Insulin and the β3-adrenoceptor differentially regulate uncoupling protein-1 expression

Molecular Endocrinology

Volumn 14, Issue 6, 2000, Pages 764-773

  Klein, Johannes ^a,b   Fasshauer, Mathias ^a   Benito, Manuel ^c   Ronald Kahn, C ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF LÜBECK   (Germany)

^c UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 3 ADRENERGIC RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOTYROSINE; PROTEIN P110; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 3; BETA ADRENERGIC RECEPTOR; CARRIER PROTEIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; ENZYME INHIBITOR; ION CHANNEL; MEMBRANE PROTEIN; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN;

ADIPOCYTE; ANIMAL CELL; ARTICLE; BETA ADRENERGIC STIMULATION; CONTROLLED STUDY; ENERGY BALANCE; ENZYME ACTIVITY; INSULIN RELEASE; INSULIN RESISTANCE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; BROWN ADIPOSE TISSUE; CELL CULTURE; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALIA;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADIPOCYTES; ADIPOSE TISSUE, BROWN; ANIMALS; CARRIER PROTEINS; CELLS, CULTURED; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENZYME ACTIVATION; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; INSULIN; ION CHANNELS; MEMBRANE PROTEINS; MICE; MITOCHONDRIAL PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASES; RECEPTORS, ADRENERGIC, BETA; RECEPTORS, ADRENERGIC, BETA-3; SIGNAL TRANSDUCTION;

EID: 0034351490     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.14.6.764     Document Type: Article

References (35)

1. Hypertension and associated metabolic abnormalities-the role of insulin resistance and the sympathoadrenal system
2. Thermogenic mechanisms in brown fat
3. Brown adipose tissue, β3-adrenergic receptors, and obesity
4. Obesity and diabetes and the β-3 adrenergic receptor
5. Increase in insulin action and fat oxidation after treatment with CL 316,243, a highly selective β3-adrenoceptor agonist in humans
6. A selective human β3 adrenergic receptor agonist increases metabolic rate in rhesus monkeys
7. The uncoupling proteins, a review
8. Synergistic effect of polymorphisms in uncoupling protein 1 and β3-adrenergic receptor genes on basal metabolic rate in obese Finns
9. Additive effects of the mutations in the β3-adrenergic receptor and uncoupling protein-1 genes on weight loss and weight maintenance in Finnish women
10. Fasting hyperinsulinemia is a predictor of increased body weight gain and obesity in Pima Indian children
11. Acute postchallenge hyperinsulinemia predicts weight gain: A prospective study
12. Reduced glucose-induced thermogenesis is present in noninsulin-dependent diabetes mellitus without obesity
13. Regulation of the uncoupling protein gene expression
14. Adrenergic regulation of brown adipocyte differentiation
15. Functional differentiation of white and brown adipocytes
16. Regulation of the uncoupling protein gene (UCP) by β1, β2, and β3-adrenergic receptor subtypes in immortalized brown adipose cell lines
17. cAMP and β γ subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells
18. The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascades
19. Insulin action and the insulin signaling network
20. The IRS-signalling system: A network of docking proteins that mediate insulin action
21. Gβγ stimulates phosphoinositide 3-kinase-γ by direct interaction with two domains of the catalytic p110 subunit
22. Syndrome X-like alterations in adult female rats due to neonatal insulin treatment
23. Hyperinsulinemia and its impact on obesity and insulin resistance
24. Activation of mitogen-activated protein kinase by norepinephrine in brown adipocytes from rats
25. The β3-adrenergic receptor activates mitogen-activated protein kinase in adipocytes through a Gi-dependent mechanism
26. Cyclic AMP stimulates the phosphorylation and activation of p42 and p44 mitogen-activated protein kinases in 3T3-F442A preadipocytes
27. Protein kinase A and protein kinase C synergistically activate the Raf-1 kinase/mitogen-activated protein kinase cascade in neonatal rat cardiomyocytes
28. Norepinephrine induces the raf-1 kinase/mitogen-activated protein kinase cascade through both α1- and β-adrenoceptors
29. cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway
30. p42/p44 mitogen-activated protein kinases activation is required for the insulin-like growth factor-I/insulin induced proliferation, but inhibits differentiation, in rat fetal brown adipocytes
31. Phosphoinositide 3-kinases: A conserved family of signal transducers
32. The uncoupling protein thermogenin during acclimation: Indications for pretranslational control
33. Induction and degradation of the uncoupling protein thermogenin in brown adipocytes in vitro and in vivo. Evidence for a rapidly degradable pool
34. β3-Adrenergic stimulation differentially inhibits insulin signaling and decreases insulin-induced glucose uptake in brown adipocytes
35. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding