-
1
-
-
0032518290
-
The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors
-
Kim RB, Fromm MF, Wandel C, Leake B, Wood AJ, Roden DM, Wilkinson GR. The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors. J Clin Invest 1998; 101: 289-94.
-
(1998)
J Clin Invest
, vol.101
, pp. 289-294
-
-
Kim, R.B.1
Fromm, M.F.2
Wandel, C.3
Leake, B.4
Wood, A.J.5
Roden, D.M.6
Wilkinson, G.R.7
-
2
-
-
0033957756
-
Influence of P-glycoprotein on the transport and metabolism of indinavir in Caco-2 cells expressing cytochrome P-450 3A4
-
Hochman JH, Chiba M, Nishime J, Yamazaki M, Lin JH. Influence of P-glycoprotein on the transport and metabolism of indinavir in Caco-2 cells expressing cytochrome P-450 3A4. J Pharmacol Exp Ther 2000; 292: 310-8.
-
(2000)
J Pharmacol Exp Ther
, vol.292
, pp. 310-318
-
-
Hochman, J.H.1
Chiba, M.2
Nishime, J.3
Yamazaki, M.4
Lin, J.H.5
-
3
-
-
0031946993
-
In vitro blood-brain barrier permeability of nevirapine compared to other HIV antiretroviral agents
-
Glynn SL, Yazdanian M. In vitro blood-brain barrier permeability of nevirapine compared to other HIV antiretroviral agents. J Pharm Sci 1998; 87: 306-10.
-
(1998)
J Pharm Sci
, vol.87
, pp. 306-310
-
-
Glynn, S.L.1
Yazdanian, M.2
-
4
-
-
0032906888
-
Disposition of ivermectin and cyclosporin a in CF-1 mice deficient in mdr1a P-glycoprotein
-
Kwei GY, Alvaro RF, Chen Q, Jenkins HJ, Hop CE, Keohane CA, Ly VT, Strauss JR, Wang RW, Wang Z, Pippert TR, Umbenhauer DR. Disposition of ivermectin and cyclosporin A in CF-1 mice deficient in mdr1a P-glycoprotein. Drug Metab Dispos 1999; 27: 581-7.
-
(1999)
Drug Metab Dispos
, vol.27
, pp. 581-587
-
-
Kwei, G.Y.1
Alvaro, R.F.2
Chen, Q.3
Jenkins, H.J.4
Hop, C.E.5
Keohane, C.A.6
Ly, V.T.7
Strauss, J.R.8
Wang, R.W.9
Wang, Z.10
Pippert, T.R.11
Umbenhauer, D.R.12
-
5
-
-
0033519964
-
Safety and efficacy of vigabatrin and carbamazepine in newly diagnosed epilepsy: A multicentre randomised double-blind study
-
Vigabatrin European Monotherapy Study Group
-
Chadwick D. Safety and efficacy of vigabatrin and carbamazepine in newly diagnosed epilepsy: a multicentre randomised double-blind study. Vigabatrin European Monotherapy Study Group. Lancet 1999; 354: 13-9.
-
(1999)
Lancet
, vol.354
, pp. 13-19
-
-
Chadwick, D.1
-
6
-
-
0034976635
-
Heterotropic cooperativity of cytochrome P450 3A4 and potential drug-drug interactions
-
Tang W, Stearns RA. Heterotropic cooperativity of cytochrome P450 3A4 and potential drug-drug interactions. Curr Drug Metab 2001; 2: 185-98.
-
(2001)
Curr Drug Metab
, vol.2
, pp. 185-198
-
-
Tang, W.1
Stearns, R.A.2
-
7
-
-
0035805536
-
Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin
-
Geick A, Eichelbaum M, Burk O. Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. J Biol Chem 2001; 276: 14581-7.
-
(2001)
J Biol Chem
, vol.276
, pp. 14581-14587
-
-
Geick, A.1
Eichelbaum, M.2
Burk, O.3
-
8
-
-
4544383423
-
Carbamazepine regulates intestinal P-glycoprotein and multidrug resistance protein MRP2 and influences disposition of talinolol in humans
-
Giessmann T, May K, Modess C, Wegner D, Hecker U, Zschiesche M, Dazert P, Grube M, Schroeder E, Warzok R, Cascorbi I, Kroemer HK, Siegmund W. Carbamazepine regulates intestinal P-glycoprotein and multidrug resistance protein MRP2 and influences disposition of talinolol in humans. Clin Pharmacol Ther 2004; 76: 192-200.
