메뉴 건너뛰기




Volumn 70, Issue 3, 2006, Pages 1143-1149

A naphthoquinone derivative, shikonin, has insulin-like actions by inhibiting both phosphatase and tensin homolog deleted on chromosome 10 and tyrosine phosphatases

Author keywords

[No Author keywords available]

Indexed keywords

1,2 NAPHTHOQUINONE; 1,4 NAPHTHOQUINONE DERIVATIVE; 2 MORPHOLINO 8 PHENYLCHROMONE; INSULIN; INSULIN RECEPTOR; NAPHTHOQUINONE; PERVANADATE; PHOSPHATASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; RECOMBINANT PHOSPHATASE AND TENSIN HOMOLOG DELETED ON CHROMOSOME 10; SHIKONIN; TYROSINE PHOSPHATASE; UNCLASSIFIED DRUG;

EID: 33747590757     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.106.025809     Document Type: Article
Times cited : (35)

References (37)
  • 1
    • 0032497842 scopus 로고    scopus 로고
    • The role of PI 3-kinase in insulin action
    • Alessi DR and Downes CP (1998) The role of PI 3-kinase in insulin action. Biochim Biophys Acta 1436:151-164.
    • (1998) Biochim Biophys Acta , vol.1436 , pp. 151-164
    • Alessi, D.R.1    Downes, C.P.2
  • 2
    • 0031036223 scopus 로고    scopus 로고
    • Protein-tyrosine phosphatase 1B complexes with the insulin receptor in vivo and is tyrosine-phosphorylated in the presence of insulin
    • Bandyopadhyay D, Kusari A, Kenner KA, Liu F, Chernoff J, Gustafson TA, and Kusari J (1997) Protein-tyrosine phosphatase 1B complexes with the insulin receptor in vivo and is tyrosine-phosphorylated in the presence of insulin. J Biol Chem 272:1639-1645.
    • (1997) J Biol Chem , vol.272 , pp. 1639-1645
    • Bandyopadhyay, D.1    Kusari, A.2    Kenner, K.A.3    Liu, F.4    Chernoff, J.5    Gustafson, T.A.6    Kusari, J.7
  • 3
    • 0033551070 scopus 로고    scopus 로고
    • New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
    • Cantley LC and Neel BG (1999) New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc Natl Acad Sci USA 96:4240-4245.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 4240-4245
    • Cantley, L.C.1    Neel, B.G.2
  • 4
    • 0035990608 scopus 로고    scopus 로고
    • Cellular pharmacology studies of shikonin derivatives
    • Chen X, Yang L, Oppenheim JJ, and Howard MZ (2002) Cellular pharmacology studies of shikonin derivatives. Phytother Res 16:199-209.
    • (2002) Phytother Res , vol.16 , pp. 199-209
    • Chen, X.1    Yang, L.2    Oppenheim, J.J.3    Howard, M.Z.4
  • 5
    • 33644513730 scopus 로고    scopus 로고
    • Beyond PTEN mutations: The PI3K pathway as an integrator of multiple inputs during tumorigenesis
    • Cully M, You H, Levine AJ, and Mak TW (2006) Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nat Rev Cancer 6:184-192.
    • (2006) Nat Rev Cancer , vol.6 , pp. 184-192
    • Cully, M.1    You, H.2    Levine, A.J.3    Mak, T.W.4
  • 8
    • 0031080770 scopus 로고    scopus 로고
    • Studies on menadione as an inhibitor of the cdc25 phosphatase
    • Ham SW, Park HJ, and Lim DH (1997) Studies on menadione as an inhibitor of the cdc25 phosphatase. Bioorg Chem 25:33-36.
    • (1997) Bioorg Chem , vol.25 , pp. 33-36
    • Ham, S.W.1    Park, H.J.2    Lim, D.H.3
  • 11
    • 0031867464 scopus 로고    scopus 로고
    • Shikonin, an ingredient of Lithospermum erythrorhizon, inhibits angiogenesis in vivo and in vitro
    • Hisa T, Kimura Y, Takada K, Suzuki F, and Takigawa M (1998) Shikonin, an ingredient of Lithospermum erythrorhizon, inhibits angiogenesis in vivo and in vitro. Anticancer Res 18:783-790.
