-
1
-
-
0032497842
-
The role of PI 3-kinase in insulin action
-
Alessi DR and Downes CP (1998) The role of PI 3-kinase in insulin action. Biochim Biophys Acta 1436:151-164.
-
(1998)
Biochim Biophys Acta
, vol.1436
, pp. 151-164
-
-
Alessi, D.R.1
Downes, C.P.2
-
2
-
-
0031036223
-
Protein-tyrosine phosphatase 1B complexes with the insulin receptor in vivo and is tyrosine-phosphorylated in the presence of insulin
-
Bandyopadhyay D, Kusari A, Kenner KA, Liu F, Chernoff J, Gustafson TA, and Kusari J (1997) Protein-tyrosine phosphatase 1B complexes with the insulin receptor in vivo and is tyrosine-phosphorylated in the presence of insulin. J Biol Chem 272:1639-1645.
-
(1997)
J Biol Chem
, vol.272
, pp. 1639-1645
-
-
Bandyopadhyay, D.1
Kusari, A.2
Kenner, K.A.3
Liu, F.4
Chernoff, J.5
Gustafson, T.A.6
Kusari, J.7
-
3
-
-
0033551070
-
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
-
Cantley LC and Neel BG (1999) New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc Natl Acad Sci USA 96:4240-4245.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 4240-4245
-
-
Cantley, L.C.1
Neel, B.G.2
-
5
-
-
33644513730
-
Beyond PTEN mutations: The PI3K pathway as an integrator of multiple inputs during tumorigenesis
-
Cully M, You H, Levine AJ, and Mak TW (2006) Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nat Rev Cancer 6:184-192.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 184-192
-
-
Cully, M.1
You, H.2
Levine, A.J.3
Mak, T.W.4
-
6
-
-
0033525870
-
Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene
-
Elchebly M, Payette P, Michaliszyn E, Cromlish W, Collins S, Loy AL, Normandin D, Cheng A, Himms-Hagen J, Chan CC, et al. (1999) Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science (Wash DC) 283:1544-1548.
-
(1999)
Science (Wash DC)
, vol.283
, pp. 1544-1548
-
-
Elchebly, M.1
Payette, P.2
Michaliszyn, E.3
Cromlish, W.4
Collins, S.5
Loy, A.L.6
Normandin, D.7
Cheng, A.8
Himms-Hagen, J.9
Chan, C.C.10
-
7
-
-
0037371765
-
Regulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTP
-
Galic S, Klingler-Hoffmann M, Fodero-Tavoletti MT, Puryer MA, Meng TC, Tonks NK, and Tiganis T (2003) Regulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTP. Mol Cell Biol 23:2096-2108.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 2096-2108
-
-
Galic, S.1
Klingler-Hoffmann, M.2
Fodero-Tavoletti, M.T.3
Puryer, M.A.4
Meng, T.C.5
Tonks, N.K.6
Tiganis, T.7
-
8
-
-
0031080770
-
Studies on menadione as an inhibitor of the cdc25 phosphatase
-
Ham SW, Park HJ, and Lim DH (1997) Studies on menadione as an inhibitor of the cdc25 phosphatase. Bioorg Chem 25:33-36.
-
(1997)
Bioorg Chem
, vol.25
, pp. 33-36
-
-
Ham, S.W.1
Park, H.J.2
Lim, D.H.3
-
9
-
-
0032558513
-
Naphthoquinone analogs as inactivators of cdc25 phosphatase
-
Ham SW, Park J, Lee SJ, Kim W, Kang K, and Choi KH (1998) Naphthoquinone analogs as inactivators of cdc25 phosphatase. Bioorg Med Chem Lett 8:2507-2510.
-
(1998)
Bioorg Med Chem Lett
, vol.8
, pp. 2507-2510
-
-
Ham, S.W.1
Park, J.2
Lee, S.J.3
Kim, W.4
Kang, K.5
Choi, K.H.6
-
10
-
-
0036671165
-
Beta-hydroxyisovalerylshikonin is a novel and potent inhibitor of protein tyrosine kinases
-
Hashimoto S, Xu Y, Masuda Y, Aiuchi T, Nakajo S, Uehara Y, Shibuya M, Yamori T, and Nakaya K (2002) Beta-hydroxyisovalerylshikonin is a novel and potent inhibitor of protein tyrosine kinases. Jpn J Cancer Res 93:944-951.
-
(2002)
Jpn J Cancer Res
, vol.93
, pp. 944-951
-
-
Hashimoto, S.1
Xu, Y.2
Masuda, Y.3
Aiuchi, T.4
Nakajo, S.5
Uehara, Y.6
Shibuya, M.7
Yamori, T.8
Nakaya, K.9
-
11
-
-
0031867464
-
Shikonin, an ingredient of Lithospermum erythrorhizon, inhibits angiogenesis in vivo and in vitro
-
Hisa T, Kimura Y, Takada K, Suzuki F, and Takigawa M (1998) Shikonin, an ingredient of Lithospermum erythrorhizon, inhibits angiogenesis in vivo and in vitro. Anticancer Res 18:783-790.
