Transformation-specific matrix metalloproteinases, MMP-7 and MMP-13, are present in epithelial cells of keratoacanthomas

Modern Pathology

Volumn 19, Issue 9, 2006, Pages 1203-1212

  Kuivanen, Tiina T ^a   Jeskanen, Leila ^a   Kyllönen, Lauri ^a   Impola, Ulla ^a   Saarialho Kere, Ulpu K ^a,b  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b STOCKHOLM SÖDER HOSPITAL   (Sweden)

Author keywords

Immune suppression; Laminin 5; MMP 10; MMP 8; MMP 9; Squamous cell cancer

Indexed keywords

COLLAGENASE 3; CYTOPLASM PROTEIN; EOSIN; GELATINASE A; GELATINASE B; HEMATOXYLIN; LAMININ; LAMININ 5GAMMA2; MATRILYSIN; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE 19; MOLECULAR MARKER; NEUTROPHIL COLLAGENASE; PROTEIN P16; STROMELYSIN 2; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CHEMICAL COMPOSITION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOPLASM; DIFFERENTIAL DIAGNOSIS; ENZYME ANALYSIS; EPITHELIUM CELL; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INFLAMMATORY INFILTRATE; KERATINOCYTE; KERATOACANTHOMA; MALE; NEOVASCULARIZATION (PATHOLOGY); PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SKIN CARCINOGENESIS; SKIN EPITHELIUM; SQUAMOUS CELL CARCINOMA;

AGED; AGED, 80 AND OVER; CARCINOMA, SQUAMOUS CELL; COLLAGENASES; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DIAGNOSIS, DIFFERENTIAL; FEMALE; FIBROBLASTS; HUMANS; IN SITU HYBRIDIZATION; KERATINOCYTES; KERATOACANTHOMA; MALE; MATRIX METALLOPROTEINASE 13; MATRIX METALLOPROTEINASE 7; MIDDLE AGED; NEOPLASM PROTEINS; RNA, MESSENGER; SKIN NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 33747622513     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.3800633     Document Type: Article

References (45)