    • (1998) Anticancer Res , vol.18 , pp. 783-790
    • Hisa, T.1    Kimura, Y.2    Takada, K.3    Suzuki, F.4    Takigawa, M.5
  • 13
    • 0029026147 scopus 로고
    • Thioalkyl derivatives of vitamin K3 and vitamin K3 oxide inhibit growth of Hep3B and HepG2 cells
    • Kerns J, Naganathan S, Dowd P, Finn FM, and Carr B (1995) Thioalkyl derivatives of vitamin K3 and vitamin K3 oxide inhibit growth of Hep3B and HepG2 cells. Bioorg Chem 23:101-108.
    • (1995) Bioorg Chem , vol.23 , pp. 101-108
    • Kerns, J.1    Naganathan, S.2    Dowd, P.3    Finn, F.M.4    Carr, B.5
  • 15
    • 0029908016 scopus 로고    scopus 로고
    • Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation
    • Kohn AD, Summers SA, Birnbaum MJ, and Roth RA (1996) Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation. J Biol Chem 271:31372-31378.
    • (1996) J Biol Chem , vol.271 , pp. 31372-31378
    • Kohn, A.D.1    Summers, S.A.2    Birnbaum, M.J.3    Roth, R.A.4
  • 16
    • 29644446699 scopus 로고    scopus 로고
    • Specific role for p85/p110beta in GTP-binding-protein-mediated activation of Akt
    • Kubo H, Hazeki K, Takasuga S, and Hazeki O (2005) Specific role for p85/p110beta in GTP-binding-protein-mediated activation of Akt. Biochem J 392:607-614.
    • (2005) Biochem J , vol.392 , pp. 607-614
    • Kubo, H.1    Hazeki, K.2    Takasuga, S.3    Hazeki, O.4
  • 17
    • 15744384803 scopus 로고    scopus 로고
    • Interaction of the insulin receptor with the receptor-like protein tyrosine phosphatases PTPα and PTPε in living cells
    • Lacasa D, Boute N, and Issad T (2005) Interaction of the insulin receptor with the receptor-like protein tyrosine phosphatases PTPα and PTPε in living cells. Mol Pharmacol 67:1206-1213.
    • (2005) Mol Pharmacol , vol.67 , pp. 1206-1213
    • Lacasa, D.1    Boute, N.2    Issad, T.3
  • 18
    • 0033615538 scopus 로고    scopus 로고
    • Crystal structure of the PTEN tumor suppressor: Implications for its phosphoinositide phosphatase activity and membrane association
    • Lee JO, Yang H, Georgescu MM, Di Cristofano A, Maehama T, Shi Y, Dixon JE, Pandolfi P, and Pavletich NP (1999) Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell 99:323-334.
    • (1999) Cell , vol.99 , pp. 323-334
    • Lee, J.O.1    Yang, H.2    Georgescu, M.M.3    Di Cristofano, A.4    Maehama, T.5    Shi, Y.6    Dixon, J.E.7    Pandolfi, P.8    Pavletich, N.P.9
  • 19
    • 0032577699 scopus 로고    scopus 로고
    • The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
    • Maehama T and Dixon JE (1998) The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 273:13375-13378.
    • (1998) J Biol Chem , vol.273 , pp. 13375-13378
    • Maehama, T.1    Dixon, J.E.2
  • 20
  • 22
    • 0034724747 scopus 로고    scopus 로고
    • The tumor suppressor PTEN negatively regulates insulin signaling in 3T3-L1 adipocytes
    • Nakashima N, Sharma PM, Imamura T, Bookstein R, and Olefsky JM (2000) The tumor suppressor PTEN negatively regulates insulin signaling in 3T3-L1 adipocytes. J Biol Chem 275:12889-12895.
    • (2000) J Biol Chem , vol.275 , pp. 12889-12895
    • Nakashima, N.1    Sharma, P.M.2    Imamura, T.3    Bookstein, R.4    Olefsky, J.M.5
  • 23
    • 0032540331 scopus 로고    scopus 로고
