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Volumn 177, Issue 5, 2006, Pages 2793-2802

EBV latent membrane protein 2A induces autoreactive B cell activation and TLR hypersensitivity

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; IMMUNOGLOBULIN; LATENT MEMBRANE PROTEIN 2; LATENT MEMBRANE PROTEIN 2A; PROTEIN SM; RIBONUCLEOPROTEIN; SM ANTIBODY; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG;

EID: 33747794039     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.177.5.2793     Document Type: Article
Times cited : (44)

References (64)
  • 1
    • 0015236918 scopus 로고
    • Raised antibody titres to EB virus in systemic lupus erythematosus
    • Evans, A. S., N. F. Rothfield, and J. C. Niederman. 1971. Raised antibody titres to EB virus in systemic lupus erythematosus. Lancet 1: 167-168.
    • (1971) Lancet , vol.1 , pp. 167-168
    • Evans, A.S.1    Rothfield, N.F.2    Niederman, J.C.3
  • 2
    • 0024317309 scopus 로고
    • High titer of antibody to the Epstein-Barr viras membrane antigen in sera from patients with rheumatoid arthritis and systemic lupus erythematosus
    • Yokochi, T., A. Yanagawa, Y. Kimura, and Y. Mizushima. 1989. High titer of antibody to the Epstein-Barr viras membrane antigen in sera from patients with rheumatoid arthritis and systemic lupus erythematosus. J. Rheumatol. 16: 1029-1032.
    • (1989) J. Rheumatol. , vol.16 , pp. 1029-1032
    • Yokochi, T.1    Yanagawa, A.2    Kimura, Y.3    Mizushima, Y.4
  • 3
    • 0023885065 scopus 로고
    • Detection of antibodies to the Epstein-Barr viras nuclear antigens in the sera from patients with systemic lupus erythematosus
    • Kitagawa, H., S. Iho, T. Yokochi, and T. Hoshino. 1988. Detection of antibodies to the Epstein-Barr viras nuclear antigens in the sera from patients with systemic lupus erythematosus. lmmunol. Lett. 17: 249-252.
    • (1988) Lmmunol. Lett. , vol.17 , pp. 249-252
    • Kitagawa, H.1    Iho, S.2    Yokochi, T.3    Hoshino, T.4
  • 5
    • 0031465706 scopus 로고    scopus 로고
    • An increased prevalence of Epstein-Barr virus infection in young patients suggests a possible etiology for systemic lupus erythematosus
    • James, J. A., K. M. Kaufman, A. D. Farris, E. Taylor-Albert, T. J. Lehman, and J. B. Harley. 1997. An increased prevalence of Epstein-Barr virus infection in young patients suggests a possible etiology for systemic lupus erythematosus. J. Clin. Invest. 100: 3019-3026.
    • (1997) J. Clin. Invest. , vol.100 , pp. 3019-3026
    • James, J.A.1    Kaufman, K.M.2    Farris, A.D.3    Taylor-Albert, E.4    Lehman, T.J.5    Harley, J.B.6
  • 6
    • 0035036288 scopus 로고    scopus 로고
    • Systemic lupus erythematosus in adults is associated with previous Epstein-Barr virus exposure
    • James, J. A., B. R. Neas, K. L. Moser, T. Hall, G. R. Bruner, A. L. Sestak, and J. B. Harley. 2001. Systemic lupus erythematosus in adults is associated with previous Epstein-Barr virus exposure. Arthritis Rheum. 44: 1122-1126.
    • (2001) Arthritis Rheum. , vol.44 , pp. 1122-1126
    • James, J.A.1    Neas, B.R.2    Moser, K.L.3    Hall, T.4    Bruner, G.R.5    Sestak, A.L.6    Harley, J.B.7
  • 8
    • 17744363265 scopus 로고    scopus 로고
    • Reactivation of Epstein-Barr virus in patients with systemic lupus erythematosus
    • Huggins, M. L., I. Todd, and R. J. Powell. 2005. Reactivation of Epstein-Barr virus in patients with systemic lupus erythematosus. Rheumatol. Int. 25: 183-187.