1. Schwartz RA. Keratoacanthoma (Review). J Am Acad Dermatol 1994;30:1-19.
2. Griffiths RW. Keratoacanthoma observed. Br J Plast Surg 2004;57:485-501.
3. Goldberg LH, Silapunt S, Beyrau K, et al. Keratoacanthoma as a postoperative complication of skin cancer excision. J Am Acad Dermatol 2004;50:753-758.
4. Hodak E, Jones RE, Ackerman AB. Solitary keratoacanthoma is a squamous-cell carcinoma: three examples with metastases. Am J Dermatopathol 1993;15:332-342.
5. Strieth S, Hartschuh W, Pilz L, et al. Carcinoma-like vascular density in atypic keratoacanthoma suggests malignant progression. Br J Cancer 2002;87:1301-1307.
6. Kerschmann RL, McCalmont TH, LeBoit PE. P53 oncoprotein expression and proliferation index in keratoacanthoma and squamous cell carcinoma. Arch Dermatol 1994;2:181-186.
7. Boukamp P. Non-melanoma skin cancer: what drives tumor development and progression? Carcinogenesis 2005;10:1657-1667.
8. Egeblad M, Werb Z. New functions for the matrix matalloproteinases in cancer progression. Nat Rev Cancer 2002;2:161-174.
9. Hojilla CV, Mohammed FF, Khokha R. Matrix metalloproteinases and their tissue inhibitors direct cell fate during cancer development. Minireview. Br J Cancer 2003;89:1817-1821.
10. Kerkelä E, Saarialho-Kere U. Matrix metalloproteinases in tumor progression: focus on basal and squamous cell skin cancer. Exp Dermatol 2003;12:109-125.
11. Ahokas K, Skoog T, Suomela S, et al. Matrilysin-2 (matrix metalloproteinase-26) is upregulated in keratinocytes during wound repair and early skin carcinogenesis. J Invest Dermatol 2005;124:849-856.
12. Karelina T, Goldberg G, Eisen A. Matrilysin (PUMP) correlates with dermal invasion during appendageal development and cutaneous neoplasia. J Invest Dermatol 1994;103:482-487.
13. Saarialho-Kere U, Kerkelä E, Jahkola T, et al. Epilysin (MMP-28) expression is associated with cell proliferation during epithelial repair. J Invest Dermatol 2002;119:14-21.
14. Impola U, Toriseva M, Suomela S, et al. Matrix metalloproteinase-19 is expressed by proliferating epithelium but disappears with neoplastic dedifferentiation. Int J Cancer 2003;103:709-716.
15. Cornelius LA, Nehring LC, Harding E, et al. Matrix metalloproteinases generate angiostatin: effects on neovascularization. J Immunol 1998;161:6845-6852.
16. Nyberg P, Heikkilä P, Sorsa T, et al. Endostatin inhibits human tongue carcinoma cell invasion and intravasation and blocks the activation of matrix metalloprotease-2, -9, and -13. J Biol Chem 2003;278:22404-22411.
17. Impola U, Jeskanen L, Ravanti L, et al. Expression of matrix metalloproteinase MMP-7 and MMP-13 and loss of MMP-19 and p16 are associated with malignant progression in chronic wounds. Br J Dermatol 2005;152:720-726.
18. Pyke C, Romer J, Kallunki P, et al. The gamma 2 chain of kalinin/laminin is preferentially expressed in invading malignant cells in human cancers. Am J Pathol 1994;145:782-791.
19. Giannelli G, Falk-Marzillier J, Schiraldi O, et al. Induction of cell migration by matrix metalloproteinase-2 cleavage of laminin-5. Science 1997;11:225-228.
20. INK4a tumor suppressor. Cancer Lett 2002;175:205-214.
21. Weedon D. Tumors of the epidermis. In: Houston MJ, (ed.). Skin Pathology, 2nd edn. Churchill Livingstone: London, 2002, pp 753-802.
22. Mukunyadzi P, Sanderson RD, Fan CY, et al. The level of syndecan-1 expression is a distinguishing feature in behavior between keratoacanthoma and invasive cutaneous squamous cell carcinoma. Mod Pathol 2002;15:45-49.
23. Prosser IW, Stenmark KR, Suthar M, et al. Regional heterogeneity of elastin and collagen gene expression in intralobararteries in response to hypoxic pulmonary hypertension as demonstrated by in situ hybridization. Am J Pathol 1989;135:1073-1088.
24. Kerkelä E, Ala-Aho R, Jeskanen L, et al. Expression of human macrophage metalloelastase (MMP-12) by tumor cells in skin cancer. J Invest Dermatol 2000;114:1113-1119.
25. Vaalamo M, Mattila L, Johansson N, et al. Distinct populations of stromal cells express collagenase-3 (MMP-13) and collagenase-1 (MMP-1) in chronic ulcers but not in normally healing wounds. J Invest Dermatol 1997;109:96-101.
26. Airola K, Johansson N, Kariniemi AL, et al. Human collagenase-3 is expressed in malignant squamous epithelium of the skin. J Invest Dermatol 1997;109:225-231.
27. Natarajan E, Saeb M, Crum CP, et al. Co-expression of p16(INK4A) and laminin 5 gamma2 by microinvasive and superficial squamous cell carcinomas in vivo and by migrating wound and senescent keratinocytes in culture. Am J Pathol 2003;163:477-491.
28. Vihinen P, Kähäri VM. Matrix metalloproteinases in cancer: prognostic markers and therapeutic targets. Int J Cancer 2002;99:157-166.
29. Ohashi A, Ishizaki M, Kawana S, et al. Mechanism of transepithelial elimination of elastic fibers in keratoacanthoma. Pathol Int 2004;54:585-594.
30. Asch PH, Basset P, Roos M, et al. Expression of stromelysin 3 in keratoacanthoma and squamous cell carcinoma. Am J Dermatopathol 1999;21:146-150.
31. Moilanen M, Pirila E, Grenman R, et al. Expression and regulation of collagenase (MMP-8) in head and neck squamous cell carcinomas. J Pathol 2002;197:72-81.
32. Fundyler O, Khanna M, Smoller B. Metalloproteinase-2 expression correlates with aggressiveness of cutaneous squamous cell carcinomas. Mod Pathol 2004;17:496-502.
33. Van Kempen LC, Rhee JS, Dehne K, et al. Epithelial carcinogenesis: dynamic interplay between neoplastic cells and their microenvironment (Review). Differentiation 2002;70:610-623.
34. Sadowski T, Dietrich S, Koschinsky F, et al. Matrix metalloproteinase 19 processes the laminin 5 gamma 2 chain and induces epithelial cell migration. Cell Mol Life Sci 2005;62:870-880.
35. Noe V, Fingleton B, Jacobs K, et al. Release of an invasion promoter E-cadherin fragment by matrilysin and stromelysin-1. J Cell Sci 2001;114:111-118.
36. Johansson N, Airola K, Grenman R, et al. Expression of collagenase-3 (matrix metalloproteinase-13) in squamous cell carcinomas of the head and neck. Am J Pathol 1997;151:499-508.
37. Ala-Aho R, Grenman R, Seth P, et al. Adenoviral delivery of p53 gene suppresses expression of collagenase-3 (MMP-13) in squamous carcinoma cells. Oncogene 2002;21:1187-1195.
38. Verdolini R, Amerio P, Goteri G, et al. Cutaneous carcinomas and preinvasive neoplastic lesions. Role of MMP-2 and MMP-9 metalloproteinases in neoplastic invasion and their relationship with proliferative activity and p53 expression. J Cutan Pathol 2001;28:120-126.
39. Stevenson D, Charalambous C, Wilson J. Epstein-Barr virus latent membrane protein 1 (CAO) up-regulates VEGF and TGFα concomitant with hyperplasia, with subsequent up-regulation of p16 and MMP9. Cancer Res 2005;65:8826-8835.
40. Tsukifugi R, Tagawa K, Hatamochi A, et al. Expression of matrix metalloproteinase -1, -2 and -3 in squamous cell carcinoma and actinic keratosis. Br J Cancer 1999;80:1087-1091.
41. Kerkelä E, Ala-aho R, Lohi J, et al. Differential patterns of stromelysin-2 (MMP-10) and MT1-MMP (MMP-14) expression in epithelial skin cancers. Br J Cancer 2001;84:659-669.
42. Krampert M, Bloch W, Sasaki T, et al. Activities of matrix metalloproteinase stromelysin-2 (MMP-10) in matrix degradation and keratinocyte organization in wounded skin. Mol Biol Cell 2004;15:5242-5254.
43. Suomela S, Kariniemi AL, Impola U, et al. Matrix metalloproteinase-19 is expressed by keratinocytes in psoriasis. Acta Derm Venereol 2003;83:108-114.
44. Pirilä E, Sharabi A, Salo T, et al. Matrix metalloproteinases process the laminin-5 γ2-chain and regulate epithelial cell migration. Biochem Biophys Res Commun 2003;303:1012-1017.
45. Hashemi RR, Bahar M, Tang N, et al. Prediction of experimental data for an independent variable using the experimental data collected for other independent variables in a study of skin cancer caused by exposure to UV radiation. Ann NY Acad Sci 2003;993:146-157