-
1
-
-
0030840351
-
Avian hairy gene expression identifies a molecular clock linked to vertebrate segmentation and somitogenesis
-
Palmeirim I., Henrique D., Ish-Horowicz D., Pourquié O. Avian hairy gene expression identifies a molecular clock linked to vertebrate segmentation and somitogenesis. Cell. 91:1997;639-648
-
(1997)
Cell
, vol.91
, pp. 639-648
-
-
Palmeirim, I.1
Henrique, D.2
Ish-Horowicz, D.3
Pourquié, O.4
-
2
-
-
0041845302
-
Oscillations, clocks and segmentation
-
Bessho Y., Kageyama R. Oscillations, clocks and segmentation. Curr Opin Genet Dev. 13:2003;379-384
-
(2003)
Curr Opin Genet Dev
, vol.13
, pp. 379-384
-
-
Bessho, Y.1
Kageyama, R.2
-
3
-
-
0038115065
-
The segmentation clock: Converting embryonic time into spatial pattern
-
Pourquié O. The segmentation clock: converting embryonic time into spatial pattern. Science. 301:2003;328-330
-
(2003)
Science
, vol.301
, pp. 328-330
-
-
Pourquié, O.1
-
4
-
-
0035514186
-
The making of the somite: Molecular events in vertebrate segmentation
-
Saga Y., Takeda H. The making of the somite: molecular events in vertebrate segmentation. Nat Rev Genet. 2:2001;835-845
-
(2001)
Nat Rev Genet
, vol.2
, pp. 835-845
-
-
Saga, Y.1
Takeda, H.2
-
5
-
-
0017122064
-
A clock and wavefront model for control of the number of repeated structures during animal morphogenesis
-
Cooke J., Zeeman E.C. A clock and wavefront model for control of the number of repeated structures during animal morphogenesis. J Theor Biol. 58:1976;455-476
-
(1976)
J Theor Biol
, vol.58
, pp. 455-476
-
-
Cooke, J.1
Zeeman, E.C.2
-
6
-
-
0344824688
-
Modulation of Notch signaling during somitogenesis
-
Weinmaster G., Kintner C. Modulation of Notch signaling during somitogenesis. Annu Rev Cell Dev Biol. 19:2003;367-395
-
(2003)
Annu Rev Cell Dev Biol
, vol.19
, pp. 367-395
-
-
Weinmaster, G.1
Kintner, C.2
-
7
-
-
0033152436
-
Periodic repression of Notch pathway genes governs the segmentation of Xenopus embryos
-
Jen W.C., Gawantka V., Pollet N., Niehrs C., Kintner C. Periodic repression of Notch pathway genes governs the segmentation of Xenopus embryos. Genes Dev. 13:1999;1486-1499
-
(1999)
Genes Dev
, vol.13
, pp. 1486-1499
-
-
Jen, W.C.1
Gawantka, V.2
Pollet, N.3
Niehrs, C.4
Kintner, C.5
-
8
-
-
0037490120
-
Involvement of Notch and Delta genes in spider segmentation
-
This thought-provoking paper suggests a conservation of segmentation mechanisms between vertebrates and arthropods. The authors show that the Notch pathway has a central role in segmentation in a spider, even though it is not involved in segmentation in Drosophila.
-
Stollewerk A., Schoppmeier M., Damen W.G. Involvement of Notch and Delta genes in spider segmentation. Nature. 423:2003;863-865 This thought-provoking paper suggests a conservation of segmentation mechanisms between vertebrates and arthropods. The authors show that the Notch pathway has a central role in segmentation in a spider, even though it is not involved in segmentation in Drosophila.
-
(2003)
Nature
, vol.423
, pp. 863-865
-
-
Stollewerk, A.1
Schoppmeier, M.2
Damen, W.G.3
-
9
-
-
0036065333
-
Periodic Lunatic fringe expression is controlled during segmentation by a cyclic transcriptional enhancer responsive to notch signaling
-
In situ hybridisation with an intron probe shows that the oscillation of Lfng mRNA levels in the mouse reflects oscillating transcription. The authors go on to identify regulatory DNA upstream of Lfng mediating two types of control, jointly critical for Lfng oscillation: one that responds directly to Notch activity to enhance expression, the other that responds indirectly to Notch signalling and inhibits expression.
