메뉴 건너뛰기




Volumn 13, Issue 4, 2006, Pages 249-253

Modern genome-wide genetic approaches to reveal intrinsic properties of stem cells

Author keywords

Genetical genomics; Genome wide; Hematopoietic stem cell; Transcriptome

Indexed keywords

MESSENGER RNA;

EID: 33747886548     PISSN: 10656251     EISSN: 15317048     Source Type: Journal    
DOI: 10.1097/01.moh.0000231422.00407.be     Document Type: Review
Times cited : (10)

References (40)
  • 1
    • 0037130961 scopus 로고    scopus 로고
    • A stem cell molecular signature
    • Ivanova NB, Dimos JT, Schaniel C, et al. A stem cell molecular signature. Science 2002; 298:601-604.
    • (2002) Science , vol.298 , pp. 601-604
    • Ivanova, N.B.1    Dimos, J.T.2    Schaniel, C.3
  • 2
    • 0037131389 scopus 로고    scopus 로고
    • 'Stemness': Transcriptional profiling of embryonic and adult stem cells
    • Ramalho-Santos M, Yoon S, Matsuzaki Y, et al. 'Stemness': transcriptional profiling of embryonic and adult stem cells. Science 2002; 298:597-600.
    • (2002) Science , vol.298 , pp. 597-600
    • Ramalho-Santos, M.1    Yoon, S.2    Matsuzaki, Y.3
  • 3
    • 55449106913 scopus 로고    scopus 로고
    • Differential expression of novel potential regulators in hematopoietic stem cells
    • Forsberg EC, Prohaska SS, Katzman S, et al. Differential expression of novel potential regulators in hematopoietic stem cells. PLoS Genet 2005; 1:e28.
    • (2005) PLoS Genet , vol.1
    • Forsberg, E.C.1    Prohaska, S.S.2    Katzman, S.3
  • 4
    • 21544467270 scopus 로고    scopus 로고
    • Cell intrinsic alterations underlie hematopoietic stem cell aging
    • Rossi DJ, Bryder D, Zahn JM, et al. Cell intrinsic alterations underlie hematopoietic stem cell aging. Proc Natl Acad Sci USA 2005; 102:9194-9199.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 9194-9199
    • Rossi, D.J.1    Bryder, D.2    Zahn, J.M.3
  • 5
    • 8844250116 scopus 로고    scopus 로고
    • Molecular signatures of proliferation and quiescence in hematopoietic stem cells
    • Venezia TA, Merchant AA, Ramos CA, et al. Molecular signatures of proliferation and quiescence in hematopoietic stem cells. PLoS Biol 2004; 2:e301.
    • (2004) PLoS Biol , vol.2
    • Venezia, T.A.1    Merchant, A.A.2    Ramos, C.A.3
  • 6
    • 11144358198 scopus 로고    scopus 로고
    • A gene atlas of the mouse and human protein-encoding transcriptomes
    • Su AI, Wiltshire T, Batalov S, et al. A gene atlas of the mouse and human protein-encoding transcriptomes. Proc Natl Acad Sci U S A 2004; 101:6062-6067.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 6062-6067
    • Su, A.I.1    Wiltshire, T.2    Batalov, S.3
  • 7
    • 27144486151 scopus 로고    scopus 로고
    • Experimental comparison and cross-validation of the Affymetrix and Illumina gene expression analysis platforms
    • Barnes M, Freudenberg J, Thompson S, et al. Experimental comparison and cross-validation of the Affymetrix and Illumina gene expression analysis platforms. Nucleic Acids Res 2005; 33:5914-5923.