    • (2005) Rheumatol. Int. , vol.25 , pp. 183-187
    • Huggins, M.L.1    Todd, I.2    Powell, R.J.3
  • 10
    • 18944396623 scopus 로고    scopus 로고
    • EBV and systemic lupus erythematosus: A new perspective
    • Gross, A. J., D. Hochberg, W. M. Rand, and D. A. Thorley-Lawson. 2005. EBV and systemic lupus erythematosus: a new perspective. J. Immunol. 174: 6599-6607.
    • (2005) J. Immunol. , vol.174 , pp. 6599-6607
    • Gross, A.J.1    Hochberg, D.2    Rand, W.M.3    Thorley-Lawson, D.A.4
  • 11
    • 0021682707 scopus 로고
    • Epstein-Barr virus-transformed lymphocytes produce monoclonal autoantibodies that react with antigens in multiple organs
    • Garzelli, C., F. E. Taub, J. E. Scharff, B. S. Prabhakar, F. Ginsberg-Fellner, and A. L. Notkins. 1984. Epstein-Barr virus-transformed lymphocytes produce monoclonal autoantibodies that react with antigens in multiple organs. J. Virol. 52: 722-725.
    • (1984) J. Virol. , vol.52 , pp. 722-725
    • Garzelli, C.1    Taub, F.E.2    Scharff, J.E.3    Prabhakar, B.S.4    Ginsberg-Fellner, F.5    Notkins, A.L.6
  • 12
    • 0023177122 scopus 로고
    • Autoantibodies in infectious mononucleosis have specificity for the glycine-alanine repeating region of the Epstein-Barr virus nuclear antigen
    • Rhodes, G., H. Rumpold, P. Kurki, K. M. Patrick, D. A. Carson, and J. H. Vaughan. 1987. Autoantibodies in infectious mononucleosis have specificity for the glycine-alanine repeating region of the Epstein-Barr virus nuclear antigen. J. Exp. Med. 165: 1026-1040.
    • (1987) J. Exp. Med. , vol.165 , pp. 1026-1040
    • Rhodes, G.1    Rumpold, H.2    Kurki, P.3    Patrick, K.M.4    Carson, D.A.5    Vaughan, J.H.6
  • 13
    • 0028967723 scopus 로고
    • Epstein-Barr virus-induced autoimmune responses. I. Immunoglobulin G autoantibodies to mimicking and nonmimicking epitopes: Presence in autoimmune disease
    • Vaughan, J. H., M. D. Nguyen, J. R. Valbracht, K. Patrick, G. H. Rhodes, H. H. Handley, and R. S. Smith. 1995. Epstein-Barr virus-induced autoimmune responses. I. Immunoglobulin G autoantibodies to mimicking and nonmimicking epitopes: presence in autoimmune disease. J. Clin. Invest. 95: 1316-1327.
    • (1995) J. Clin. Invest. , vol.95 , pp. 1316-1327
    • Vaughan, J.H.1    Nguyen, M.D.2    Valbracht, J.R.3    Patrick, K.4    Rhodes, G.H.5    Handley, H.H.6    Smith, R.S.7
  • 14
    • 0028954829 scopus 로고
    • Epstein-Barr virus-induced autoimmune responses. I. Immunoglobulin M autoantibodies to proteins mimicking and not mimicking Epstein-Barr virus nuclear antigen-1
    • Vaughan, J. H., J. R. Valbracht, M. D. Nguyen, H. H. Handley, R. S. Smith, K. Patrick, and G. H. Rhodes. 1995. Epstein-Barr virus-induced autoimmune responses. I. Immunoglobulin M autoantibodies to proteins mimicking and not mimicking Epstein-Barr virus nuclear antigen-1. J. Clin. Invest. 95: 1306-1315.
    • (1995) J. Clin. Invest. , vol.95 , pp. 1306-1315
    • Vaughan, J.H.1    Valbracht, J.R.2    Nguyen, M.D.3    Handley, H.H.4    Smith, R.S.5    Patrick, K.6    Rhodes, G.H.7
  • 15
    • 0027529432 scopus 로고
    • Autoantibodies from patients with systemic lupus erythematosus bind a shared sequence of SmD and Epstein-Barr virus-encoded nuclear antigen EBNA I
    • Sabbatini, A., S. Bombardieri, and P. Migliorini. 1993. Autoantibodies from patients with systemic lupus erythematosus bind a shared sequence of SmD and Epstein-Barr virus-encoded nuclear antigen EBNA I. Eur. J. Immunol. 23: 1146-1152.
