Matrix metalloproteinase-19 is expressed by proliferating epithelium but disappears with neoplastic dedifferentiation

International Journal of Cancer

Volumn 103, Issue 6, 2003, Pages 709-716

  Impola, Ulla ^a   Toriseva, Mervi ^b,c,d   Suomela, Sari ^a   Jeskanen, Leila ^a   Hieta, Niina ^b,c,d   Jahkola, Tiina ^a   Grenman, Reidar ^b   Kähäri, Veli Matti ^b,c,d   Saarialho Kere, Ulpu ^a  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b TURKU UNIVERSITY HOSPITAL   (Finland)

^c UNIVERSITY OF TURKU   (Finland)

^d ÅBO AKADEMI UNIVERSITY   (Finland)

Author keywords

Keratinocyte; Skin cancer; Tumor necrosis factor ; Wound healing

Indexed keywords

MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE 19; MESSENGER RNA; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN P63; PROTEINASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UVOMORULIN; ZINC DERIVATIVE;

ANGIOGENESIS; ARTICLE; CANCER GROWTH; CANCER INVASION; CELL DIFFERENTIATION; CELL PROLIFERATION; CHROMOSOMAL LOCALIZATION; CHROMOSOME STRUCTURE; CONTROLLED STUDY; ENDOTHELIUM CELL; EPITHELIUM CELL; HEAD AND NECK CANCER; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; KERATINOCYTE; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN CANCER; STROMA; VASCULAR SMOOTH MUSCLE; WESTERN BLOTTING;

BLOTTING, NORTHERN; BLOTTING, WESTERN; CARCINOMA, BASAL CELL; CARCINOMA, SQUAMOUS CELL; CELL DIFFERENTIATION; CELL DIVISION; CELL TRANSFORMATION, NEOPLASTIC; DOWN-REGULATION; FEMALE; FIBROBLASTS; HUMANS; IMMUNOENZYME TECHNIQUES; KERATINOCYTES; MALE; METALLOENDOPEPTIDASES; MIDDLE AGED; RNA, MESSENGER; SKIN NEOPLASMS; TETRADECANOYLPHORBOL ACETATE; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0037348609     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.10902     Document Type: Article

References (41)

