. Regulation of segmental patterning by retinoic acid signaling during Xenopus somitogenesis. Dev Cell 6:205-218.
41. Morimoto M, Takahashi Y, Endo M, Saga Y. 2005. The Mesp2 transcription factor establishes segmental borders by suppressing Notch activity. Nature 435:354-359.
42. Nacke S, Schafer R, Habre de Angelis M, Mundlos S. 2000. Mouse mutant "rib-vertebrae" (rv): a defect in somite polarity. Dev Dyn 219:192-200.
43. Palmeirim I, Henrique D, Ish-Horowicz D, Pourquie O. 1997. Avian hairy gene expression identifies a molecular clock linked to vertebrate segmentation and somitogenesis. Cell 91:639-648.
44. Pourquie O, Kusumi K. 2001. When body segmentation goes wrong. Clin Genet 60:409-416.
45. Saga Y, Hata N, Koseki H, Taketo MM. 1997. Mesp2: a novel mouse gene expressed in the presegmented mesoderm and essential for segmentation initiation. Genes Dev 11:1827-1839.
46. Saude L, Lourenco R, Goncalves A, Palmeirim I. 2005. terra is a left-right asymmetry gene required for left-right synchronization of the segmentation clock. Nat Cell Biol 7:918-920.
47. Selkoe D, Kopan R. 2003. Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration. Annu Rev Neurosci 26:565-597.
48. Seo KW, Wang Y, Kokubo H, Kettlewell JR, Zarkower DA, Johnson RL. 2006. Targeted disruption of the DM domain containing transcription factor Dmrt2 reveals an essential role in somite patterning. Dev Biol 290:200-210.
49. Sirbu IO, Duester G. 2006. Retinoic-acid signaling in node ectoderm and posterior neural plate directs left-right patterning of somitic mesoderm. Nat Cell Biol 8:271-277.
50. Sparrow DB, Chapman G, Wouters MA, Whittock NV, Ellard S, Fatkin D, Turnpenny PD, Kusumi K, Sillence D, Dunwoodie SL. 2006. Mutation of the LUNATIC FRINGE gene in humans causes spondylocostal dysostosis with a severe vertebral phenotype. Am J Hum Genet 78:28-37.
51. Takahashi Y, Koizumi K, Takagi A, Kitajima S, Inoue T, Koseki H, Saga Y. 2000. Mesp2 initiates somite segmentation through the Notch signaling pathway. Nat Genet 25:390-396.
52. Turnpenny PD, Kusumi K. 2003. DLL3 and spondylocostal dysostosis. In: Epstein CJ, Erickson RP, Wynshaw-Boris A, editors. Inborn errors of development. New York: Oxford University Press. p 470-481.
53. Vermot J, Pourquie O. 2005. Retinoic acid coordinates somitogenesis and left-right patterning in vertebrate embryos. Nature 435:215-220.
54. Vermot J, Gallego Llamas J, Fraulob V, Niederreither K, Chambon P, Dolle P. 2005. Retinoic acid controls the bilateral symmetry of somite formation in the mouse embryo. Science 308:563-566.
55. Watabe-Rudolph M, Schlautmann N, Papaioannou VE, Gossler A. 2002. The mouse rib-vertebrae mutation is a hypomorphic Tbx6 allele. Mech Dev 119:251-256.
56. Weinmaster G, Kintner C. 2003. Modulation of Notch signaling during somitogenesis. Annu Rev Cell Dev Biol 19:367-395.
57. White PH, Chapman DL. 2005. Dll1 is a downstream target of Tbx6 in the paraxial mesoderm. Genesis 42:193-202.
58. White PH, Farkas DR, McFadden EE, Chapman DL. 2003. Defective somite patterning in mouse embryos with reduced levels of Tbx6. Development 130:1681-1690.
59. White PH, Farkas DR, Chapman DL. 2005. Regulation of Tbx6 expression by Notch signaling. Genesis 42:61-70.
60. Whittock NV, Sparrow DB, Wouters MA, Sillence D, Ellard S, Dunwoodie SL, Turnpenny PD. 2004. Mutated MESP2 causes spondylocostal dysostosis in humans. Am J Hum Genet 74:1249-1254.
61. Yasuhiko Y, Haraguchi S, Kitajima S, Takahashi Y, Kanno J, Saga Y. 2006. Tbx6-mediated Notch signaling controls somite-specific Mesp2 expression. Proc Natl Acad Sci U S A 10:3651-3656.
62. Zakany J, Kmita M, Alarcon P, de la Pompa JL, Duboule D. 2001. Localized and transient transcription of Hox genes suggests a link between patterning and the segmentation clock. Cell 106:207-217.
63. Zhang N, Gridley T. 1998. Defects in somite formation in Lunatic fringe deficient mice. Nature 394:374-377.
64. Zhang N, Norton CR, Gridley T. 2002. Segmentation defects of Notch pathway mutants and absence of a synergistic phenotype in lunatic fringe/radical fringe double mutant mice. Genesis 33:21-28.