-
Morales A.V., Yasuda Y., Ish-Horowicz D. Periodic Lunatic fringe expression is controlled during segmentation by a cyclic transcriptional enhancer responsive to notch signaling. Dev Cell. 3:2002;63-74 In situ hybridisation with an intron probe shows that the oscillation of Lfng mRNA levels in the mouse reflects oscillating transcription. The authors go on to identify regulatory DNA upstream of Lfng mediating two types of control, jointly critical for Lfng oscillation: one that responds directly to Notch activity to enhance expression, the other that responds indirectly to Notch signalling and inhibits expression.
-
(2002)
Dev Cell
, vol.3
, pp. 63-74
-
-
Morales, A.V.1
Yasuda, Y.2
Ish-Horowicz, D.3
-
10
-
-
0036065035
-
Clock regulatory elements control cyclic expression of Lunatic fringe during somitogenesis
-
This paper identifies a 'clock element' in the regulatory region of the Lfng gene, necessary and sufficient to drive cyclic expression in the posterior presomitic mesoderm. A separate regulatory element drives expression of Lfng in the forming somites. Mutational analysis points to a regulation of the clock element by bHLH proteins such as Hes.
-
Cole S.E., Levorse J.M., Tilghman S.M., Vogt T.F. Clock regulatory elements control cyclic expression of Lunatic fringe during somitogenesis. Dev Cell. 3:2002;75-84 This paper identifies a 'clock element' in the regulatory region of the Lfng gene, necessary and sufficient to drive cyclic expression in the posterior presomitic mesoderm. A separate regulatory element drives expression of Lfng in the forming somites. Mutational analysis points to a regulation of the clock element by bHLH proteins such as Hes.
-
(2002)
Dev Cell
, vol.3
, pp. 75-84
-
-
Cole, S.E.1
Levorse, J.M.2
Tilghman, S.M.3
Vogt, T.F.4
-
11
-
-
0037448536
-
Periodic notch inhibition by lunatic fringe underlies the chick segmentation clock
-
This paper proposes that the segmentation clock is based on a Lfng negative feedback loop. Peaks of Lfng protein expression coincide with troughs of Lfng mRNA expression. Artificial overexpression of Lfng inhibits expression of endogenous Lfng. Artificial overexpression of activated Notch promotes expression of Lfng, while blockade of Notch activation prevents Lfng expression. The authors thus suggest that in this system, unlike others, the effect of Lfng is to inhibit, rather than potentiate, the activation of Notch by Delta.
-
Dale J.K., Maroto M., Dequeant M.L., Malapert P., McGrew M., Pourquié O. Periodic notch inhibition by lunatic fringe underlies the chick segmentation clock. Nature. 421:2003;275-278 This paper proposes that the segmentation clock is based on a Lfng negative feedback loop. Peaks of Lfng protein expression coincide with troughs of Lfng mRNA expression. Artificial overexpression of Lfng inhibits expression of endogenous Lfng. Artificial overexpression of activated Notch promotes expression of Lfng, while blockade of Notch activation prevents Lfng expression. The authors thus suggest that in this system, unlike others, the effect of Lfng is to inhibit, rather than potentiate, the activation of Notch by Delta.