    • (1993) Eur. J. Immunol. , vol.23 , pp. 1146-1152
    • Sabbatini, A.1    Bombardieri, S.2    Migliorini, P.3
  • 16
    • 13444287958 scopus 로고    scopus 로고
    • Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry
    • McClain, M. T., L. D. Heinlen, G. J. Dennis, J. Roebuck, J. B. Harley, and J. A. James. 2005. Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry. Nat. Med. 11: 85-89.
    • (2005) Nat. Med. , vol.11 , pp. 85-89
    • McClain, M.T.1    Heinlen, L.D.2    Dennis, G.J.3    Roebuck, J.4    Harley, J.B.5    James, J.A.6
  • 17
    • 8444252900 scopus 로고    scopus 로고
    • Expression of the Epstein-Barr virus nuclear antigen-1 (EBNA-1) in the mouse can elicit the production of anti-dsDNA and anti-Sm antibodies
    • Sundar, K., S. Jacques, P. Gottlieb, R. Villars, M. E. Benito, D. K. Taylor, and L. A. Spatz. 2004. Expression of the Epstein-Barr virus nuclear antigen-1 (EBNA-1) in the mouse can elicit the production of anti-dsDNA and anti-Sm antibodies. J. Autoimmun. 23: 127-140.
    • (2004) J. Autoimmun. , vol.23 , pp. 127-140
    • Sundar, K.1    Jacques, S.2    Gottlieb, P.3    Villars, R.4    Benito, M.E.5    Taylor, D.K.6    Spatz, L.A.7
  • 18
    • 0030840877 scopus 로고    scopus 로고
    • Lupus humoral autoimmunity after short peptide immunization
    • James, J. A., R. H. Scofield, and J. B. Harley. 1997. Lupus humoral autoimmunity after short peptide immunization. Ann. NY Acad. Sci. 815: 124-127.
    • (1997) Ann. NY Acad. Sci. , vol.815 , pp. 124-127
    • James, J.A.1    Scofield, R.H.2    Harley, J.B.3
  • 19
    • 9644279753 scopus 로고    scopus 로고
    • Epstein-Barr viras (EBV) LMP2A mediates B lymphocyte survival through constitutive activation of the Ras/PI3K/Akt pathway
    • Portis, T., and R. Longnecker. 2004. Epstein-Barr viras (EBV) LMP2A mediates B lymphocyte survival through constitutive activation of the Ras/PI3K/Akt pathway. Oncogene 23: 8619-8628.
    • (2004) Oncogene , vol.23 , pp. 8619-8628
    • Portis, T.1    Longnecker, R.2
  • 20
    • 0027211796 scopus 로고
    • Epstein-Barr virus latent membrane protein 2A blocks calcium mobilization in B lymphocytes
    • Miller, C. L., R. Longnecker, and E. Kieff. 1993. Epstein-Barr virus latent membrane protein 2A blocks calcium mobilization in B lymphocytes. J. Virol. 67: 3087-3094.
    • (1993) J. Virol. , vol.67 , pp. 3087-3094
    • Miller, C.L.1    Longnecker, R.2    Kieff, E.3
  • 21
    • 0028970289 scopus 로고
    • Integral membrane protein 2 of Epstein-Barr virus regulates reactivation from latency through dominant negative effects on protein-tyrosine kinases
    • Miller, C. L., A. L. Burkhardt, J. H. Lee, B. Stealey, R. Longnecker, J. B. Bolen, and E. Kieff. 1995. Integral membrane protein 2 of Epstein-Barr virus regulates reactivation from latency through dominant negative effects on protein-tyrosine kinases. Immunity 2: 155-166.
    • (1995) Immunity , vol.2 , pp. 155-166
    • Miller, C.L.1    Burkhardt, A.L.2    Lee, J.H.3    Stealey, B.4    Longnecker, R.5    Bolen, J.B.6    Kieff, E.7
  • 22
    • 0032169313 scopus 로고    scopus 로고
    • Epstein-Barr virus LMP2A drives B cell development and survival in the absence of normal B cell receptor signals
    • Caldwell, R. G., J. B. Wilson, S. J. Anderson, and R. Longnecker. 1998. Epstein-Barr virus LMP2A drives B cell development and survival in the absence of normal B cell receptor signals. Immunity 9: 405-411.
