Activin inhibits the human Pit-1 gene promoter through the p38 kinase pathway in a smad-independent manner

Endocrinology

Volumn 147, Issue 9, 2006, Pages 4351-4362

  De Guise, Chantal ^a   Lacerte, Annie ^a   Rafiei, Shahrzad ^a   Reynaud, Rachel ^a,b   Roy, Melanie ^a   Brue, Thierry ^b   Lebrun, Jean Jacques ^a,c  

^a ROYAL VICTORIA HOSPITAL   (Canada)

^b TIMONE HOSPITAL   (France)

^c Institut national du cancer du Canada   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN; MITOGEN ACTIVATED PROTEIN KINASE P38; PROLACTIN; SMAD PROTEIN; TRANSCRIPTION FACTOR PIT 1; TRANSFORMING GROWTH FACTOR BETA;

ADENOHYPOPHYSIS; ANIMAL CELL; ARTICLE; CELL GROWTH; CHINESE HAMSTER; ENZYME ACTIVITY; GENE CONTROL; GENE EXPRESSION; HORMONAL REGULATION; HORMONE SYNTHESIS; NONHUMAN; OVARY CELL; PRIORITY JOURNAL; PROMOTER REGION; RAT; SIGNAL TRANSDUCTION;

ACTIVINS; ANIMALS; BLOTTING, WESTERN; CELL LINE; CHO CELLS; CRICETINAE; ENZYME ACTIVATION; GENE EXPRESSION; HUMANS; LUCIFERASES; MUTAGENESIS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PITUITARY GLAND; PROLACTIN; PROMOTER REGIONS (GENETICS); RATS; RECOMBINANT FUSION PROTEINS; SMAD PROTEINS, RECEPTOR-REGULATED; TRANSCRIPTION FACTOR PIT-1; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 33747597788     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2006-0444     Document Type: Article

References (45)

