-
1
-
-
0035950188
-
New frontiers in Alzheimer's disease genetics
-
Tanzi RE, Bertram L. New frontiers in Alzheimer's disease genetics. Neuron 2001;32:181-184.
-
(2001)
Neuron
, vol.32
, pp. 181-184
-
-
Tanzi, R.E.1
Bertram, L.2
-
2
-
-
0035066332
-
Alzheimer's disease: Genes, proteins, and therapy
-
Selkoe DJ. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev 2001;81:741-766.
-
(2001)
Physiol Rev
, vol.81
, pp. 741-766
-
-
Selkoe, D.J.1
-
3
-
-
0036548070
-
Gamma-Secretase, Notch, Abeta and Alzheimer's disease: Where do the presenilins fit in?
-
Sisodia SS, St George-Hyslop PH. gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in? Nat Rev Neurosci 2002;3:281-290.
-
(2002)
Nat Rev Neurosci
, vol.3
, pp. 281-290
-
-
Sisodia, S.S.1
St. George-Hyslop, P.H.2
-
4
-
-
0033595706
-
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
-
Vassar R, Bennett BD, Babu-Khan S, et al. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 1999;286:735-741.
-
(1999)
Science
, vol.286
, pp. 735-741
-
-
Vassar, R.1
Bennett, B.D.2
Babu-Khan, S.3
-
5
-
-
0033382226
-
Identification of a novel aspartic protease (Asp 2) as beta-secretase
-
Hussain I, Powell D, Howlett DR, et al. Identification of a novel aspartic protease (Asp 2) as beta-secretase. Mol Cell Neurosci 1999;14:419-427.
-
(1999)
Mol Cell Neurosci
, vol.14
, pp. 419-427
-
-
Hussain, I.1
Powell, D.2
Howlett, D.R.3
-
6
-
-
0033613129
-
Cellular mechanisms of beta-amyloid production and secretion
-
Sinha S, Lieberburg I. Cellular mechanisms of beta-amyloid production and secretion. Proc Natl Acad Sci USA 1999;96:11049-11053.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 11049-11053
-
-
Sinha, S.1
Lieberburg, I.2
-
7
-
-
0033518264
-
Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity
-
Yan R, Bienkowski MJ, Shuck ME, et al. Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity. Nature 1999;402:533-537.
-
(1999)
Nature
, vol.402
, pp. 533-537
-
-
Yan, R.1
Bienkowski, M.J.2
Shuck, M.E.3
-
8
-
-
0025295039
-
Cleavage of amyloid beta peptide during constitutive processing of its precursor
-
Esch FS, Keim PS, Beattie EC, et al. Cleavage of amyloid beta peptide during constitutive processing of its precursor. Science 1990;248:1122-1124.
-
(1990)
Science
, vol.248
, pp. 1122-1124
-
-
Esch, F.S.1
Keim, P.S.2
Beattie, E.C.3
-
9
-
-
0025373508
-
Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing
-
Sisodia SS, Koo EH, Beyreuther K, Unterbeck A, Price DL. Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing. Science 1990;248:492-495.
-
(1990)
Science
, vol.248
, pp. 492-495
-
-
Sisodia, S.S.1
Koo, E.H.2
Beyreuther, K.3
Unterbeck, A.4
Price, D.L.5
-
10
-
-
0041357787
-
The secretases of Alzheimer's disease
-
Wolfe MS. The secretases of Alzheimer's disease. Curr Top Dev Biol 2003;54:233-261.
-
(2003)
Curr Top Dev Biol
, vol.54
, pp. 233-261
-
-
Wolfe, M.S.1
-
11
-
-
0035929554
-
Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch
-
Gu Y, Misonou H, Sato T, Dohmae N, Takio K, Ihara Y. Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch. J Biol Chem 2001;276:35235-35238.