    • (1998) Immunity , vol.9 , pp. 405-411
    • Caldwell, R.G.1    Wilson, J.B.2    Anderson, S.J.3    Longnecker, R.4
  • 23
    • 19944382176 scopus 로고    scopus 로고
    • Epstein-Barr viras LMP2A alters in vivo and in vitro models of B cell anergy, but not deletion, in response to autoantigen
    • Swanson-Mungerson, M. A., R. G. Caldwell, R. Bultema, and R. Longnecker. 2005. Epstein-Barr viras LMP2A alters in vivo and in vitro models of B cell anergy, but not deletion, in response to autoantigen. J. Virol. 79: 7355-7362.
    • (2005) J. Virol. , vol.79 , pp. 7355-7362
    • Swanson-Mungerson, M.A.1    Caldwell, R.G.2    Bultema, R.3    Longnecker, R.4
  • 24
    • 0032006227 scopus 로고    scopus 로고
    • Autoreactive B cell regulation: Peripheral induction of developmental arrest by lupus-associated autoantigens
    • Santulli-Marotto, S., M, W. Retter, R. Gee, M. J. Mamula, and S. H. Clarke. 1998. Autoreactive B cell regulation: peripheral induction of developmental arrest by lupus-associated autoantigens. Immunity 8: 209-219.
    • (1998) Immunity , vol.8 , pp. 209-219
    • Santulli-Marotto, S.1    Retter, M.W.2    Gee, R.3    Mamula, M.J.4    Clarke, S.H.5
  • 25
    • 0036134880 scopus 로고    scopus 로고
    • Low-affinity anti-Smith antigen B cells are regulated by anergy as opposed to developmental arrest or differentiation to B-1
    • Borrero, M., and S. H. Clarke. 2002. Low-affinity anti-Smith antigen B cells are regulated by anergy as opposed to developmental arrest or differentiation to B-1. J. Immunol. 168: 13-21.
    • (2002) J. Immunol. , vol.168 , pp. 13-21
    • Borrero, M.1    Clarke, S.H.2
  • 27
    • 0142219442 scopus 로고    scopus 로고
    • Blimp-1 is required for the formation of Immunoglobulin secreting plasma cells and pre-plasma memory B cells
    • Shapiro-Shelef, M., K. I. Lin, L. J. McHeyzer-Williams, J. Liao, M. G. McHeyzer-Williams, and K. Calame. 2003. Blimp-1 is required for the formation of Immunoglobulin secreting plasma cells and pre-plasma memory B cells. Immunity 19: 607-620.
    • (2003) Immunity , vol.19 , pp. 607-620
    • Shapiro-Shelef, M.1    Lin, K.I.2    McHeyzer-Williams, L.J.3    Liao, J.4    McHeyzer-Williams, M.G.5    Calame, K.6
  • 30
    • 0346734179 scopus 로고    scopus 로고
    • Impaired clearance of apoptotic cells induces the activation of autoreactive anti-Sm marginal zone and B-1 B cells
    • Qian, Y., H. Wang, and S. H. Clarke. 2004. Impaired clearance of apoptotic cells induces the activation of autoreactive anti-Sm marginal zone and B-1 B cells. J. Immunol. 172: 625-635.
    • (2004) J. Immunol. , vol.172 , pp. 625-635
    • Qian, Y.1    Wang, H.2    Clarke, S.H.3
  • 31
    • 0027207242 scopus 로고
    • Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I κBα: A mechanism for NF-κB activation
    • Beg, A. A., T. S. Finco, P. V. Nantermet, and A. S. Baldwin, Jr. 1993. Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I κBα: a mechanism for NF-κB activation. Mol. Cell. Biol. 13: 3301-3310.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 3301-3310
    • Beg, A.A.1    Finco, T.S.2    Nantermet, P.V.3    Baldwin Jr., A.S.4
  • 32
    • 0037441994 scopus 로고    scopus 로고
    • NF-κB hyperactivation has differential effects on the APC function of nonobese diabetic mouse macrophages
    • Sen, P., S. Bhattacharyya, M. Wallet, C. P. Wong, B. Poligone, M. Sen, A. S. Baldwin, Jr., and R. Tisch. 2003. NF-κB hyperactivation has differential effects on the APC function of nonobese diabetic mouse macrophages. J. Immunol. 170: 1770-1780.