-
(1998)
Anticancer Res
, vol.18
, pp. 783-790
-
-
Hisa, T.1
Kimura, Y.2
Takada, K.3
Suzuki, F.4
Takigawa, M.5
-
12
-
-
0036086005
-
Shikonin stimulates glucose uptake in 3T3-L1 adipocytes via an insulin-independent tyrosine kinase pathway
-
Kamei R, Kitagawa Y, Kadokura M, Hattori F, Hazeki O, Ebina Y, Nishihara T, and Oikawa S (2002) Shikonin stimulates glucose uptake in 3T3-L1 adipocytes via an insulin-independent tyrosine kinase pathway. Biochem Biophys Res Commun 292:642-651.
-
(2002)
Biochem Biophys Res Commun
, vol.292
, pp. 642-651
-
-
Kamei, R.1
Kitagawa, Y.2
Kadokura, M.3
Hattori, F.4
Hazeki, O.5
Ebina, Y.6
Nishihara, T.7
Oikawa, S.8
-
13
-
-
0029026147
-
Thioalkyl derivatives of vitamin K3 and vitamin K3 oxide inhibit growth of Hep3B and HepG2 cells
-
Kerns J, Naganathan S, Dowd P, Finn FM, and Carr B (1995) Thioalkyl derivatives of vitamin K3 and vitamin K3 oxide inhibit growth of Hep3B and HepG2 cells. Bioorg Chem 23:101-108.
-
(1995)
Bioorg Chem
, vol.23
, pp. 101-108
-
-
Kerns, J.1
Naganathan, S.2
Dowd, P.3
Finn, F.M.4
Carr, B.5
-
14
-
-
0033942614
-
Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice
-
Klaman LD, Boss O, Peroni OD, Kim JK, Martino JL, Zabolotny JM, Moghal N, Lubkin M, Kim YB, Sharpe AH, et al. (2000) Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice. Mol Cell Biol 20:5479-5489.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 5479-5489
-
-
Klaman, L.D.1
Boss, O.2
Peroni, O.D.3
Kim, J.K.4
Martino, J.L.5
Zabolotny, J.M.6
Moghal, N.7
Lubkin, M.8
Kim, Y.B.9
Sharpe, A.H.10
-
15
-
-
0029908016
-
Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation
-
Kohn AD, Summers SA, Birnbaum MJ, and Roth RA (1996) Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation. J Biol Chem 271:31372-31378.
-
(1996)
J Biol Chem
, vol.271
, pp. 31372-31378
-
-
Kohn, A.D.1
Summers, S.A.2
Birnbaum, M.J.3
Roth, R.A.4
-
16
-
-
29644446699
-
Specific role for p85/p110beta in GTP-binding-protein-mediated activation of Akt
-
Kubo H, Hazeki K, Takasuga S, and Hazeki O (2005) Specific role for p85/p110beta in GTP-binding-protein-mediated activation of Akt. Biochem J 392:607-614.
-
(2005)
Biochem J
, vol.392
, pp. 607-614
-
-
Kubo, H.1
Hazeki, K.2
Takasuga, S.3
Hazeki, O.4
-
17
-
-
15744384803
-
Interaction of the insulin receptor with the receptor-like protein tyrosine phosphatases PTPα and PTPε in living cells
-
Lacasa D, Boute N, and Issad T (2005) Interaction of the insulin receptor with the receptor-like protein tyrosine phosphatases PTPα and PTPε in living cells. Mol Pharmacol 67:1206-1213.
-
(2005)
Mol Pharmacol
, vol.67
, pp. 1206-1213
-
-
Lacasa, D.1
Boute, N.2
Issad, T.3
-
18
-
-
0033615538
-
Crystal structure of the PTEN tumor suppressor: Implications for its phosphoinositide phosphatase activity and membrane association
-
Lee JO, Yang H, Georgescu MM, Di Cristofano A, Maehama T, Shi Y, Dixon JE, Pandolfi P, and Pavletich NP (1999) Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell 99:323-334.
-
(1999)
Cell
, vol.99
, pp. 323-334
-
-
Lee, J.O.1
Yang, H.2
Georgescu, M.M.3
Di Cristofano, A.4
Maehama, T.5
Shi, Y.6
Dixon, J.E.7
Pandolfi, P.8
Pavletich, N.P.9
-
19
-
-
0032577699
-
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
-
Maehama T and Dixon JE (1998) The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 273:13375-13378.