    • (2005) Nucleic Acids Res , vol.33 , pp. 5914-5923
    • Barnes, M.1    Freudenberg, J.2    Thompson, S.3
  • 8
    • 0036682376 scopus 로고    scopus 로고
    • Meta-analysis of microarrays: Interstudy validation of gene expression profiles reveals pathway dysregulation in prostate cancer
    • Rhodes DR, Barrette TR, Rubin MA, et al. Meta-analysis of microarrays: interstudy validation of gene expression profiles reveals pathway dysregulation in prostate cancer. Cancer Res 2002; 62:4427-4433.
    • (2002) Cancer Res , vol.62 , pp. 4427-4433
    • Rhodes, D.R.1    Barrette, T.R.2    Rubin, M.A.3
  • 9
    • 30444448896 scopus 로고    scopus 로고
    • Hematopoietic stem cells do not engraft with absolute efficiencies
    • Camargo FD, Chambers SM, Drew E, et al. Hematopoietic stem cells do not engraft with absolute efficiencies. Blood 2006; 107:501-507. This study provides a direct comparison of different mouse hematopoietic stem cell sorting strategies, and shows which strategies overlap.
    • (2006) Blood , vol.107 , pp. 501-507
    • Camargo, F.D.1    Chambers, S.M.2    Drew, E.3
  • 10
    • 20144383240 scopus 로고    scopus 로고
    • Uncovering regulatory pathways that affect hematopoietic stem cell function using 'genetical genomics'
    • Bystrykh L, Weersing E, Dontje B, et al. Uncovering regulatory pathways that affect hematopoietic stem cell function using 'genetical genomics'. Nat Genet 2005; 37:225-232. This paper serves as a guide to www.genenetwork.org and allows network construction of hematopoietic stem cell genes.
    • (2005) Nat Genet , vol.37 , pp. 225-232
    • Bystrykh, L.1    Weersing, E.2    Dontje, B.3
  • 11
    • 11144358111 scopus 로고    scopus 로고
    • Prognostically useful gene-expression profiles in acute myeloid leukemia
    • Valk PJ, Verhaak RG, Beijen MA, et al. Prognostically useful gene-expression profiles in acute myeloid leukemia. N Engl J Med 2004; 350:1617-1628.
    • (2004) N Engl J Med , vol.350 , pp. 1617-1628
    • Valk, P.J.1    Verhaak, R.G.2    Beijen, M.A.3
  • 12
    • 33744992011 scopus 로고    scopus 로고
    • Differential mRNA processing in hematopoietic stem cells
    • Bowman TV, McCooey AJ, Merchant AA, et al. Differential mRNA processing in hematopoietic stem cells. Stem Cells 2006; 24:662-670. Careful analysis of splice variants within the hematopoietic stem cell transcriptome.
    • (2006) Stem Cells , vol.24 , pp. 662-670
    • Bowman, T.V.1    McCooey, A.J.2    Merchant, A.A.3
  • 13
    • 26444554538 scopus 로고    scopus 로고
    • Diversification of stem cell molecular repertoire by alternative splicing
    • Pritsker M, Doniger TT, Kramer LC, et al. Diversification of stem cell molecular repertoire by alternative splicing. Proc Natl Acad Sci USA 2005; 102:14290-14295. Careful analysis of splice variants within the hematopoietic stem cell transcriptome.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 14290-14295
    • Pritsker, M.1    Doniger, T.T.2    Kramer, L.C.3
  • 14
    • 32544447694 scopus 로고    scopus 로고
    • A statistical multiprobe model for analyzing cis and trans genes in genetical genomics experiments with short-oligonucleotide arrays
    • Alberts R, Terpstra P, Bystrykh LV, et al. A statistical multiprobe model for analyzing cis and trans genes in genetical genomics experiments with short-oligonucleotide arrays. Genetics 2005; 171:1437-1439.
    • (2005) Genetics , vol.171 , pp. 1437-1439
    • Alberts, R.1    Terpstra, P.2    Bystrykh, L.V.3
  • 15
    • 13944262052 scopus 로고    scopus 로고
    • A custom microarray platform for analysis of microRNA gene expression
    • Thomson JM, Parker J, Perou CM, Hammond SM. A custom microarray platform for analysis of microRNA gene expression. Nat Meth 2004; 1:47-53.