-
(2003)
Nature
, vol.421
, pp. 275-278
-
-
Dale, J.K.1
Maroto, M.2
Dequeant, M.L.3
Malapert, P.4
McGrew, M.5
Pourquié, O.6
-
12
-
-
13144297173
-
The lunatic fringe gene is a target of the molecular clock linked to somite segmentation in avian embryos
-
McGrew M.J., Dale J.K., Fraboulet S., Pourquié O. The lunatic fringe gene is a target of the molecular clock linked to somite segmentation in avian embryos. Curr Biol. 8:1998;979-982
-
(1998)
Curr Biol
, vol.8
, pp. 979-982
-
-
McGrew, M.J.1
Dale, J.K.2
Fraboulet, S.3
Pourquié, O.4
-
13
-
-
0033104404
-
Dynamic expression of lunatic fringe suggests a link between Notch signaling and an autonomous cellular oscillator driving somite segmentation
-
Aulehla A., Johnson R.L. Dynamic expression of lunatic fringe suggests a link between Notch signaling and an autonomous cellular oscillator driving somite segmentation. Dev Biol. 207:1999;49-61
-
(1999)
Dev Biol
, vol.207
, pp. 49-61
-
-
Aulehla, A.1
Johnson, R.L.2
-
14
-
-
0032560766
-
Defects in somite formation in lunatic fringe-deficient mice
-
Zhang N., Gridley T. Defects in somite formation in lunatic fringe-deficient mice. Nature. 394:1998;374-377
-
(1998)
Nature
, vol.394
, pp. 374-377
-
-
Zhang, N.1
Gridley, T.2
-
15
-
-
0032560814
-
Lunatic fringe is an essential mediator of somite segmentation and patterning
-
Evrard Y.A., Lun Y., Aulehla A., Gan L., Johnson R.L. lunatic fringe is an essential mediator of somite segmentation and patterning. Nature. 394:1998;377-381
-
(1998)
Nature
, vol.394
, pp. 377-381
-
-
Evrard, Y.A.1
Lun, Y.2
Aulehla, A.3
Gan, L.4
Johnson, R.L.5
-
16
-
-
0037380655
-
Transcriptional oscillation of lunatic fringe is essential for somitogenesis
-
This paper tests directly whether gene expression in the PSM actually needs to be cyclic. The authors generate mice with constant uniform expression of Lfng in the PSM and show that they display segmentation defects similar to Lfng-null mice. Thus, cycling of Lfng expression is necessary for proper somite segmentation. However, cyclic transcription from the endogenous Lfng locus is not abolished, suggesting that the cycling of Lfng expression is driven by some other oscillator and that its critical role is in the downstream process of somite boundary formation.
-
Serth K., Schuster-Gossler K., Cordes R., Gossler A. Transcriptional oscillation of lunatic fringe is essential for somitogenesis. Genes Dev. 17:2003;912-925 This paper tests directly whether gene expression in the PSM actually needs to be cyclic. The authors generate mice with constant uniform expression of Lfng in the PSM and show that they display segmentation defects similar to Lfng-null mice. Thus, cycling of Lfng expression is necessary for proper somite segmentation. However, cyclic transcription from the endogenous Lfng locus is not abolished, suggesting that the cycling of Lfng expression is driven by some other oscillator and that its critical role is in the downstream process of somite boundary formation.
-
(2003)
Genes Dev
, vol.17
, pp. 912-925
-
-
Serth, K.1
Schuster-Gossler, K.2
Cordes, R.3
Gossler, A.4
-
17
-
-
0036678153
-
Morphological boundary forms by a novel inductive event mediated by Lunatic fringe and Notch during somitic segmentation
-
Sato Y., Yasuda K., Takahashi Y. Morphological boundary forms by a novel inductive event mediated by Lunatic fringe and Notch during somitic segmentation. Development. 129:2002;3633-3644
-
(2002)
Development
, vol.129
, pp. 3633-3644
-
-
Sato, Y.1
Yasuda, K.2
Takahashi, Y.3
-
18
-
-
0034961853
-
Zebrafish lunatic fringe demarcates segmental boundaries
-
Prince V.E., Holley S.A., Bally-Cuif L., Prabhakaran B., Oates A.C., Ho R.K., Vogt T.F. Zebrafish lunatic fringe demarcates segmental boundaries. Mech Dev. 105:2001;175-180
-
(2001)
Mech Dev
, vol.105
, pp. 175-180
-
-
Prince, V.E.1
Holley, S.A.2
Bally-Cuif, L.3
Prabhakaran, B.4
Oates, A.C.5
Ho, R.K.6
Vogt, T.F.7
-
19
-
-
0035163040
-
Homologues of c-hairy1 (her9) and lunatic fringe in zebrafish are expressed in the developing central nervous system, but not in the presomitic mesoderm
-
Leve C., Gajewski M., Rohr K.B., Tautz D. Homologues of c-hairy1 (her9) and lunatic fringe in zebrafish are expressed in the developing central nervous system, but not in the presomitic mesoderm. Dev Genes Evol. 211:2001;493-500
-
(2001)
Dev Genes Evol
, vol.211
, pp. 493-500
-
-
Leve, C.1
Gajewski, M.2
Rohr, K.B.3
Tautz, D.4
-
20
-
-
0035887251
-
Dynamic expression and essential functions of Hes7 in somite segmentation
-
Bessho Y., Sakata R., Komatsu S., Shiota K., Yamada S., Kageyama R. Dynamic expression and essential functions of Hes7 in somite segmentation. Genes Dev. 15:2001;2642-2647
-
(2001)
Genes Dev
, vol.15
, pp. 2642-2647
-
-
Bessho, Y.1
Sakata, R.2
Komatsu, S.3
Shiota, K.4
Yamada, S.5
Kageyama, R.6
-
21
-
-
0038046204
-
Periodic repression by the bHLH factor Hes7 is an essential mechanism for the somite segmentation clock
-
Hes7 is needed for operation of the mouse somitogenesis oscillator, and its product inhibits its own expression (as well as that of Lfng). A Hes7 negative feedback loop is thus a strong candidate for the role of fundamental oscillator.