    • (2003) J. Immunol. , vol.170 , pp. 1770-1780
    • Sen, P.1    Bhattacharyya, S.2    Wallet, M.3    Wong, C.P.4    Poligone, B.5    Sen, M.6    Baldwin Jr., A.S.7    Tisch, R.8
  • 33
    • 0035865056 scopus 로고    scopus 로고
    • Lupus-specific antiribonucleoprotein B cell tolerance in nonautoimmune mice is maintained by differentiation to B-1 and governed by B cell receptor signaling thresholds
    • Qian, Y., C. Santiago, M. Borrero, T. F. Tedder, and S. H. Clarke. 2001. Lupus-specific antiribonucleoprotein B cell tolerance in nonautoimmune mice is maintained by differentiation to B-1 and governed by B cell receptor signaling thresholds. J. Immunol. 166: 2412-2419.
    • (2001) J. Immunol. , vol.166 , pp. 2412-2419
    • Qian, Y.1    Santiago, C.2    Borrero, M.3    Tedder, T.F.4    Clarke, S.H.5
  • 35
    • 0034653392 scopus 로고    scopus 로고
    • Identification of a precursor to phosphatidyl choline-specific B-1 cells suggesting that B-1 cells differentiate from splenic conventional B cells in vivo: Cyclosporin a blocks differentiation to B-1
    • Arnold, L. W., S. K. McCray, C. Tatu, and S. H. Clarke. 2000. Identification of a precursor to phosphatidyl choline-specific B-1 cells suggesting that B-1 cells differentiate from splenic conventional B cells in vivo: cyclosporin A blocks differentiation to B-1. J. Immunol. 164: 2924-2930.
    • (2000) J. Immunol. , vol.164 , pp. 2924-2930
    • Arnold, L.W.1    McCray, S.K.2    Tatu, C.3    Clarke, S.H.4
  • 36
    • 0028088994 scopus 로고
    • An integral membrane protein (LMP2) blocks reactivation of Epstein-Barr virus from latency following surface immunoglobulin crosslinking
    • Miller, C. L., J. H. Lee, E. Kieff, and R. Longnecker. 1994. An integral membrane protein (LMP2) blocks reactivation of Epstein-Barr virus from latency following surface immunoglobulin crosslinking. Proc. Natl. Acad. Sci. USA 91: 772-776.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 772-776
    • Miller, C.L.1    Lee, J.H.2    Kieff, E.3    Longnecker, R.4
  • 42
    • 0033756107 scopus 로고    scopus 로고
    • Epstein-Barr virus LMP2A transforms epithelial cells, inhibits cell differentiation, and activates Akt
    • Scholle, F., K. M. Bendt, and N. Raab-Traub. 2000. Epstein-Barr virus LMP2A transforms epithelial cells, inhibits cell differentiation, and activates Akt. J. Virol. 74: 10681-10689.
    • (2000) J. Virol. , vol.74 , pp. 10681-10689
    • Scholle, F.1    Bendt, K.M.2    Raab-Traub, N.3
  • 43
    • 0842326032 scopus 로고    scopus 로고
    • Latent membrane protein 2A inhibits transforming growth factor β1-induced apoptosis through the phosphatidylinositol 3-kinase/Akt pathway
    • Fukuda, M., and R. Longnecker. 2004. Latent membrane protein 2A inhibits transforming growth factor β1-induced apoptosis through the phosphatidylinositol 3-kinase/Akt pathway. J. Virol. 78: 1697-1705.
    • (2004) J. Virol. , vol.78 , pp. 1697-1705
    • Fukuda, M.1    Longnecker, R.2
  • 44
    • 14844362908 scopus 로고    scopus 로고
    • Inhibition of neutrophil apoptosis by TLR agonists in whole blood: Involvement of the phosphoinositide 3-kinase/Akt and NF-κB signaling pathways, leading to increased levels of Mc1-1, Al, and phosphorylated Bad
    • Francois, S., J. El Benna, P. M. Dang, E. Pedruzzi, M. A. Gougerot-Pocidalo, and C. Elbim. 2005. Inhibition of neutrophil apoptosis by TLR agonists in whole blood: involvement of the phosphoinositide 3-kinase/Akt and NF-κB signaling pathways, leading to increased levels of Mc1-1, Al, and phosphorylated Bad. J. Immunol. 174: 3633-3642.