-
(2001)
J Biol Chem
, vol.276
, pp. 35235-35238
-
-
Gu, Y.1
Misonou, H.2
Sato, T.3
Dohmae, N.4
Takio, K.5
Ihara, Y.6
-
12
-
-
0034774969
-
Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch
-
Sastre M, Steiner H, Fuchs K, et al. Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch. EMBO Rep 2001;2:835-841.
-
(2001)
EMBO Rep
, vol.2
, pp. 835-841
-
-
Sastre, M.1
Steiner, H.2
Fuchs, K.3
-
13
-
-
0035941278
-
Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma - Secretase processing of the APP and Notch1 transmembrane domains
-
Yu C, Kim SH, Ikeuchi T, et al. Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma - secretase processing of the APP and Notch1 transmembrane domains. J Biol Chem 2001;276:43756-43760.
-
(2001)
J Biol Chem
, vol.276
, pp. 43756-43760
-
-
Yu, C.1
Kim, S.H.2
Ikeuchi, T.3
-
15
-
-
0034795651
-
Acyl-coenzyme A: Cholesterol acyltransferase modulates the generation of the amyloid beta-peptide
-
Puglielli L, Konopka G, Pack-Chung E, et al. Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide. Nat Cell Biol 2001;3:905-912.
-
(2001)
Nat Cell Biol
, vol.3
, pp. 905-912
-
-
Puglielli, L.1
Konopka, G.2
Pack-Chung, E.3
-
16
-
-
0031746979
-
A detergent-insoluble membrane compartment contains a beta in vivo
-
Lee SJ, Liyanage U, Bickel PE, Xia W, Lansbury PT Jr, Kosik KS. A detergent-insoluble membrane compartment contains A beta in vivo. Nat Med 1998;4:730-734.
-
(1998)
Nat Med
, vol.4
, pp. 730-734
-
-
Lee, S.J.1
Liyanage, U.2
Bickel, P.E.3
Xia, W.4
Lansbury Jr., P.T.5
Kosik, K.S.6
-
17
-
-
0026316233
-
The Alzheimer amyloid precursor is associated with the detergent-insoluble cytoskeleton
-
Refolo LM, Wittenberg IS, Friedrich VL Jr, Robakis NK. The Alzheimer amyloid precursor is associated with the detergent-insoluble cytoskeleton. J Neurosci 1991;11:3888-3897.
-
(1991)
J Neurosci
, vol.11
, pp. 3888-3897
-
-
Refolo, L.M.1
Wittenberg, I.S.2
Friedrich Jr., V.L.3
Robakis, N.K.4
-
18
-
-
0033571721
-
Amyloid precursor protein, although partially detergent-insoluble in mouse cerebral cortex, behaves as an atypical lipid raft protein
-
Parkin ET, Turner AJ, Hooper NM. Amyloid precursor protein, although partially detergent-insoluble in mouse cerebral cortex, behaves as an atypical lipid raft protein. Biochem J 1999;344 Pt 1:23-30.
-
(1999)
Biochem J
, vol.344
, Issue.PART 1
, pp. 23-30
-
-
Parkin, E.T.1
Turner, A.J.2
Hooper, N.M.3
-
19
-
-
0032516749
-
Cholesterol-dependent generation of a unique amyloid beta-protein from apically missorted amyloid precursor protein in MDCK cells
-
Mizuno T, Haass C, Michikawa M, Yanagisawa K. Cholesterol-dependent generation of a unique amyloid beta-protein from apically missorted amyloid precursor protein in MDCK cells. Biochim Biophys Acta 1998;1373:119-130.
-
(1998)
Biochim Biophys Acta
, vol.1373
, pp. 119-130
-
-
Mizuno, T.1
Haass, C.2
Michikawa, M.3
Yanagisawa, K.4
-
20
-
-
0029671454
-
Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein
-
Bodovitz S, Klein WL. Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein. J Biol Chem 1996;271:4436-4440.