-
(2004)
Clin Pharmacol Ther
, vol.76
, pp. 192-200
-
-
Giessmann, T.1
May, K.2
Modess, C.3
Wegner, D.4
Hecker, U.5
Zschiesche, M.6
Dazert, P.7
Grube, M.8
Schroeder, E.9
Warzok, R.10
Cascorbi, I.11
Kroemer, H.K.12
Siegmund, W.13
-
9
-
-
0032693058
-
Over-expression of P-glycoprotein in malformations of cortical development
-
Sisodiya SM, Heffernan J, Squier MV. Over-expression of P-glycoprotein in malformations of cortical development. Neuroreport 1999; 10: 3437-41.
-
(1999)
Neuroreport
, vol.10
, pp. 3437-3441
-
-
Sisodiya, S.M.1
Heffernan, J.2
Squier, M.V.3
-
10
-
-
0036156280
-
Drug resistance in epilepsy: Expression of drug resistance proteins in common causes of refractory epilepsy
-
Sisodiya SM, Lin WR, Harding BN, Squier MV, Thom M. Drug resistance in epilepsy: expression of drug resistance proteins in common causes of refractory epilepsy. Brain 2002; 125: 22-31.
-
(2002)
Brain
, vol.125
, pp. 22-31
-
-
Sisodiya, S.M.1
Lin, W.R.2
Harding, B.N.3
Squier, M.V.4
Thom, M.5
-
11
-
-
0028895740
-
MDR1 gene expression in brain of patients with medically intractable epilepsy
-
Tishler DM, Weinberg KI, Hinton DR, Barbaro N, Annett GM, Raffel C. MDR1 gene expression in brain of patients with medically intractable epilepsy. Epilepsia 1995; 36: 1-6.
-
(1995)
Epilepsia
, vol.36
, pp. 1-6
-
-
Tishler, D.M.1
Weinberg, K.I.2
Hinton, D.R.3
Barbaro, N.4
Annett, G.M.5
Raffel, C.6
-
12
-
-
0035046689
-
A human lymphocyte based ex vivo assay to study the effect of drugs on P-glycoprotein (P-gp) function
-
Parasrampuria DA, Lantz MV, Benet LZ. A human lymphocyte based ex vivo assay to study the effect of drugs on P-glycoprotein (P-gp) function. Pharm Res 2001; 18: 39-44.
-
(2001)
Pharm Res
, vol.18
, pp. 39-44
-
-
Parasrampuria, D.A.1
Lantz, M.V.2
Benet, L.Z.3
-
13
-
-
0042627777
-
The effects of protease inhibitors and nonnucleoside reverse transcriptase inhibitors on p-glycoprotein expression in peripheral blood mononuclear cells in vitro
-
Chandler B, Almond L, Ford J, Owen A, Hoggard P, Khoo SH, Back D. The effects of protease inhibitors and nonnucleoside reverse transcriptase inhibitors on p-glycoprotein expression in peripheral blood mononuclear cells in vitro. J Acquir Immune Defic Syndr 2003; 33: 551-6.
-
(2003)
J Acquir Immune Defic Syndr
, vol.33
, pp. 551-556
-
-
Chandler, B.1
Almond, L.2
Ford, J.3
Owen, A.4
Hoggard, P.5
Khoo, S.H.6
Back, D.7
-
14
-
-
0242364701
-
Expression of P-glycoprotein, multidrug-resistance proteins 1 and 2 in CEM, CEM (VBL), CEM (E1000), MDCKII (MRP1) and MDCKII (MRP2) cell lines
-
Owen A, Hartkoorn RC, Khoo S, Back D. Expression of P-glycoprotein, multidrug-resistance proteins 1 and 2 in CEM, CEM (VBL), CEM (E1000), MDCKII (MRP1) and MDCKII (MRP2) cell lines. Aids 2003; 17: 2276-8.
-
(2003)
Aids
, vol.17
, pp. 2276-2278
-
-
Owen, A.1
Hartkoorn, R.C.2
Khoo, S.3
Back, D.4
-
15
-
-
6344294111
-
Functional correlation of P-glycoprotein expression and genotype with expression of the human immunodeficiency virus type 1 coreceptor CXCR4
-
Owen A, Chandler B, Bray PG, Ward SA, Hart CA, Back DJ, Khoo SH. Functional correlation of P-glycoprotein expression and genotype with expression of the human immunodeficiency virus type 1 coreceptor CXCR4. J Virol 2004; 78: 12022-9.