    • (2005) J. Immunol. , vol.174 , pp. 3633-3642
    • Francois, S.1    El Benna, J.2    Dang, P.M.3    Pedruzzi, E.4    Gougerot-Pocidalo, M.A.5    Elbim, C.6
  • 45
    • 0037352702 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase is involved in Toll-like receptor 4-mediated cytokine expression in mouse macrophages
    • Ojaniemi, M., V. Glumoff, K. Harju, M. Liljeroos, K. Vuori, and M. Hallman. 2003. Phosphatidylinositol 3-kinase is involved in Toll-like receptor 4-mediated cytokine expression in mouse macrophages. Eur. J. Immunol. 33: 597-605.
    • (2003) Eur. J. Immunol. , vol.33 , pp. 597-605
    • Ojaniemi, M.1    Glumoff, V.2    Harju, K.3    Liljeroos, M.4    Vuori, K.5    Hallman, M.6
  • 46
    • 0037080024 scopus 로고    scopus 로고
    • Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines
    • Zarember, K. A., and P. J. Godowski. 2002. Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines. J. Immunol. 168: 554-561.
    • (2002) J. Immunol. , vol.168 , pp. 554-561
    • Zarember, K.A.1    Godowski, P.J.2
  • 47
    • 0028939583 scopus 로고
    • A novel form of Epstein-Barr virus latency in normal B cells in vivo
    • Miyashita, E. M., B. Yang, K. M. Lam, D. H. Crawford, and D. A. Thorley-Lawson. 1995. A novel form of Epstein-Barr virus latency in normal B cells in vivo. Cell 80: 593-601.
    • (1995) Cell , vol.80 , pp. 593-601
    • Miyashita, E.M.1    Yang, B.2    Lam, K.M.3    Crawford, D.H.4    Thorley-Lawson, D.A.5
  • 49
    • 0029904098 scopus 로고    scopus 로고
    • Association of Epstein-Barr virus (EBV) with Sjogren's syndrome: Differential EBV expression between epithelial cells and lymphocytes in salivary glands
    • Wen, S., N. Shimizu, H. Yoshiyama, Y. Mizugaki, F. Shinozaki, and K. Takada. 1996. Association of Epstein-Barr virus (EBV) with Sjogren's syndrome: differential EBV expression between epithelial cells and lymphocytes in salivary glands. Am. J. Pathol. 149: 1511-1517.
    • (1996) Am. J. Pathol. , vol.149 , pp. 1511-1517
    • Wen, S.1    Shimizu, N.2    Yoshiyama, H.3    Mizugaki, Y.4    Shinozaki, F.5    Takada, K.6
  • 51
    • 0034001316 scopus 로고    scopus 로고
    • Epstein-Barr virus and multiple sclerosis
    • Ascherio, A., and M. Munch. 2000. Epstein-Barr virus and multiple sclerosis. Epidemiology 11: 220-224.
    • (2000) Epidemiology , vol.11 , pp. 220-224
    • Ascherio, A.1    Munch, M.2
  • 53
    • 0033610075 scopus 로고    scopus 로고
    • A model for persistent infection with Epstein-Barr virus: The stealth virus of human B cells
    • Thorley-Lawson, D. A., and G. I. Babcock. 1999. A model for persistent infection with Epstein-Barr virus: the stealth virus of human B cells. Life Sci. 65: 1433-1453.
    • (1999) Life Sci. , vol.65 , pp. 1433-1453
    • Thorley-Lawson, D.A.1    Babcock, G.I.2
  • 54
    • 0033105637 scopus 로고    scopus 로고
    • The EBV transforming protein, latent membrane protein 1, mimics and cooperates with CD40 signaling in B lymphocytes
    • Busch, L. K., and G. A. Bishop. 1999. The EBV transforming protein, latent membrane protein 1, mimics and cooperates with CD40 signaling in B lymphocytes. J. Immunol. 162: 2555-2561.