1. Heaney AP, Melmed S 2004 Molecular targets in pituitary tumours. Nat Rev Cancer 4:285-295
2. Ben-Jonathan N, Hnasko R 2001 Dopamine as a prolactin (PRL) inhibitor. Endocr Rev 22:724-763
3. Asa SL, Ezzat S 1998 The cytogenesis and pathogenesis of pituitary adenomas. Endocr Rev 19:798-827
4. Missale C, Nash SR, Robinson SW, Jaber M, Caron MG 1998 Dopamine receptors: from structure to function. Physiol Rev 78:189-225
5. Bevan JS, Davis JR 1994 Cabergoline: an advance in dopaminergic therapy. Clin Endocrinol (Oxf) 41:709-712
6. Diamond SE, Chiono M, Gutierrez-Hartmann A 1999 Reconstitution of the protein kinase A response of the rat prolactin promoter: differential effects of distinct Pit-1 isoforms and functional interaction with Oct-1. Mol Endocrinol 13:228-238
7. Holloway JM, Szeto DP, Scully KM, Glass CK, Rosenfeld MG 1995 Pit-1 binding to specific DNA sites as a monomer or dimer determines gene-specific use of a tyrosine-dependent synergy domain. Genes Dev 9:1992-2006
8. Nalda AM, Martial JA, Muller M 1997 The glucocorticoid receptor inhibits the human prolactin gene expression by interference with Pit-1 activity. Mol Cell Endocrinol 134:129-137
9. Nowakowski BE, Maurer RA 1994 Multiple Pit-1-binding sites facilitate estrogen responsiveness of the prolactin gene. Mol Endocrinol 8:1742-1749
10. Lipkin SM, Naar AM, Kalla KA, Sack RA, Rosenfeld MG 1993 Identification of a novel zinc finger protein binding a conserved element critical for Pit-1-dependent growth hormone gene expression. Genes Dev 7:1674-1687
11. Aguirre A, Castro-Palomino N, De la Fuente J, Ovidio Castro FO 1998 Expression of human erythropoietin transgenes and of the endogenous WAP gene in the mammary gland of transgenic rabbits during gestation and lactation. Transgenic Res 7:311-317
12. Steinfelder HJ, Hauser P, Nakayama Y, Radovick S, McClaskey JH, Taylor T, Weintraub BD, Wondisford FE 1991 Thyrotropin-releasing hormone regulation of human TSHB expression: role of a pituitary-specific transcription factor (Pit-1/GHF-1) and potential interaction with a thyroid hormone-inhibitory element. Proc Natl Acad Sci USA 88:3130-3134
13. McCormick A, Brady H, Theill LE, Karin M 1990 Regulation of the pituitary-specific homeobox gene GHF1 by cell-autonomous and environmental cues. Nature 345:829-832
14. Jong MT, Raaka BM, Samuels HH 1994 A sequence in the rat Pit-1 gene promoter confers synergistic activation by glucocorticoids and protein kinase-C. Mol Endocrinol 8:1320-1327
15. Sanchez-Pacheco A, Palomino T, Aranda A 1995 Negative regulation of expression of the pituitary-specific transcription factor GHF-1/Pit-1 by thyroid hormones through interference with promoter enhancer elements. Mol Cell Biol 15:6322-6330
16. Delhase M, Castrillo JL, de la Hoya M, Rajas F, Hooghe-Peters EL 1996 AP-1 and Oct-1 transcription factors down-regulate the expression of the human PIT1/GHF1 gene. J Biol Chem 271:32349-32358
17. Kaji H, Canaff L, Lebrun JJ, Goltzman D, Hendy GN 2001 Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type β signaling. Proc Natl Acad Sci USA 98:3837-3842
18. Lacerte A, Lee EH, Reynaud R, Canaff L, De Guise C, Devost D, Ali S, Hendy GN, Lebrun JJ 2004 Activin inhibits pituitary prolactin expression and cell growth through Smads, Pit-1 and menin. Mol Endocrinol 18:1558-1569
19. Lebrun JJ, Chen Y, Vale WW 1997 Receptor serine kinases and signaling by activins and inhibins. In: Aono T, Sugino H, Vale WW, eds. Inhibin, activin and follistatin: regulatory functions in system and cell biology. New York: Springer-Verlag; 1-21
20. Massague J 1998 TGF-β signal transduction. Annu Rev Biochem 67:753-791
21. Nakamura T, Takio K, Eto Y, Shibai H, Titani K, Sugino H 1990 Activin-binding protein from rat ovary is follistatin. Science 247:836-838
22. Lebrun JJ, Takabe K, Chen Y, Vale W 1999 Roles of pathway-specific and inhibitory Smads in activin receptor signaling. Mol Endocrinol 13:15-23
23. Hartsough MT, Mulder KM 1997 Transforming growth factor-β signaling in epithelial cells. Pharmacol Ther 75:21-41
24. Frey RS, Mulder KM 1997 Involvement of extracellular signal-regulated kinase 2 and stress-activated protein kinase/Jun N-terminal kinase activation by transforming growth factor β in the negative growth control of breast cancer cells. Cancer Res 57:628-633