-
(1998)
J Biol Chem
, vol.273
, pp. 13375-13378
-
-
Maehama, T.1
Dixon, J.E.2
-
21
-
-
0029117217
-
Selective down-regulation of the insulin receptor signal by protein-tyrosine phosphatases α and ε
-
Moller NP, Moller KB, Lammers R, Kharitonenkov A, Hoppe E, Wiberg FC, Sures I, and Ullrich A (1995) Selective down-regulation of the insulin receptor signal by protein-tyrosine phosphatases α and ε. J Biol Chem 270:23126-23131.
-
(1995)
J Biol Chem
, vol.270
, pp. 23126-23131
-
-
Moller, N.P.1
Moller, K.B.2
Lammers, R.3
Kharitonenkov, A.4
Hoppe, E.5
Wiberg, F.C.6
Sures, I.7
Ullrich, A.8
-
22
-
-
0034724747
-
The tumor suppressor PTEN negatively regulates insulin signaling in 3T3-L1 adipocytes
-
Nakashima N, Sharma PM, Imamura T, Bookstein R, and Olefsky JM (2000) The tumor suppressor PTEN negatively regulates insulin signaling in 3T3-L1 adipocytes. J Biol Chem 275:12889-12895.
-
(2000)
J Biol Chem
, vol.275
, pp. 12889-12895
-
-
Nakashima, N.1
Sharma, P.M.2
Imamura, T.3
Bookstein, R.4
Olefsky, J.M.5
-
23
-
-
0032540331
-
Cell growth inhibition by a novel vitamin K is associated with induction of protein tyrosine phosphorylation
-
Ni R, Nishikawa Y, and Carr BI (1998) Cell growth inhibition by a novel vitamin K is associated with induction of protein tyrosine phosphorylation. J Biol Chem 273:9906-9911.
-
(1998)
J Biol Chem
, vol.273
, pp. 9906-9911
-
-
Ni, R.1
Nishikawa, Y.2
Carr, B.I.3
-
24
-
-
17844371042
-
Regulation of phosphoinositide metabolism, Akt phosphorylation, and glucose transport by PTEN (phosphatase and tensin homolog deleted on chromosome 10) in 3T3-L1 adipocytes
-
Ono H, Katagiri H, Funaki M, Anai M, Inukai K, Fukushima Y, Sakoda H, Ogihara T, Onishi Y, Fujishiro M, et al. (2001) Regulation of phosphoinositide metabolism, Akt phosphorylation, and glucose transport by PTEN (phosphatase and tensin homolog deleted on chromosome 10) in 3T3-L1 adipocytes. Mol Endocrinol 15:1411-1422.
-
(2001)
Mol Endocrinol
, vol.15
, pp. 1411-1422
-
-
Ono, H.1
Katagiri, H.2
Funaki, M.3
Anai, M.4
Inukai, K.5
Fukushima, Y.6
Sakoda, H.7
Ogihara, T.8
Onishi, Y.9
Fujishiro, M.10
-
25
-
-
0033084064
-
The chemistry and biology of alkannin, shikonin, and related naphthazarin natural products
-
Papageorgiou VP, Assimopoulou AN, Couladouros EA, Hepworth D, and Nicolaou KC (1999) The chemistry and biology of alkannin, shikonin, and related naphthazarin natural products. Angewandte Chem Int Ed 38:270-301.
-
(1999)
Angewandte Chem Int Ed
, vol.38
, pp. 270-301
-
-
Papageorgiou, V.P.1
Assimopoulou, A.N.2
Couladouros, E.A.3
Hepworth, D.4
Nicolaou, K.C.5
-
26
-
-
0034507958
-
Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B
-
Salmeen A, Andersen JN, Myers MP, Tonks NK, and Barford D (2000) Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B. Mol Cell 6:1401-1412.
-
(2000)
Mol Cell
, vol.6
, pp. 1401-1412
-
-
Salmeen, A.1
Andersen, J.N.2
Myers, M.P.3
Tonks, N.K.4
Barford, D.5
-
27
-
-
0017697921
-
Antitumor activity of shikonin and its derivatives
-
Sankawa U, Ebizuka Y, Miyazaki T, Isomura Y, and Otsuka H (1977) Antitumor activity of shikonin and its derivatives. Chem Pharm Bull (Tokyo) 25:2392-2395.
-
(1977)
Chem Pharm Bull (Tokyo)
, vol.25
, pp. 2392-2395
-
-
Sankawa, U.1
Ebizuka, Y.2
Miyazaki, T.3
Isomura, Y.4
Otsuka, H.5
-
29
-
-
1242339613
-
Shikonins, phytocompounds from Lithospermum erythrorhizon, inhibit the transcriptional activation of human tumor necrosis factor α promoter in vivo
-
Staniforth V, Wang SY, Shyur LF, and Yang NS (2004) Shikonins, phytocompounds from Lithospermum erythrorhizon, inhibit the transcriptional activation of human tumor necrosis factor α promoter in vivo. J Biol Chem 279:5877-5885.