    • (1999) J. Immunol. , vol.162 , pp. 2555-2561
    • Busch, L.K.1    Bishop, G.A.2
  • 55
    • 0038142387 scopus 로고    scopus 로고
    • A role for Toll-like receptors in acquired immunity: Up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells
    • Bernasconi, N. L., N. Onai, and A. Lanzavecchia. 2003. A role for Toll-like receptors in acquired immunity: up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells. Blood 101: 4500-4504.
    • (2003) Blood , vol.101 , pp. 4500-4504
    • Bernasconi, N.L.1    Onai, N.2    Lanzavecchia, A.3
  • 56
    • 0037073930 scopus 로고    scopus 로고
    • Maintenance of serological memory by polyclonal activation of human memory B cells
    • Bemasconi, N. L., E. Traggiai, and A. Lanzavecchia. 2002. Maintenance of serological memory by polyclonal activation of human memory B cells. Science 298: 2199-2202.
    • (2002) Science , vol.298 , pp. 2199-2202
    • Bemasconi, N.L.1    Traggiai, E.2    Lanzavecchia, A.3
  • 57
    • 7044223152 scopus 로고    scopus 로고
    • Genetics of human systemic lupus erythematosus: The emerging picture
    • Nath, S. K., J. Kilpatrick, and J. B. Harley. 2004. Genetics of human systemic lupus erythematosus: the emerging picture. Curr. Opin. Immunol. 16: 794-800.
    • (2004) Curr. Opin. Immunol. , vol.16 , pp. 794-800
    • Nath, S.K.1    Kilpatrick, J.2    Harley, J.B.3
  • 58
    • 0034816964 scopus 로고    scopus 로고
    • Delineating the genetic basis of systemic lupus erythematosus
    • Wakeland, E. K., K. Liu, R. R. Graham, and T. W. Behrens. 2001. Delineating the genetic basis of systemic lupus erythematosus. Immunity 15: 397-408.
    • (2001) Immunity , vol.15 , pp. 397-408
    • Wakeland, E.K.1    Liu, K.2    Graham, R.R.3    Behrens, T.W.4
  • 59
    • 0035871845 scopus 로고    scopus 로고
    • Anti-Sm B cell differentiation in Ig transgenic MRL/Mp-lpr/lpr mice: Altered differentiation and an accelerated response
    • Santulli-Marotto, S., Y. Qian, S. Ferguson, and S. H. Clarice. 2001. Anti-Sm B cell differentiation in Ig transgenic MRL/Mp-lpr/lpr mice: altered differentiation and an accelerated response. J. Immunol. 166: 5292-5299.
    • (2001) J. Immunol. , vol.166 , pp. 5292-5299
    • Santulli-Marotto, S.1    Qian, Y.2    Ferguson, S.3    Clarice, S.H.4
  • 61
    • 0037144519 scopus 로고    scopus 로고
    • Evolution of autoantibody responses via somatic hypermutation outside of germinal centers
    • William, J., C. Euler, S. Christensen, and M. J. Shlomchik. 2002. Evolution of autoantibody responses via somatic hypermutation outside of germinal centers. Science 297: 2066-2070.
    • (2002) Science , vol.297 , pp. 2066-2070
    • William, J.1    Euler, C.2    Christensen, S.3    Shlomchik, M.J.4
  • 62
    • 11144245265 scopus 로고    scopus 로고
    • Terminal differentiation into plasma cells initiates the replicative cycle of Epstein-Barr virus in vivo
    • Laichalk, L. L., and D. A. Thorley-Lawson. 2005. Terminal differentiation into plasma cells initiates the replicative cycle of Epstein-Barr virus in vivo. J. Virol. 79: 1296-1307.
    • (2005) J. Virol. , vol.79 , pp. 1296-1307
    • Laichalk, L.L.1    Thorley-Lawson, D.A.2
  • 64
    • 33745115404 scopus 로고    scopus 로고
    • Epstein-Barr virus and molecular mimicry in systemic lupus erythematosus
    • Poole, B. D., R. H. Scofield, J. B. Harley, and J. A. James. 2006. Epstein-Barr virus and molecular mimicry in systemic lupus erythematosus. Autoimmunity 39: 63-70.
    • (2006) Autoimmunity , vol.39 , pp. 63-70
    • Poole, B.D.1    Scofield, R.H.2    Harley, J.B.3    James, J.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.