-
(1996)
J Biol Chem
, vol.271
, pp. 4436-4440
-
-
Bodovitz, S.1
Klein, W.L.2
-
21
-
-
0032568552
-
Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons
-
Simons M, Keller P, De Strooper B, Beyreuther K, Dotti CG, Simons K. Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons. Proc Natl Acad Sci USA 1998;95:6460-6464.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 6460-6464
-
-
Simons, M.1
Keller, P.2
De Strooper, B.3
Beyreuther, K.4
Dotti, C.G.5
Simons, K.6
-
22
-
-
0033519601
-
The role of cholesterol in the biosynthesis of beta-amyloid
-
Frears ER, Stephens DJ, Walters CE, Davies H, Austen BM. The role of cholesterol in the biosynthesis of beta-amyloid. Neuroreport 1999;10:1699-1705.
-
(1999)
Neuroreport
, vol.10
, pp. 1699-1705
-
-
Frears, E.R.1
Stephens, D.J.2
Walters, C.E.3
Davies, H.4
Austen, B.M.5
-
23
-
-
0032568843
-
Modulation of secreted beta-amyloid precursor protein and amyloid beta-peptide in brain by cholesterol
-
Howland DS, Trusko SP, Savage MJ, et al. Modulation of secreted beta-amyloid precursor protein and amyloid beta-peptide in brain by cholesterol. J Biol Chem 1998;273:16576-16582.
-
(1998)
J Biol Chem
, vol.273
, pp. 16576-16582
-
-
Howland, D.S.1
Trusko, S.P.2
Savage, M.J.3
-
24
-
-
0033833354
-
Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model
-
Refolo LM, Malester B, LaFrancois J, et al. Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model. Neurobiol Dis 2000;7:321-331.
-
(2000)
Neurobiol Dis
, vol.7
, pp. 321-331
-
-
Refolo, L.M.1
Malester, B.2
LaFrancois, J.3
-
25
-
-
4544225643
-
Effects of RNA interference-mediated silencing of gamma-secretase complex components on cell sensitivity to caspase-3 activation
-
Xie Z, Romano DM, Kovacs DM, Tanzi RE. Effects of RNA interference-mediated silencing of gamma-secretase complex components on cell sensitivity to caspase-3 activation. J Biol Chem 2004;279:34130-34137.
-
(2004)
J Biol Chem
, vol.279
, pp. 34130-34137
-
-
Xie, Z.1
Romano, D.M.2
Kovacs, D.M.3
Tanzi, R.E.4
-
26
-
-
2342447294
-
Hypocapnia induces caspase-3 activation and increases a-beta production
-
Xie Z, Moir R, Romano DM, Tesco G, Kovacs D, Tanzi R. Hypocapnia induces caspase-3 activation and increases a-beta production. Neurodegenerative Dis 2004;1:29-37.
-
(2004)
Neurodegenerative Dis
, vol.1
, pp. 29-37
-
-
Xie, Z.1
Moir, R.2
Romano, D.M.3
Tesco, G.4
Kovacs, D.5
Tanzi, R.6
-
27
-
-
0023447252
-
Lipofection: A highly efficient, lipid-mediated DNA-transfection procedure
-
Felgner PL, Gadek TR, Holm M, et al. Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure. Proc Natl Acad Sci USA 1987;84:7413-7417.
-
(1987)
Proc Natl Acad Sci USA
, vol.84
, pp. 7413-7417
-
-
Felgner, P.L.1
Gadek, T.R.2
Holm, M.3
-
29
-
-
0020339802
-
Gene transfer into mouse lyoma cells by electroporation in high electric fields
-
Neumann E, Schaefer-Ridder M, Wang Y, Hofschneider PH. Gene transfer into mouse lyoma cells by electroporation in high electric fields. EMBO J 1982;1:841-845.
-
(1982)
EMBO J
, vol.1
, pp. 841-845
-
-
Neumann, E.1
Schaefer-Ridder, M.2
Wang, Y.3
Hofschneider, P.H.4
|