25. Engel ME, McDonnell MA, Law BK, Moses HL 1999 Interdependent SMAD and JNK signaling in transforming growth factor-β-mediated transcription. J Biol Chem 274:37413-37420
26. Hocevar BA, Brown TL, Howe PH 1999 TGF-β induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway. EMBO J 18:1345-1356
27. Cocolakis E, Lemay S, Ali S, Lebrun JJ 2001 The p38 MAPK pathway is required for cell growth inhibition of human breast cancer cells in response to activin. J Biol Chem 276:18430-18436
28. Hanafusa H, Ninomiya-Tsuji J, Masuyama N, Nishita M, Fujisawa J, Shibuya H, Matsumoto K, Nishida E 1999 Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-β-induced gene expression. J Biol Chem 274:27161-27167
29. Bakin AV, Tomlinson AK, Bhowmick NA, Moses HL, Arteaga CL 2000 Phosphatidylinositol-3 kinase function is required for TGFβ-mediated epithelial to mesenchymal transition and cell migration. J Biol Chem 275:36803-36810
30. Derynck R, Zhang YE 2003 Smad-dependent and Smad-independent pathways in TGF-β family signalling. Nature 425:577-584
31. Itoh S, Thorikay M, Kowanetz M, Moustakas A, Itoh F, Heldin CH, ten Dijke P 2003 Elucidation of Smad requirement in transforming growth factor-β type I receptor-induced responses. J Biol Chem 278:3751-3761
32. Keech CA, Gutierrez-Hartmann A 1989 Analysis of rat prolactin promoter sequences that mediate pituitary-specific and 3′,5′-cyclic adenosine monophosphate-regulated gene expression in vivo. Mol Endocrinol 3:832-839
33. Keech CA, Gutierrez-Hartmann A 1991 Insulin activation of rat prolactin promoter activity. Mol Cell Endocrinol 78:55-60
34. Tashjian Jr AH, Yasumura Y, Levine L, Sato GH, Parker ML 1968 Establishment of clonal strains of rat pituitary tumor cells that secrete growth hormone. Endocrinology 82:342-352
35. Chen RP, Ingraham HA, Treacy MN, Albert VR, Wilson L, Rosenfeld MG 1990 Autoregulation of pit-1 gene expression mediated by two cis-active promoter elements. Nature 346:583-586
36. McCormick A, Brady H, Fukushima J, Karin M 1991 The pituitary-specific regulatory gene GHF1 contains a minimal cell type-specific promoter centered around its TATA box. Genes Dev 5:1490-1503
37. Wrana JL, Attisano L, Carcamo J, Zentella A, Doody J, Laiho M, Wang XF, Massague J 1992 TGF β signals through a heteromeric protein kinase receptor complex. Cell 71:1003-1014
38. Liu X, Sun Y, Constantinescu SN, Karam E, Weinberg RA, Lodish HF 1997 Transforming growth factor β-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells. Proc Natl Acad Sci USA 94:10669-10674
39. Ishisaki A, Yamato K, Hashimoto S, Nakao A, Tamaki K, Nonaka K, ten Dijke P, Sugino H, Nishihara T 1999 Differential inhibition of Smad6 and Smad7 on bone morphogenetic protein- and activin-mediated growth arrest and apoptosis in B cells. J Biol Chem 274:13637-13642
40. Moustakas A, Souchelnytskyi S, Heldin CH 2001 Smad regulation in TGF-β signal transduction. J Cell Sci 114:4359-4369
41. Nakao A, Afrakhte M, Moren A, Nakayama T, Christian JL, Heuchel R, Itoh S, Kawabata M, Heldin NE, Heldin CH, ten Dijke P 1997 Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling. Nature 389:631-635
42. Matthay MA, Thiery JP, Lafont F, Stampfer F, Boyer B 1993 Transient effect of epidermal growth factor on the motility of an immortalized mammary epithelial cell line. J Cell Sci 106:869-878
43. Yakymovych I, Engstrom U, Grimsby S, Heldin CH, Souchelnytskyi S 2002 Inhibition of transforming growth factor-β signaling by low molecular weight compounds interfering with ATP- or substrate-binding sites of the TGFβ type I receptor kinase. Biochemistry 41:11000-11007
44. Yamada Y, Yamamoto H, Yonehara T, Kanasaki H, Nakanishi H, Miyamoto E, Miyazaki K 2004 Differential activation of the luteinizing hormone β-subunit promoter by activin and gonadotropin-releasing hormone: a role for the mitogen-activated protein kinase signaling pathway in LβT2 gonadotrophs. Biol Reprod 70:236-243
45. Safwat N, Ninomiya-Tsuji J, Gore AJ, Miller WL 2005 Transforming growth factor β-activated kinase 1 is a key mediator of ovine follicle-stimulating hormone β-subunit expression. Endocrinology 146:4814-4824