-
(2004)
J Virol
, vol.78
, pp. 12022-12029
-
-
Owen, A.1
Chandler, B.2
Bray, P.G.3
Ward, S.A.4
Hart, C.A.5
Back, D.J.6
Khoo, S.H.7
-
16
-
-
7244225172
-
Expression of pregnane-X-receptor transcript in peripheral blood mononuclear cells and correlation with MDR1 mRNA
-
Owen A, Chandler B, Back DJ, Khoo SH. Expression of pregnane-X-receptor transcript in peripheral blood mononuclear cells and correlation with MDR1 mRNA. Antivir Ther 2004; 9: 819-21.
-
(2004)
Antivir Ther
, vol.9
, pp. 819-821
-
-
Owen, A.1
Chandler, B.2
Back, D.J.3
Khoo, S.H.4
-
17
-
-
15244350810
-
Relationship between the C3435T and G2677T(A) polymorphisms in the ABCB1 gene and P-glycoprotein expression in human liver
-
Owen A, Goldring C, Morgan P, Chadwick D, Park BK, Pirmohamed M. Relationship between the C3435T and G2677T(A) polymorphisms in the ABCB1 gene and P-glycoprotein expression in human liver. Br J Clin Pharmacol 2005; 59: 365-70.
-
(2005)
Br J Clin Pharmacol
, vol.59
, pp. 365-370
-
-
Owen, A.1
Goldring, C.2
Morgan, P.3
Chadwick, D.4
Park, B.K.5
Pirmohamed, M.6
-
18
-
-
0033867101
-
Hepatocellular response to chemical stress in CD-1 mice: Induction of early genes and gamma-glutamylcysteine synthetase
-
Kitteringham NR, Powell H, Clement YN, Dodd CC, Tettey JN, Pirmohamed M, Smith DA, McLellan LI, Kevin Park B. Hepatocellular response to chemical stress in CD-1 mice: induction of early genes and gamma-glutamylcysteine synthetase. Hepatology 2000; 32: 321-33.
-
(2000)
Hepatology
, vol.32
, pp. 321-333
-
-
Kitteringham, N.R.1
Powell, H.2
Clement, Y.N.3
Dodd, C.C.4
Tettey, J.N.5
Pirmohamed, M.6
Smith, D.A.7
McLellan, L.I.8
Kevin Park, B.9
-
19
-
-
0013950651
-
Sensitivity of cultured human lymphoblasts (CCRF-CEM cells) to inhibition by thymidine
-
Schachtschabel DO, Lazarus H, Farber S, Foley GE. Sensitivity of cultured human lymphoblasts (CCRF-CEM cells) to inhibition by thymidine. Exp Cell Res 1966; 43: 512-4.
-
(1966)
Exp Cell Res
, vol.43
, pp. 512-514
-
-
Schachtschabel, D.O.1
Lazarus, H.2
Farber, S.3
Foley, G.E.4
-
20
-
-
0036130610
-
Time-course of hepatic cytochrome P450 subfamily induction by chronic carbamazepine treatment in rats
-
Yamashita H, Kazawa T, Minatogawa Y, Ebisawa T, Yamauchi T. Time-course of hepatic cytochrome P450 subfamily induction by chronic carbamazepine treatment in rats. Int J Neuropsychopharmacol 2002; 5: 47-52.
-
(2002)
Int J Neuropsychopharmacol
, vol.5
, pp. 47-52
-
-
Yamashita, H.1
Kazawa, T.2
Minatogawa, Y.3
Ebisawa, T.4
Yamauchi, T.5
-
21
-
-
0028880851
-
Nuclear immunolocalization of P-glycoprotein in multidrug-resistant cell lines showing similar mechanisms of doxorubicin distribution
-
Baldini N, Scotlandi K, Serra M, Shikita T, Zini N, Ognibene A, Santi S, Ferracini R, Maraldi NM. Nuclear immunolocalization of P-glycoprotein in multidrug-resistant cell lines showing similar mechanisms of doxorubicin distribution. Eur J Cell Biol 1995; 68: 226-39.
-
(1995)
Eur J Cell Biol
, vol.68
, pp. 226-239
-
-
Baldini, N.1
Scotlandi, K.2
Serra, M.3
Shikita, T.4
Zini, N.5
Ognibene, A.6
Santi, S.7
Ferracini, R.8
Maraldi, N.M.9
-
22
-
-
0031941406
-
Detection of P-glycoprotein in the Golgi apparatus of drug-untreated human melanoma cells
-
Molinari A, Calcabrini A, Meschini S, Stringaro A, Del Bufalo D, Cianfriglia M, Arancia G. Detection of P-glycoprotein in the Golgi apparatus of drug-untreated human melanoma cells. Int J Cancer 1998; 75: 885-93.