    • (2004) Nat Meth , vol.1 , pp. 47-53
    • Thomson, J.M.1    Parker, J.2    Perou, C.M.3    Hammond, S.M.4
  • 16
    • 20544458318 scopus 로고    scopus 로고
    • Stem cell division is regulated by the microRNA pathway
    • Hatfield SD, Shcherbata HR, Fischer KA, et al. Stem cell division is regulated by the microRNA pathway. Nature 2005; 435:974-978.
    • (2005) Nature , vol.435 , pp. 974-978
    • Hatfield, S.D.1    Shcherbata, H.R.2    Fischer, K.A.3
  • 17
    • 0346727524 scopus 로고    scopus 로고
    • MicroRNAs modulate hematopoietic lineage differentiation
    • Chen CZ, Li L, Lodish HF, Bartel DP. MicroRNAs modulate hematopoietic lineage differentiation. Science 2004; 303:83-86.
    • (2004) Science , vol.303 , pp. 83-86
    • Chen, C.Z.1    Li, L.2    Lodish, H.F.3    Bartel, D.P.4
  • 18
    • 21244463426 scopus 로고    scopus 로고
    • SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells
    • Kiel MJ, Yilmaz OH, Iwashita T, et al. SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell 2005; 121:1109-1121. A novel method to purify mouse hematopoietic stem cells is presented. This method appears to be technically quite straightforward.
    • (2005) Cell , vol.121 , pp. 1109-1121
    • Kiel, M.J.1    Yilmaz, O.H.2    Iwashita, T.3
  • 19
    • 33344469959 scopus 로고    scopus 로고
    • The Polycomb group gene Ezh2 prevents hematopoietic stem cell exhaustion
    • Kamminga LM, Bystrykh LV, De Boer A, et al. The Polycomb group gene Ezh2 prevents hematopoietic stem cell exhaustion. Blood 2006; 107:2170-2179. First report of a gene (and some of its putative partners) that prevents hematopoietic stem cell senescence. Links chromatin remodeling with stem cell aging.
    • (2006) Blood , vol.107 , pp. 2170-2179
    • Kamminga, L.M.1    Bystrykh, L.V.2    De Boer, A.3
  • 20
    • 32244436673 scopus 로고    scopus 로고
    • Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells
    • Zhang CC, Kaba M, Ge G, et al. Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells. Nat Med 2006; 12:240-245.
    • (2006) Nat Med , vol.12 , pp. 240-245
    • Zhang, C.C.1    Kaba, M.2    Ge, G.3
  • 21
    • 10344258563 scopus 로고    scopus 로고
    • Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1
    • Iwama A, Oguro H, Negishi M, et al. Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1. Immunity 2004; 21:843-851.
    • (2004) Immunity , vol.21 , pp. 843-851
    • Iwama, A.1    Oguro, H.2    Negishi, M.3
  • 22
    • 19944400789 scopus 로고    scopus 로고
    • Quantification of self-renewal capacity in single hematopoietic stem cells from normal and Lnk-deficient mice
    • Ema H, Sudo K, Seita J, et al. Quantification of self-renewal capacity in single hematopoietic stem cells from normal and Lnk-deficient mice. Dev Cell 2005; 8:907-914. This paper estimates the number of self-renewal divisions a single stem cell can undergo to be around 10. This is a low number compared to previous estimates.
    • (2005) Dev Cell , vol.8 , pp. 907-914
    • Ema, H.1    Sudo, K.2    Seita, J.3
  • 23
    • 13344294981 scopus 로고    scopus 로고
    • c-Myb and p300 regulate hematopoietic stem cell proliferation and differentiation
    • Sandberg ML, Sutton SE, Pletcher MT, et al. c-Myb and p300 regulate hematopoietic stem cell proliferation and differentiation. Dev Cell 2005; 8:153-166. First report describing N-ethyl-N-nitrosourea-induced stem cell phenotype and identification of the causative gene.
    • (2005) Dev Cell , vol.8 , pp. 153-166
    • Sandberg, M.L.1    Sutton, S.E.2    Pletcher, M.T.3
  • 24
    • 2342578680 scopus 로고    scopus 로고
    • -/- mice: C-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling
    • -/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling. Proc Natl Acad Sci USA 2004; 101:6553-6558.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 6553-6558
    • Carpinelli, M.R.1    Hilton, D.J.2    Metcalf, D.3
  • 25
    • 14644441018 scopus 로고    scopus 로고
    • The Collaborative Cross, a community resource for the genetic analysis of complex traits
    • Churchill GA, Airey DC, Allayee H, et al. The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet 2004; 36:1133-1137.
    • (2004) Nat Genet , vol.36 , pp. 1133-1137
    • Churchill, G.A.1    Airey, D.C.2    Allayee, H.3
  • 26
    • 17044426724 scopus 로고    scopus 로고
    • Regulation of hematopoietic stem cell aging in vivo by a distinct genetic element
    • Geiger H, Rennebeck G, Van Zant G. Regulation of hematopoietic stem cell aging in vivo by a distinct genetic element. Proc Natl Acad Sci USA 2005; 102:5102-5107.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 5102-5107
    • Geiger, H.1    Rennebeck, G.2    Van Zant, G.3
  • 27
    • 0037306536 scopus 로고    scopus 로고
    • Studying complex biological systems using multifactorial perturbation
    • Jansen RC. Studying complex biological systems using multifactorial perturbation. Nat Rev Genet 2003; 4:145-151.
    • (2003) Nat Rev Genet , vol.4 , pp. 145-151
    • Jansen, R.C.1
  • 28
    • 20144386111 scopus 로고    scopus 로고
    • Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function
    • Chesler EJ, Lu L, Shou S, et al. Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function. Nat Genet 2005; 37:233-242.
    • (2005) Nat Genet , vol.37 , pp. 233-242
    • Chesler, E.J.1    Lu, L.2    Shou, S.3
  • 29
    • 27644482314 scopus 로고    scopus 로고
    • Mapping determinants of human gene expression by regional and genome-wide association
    • Cheung VG, Spielman RS, Ewens KG, et al. Mapping determinants of human gene expression by regional and genome-wide association. Nature 2005; 437:1365-1369.
    • (2005) Nature , vol.437 , pp. 1365-1369
    • Cheung, V.G.1    Spielman, R.S.2    Ewens, K.G.3
  • 30
    • 27644549928 scopus 로고    scopus 로고
    • Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits
    • Mehrabian M, Allayee H, Stockton J, et al. Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits. Nat Genet 2005; 37:1224-1233.
    • (2005) Nat Genet , vol.37 , pp. 1224-1233
    • Mehrabian, M.1    Allayee, H.2    Stockton, J.3
  • 31
    • 0037452982 scopus 로고    scopus 로고
    • Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse
    • Wiltshire T, Pletcher MT, Batalov S, et al. Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse. Proc Natl Acad Sci USA 2003; 100:3380-3385.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 3380-3385
    • Wiltshire, T.1    Pletcher, M.T.2    Batalov, S.3
  • 32
    • 2942618531 scopus 로고    scopus 로고
    • Polycomb group gene mel-18 modulates the self-renewal activity and cell cycle status of hematopoietic stem cells
    • Kajiume T, Ninomiya Y, Ishihara H, et al. Polycomb group gene mel-18 modulates the self-renewal activity and cell cycle status of hematopoietic stem cells. Exp Hematol 2004; 32:571-578.