-
(2004)
J Biol Chem
, vol.279
, pp. 5877-5885
-
-
Staniforth, V.1
Wang, S.Y.2
Shyur, L.F.3
Yang, N.S.4
-
30
-
-
0033538526
-
Enhancement by adenosine of insulin-induced activation of phosphoinositide 3-kinase and protein kinase B in rat adipocytes
-
Takasuga S, Katada T, Ui M, and Hazeki O (1999) Enhancement by adenosine of insulin-induced activation of phosphoinositide 3-kinase and protein kinase B in rat adipocytes. J Biol Chem 274:19545-19550.
-
(1999)
J Biol Chem
, vol.274
, pp. 19545-19550
-
-
Takasuga, S.1
Katada, T.2
Ui, M.3
Hazeki, O.4
-
31
-
-
0022450008
-
A comparative study on anti-inflammatory activities of the enantiomers, shikonin and alkannin
-
Tanaka S, Tajima M, Tsukada M, and Tabata M (1986) A comparative study on anti-inflammatory activities of the enantiomers, shikonin and alkannin. J Nat Prod 49:466-469.
-
(1986)
J Nat Prod
, vol.49
, pp. 466-469
-
-
Tanaka, S.1
Tajima, M.2
Tsukada, M.3
Tabata, M.4
-
32
-
-
0035942509
-
Potent reversible inhibitors of the protein tyrosine phosphatase CD45
-
Urbanek RA, Suchard SJ, Steelman GB, Knappenberger KS, Sygowski LA, Veale CA, and Chapdelaine MJ (2001) Potent reversible inhibitors of the protein tyrosine phosphatase CD45. J Med Chem 44:1777-1793.
-
(2001)
J Med Chem
, vol.44
, pp. 1777-1793
-
-
Urbanek, R.A.1
Suchard, S.J.2
Steelman, G.B.3
Knappenberger, K.S.4
Sygowski, L.A.5
Veale, C.A.6
Chapdelaine, M.J.7
-
33
-
-
0039619868
-
Identification of tyrosine phosphatases that dephosphorylate the insulin receptor. A brute force approach based on "substrate-trapping" mutants
-
Wälchli S, Curchod M-L, Gobert RP, Arkinstall S, and van Huijsduijnen RH (2000) Identification of tyrosine phosphatases that dephosphorylate the insulin receptor. A brute force approach based on "substrate-trapping" mutants. J Biol Chem 275:9792-9796.
-
(2000)
J Biol Chem
, vol.275
, pp. 9792-9796
-
-
Wälchli, S.1
Curchod, M.-L.2
Gobert, R.P.3
Arkinstall, S.4
Van Huijsduijnen, R.H.5
-
34
-
-
0030957863
-
Impairment of phosphatidylinositol signaling in acetylshikonin-treated neutrophils
-
Wang JP and Kuo SC (1997) Impairment of phosphatidylinositol signaling in acetylshikonin-treated neutrophils. Biochem Pharmacol 53:1173-1177.
-
(1997)
Biochem Pharmacol
, vol.53
, pp. 1173-1177
-
-
Wang, J.P.1
Kuo, S.C.2
-
35
-
-
0030949165
-
Investigation of the inhibition by acetylshikonin of the respiratory burst in rat neutrophils
-
Wang JP, Tsao LT, Raung SL, Hsu MF, and Kuo SC (1997) Investigation of the inhibition by acetylshikonin of the respiratory burst in rat neutrophils. Br J Pharmacol 121:409-416.
-
(1997)
Br J Pharmacol
, vol.121
, pp. 409-416
-
-
Wang, J.P.1
Tsao, L.T.2
Raung, S.L.3
Hsu, M.F.4
Kuo, S.C.5
-
36
-
-
0028227732
-
Suicide inactivation of human prostatic acid phosphatase and a phosphotyrosine phosphatase
-
Wang Q, Dechert U, Jirik F, and Withers SG (1994) Suicide inactivation of human prostatic acid phosphatase and a phosphotyrosine phosphatase. Biochem Biophys Res Commun 200:577-583.
-
(1994)
Biochem Biophys Res Commun
, vol.200
, pp. 577-583
-
-
Wang, Q.1
Dechert, U.2
Jirik, F.3
Withers, S.G.4
-
37
-
-
0032497832
-
Structure and function of phosphoinositide 3-kinases
-
Wymann MP and Pirola L (1998) Structure and function of phosphoinositide 3-kinases. Biochim Biophys Acta 1436:127-150.
-
(1998)
Biochim Biophys Acta
, vol.1436
, pp. 127-150
-
-
Wymann, M.P.1
Pirola, L.2
|