The role of adiponectin in atherosclerosis and thrombosis

Clinical and Applied Thrombosis/Hemostasis

Volumn 12, Issue 2, 2006, Pages 163-168

  Ekmekci, Hakan ^a,c   Ekmekci, Ozlem B ^b  

^a ISTANBUL UNIVERSITY   (Turkey)

^b ISTANBUL UNIVERSITY   (Turkey)

^c M Hasan Kazim SokErsevenler Sit   (Turkey)

Author keywords

Adiponectin; Atherosclerosis; Thrombosis

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; LIPOPROTEIN; NITRIC OXIDE; PROTEIN; VASCULOTROPIN;

ATHEROGENESIS; ATHEROSCLEROSIS; BIOSYNTHESIS; BLOOD VESSEL WALL; CARDIOVASCULAR DISEASE; CELL ADHESION; CORONARY ARTERY DISEASE; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENDOTHELIUM LESION; EPIDEMIOLOGICAL DATA; HUMAN; LIPID METABOLISM; LIPID TRANSPORT; METABOLIC REGULATION; MONOCYTE; MORBIDITY; MORTALITY; NONHUMAN; OBESITY; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN FUNCTION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; REVIEW; RISK FACTOR; THROMBOGENESIS; THROMBOSIS; VASCULAR ENDOTHELIUM; METABOLISM; PATHOLOGY; PHYSIOLOGY;

ADIPONECTIN; ATHEROSCLEROSIS; ENDOTHELIUM, VASCULAR; HUMANS; LIPOPROTEINS; MONOCYTES; THROMBOSIS;

EID: 33747806287     PISSN: 10760296     EISSN: None     Source Type: Journal    
DOI: 10.1177/107602960601200203     Document Type: Review

References (48)