    • (2004) Exp Hematol , vol.32 , pp. 571-578
    • Kajiume, T.1    Ninomiya, Y.2    Ishihara, H.3
  • 33
    • 20444371017 scopus 로고    scopus 로고
    • The telomerase reverse transcriptase regulates chromatin state and DNA damage responses
    • Masutomi K, Possemato R, Wong JM, et al. The telomerase reverse transcriptase regulates chromatin state and DNA damage responses. Proc Natl Acad Sci USA 2005; 102:8222-8227.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 8222-8227
    • Masutomi, K.1    Possemato, R.2    Wong, J.M.3
  • 34
    • 20144388533 scopus 로고    scopus 로고
    • Valproic acid stimulates proliferation and self-renewal of hematopoietic stem cells
    • Bug G, Gul H, Schwarz K, et al. Valproic acid stimulates proliferation and self-renewal of hematopoietic stem cells. Cancer Res 2005; 65:2537-2541.
    • (2005) Cancer Res , vol.65 , pp. 2537-2541
    • Bug, G.1    Gul, H.2    Schwarz, K.3
  • 35
    • 20044384522 scopus 로고    scopus 로고
    • Mapping of genetic and epigenetic regulatory networks using microarrays
    • Van Steensel B. Mapping of genetic and epigenetic regulatory networks using microarrays. Nat Genet 2005; 37 (Suppl):S18-S24.
    • (2005) Nat Genet , vol.37 , Issue.SUPPL.
    • Van Steensel, B.1
  • 36
    • 9644268153 scopus 로고    scopus 로고
    • Rapid analysis of the DNA-binding specificities of transcription factors with DNA microarrays
    • Mukherjee S, Berger MF, Jona G, et al. Rapid analysis of the DNA-binding specificities of transcription factors with DNA microarrays. Nat Genet 2004; 36:1331-1339.
    • (2004) Nat Genet , vol.36 , pp. 1331-1339
    • Mukherjee, S.1    Berger, M.F.2    Jona, G.3
  • 37
    • 23844519339 scopus 로고    scopus 로고
    • A high-resolution map of active promoters in the human genome
    • Kim TH, Barrera LO, Zheng M, et al. A high-resolution map of active promoters in the human genome. Nature 2005; 436:876-880. These data on human fibroblasts document the power of genome-wide promoter analyses, and hold great promise for stem cell biology.
    • (2005) Nature , vol.436 , pp. 876-880
    • Kim, T.H.1    Barrera, L.O.2    Zheng, M.3
  • 38
    • 27144469889 scopus 로고    scopus 로고
    • Fli1, Elf1, and Ets1 regulate the proximal promoter of the LMO2 gene in endothelial cells
    • Landry JR, Kinston S, Knezevic K, et al. Fli1, Elf1, and Ets1 regulate the proximal promoter of the LMO2 gene in endothelial cells. Blood 2005; 106:2680-2687. This paper underscores the relevance of comparing genomic information from multiple species to identify conserved regulatory regions.
    • (2005) Blood , vol.106 , pp. 2680-2687
    • Landry, J.R.1    Kinston, S.2    Knezevic, K.3
  • 39
    • 27144530248 scopus 로고    scopus 로고
    • Towards a proteome-scale map of the human protein-protein interaction network
    • Rual JF, Venkatesan K, Hao T, et al. Towards a proteome-scale map of the human protein-protein interaction network. Nature 2005; 437:1173-1178.
    • (2005) Nature , vol.437 , pp. 1173-1178
    • Rual, J.F.1    Venkatesan, K.2    Hao, T.3
  • 40
    • 5444255213 scopus 로고    scopus 로고
    • The active spatial organization of the beta-globin locus requires the transcription factor EKLF
    • Drissen R, Palstra RJ, Gillemans N, et al. The active spatial organization of the beta-globin locus requires the transcription factor EKLF. Genes Dev 2004; 18:2485-2490.
    • (2004) Genes Dev , vol.18 , pp. 2485-2490
    • Drissen, R.1    Palstra, R.J.2    Gillemans, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.