1. Nagase H, Woesner JF. Matrix metalloproteinases. J Biol Chem 1999;274:21491-4.
2. Uria JA, Lopez-Otin C. Matrilysin-2, a new matrix metalloproteinase expressed in human tumors and showing the minimal domain organization required for secretion, latency, and activity. Cancer Res 2000;60:4745-51.
3. Lohi J, Wilson CL, Roby JD, Parks WC. Epilysin, a novel human matrix metalloproteinase (MMP-28) expressed in testis and keratinocytes and in response to injury. J Biol Chem 2001;276:10134-44.
4. Kahari VM, Saarialho-Kere U. Matrix metalloproteinases and their inhibitors in tumour growth and invasion. Ann Med 1999;31:34-45.
5. Parks WC. Matrix metalloproteinases in repair. Wound Repair Regen 1999;7:423-32.
6. Cossins J, Dudgeon TJ, Catlin G, Gearing AJ, Clements JM. Identification of MMP-18, a putative novel human matrix metalloproteinase. Biochem Biophys Res Commun 1996;12:494-8.
7. Pendas AM, Knauper V, Puente XS, Llano E, Mattei MG, Apte S, Murphy G, Lopez-Otin C. Identification and characterization of a novel human matrix metalloproteinase with unique structural characteristics, chromosomal location, and tissue distribution. J Biol Chem 1997;272:4281-6.
8. Marchenko GN, Strongin AY. MMP-28, a new human matrix metalloproteinase with an unusual cysteine-switch sequence is widely expressed in tumors. Gene 2001;265:87-93.
9. Stracke JO, Fosang AJ, Last K, Mercuri FA, Pendas AM, Llano E, Perris R, Di Cesare PE, Murphy G, Knauper V. Matrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matrix protein (COMP). FEBS Lett 2000;478:52-6.
10. Stracke JO, Hutton M, Stewart M, Pendas AM, Smith B, Lopez-Otin C, Murphy G, Knauper V. Biochemical characterization of the catalytic domain of human matrix metalloproteinase 19. Evidence for a role as a potent basement membrane degrading enzyme. J Biol Chem 2000;275:14809-16.
11. Sedlacek R, Mauch S, Kolb B, Schatzlein C, Eibel H, Peter HH, Schmitt J, Krawinkel U. Matrix metalloproteinase MMP-19 (RASI-1) is expressed on the surface of activated peripheral blood mononuclear cells and is detected as an autoantigen in rheumatoid arthritis. Immunobiology 1998;198:408-23.
12. Kolb C, Mauch S, Krawinkel U, Sedlacek R. Matrix metalloproteinase-19 in capillary endothelial cells: expression in acutely, but not in chronically, inflamed synovium. Exp Cell Res 1999;250:122-30.
13. Konttinen YT, Ainola M, Valleala H, Ma J, Ida H, Mandelin J, Kinne RW, Santavirta S, Sorsa T, Lopez-Otin C, Takagi M. Analysis of 16 different matrix metalloproteinases (MMP-1 to MMP-20) in the synovial membrane: different profiles in trauma and rheumatoid arthritis. Ann Rheum Dis 1999;58:691-7.
14. Rechardt O, Elomaa O, Vaalamo M, Paakkonen K, Jahkola T, Hook-Nikanne J, Hembry RM, Hakkinen L, Kere J, Saarialho-Kere U. Stromelysin-2 is upregulated during normal wound repair and is induced by cytokines. J Invest Dermatol 2000;115:778-87.
15. Saarialho-Kere UK, Kovacs SO, Pentland AP, Olerud JE, Welgus HG, Parks WC. Cell-matrix interactions modulate interstitial collagenase expression by human keratinocytes actively involved in wound healing. J Clin Invest 1993;92:2858-66.
16. Von Boguslawski K. Immunohistochemical detection of progesterone receptors in paraffin sections. APMIS 1994;102:641-64.
17. Cattoretti F, Becker MHG, Key F, Duchrow M, Schluter C, Falle J, Ferdes J. Monoclonal antibodies against recombinant parts of the Ki-67 antigen (Mib1 and Mib3) detect proliferating cells in microwave-processed formalin-fixed paraffin sections. J Pathol 1992;168: 357-63.
18. Montonen O, Ezer S, Laurikkala J, Karjalainen-Lindsberg M-L, Thesleff I, Kere J, Saarialho-Kere U. Expression of the anhidrotic ectodermal dysplasia gene is reduced in skin cancer and correlates with E-cadherin expression. Exp Dermatol 1998;7:168-74.
19. Boukamp P, Petrussevska RT, Breitkreutz D, Hornung J, Markham A, Fusenig NE. Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J Cell Biol 1988;106:761-71.