1. Calle EC, Thun MJ, Petrelli JM, et al. Body-mass index and mortality in a prospective cohort of U.S. adults. N Engl J Med 1999;341:1097.
2. Spiegelmen BM, Choy L, Hotamisligil GS, et al. Regulation of adipocyte gene expression in differentation and syndromes of obesity/diabetes. J Biol Chem 1993;268:6823.
3. Matsuzawa Y, Funahashi T, Nakamura T. Molecular mechanism of metabolic syndrome X: Contribution of adipocyte-derived bioactive substances. Ann NY Acad Sci 1999;892:146.
4. Friedman JM. Obesity in the new millenium. Nature 2000;404:632.
5. Hotamisligil GS. The role of TNF-α and TNG receptors in obesity and insulin resistance. J Intern Med 1999;245:621.
6. Shimomura I, Funahashi T, Takahashi M, et al. Enhanced expression of PAI-1 in visceral fat. Possible contributor to vascular disease in obesity. Nat Med 1996;2:800.
7. White RT, Damm D, Hancock N, et al. Human adipsin is identical to complement factor D and is expressed in high levels in adipose tissue. J Biol Chem 1992;267:9210.
8. Steppan CM, Bailey ST, Bhat S, et al. The hormone resistin links obesity to diabetes. Nature 2001;409:307.
9. Maeda K, Okubo K, Shimomura I, et al. cDNA clonning and expression of novel adipose specific collogen like factor apM1 (adipose most abundant gene transcript 1). Biochem Biophys Res Commun 1996;221:286.
10. Scherer PE, Williams S, Fogliano M, et al. A novel serum protein similar to C1q produced exclusively in adipocytes. J Biol Chem 1995;270:26746.
11. Hu E, Liang P, Spiegelman BM. Adipo Q is a novel adipose-specific gene dysregulated in obesity. J Biol Chem 1996;271:10697.
12. Arita Y, Kihara S, Ouchi N, et al. Paradoxical decrease of an adipose-specific protein, adiponectin in obesity. Biochem Biophys Res Commun 1999;257:79.
13. Saito K, Tobe T, Minoshima S, et al. Organization of the gene for gelatin-binding protein (GBP 28). Gene 1999;229:67.
14. Takahashi M, Arita Y, Yamagata K, et al. Genomic structure and mutations in adipose-spesific gene, adiponectin. Int J Obes Relat Metab Disord 2000;24:861.
15. Yamauchi T, Kamon J, Ito Y, et al. Clonning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 2003;423:762.
16. Berg AH, Combs TP, Scherer PE. Acrp 30/adiponectin: An adipocytokine regulating glucose and lipid metabolism. Trends Endocrinol Metab 2002;13:84.
17. Shimada K, Miyazaki T, Daida H. Adiponectin and atherosclerotic disease. Clin Chim Acta 2004;344:1.
18. Halleux CM, Takahashi M, Delporte MI, et al. Secretion of adiponectin and regulation of apM1 gene expression in human visceral adipose tissue. Biochem Biophys Res Commun 2001;288:1102.
19. Moore GB, Chapman H, Holder JG, et al. Differential regulation of adipocytokine mRNAs by risiglitazone in db/db mice. Biochem Biophys Res Commun 2001;286:735.
20. Wang Y, Xu A, Knight C, et al. Hydroxylation and glycosylation of the four conserved ltsine residues in the collagenaus domain of adiponectin: Potential role in the modulation of its insulin-sensitizing activity. J Biol Chem 2002;277:19521.
21. Sato L, Yasukawa Z, Honda N, et al. Identification and adipocyte differentiation-dependent expression of the unique disialic acid residue in an adipose tissue-specific glycoprotein adipoQ. J Biol Chem 2001;276:28849.
22. Zoccali C, Mallamaci F, Tripepr G, et al. Adiponectin, metabolic risk factors, and cardiovascular events among patients with endstage renal disease. J Am Soc Nephrol 2002;13:134.
23. Chen H, Montagnani M, Funahashi T,et al. Adiponectin stimulates production of nitric oxide in vascular endothelial cells. J Biol Chem 2003;278(45):45021.
24. Chandran M, Ciaraldi T, Phillips SA, Henry RR. Adiponectin: More than just another fat cell hormone. Diabetes Care 2003;26(8):2442.
25. Ross R. The pathogenesis of atherosclerosis: A perspective for the 1990s. Nature 1993;362:801.
26. Arita Y, Kihara S, Ouchi N, et al. Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-vinding protein and regulates growth factor-induced common post receptor signal in vascular smooth muscle cell. Circulation 2002;18(105):2893.
27. Ouchi N, Kihara S, Funahashi T, et al. Reciprocal association of C-reactive protein with adiponectin in blood streams and adipose tissue. Circulation 2003;107:671.
28. Matsuda M, Shimomura I, Sata M, et al. Role of adiponectin in preventing vascular stenosis: The missing link of adipo-vascular axis. J Biol Chem 2002;277:37487.
29. Vionet N, Hani El-H, Dupont S, et al. Genome wide search for type 2 diabetes susceptibility genes in french whites: Evidence for novel susceptibility locus for early onset diabetes on chromosome 3q27-q ter and independent replication of a type 2 diabetes locus on chromosome 1q21-q27. Am J Hum Genet 2000;67:1470.
30. Okamoto Y, Arita Y, Nishida M, et al. An adipocyte-derived plasma protein, adiponectin, adheres to injures vascular walls. Horm Metab Res 2000;32:47.
31. Ouchi N, Kihara S, Arita Y, et al. Novel modulator for endothelial adhesion molecules: Adipocyte-derived plasma protein adiponectin. Circulation 1999;100:2473.
32. Ouchi N, Kihara S, Arita Y, et al. Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappa B signalling yhrough a cAMP-dependent pathway. Circulation 2000;102:1296.
33. Yamauchi T, Kamon J, Waki T, et al. The fat derived hormone adiponectin reserves insulin resistance associated with both lipoatrophy and obesity. Nat Med 2001;7:941.
34. Kappes A, Loffler G. Influences of ionomycin, dibutyryl-cycloAMP and tumor necrosis factor alpha on intracellular amount and secretion of apM1 in differentiating primary human preadipocytes. Hormone Metab Res 2000;32:548.
35. Adamczak M, Wieck A, Funahashi T, et al. Decreased plasma adiponectin concentration in patients with essential hypertension. Am J Hypertens 2003;16:72.
36. Hotta K, Funahashi T, Arita Y, et al. Plasma concentration of a novel adipose spesific protein adiponectin in type 2 diabetic patients. Arterioscler Thromb Vasc Biol 2000;20:1595.
37. Kumada M, Kihara S, Sumitsuji S, et al. Association of hypoadiponectinemia with coronary artery disease in men. Arterioscler Thromb Vasc Biol 2003;23:85.
38. Nakamuro Y, Shimada K, Fukuda D, et al. Implications of plasma concentrations of adiponectin in patients with coronary artery disease. Heart 2004;90(5):528.
39. Lakka HM, Laaksonen DE, Lakka TA, et al. The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA 2002;288:2709.
40. Lip GY, Edmunds E, Beevers DG. Should patients with hypertension receive antithrombotic therapy? J Intern Med 2001;249:205.
41. Gonzalez MA, Selwyn AP. Endothelial function, inflammation, and prognosis in cardiovascular disease. Am J Med 2003;115:99.
42. Schachinger V, Britten MB, Zeiher AM. Prognostic impact of coronary vasodilator dysfunction on adverse longterm outcome of coronary heart disease. Circulation 2000;101:1899.
43. Ouchi N, Kihara S, Arita Y, et al. Adipocyte-derived plasma protein, adiponectin, suppresses lipid acumulation and class A scavenger receptor expression in human monocyte-derived macrophages. Circulation 2001;103:1057.
44. Price DT, Loscalzo J. Cellular adhesion molecules and atherogenesis. Am J Med 1999;107:85.
45. Radomski MW, Moncada S. Regulation of vascular homeostasis by nitric oxide. Thromb Haemost 1993;70:36.
46. Riddell DR, Owen JS. Nitric oxide and platelet aggregation. Vitam Horm 1999;57:25.
47. Sogo N, Magid KS, Shaw CA, et al. Inhibition of human platelet aggregation by nitric oxide donor drugs: Relative contribution of cGMP-independent mechanism. Biochem Biophys Res Commun 2000;279(2):412.
48. Loscalzo J. Nitric oxide insufficiency, platelet activation, and arterial thrombosis. Circ Res 2001;88:756.