-
Bessho Y., Hirata H., Masamizu Y., Kageyama R. Periodic repression by the bHLH factor Hes7 is an essential mechanism for the somite segmentation clock. Genes Dev. 17:2003;1451-1456 Hes7 is needed for operation of the mouse somitogenesis oscillator, and its product inhibits its own expression (as well as that of Lfng). A Hes7 negative feedback loop is thus a strong candidate for the role of fundamental oscillator.
-
(2003)
Genes Dev
, vol.17
, pp. 1451-1456
-
-
Bessho, Y.1
Hirata, H.2
Masamizu, Y.3
Kageyama, R.4
-
22
-
-
0037174669
-
Oscillatory expression of the bHLH factor Hes1 regulated by a negative feedback loop
-
Hes1 expression oscillates in cultured cells upon serum stimulation. Because Hes1 is one of the genes expressed cyclically in the mouse PSM, this raises the possibility that Hes1 has an intrinsic propensity to oscillate, made manifest when synchronisation of the oscillations is forced by an external stimulus. The authors hypothesise that oscillations result from the capacity of Hes1 protein to repress transcription of Hes1 - a theory consistent with the cell-autonomous character of the oscillations.
-
Hirata H., Yoshiura S., Ohtsuka T., Bessho Y., Harada T., Yoshikawa K., Kageyama R. Oscillatory expression of the bHLH factor Hes1 regulated by a negative feedback loop. Science. 298:2002;840-843 Hes1 expression oscillates in cultured cells upon serum stimulation. Because Hes1 is one of the genes expressed cyclically in the mouse PSM, this raises the possibility that Hes1 has an intrinsic propensity to oscillate, made manifest when synchronisation of the oscillations is forced by an external stimulus. The authors hypothesise that oscillations result from the capacity of Hes1 protein to repress transcription of Hes1 - a theory consistent with the cell-autonomous character of the oscillations.
-
(2002)
Science
, vol.298
, pp. 840-843
-
-
Hirata, H.1
Yoshiura, S.2
Ohtsuka, T.3
Bessho, Y.4
Harada, T.5
Yoshikawa, K.6
Kageyama, R.7
-
23
-
-
0036332729
-
Her1 and the notch pathway function within the oscillator mechanism that regulates zebrafish somitogenesis
-
This paper uses morpholino-mediated knock-down of gene expression and analysis of mutant zebrafish to demonstrate the requirement for her1 and the Notch pathway in the generation of cyclic gene expression in the zebrafish PSM. The authors propose that a negative feedback loop (Notch → her1 - Notch) constitutes the core oscillator.
-
Holley S.A., Julich D., Rauch G.J., Geisler R., Nusslein-Volhard C. her1 and the notch pathway function within the oscillator mechanism that regulates zebrafish somitogenesis. Development. 129:2002;1175-1183 This paper uses morpholino-mediated knock-down of gene expression and analysis of mutant zebrafish to demonstrate the requirement for her1 and the Notch pathway in the generation of cyclic gene expression in the zebrafish PSM. The authors propose that a negative feedback loop (Notch → her1 - Notch) constitutes the core oscillator.
-
(2002)
Development
, vol.129
, pp. 1175-1183
-
-
Holley, S.A.1
Julich, D.2
Rauch, G.J.3
Geisler, R.4
Nusslein-Volhard, C.5
-
24
-
-
0032808520
-
Her1, a zebrafish pair-rule like gene, acts downstream of Notch signalling to control somite development
-
Takke C., Campos-Ortega J.A. her1, a zebrafish pair-rule like gene, acts downstream of Notch signalling to control somite development. Development. 126:1999;3005-3014
-
(1999)
Development
, vol.126
, pp. 3005-3014
-
-
Takke, C.1
Campos-Ortega, J.A.2
-
25
-
-
0035984002
-
Hairy/E(spl)-related (Her) genes are central components of the segmentation oscillator and display redundancy with the Delta/Notch signaling pathway in the formation of anterior segmental boundaries in the zebrafish
-
••], this paper identifies the combined requirement for the two linked bHLH repressor proteins Her1 and Her7 in the zebrafish segmentation clock.