-
(1998)
Int J Cancer
, vol.75
, pp. 885-893
-
-
Molinari, A.1
Calcabrini, A.2
Meschini, S.3
Stringaro, A.4
Del Bufalo, D.5
Cianfriglia, M.6
Arancia, G.7
-
23
-
-
0035038919
-
The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux
-
Synold TW, Dussault I, Forman BM. The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux. Nat Med 2001; 7: 584-90.
-
(2001)
Nat Med
, vol.7
, pp. 584-590
-
-
Synold, T.W.1
Dussault, I.2
Forman, B.M.3
-
24
-
-
0032702726
-
The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module
-
Goodwin B, Hodgson E, Liddle C. The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module. Mol Pharmacol 1999; 56: 1329-39.
-
(1999)
Mol Pharmacol
, vol.56
, pp. 1329-1339
-
-
Goodwin, B.1
Hodgson, E.2
Liddle, C.3
-
25
-
-
0036209248
-
Regulation of xenobiotic and bile acid metabolism by the nuclear pregnane X receptor
-
Kliewer SA, Willson TM. Regulation of xenobiotic and bile acid metabolism by the nuclear pregnane X receptor. J Lipid Res 2002; 43: 359-64.
-
(2002)
J Lipid Res
, vol.43
, pp. 359-364
-
-
Kliewer, S.A.1
Willson, T.M.2
-
26
-
-
0033836868
-
Drug interaction between St. John's wort and cyclosporine
-
Barone GW, Gurley BJ, Ketel BL, Lightfoot ML, Abul-Ezz SR. Drug interaction between St. John's wort and cyclosporine. Ann Pharmacother 2000; 34: 1013-6.
-
(2000)
Ann Pharmacother
, vol.34
, pp. 1013-1016
-
-
Barone, G.W.1
Gurley, B.J.2
Ketel, B.L.3
Lightfoot, M.L.4
Abul-Ezz, S.R.5
-
27
-
-
0036515846
-
Receptor-dependent transcriptional activation of cytochrome P4503A genes: Induction mechanisms, species differences and interindividual variation in man
-
Gibson GG, Plant NJ, Swales KE, Ayrton A, El-Sankary W. Receptor-dependent transcriptional activation of cytochrome P4503A genes: induction mechanisms, species differences and interindividual variation in man. Xenobiotica 2002; 32: 165-206.
-
(2002)
Xenobiotica
, vol.32
, pp. 165-206
-
-
Gibson, G.G.1
Plant, N.J.2
Swales, K.E.3
Ayrton, A.4
El-Sankary, W.5
-
28
-
-
0030484780
-
Drug interaction between cyclosporine and two antimicrobial agents, josamycin and rifampicin, in organ-transplanted patients
-
Capone D, Aiello C, Santoro GA, Gentile A, Stanziale P, D'Alessandro R, Imperatore P, Basile V. Drug interaction between cyclosporine and two antimicrobial agents, josamycin and rifampicin, in organ-transplanted patients. Int J Clin Pharmacol Res 1996; 16: 73-6.
-
(1996)
Int J Clin Pharmacol Res
, vol.16
, pp. 73-76
-
-
Capone, D.1
Aiello, C.2
Santoro, G.A.3
Gentile, A.4
Stanziale, P.5
D'Alessandro, R.6
Imperatore, P.7
Basile, V.8
-
29
-
-
0024511702
-
Cyclosporine pharmacokinetic drug interactions
-
Baciewicz AM, Baciewicz FA Jr. Cyclosporine pharmacokinetic drug interactions. Am J Surg 1989; 157: 264-71.
-
(1989)
Am J Surg
, vol.157
, pp. 264-271
-
-
Baciewicz, A.M.1
Baciewicz Jr., F.A.2
-
30
-
-
0029815563
-
Clinically significant pharmacokinetic drug interactions with carbamazepine. An update
-
Spina E, Pisani F, Perucca E. Clinically significant pharmacokinetic drug interactions with carbamazepine. An update. Clin Pharmacokinet 1996; 31: 198-214.
-
(1996)
Clin Pharmacokinet
, vol.31
, pp. 198-214
-
-
Spina, E.1
Pisani, F.2
Perucca, E.3
-
31
-
-
0032754284
-
The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin
-
Greiner B, Eichelbaum M, Fritz P, Kreichgauer HP, von Richter O, Zundler J, Kroemer HK. The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin. J Clin Invest 1999; 104: 147-53.