20. Boukamp P, Stanbridge EJ, Foo DY, Cerutti PA, Fusenig NE. c-Ha ras oncogene expression in immortalized human keratinocytes (Ha-CaT) alters growth potential in vivo but lacks correlation with malignancy. Cancer Res 1990;50:2840-7.
21. Ahonen M, Ala-aho R, Baker AH, George SJ, Grénman R, Saarialho-Kere, Kähäri V-M. Antitumor activity and by-stander effect of adenovirally delivered tissue inhibitor of metalloproteinases-3. Mol Ther 2002;5:705-15.
22. Servomaa K, Kiuru A, Grénman R, Pekkola-Heino K, Pulkkinen JO, Rytömaa T. p53 mutations associated with increased sensitivity to ionizing radiation in human head and neck cancer cell lines. Cell Prolif 1996;29:219-30.
23. Chomezynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987;162:156-9.
24. Reunanen N, Westermarck J, Häkkinen L, Holmström TH, Elo I, Eriksson JE, Kähäri V-M. Enhancement of fibroblast collagenase (matrix metalloproteinase-1) gene expression by ceramide is mediated by extracellular signal-regulated and stress-activated protein kinase pathways. J Biol Chem 1998;273:5137-45.
25. Parsa R, Yang A, McKeon F, Green H. Association of p63 with proliferative potential in normal and neoplastic human keratinocytes. J Invest Dermatol 1999;113:1099-105.
26. Djonov V, Hogger K, Sedlacek R, Laissue J, Draeger A. MMP-19: cellular localization of a novel metalloproteinase within normal breast tissue and mammary gland tumours. J Pathol 2001;195:147-55.
27. Saarialho-Kere U, Kerkelä E, Jahkola T, Suomela S, Keski-Oja J, Lohi J. Epilysin (MMP-28) expression is associated with cell proliferation during epithelial repair. J Invest Dermatol 2002;119:14-21.
28. Murray GI. Matrix metalloproteinases: a multifunctional group of molecules J Pathol 2001;195:135-7.
29. Vihinen P, Kähäri V-M. Matrix metalloproteinases in cancer: prognostic markers and therapeutic agents. Int J Cancer 2002;99:157-66.
30. Johansson N, Westermarck J, Leppä S, Häkkinen L, Koivisto L, Lopez-Otin C, Peltonen J, Heino J, Kähäri VM. Collagenase-13 (MMP-13) gene expression by HaCaT keratinocytes is enhanced by tumor necrosis factor-α and transforming growth factor-β. Cell Growth Differ 1997;8:243-50
31. Kerkelä E, Ala-Aho R, Jeskanen L, Rechardt O, Grenman R, Shapiro SD, Kähäri VM, Saarialho-Kere U. Expression of human macrophage metalloelastase (MMP-12) by tumor cells in skin cancer. J Invest Dermatol 2000;114:1113-9.
32. Mueller MS, Mauch S, Sedlacek R. Structure of the human MMP-19 gene. Gene 2000;252:27-37.
33. Gutman A, Wasylyk B. The collagenase gene promoter contains a TPA and oncogene-responsive unit encompassing the PEA3 and AP-1 binding sites. EMBO J 1990;9:2241-6.
34. Tomic-Canic M, Komine M, Freedberg IM, Blumenberg M. Epidermal signal transduction and transcription factor activation in activated keratinocytes. J Dermatol Sci 1998;17:167-81.
35. Feiken E, Romer J, Eriksen J, Lund LR. Neutrophils express tumor necrosis factor-1 during mouse skin wound healing. J Invest Dermatol 1995;105:120-3.
36. Bos JD, Kapsenberg ML. The skin immune system: progress in cutaneous biology. Immunol Today 1993;14:75-8
37. Pillai S, Bikle DD. Eessalu TE, Aggarwal BB, Elias PM. Binding and biological effects of tumor necrosis factor alpha on cultured human neonatal foreskin keratinocytes. J Clin Invest 1989;83:816-21.
38. Symington FW. Lymphotoxin, tumor necrosis factor, and gamma interferon are cytostatic for normal human keratinocytes J Invest Dermatol 1989;92:798-805.
39. Uchi H, Terao H, Koga T, Furue M. Cytokines and chemokines in the epidermis. J Dermatol Sci 2000;24(Suppl 1):S29-38.
40. Mauch S, Kolb C, Kolb B, Sadowski T, Sedlacek R. Matrix metalloproteinase-19 is expressed in myeloid cells in an adhesion-dependent manner and associates with the cell surface. J Immunol 2002; 168:1244-51.
41. Turksen K, Kupper T, Degenstein L, Williams I, Fuchs E. Interleukin 6: insights to its function in skin by overexpression in transgenic mice. Proc Natl Acad Sci USA 1992;89:5068-72.