-
••], this paper identifies the combined requirement for the two linked bHLH repressor proteins Her1 and Her7 in the zebrafish segmentation clock.
-
(2002)
Development
, vol.129
, pp. 2929-2946
-
-
Oates, A.C.1
Ho, R.K.2
-
26
-
-
0036679340
-
Two linked hairy/Enhancer of split-related zebrafish genes, her1 and her7, function together to refine alternating somite boundaries
-
••] define partially redundant roles for her1 and her7 in the generation of cyclic expression patterns.
-
••] define partially redundant roles for her1 and her7 in the generation of cyclic expression patterns.
-
(2002)
Development
, vol.129
, pp. 3693-3704
-
-
Henry, C.A.1
Urban, M.K.2
Dill, K.K.3
Merlie, J.P.4
Page, M.F.5
Kimmel, C.B.6
Amacher, S.L.7
-
27
-
-
0042673755
-
Anterior and posterior waves of cyclic her1 gene expression are differentially regulated in the presomitic mesoderm of zebrafish
-
The zebrafish her1 and her7 genes lie just 11 kb apart, in head-to-head orientation. Two distinct regulatory regions are identified in the DNA that lies between them, driving cyclic expression of her1 (and possibly of her7 also) in the posterior and anterior PSM. Her7 is shown to act as a repressor of her1 transcription, but, unexpectedly, the regulatory element driving anterior expression of her1 appears to be under positive control by Her1.
-
Gajewski M., Sieger D., Alt B., Leve C., Hans S., Wolff C., Rohr K.B., Tautz D. Anterior and posterior waves of cyclic her1 gene expression are differentially regulated in the presomitic mesoderm of zebrafish. Development. 130:2003;4269-4278 The zebrafish her1 and her7 genes lie just 11 kb apart, in head-to-head orientation. Two distinct regulatory regions are identified in the DNA that lies between them, driving cyclic expression of her1 (and possibly of her7 also) in the posterior and anterior PSM. Her7 is shown to act as a repressor of her1 transcription, but, unexpectedly, the regulatory element driving anterior expression of her1 appears to be under positive control by Her1.
-
(2003)
Development
, vol.130
, pp. 4269-4278
-
-
Gajewski, M.1
Sieger, D.2
Alt, B.3
Leve, C.4
Hans, S.5
Wolff, C.6
Rohr, K.B.7
Tautz, D.8
-
28
-
-
0041677612
-
Autoinhibition with transcriptional delay: A simple mechanism for the zebrafish somitogenesis oscillator
-
Mathematical modelling shows that a single gene whose product directly inhibits its own expression can generate sustained oscillations, but only on condition that the lifetimes of the gene transcript and corresponding protein are short compared with the time it takes to make each type of molecule. Applied to the zebrafish bHLH repressor genes her1 and her7, the model shows that the physical properties of these genes lead to a prediction for the oscillation period that is consistent with the observed 30′-period of the zebrafish segmentation clock. The delay elapsing from initiation to completion of the synthesis of a functional mRNA molecule is identified as the chief determinant of the period. An extension of the model shows how Delta-Notch signalling can synchronise the her1/7 oscillations in adjacent cells.
-
Lewis J. Autoinhibition with transcriptional delay: a simple mechanism for the zebrafish somitogenesis oscillator. Curr Biol. 13:2003;1398-1408 Mathematical modelling shows that a single gene whose product directly inhibits its own expression can generate sustained oscillations, but only on condition that the lifetimes of the gene transcript and corresponding protein are short compared with the time it takes to make each type of molecule. Applied to the zebrafish bHLH repressor genes her1 and her7, the model shows that the physical properties of these genes lead to a prediction for the oscillation period that is consistent with the observed 30′-period of the zebrafish segmentation clock. The delay elapsing from initiation to completion of the synthesis of a functional mRNA molecule is identified as the chief determinant of the period. An extension of the model shows how Delta-Notch signalling can synchronise the her1/7 oscillations in adjacent cells.
-
(2003)
Curr Biol
, vol.13
, pp. 1398-1408
-
-
Lewis, J.1
-
29
-
-
0034707072
-
Notch signalling and the synchronization of the somite segmentation clock
-
Jiang Y.J., Aerne B.L., Smithers L., Haddon C., Ish-Horowicz D., Lewis J. Notch signalling and the synchronization of the somite segmentation clock. Nature. 408:2000;475-479
-
(2000)
Nature
, vol.408
, pp. 475-479
-
-
Jiang, Y.J.1
Aerne, B.L.2
Smithers, L.3
Haddon, C.4
Ish-Horowicz, D.5
Lewis, J.6
-
30
-
-
0034234968
-
Control of her1 expression during zebrafish somitogenesis by a delta-dependent oscillator and an independent wave-front activity
-
Holley S.A., Geisler R., Nusslein-Volhard C. Control of her1 expression during zebrafish somitogenesis by a delta-dependent oscillator and an independent wave-front activity. Genes Dev. 14:2000;1678-1690
-
(2000)
Genes Dev
, vol.14
, pp. 1678-1690
-
-
Holley, S.A.1
Geisler, R.2
Nusslein-Volhard, C.3
-
31
-
-
0037344080
-
Wnt3a plays a major role in the segmentation clock controlling somitogenesis
-
This paper proposes that the segmentation clock in mice is based on cyclic activation of the Wnt signalling pathway. Transcription of the Wnt pathway negative regulator Axin2 oscillates in the mouse PSM, and forced constant expression of Axin2 impairs segmentation. A negative feedback loop is created because the Axin2 gene is itself positively regulated by Wnt signalling. Whereas oscillations of Axin2 are preserved in Notch pathway mutants, oscillations of Notch pathway components are lost in a Wnt3a hypomorphic mutant (although this could be secondary to the downregulation of Fgf8 expression, which is dependent on Wnt3a). Thus, a Wnt-based oscillator might be the driver of oscillation in Notch pathway activity.
-
Aulehla A., Wehrle C., Brand-Saberi B., Kemler R., Gossler A., Kanzler B., Herrmann B.G. Wnt3a plays a major role in the segmentation clock controlling somitogenesis. Dev Cell. 4:2003;395-406 This paper proposes that the segmentation clock in mice is based on cyclic activation of the Wnt signalling pathway. Transcription of the Wnt pathway negative regulator Axin2 oscillates in the mouse PSM, and forced constant expression of Axin2 impairs segmentation. A negative feedback loop is created because the Axin2 gene is itself positively regulated by Wnt signalling. Whereas oscillations of Axin2 are preserved in Notch pathway mutants, oscillations of Notch pathway components are lost in a Wnt3a hypomorphic mutant (although this could be secondary to the downregulation of Fgf8 expression, which is dependent on Wnt3a). Thus, a Wnt-based oscillator might be the driver of oscillation in Notch pathway activity.
-
(2003)
Dev Cell
, vol.4
, pp. 395-406
-
-
Aulehla, A.1
Wehrle, C.2
Brand-Saberi, B.3
Kemler, R.4
Gossler, A.5
Kanzler, B.6
Herrmann, B.G.7
-
32
-
-
0032562603
-
Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta
-
Behrens J., Jerchow B.A., Wurtele M., Grimm J., Asbrand C., Wirtz R., Kuhl M., Wedlich D., Birchmeier W. Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta. Science. 280:1998;596-599
-
(1998)
Science
, vol.280
, pp. 596-599
-
-
Behrens, J.1
Jerchow, B.A.2
Wurtele, M.3
Grimm, J.4
Asbrand, C.5
Wirtz, R.6
Kuhl, M.7
Wedlich, D.8
Birchmeier, W.9
-
33
-
-
0043180477
-
Oscillatory expression of Hes1, p53 and NF-kappaB driven by transcriptional time delays
-
Monk N.A.M. Oscillatory expression of Hes1, p53 and NF-kappaB driven by transcriptional time delays. Curr Biol. 13:2003;1409-1413
-
(2003)
Curr Biol
, vol.13
, pp. 1409-1413
-
-
Monk, N.A.M.1
-
34
-
-
3042842911
-
Instability of Hes7 protein is critical for the somite segmentation clock
-
in press.
-
Hirata H, Bessho Y, Kokubu H, Masamizu Y, Yamada S, Lewis J, Kageyama R: Instability of Hes7 protein is critical for the somite segmentation clock. Nat Genet 2004, in press.