-
(1999)
J Clin Invest
, vol.104
, pp. 147-153
-
-
Greiner, B.1
Eichelbaum, M.2
Fritz, P.3
Kreichgauer, H.P.4
Von Richter, O.5
Zundler, J.6
Kroemer, H.K.7
-
32
-
-
0000006828
-
Pharmacokinetic interaction of digoxin with an herbal extract from St John's wort (Hypericum perforatum)
-
Johne A, Brockmoller J, Bauer S, Maurer A, Langheinrich M, Roots I. Pharmacokinetic interaction of digoxin with an herbal extract from St John's wort (Hypericum perforatum) Clin Pharmacol Ther 1999; 66: 338-45.
-
(1999)
Clin Pharmacol Ther
, vol.66
, pp. 338-345
-
-
Johne, A.1
Brockmoller, J.2
Bauer, S.3
Maurer, A.4
Langheinrich, M.5
Roots, I.6
-
33
-
-
1442360354
-
Whole-blood cultures from renal-transplant patients stimulated ex vivo show that the effects of cyclosporine on lymphocyte proliferation are related to Pglycoprotein expression
-
Singh D, Alexander J, Owen A, Rustom R, Bone M, Hammad A, Roberts N, Park K, Pirmohamed M. Whole-blood cultures from renal-transplant patients stimulated ex vivo show that the effects of cyclosporine on lymphocyte proliferation are related to Pglycoprotein expression. Transplantation 2004; 77: 557-61.
-
(2004)
Transplantation
, vol.77
, pp. 557-561
-
-
Singh, D.1
Alexander, J.2
Owen, A.3
Rustom, R.4
Bone, M.5
Hammad, A.6
Roberts, N.7
Park, K.8
Pirmohamed, M.9
-
34
-
-
0036135007
-
Induction of multidrug resistance-1 and cytochrome P450 mRNAs in human mononuclear cells by rifampin
-
Asghar A, Gorski JC, Haehner-Daniels B, Hall SD. Induction of multidrug resistance-1 and cytochrome P450 mRNAs in human mononuclear cells by rifampin. Drug Metab Dispos 2002; 30: 20-6.
-
(2002)
Drug Metab Dispos
, vol.30
, pp. 20-26
-
-
Asghar, A.1
Gorski, J.C.2
Haehner-Daniels, B.3
Hall, S.D.4
-
35
-
-
0028235901
-
Lymphocyte microsomal epoxide hydrolase in patients on carbamazepine therapy
-
Pirmohamed M, Allott R, Green VJ, Kitteringham NR, Chadwick D, Park BK. Lymphocyte microsomal epoxide hydrolase in patients on carbamazepine therapy. Br J Clin Pharmacol 1994; 37: 577-81.
-
(1994)
Br J Clin Pharmacol
, vol.37
, pp. 577-581
-
-
Pirmohamed, M.1
Allott, R.2
Green, V.J.3
Kitteringham, N.R.4
Chadwick, D.5
Park, B.K.6
-
36
-
-
0037101618
-
Limbic seizures induce P-glycoprotein in rodent brain: Functional implications for pharmacoresistance
-
Rizzi M, Caccia S, Guiso G, Richichi C, Gorter JA, Aronica E, Aliprandi M, Bagnati R, Fanelli R, D'Incalci M, Samanin R, Vezzani A. Limbic seizures induce P-glycoprotein in rodent brain: functional implications for pharmacoresistance. J Neurosci 2002; 22: 5833-9.
-
(2002)
J Neurosci
, vol.22
, pp. 5833-5839
-
-
Rizzi, M.1
Caccia, S.2
Guiso, G.3
Richichi, C.4
Gorter, J.A.5
Aronica, E.6
Aliprandi, M.7
Bagnati, R.8
Fanelli, R.9
D'Incalci, M.10
Samanin, R.11
Vezzani, A.12
-
37
-
-
0037403686
-
Regulation of CYP3A4 expression in human hepatocytes by pharmaceuticals and natural products
-
Raucy JL. Regulation of CYP3A4 expression in human hepatocytes by pharmaceuticals and natural products. Drug Metab Dispos 2003; 31: 533-9.
-
(2003)
Drug Metab Dispos
, vol.31
, pp. 533-539
-
-
Raucy, J.L.1
-
38
-
-
0030059953
-
Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells
-
Schuetz EG, Beck WT, Schuetz JD. Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells. Mol Pharmacol 1996; 49: 311-8.
-
(1996)
Mol Pharmacol
, vol.49
, pp. 311-318
-
-
Schuetz, E.G.1
Beck, W.T.2
Schuetz, J.D.3
|