Polymorphic Deletion of Three Intracellular Acidic Residues of the α2B-Adrenergic Receptor Decreases G Protein-coupled Receptor Kinase-mediated Phosphorylation and Desensitization

Journal of Biological Chemistry

Volumn 276, Issue 7, 2001, Pages 4917-4922

  Small, Kersten M ^b   Brown, Kari M ^b   Forbes, Susan L ^b   Liggett, Stephen B ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL ORGANS; CELLS; ENZYMES; PROTEINS;

AGONIST-PROMOTED PHOSPHORYLATION; INTRACELLULAR ACIDIC RESIDUES;

BIOCHEMISTRY;

ADENYLATE CYCLASE; ADRENERGIC RECEPTOR; ALPHA 2A ADRENERGIC RECEPTOR; ALPHA 2B ADRENERGIC RECEPTOR; G PROTEIN COUPLED RECEPTOR KINASE; GLUTAMIC ACID; ADRENERGIC RECEPTOR ALPHA 2B; ADRENERGIC RECEPTOR ALPHA-2B; ALPHA 2 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE; NORADRENALIN;

ARTICLE; CAUCASIAN; CELL STRAIN COS1; CHO CELL; DNA POLYMORPHISM; ENZYME PHOSPHORYLATION; GENE DELETION; GENE EXPRESSION; HUMAN; LIGAND BINDING; NEGRO; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; AMINO ACID SEQUENCE; ANIMAL; DOWN REGULATION; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETIC TRANSFECTION; GENETICS; HAMSTER; METABOLISM; MOLECULAR GENETICS; PHOSPHORYLATION; PHYSIOLOGY;

CRICETINAE; CRICETULUS GRISEUS;

ADENYLATE CYCLASE; AMINO ACID SEQUENCE; ANIMALS; BETA-ADRENERGIC RECEPTOR KINASE; CHO CELLS; COS CELLS; CRICETINAE; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOWN-REGULATION; GENE FREQUENCY; MOLECULAR SEQUENCE DATA; NOREPINEPHRINE; PHOSPHORYLATION; POLYMORPHISM, GENETIC; RECEPTORS, ADRENERGIC, ALPHA-2; SEQUENCE DELETION; TRANSFECTION;

EID: 0035895936     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M008118200     Document Type: Article

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