-
(2004)
Nat Genet
-
-
Hirata, H.1
Bessho, Y.2
Kokubu, H.3
Masamizu, Y.4
Yamada, S.5
Lewis, J.6
Kageyama, R.7
-
36
-
-
0035958586
-
FGF signaling controls somite boundary position and regulates segmentation clock control of spatiotemporal Hox gene activation
-
Dubrulle J., McGrew M.J., Pourquié O. FGF signaling controls somite boundary position and regulates segmentation clock control of spatiotemporal Hox gene activation. Cell. 106:2001;219-232
-
(2001)
Cell
, vol.106
, pp. 219-232
-
-
Dubrulle, J.1
McGrew, M.J.2
Pourquié, O.3
-
37
-
-
0842264188
-
Fgf8 mRNA decay establishes a gradient that couples axial elongation to patterning in the vertebrate embryo
-
A graded FGF8 signal delimits the region in which the segmentation oscillator functions. This paper shows that fgf8 mRNA is made at the tail end of the embryo, which leaves behind a trail of PSM cells in which the mRNA is gradually degraded. Thus the length of the PSM (the domain of the oscillator) is a reflection of the degradation kinetics of fgf8 mRNA.
-
Dubrulle J., Pourquié O. fgf8 mRNA decay establishes a gradient that couples axial elongation to patterning in the vertebrate embryo. Nature. 427:2004;419-422 A graded FGF8 signal delimits the region in which the segmentation oscillator functions. This paper shows that fgf8 mRNA is made at the tail end of the embryo, which leaves behind a trail of PSM cells in which the mRNA is gradually degraded. Thus the length of the PSM (the domain of the oscillator) is a reflection of the degradation kinetics of fgf8 mRNA.
-
(2004)
Nature
, vol.427
, pp. 419-422
-
-
Dubrulle, J.1
Pourquié, O.2
-
38
-
-
0141862018
-
Opposing FGF and retinoid pathways control ventral neural pattern, neuronal differentiation, and segmentation during body axis extension
-
Diez del Corral R., Olivera-Martinez I., Goriely A., Gale E., Maden M., Storey K. Opposing FGF and retinoid pathways control ventral neural pattern, neuronal differentiation, and segmentation during body axis extension. Neuron. 40:2003;65-79
-
(2003)
Neuron
, vol.40
, pp. 65-79
-
-
Diez Del Corral, R.1
Olivera-Martinez, I.2
Goriely, A.3
Gale, E.4
Maden, M.5
Storey, K.6
-
39
-
-
0035214904
-
Fgf/MAPK signalling is a crucial positional cue in somite boundary formation
-
Sawada A., Shinya M., Jiang Y.J., Kawakami A., Kuroiwa A., Takeda H. Fgf/MAPK signalling is a crucial positional cue in somite boundary formation. Development. 128:2001;4873-4880
-
(2001)
Development
, vol.128
, pp. 4873-4880
-
-
Sawada, A.1
Shinya, M.2
Jiang, Y.J.3
Kawakami, A.4
Kuroiwa, A.5
Takeda, H.6
-
40
-
-
0141613751
-
Feedback loops comprising Dll1, Dll3 and Mesp2, and differential involvement of Psen1 are essential for rostrocaudal patterning of somites
-
Takahashi Y., Inoue T., Gossler A., Saga Y. Feedback loops comprising Dll1, Dll3 and Mesp2, and differential involvement of Psen1 are essential for rostrocaudal patterning of somites. Development. 130:2003;4259-4268
-
(2003)
Development
, vol.130
, pp. 4259-4268
-
-
Takahashi, Y.1
Inoue, T.2
Gossler, A.3
Saga, Y.4
-
41
-
-
0030938788
-
The Notch ligand, X-Delta-2, mediates segmentation of the paraxial mesoderm in Xenopus embryos
-
Jen W.C., Wettstein D., Turner D., Chitnis A., Kintner C. The Notch ligand, X-Delta-2, mediates segmentation of the paraxial mesoderm in Xenopus embryos. Development. 124:1997;1169-1178
-
(1997)
Development
, vol.124
, pp. 1169-1178
-
-
Jen, W.C.1
Wettstein, D.2
Turner, D.3
Chitnis, A.4
Kintner, C.5
-
42
-
-
0034098483
-
Notch signalling is required for cyclic expression of the hairy-like gene HES1 in the presomitic mesoderm
-
Jouve C., Palmeirim I., Henrique D., Beckers J., Gossler A., Ish-Horowicz D., Pourquié O. Notch signalling is required for cyclic expression of the hairy-like gene HES1 in the presomitic mesoderm. Development. 127:2000;1421-1429
-
(2000)
Development
, vol.127
, pp. 1421-1429
-
-
Jouve, C.1
Palmeirim, I.2
Henrique, D.3
Beckers, J.4
Gossler, A.5
Ish-Horowicz, D.6
Pourquié, O.7
-
43
-
-
0034331260
-
Oscillating expression of c-Hey2 in the presomitic mesoderm suggests that the segmentation clock may use combinatorial signaling through multiple interacting bHLH factors
-
Leimeister C., Dale K., Fischer A., Klamt B., Hrabe de Angelis M., Radtke F., McGrew M.J., Pourquié O., Gessler M. Oscillating expression of c-Hey2 in the presomitic mesoderm suggests that the segmentation clock may use combinatorial signaling through multiple interacting bHLH factors. Dev Biol. 227:2000;91-103
-
(2000)
Dev Biol
, vol.227
, pp. 91-103
-
-
Leimeister, C.1
Dale, K.2
Fischer, A.3
Klamt, B.4
Hrabe De Angelis, M.5
Radtke, F.6
McGrew, M.J.7
Pourquié, O.8
Gessler, M.9
-
44
-
-
0034090969
-
Zebrafish mesp family genes, mesp-a and mesp-b are segmentally expressed in the presomitic mesoderm, and mesp-b confers the anterior identity to the developing somites
-
Sawada A., Fritz A., Jiang Y-J., Yamamoto A., Yamasu K., Kuroiwa A., Saga Y., Takeda H. Zebrafish mesp family genes, mesp-a and mesp-b are segmentally expressed in the presomitic mesoderm, and mesp-b confers the anterior identity to the developing somites. Development. 127:2000;1691-1702
-
(2000)
Development
, vol.127
, pp. 1691-1702
-
-
Sawada, A.1
Fritz, A.2
Jiang, Y.-J.3
Yamamoto, A.4
Yamasu, K.5
Kuroiwa, A.6
Saga, Y.7
Takeda, H.8
-
45
-
-
0038451096
-
Cyclic expression of esr9 gene in Xenopus presomitic mesoderm
-
Li Y., Fenger U., Niehrs C., Pollet N. Cyclic expression of esr9 gene in Xenopus presomitic mesoderm. Differentiation. 71:2003;83-89
-
(2003)
Differentiation
, vol.71
, pp. 83-89
-
-
Li, Y.1
Fenger, U.2
Niehrs, C.3
Pollet, N.4
-
46
-
-
0033528998
-
Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouse
-
del Barco Barrantes I., Elia A.J., Wünsch K., Hrabé de Angelis M., Mak T.W., Rossant J., Conlon R.A., Gossler A., de la Pompa J.L. Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouse. Curr Biol. 9:1999;470-480
-
(1999)
Curr Biol
, vol.9
, pp. 470-480
-
-
Del Barco Barrantes, I.1
Elia, A.J.2
Wünsch, K.3
Hrabé De Angelis, M.4
Mak, T.W.5
Rossant, J.6
Conlon, R.A.7
Gossler, A.8
De La Pompa, J.L.9
-
47
-
-
0141860124
-
The role of Suppressor of Hairless in Notch mediated signalling during zebrafish somitogenesis
-
Sieger D., Tautz D., Gajewski M. The role of Suppressor of Hairless in Notch mediated signalling during zebrafish somitogenesis. Mech Dev. 120:2003;1083-1094
-
(2003)
Mech Dev
, vol.120
, pp. 1083-1094
-
-
Sieger, D.1
Tautz, D.2
Gajewski, M.3
-
48
-
-
3142555604
-
RPTPψ is required for Delta/Notch signalling and cyclic gene expression in the presomitic mesoderm
-
in press.
-
Aerne BL, Ish-Horowicz D: RPTPψ is required for Delta/Notch signalling and cyclic gene expression in the presomitic mesoderm. Development 2004, in press.
-
(2004)
Development
-
-
Aerne, B.L.1
Ish-Horowicz, D.2
|