    • Cell growth inhibition by a novel vitamin K is associated with induction of protein tyrosine phosphorylation
    • Ni R, Nishikawa Y, and Carr BI (1998) Cell growth inhibition by a novel vitamin K is associated with induction of protein tyrosine phosphorylation. J Biol Chem 273:9906-9911.
    • (1998) J Biol Chem , vol.273 , pp. 9906-9911
    • Ni, R.1    Nishikawa, Y.2    Carr, B.I.3
  • 24
    • 17844371042 scopus 로고    scopus 로고
    • Regulation of phosphoinositide metabolism, Akt phosphorylation, and glucose transport by PTEN (phosphatase and tensin homolog deleted on chromosome 10) in 3T3-L1 adipocytes
    • Ono H, Katagiri H, Funaki M, Anai M, Inukai K, Fukushima Y, Sakoda H, Ogihara T, Onishi Y, Fujishiro M, et al. (2001) Regulation of phosphoinositide metabolism, Akt phosphorylation, and glucose transport by PTEN (phosphatase and tensin homolog deleted on chromosome 10) in 3T3-L1 adipocytes. Mol Endocrinol 15:1411-1422.
    • (2001) Mol Endocrinol , vol.15 , pp. 1411-1422
    • Ono, H.1    Katagiri, H.2    Funaki, M.3    Anai, M.4    Inukai, K.5    Fukushima, Y.6    Sakoda, H.7    Ogihara, T.8    Onishi, Y.9    Fujishiro, M.10
  • 26
    • 0034507958 scopus 로고    scopus 로고
    • Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B
    • Salmeen A, Andersen JN, Myers MP, Tonks NK, and Barford D (2000) Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B. Mol Cell 6:1401-1412.
    • (2000) Mol Cell , vol.6 , pp. 1401-1412
    • Salmeen, A.1    Andersen, J.N.2    Myers, M.P.3    Tonks, N.K.4    Barford, D.5
  • 28
    • 2442601508 scopus 로고    scopus 로고
    • Bisperoxovanadium compounds are potent PTEN inhibitors
    • Schmid AC, Byrne RD, Vilar R, and Woscholski R (2004) Bisperoxovanadium compounds are potent PTEN inhibitors. FEBS Lett 566:35-38.
    • (2004) FEBS Lett , vol.566 , pp. 35-38
    • Schmid, A.C.1    Byrne, R.D.2    Vilar, R.3    Woscholski, R.4
  • 29
    • 1242339613 scopus 로고    scopus 로고
    • Shikonins, phytocompounds from Lithospermum erythrorhizon, inhibit the transcriptional activation of human tumor necrosis factor α promoter in vivo
    • Staniforth V, Wang SY, Shyur LF, and Yang NS (2004) Shikonins, phytocompounds from Lithospermum erythrorhizon, inhibit the transcriptional activation of human tumor necrosis factor α promoter in vivo. J Biol Chem 279:5877-5885.
    • (2004) J Biol Chem , vol.279 , pp. 5877-5885
    • Staniforth, V.1    Wang, S.Y.2    Shyur, L.F.3    Yang, N.S.4
  • 30
    • 0033538526 scopus 로고    scopus 로고
    • Enhancement by adenosine of insulin-induced activation of phosphoinositide 3-kinase and protein kinase B in rat adipocytes
    • Takasuga S, Katada T, Ui M, and Hazeki O (1999) Enhancement by adenosine of insulin-induced activation of phosphoinositide 3-kinase and protein kinase B in rat adipocytes. J Biol Chem 274:19545-19550.
    • (1999) J Biol Chem , vol.274 , pp. 19545-19550
    • Takasuga, S.1    Katada, T.2    Ui, M.3    Hazeki, O.4
  • 31
    • 0022450008 scopus 로고
    • A comparative study on anti-inflammatory activities of the enantiomers, shikonin and alkannin
    • Tanaka S, Tajima M, Tsukada M, and Tabata M (1986) A comparative study on anti-inflammatory activities of the enantiomers, shikonin and alkannin. J Nat Prod 49:466-469.
    • (1986) J Nat Prod , vol.49 , pp. 466-469
    • Tanaka, S.1    Tajima, M.2    Tsukada, M.3    Tabata, M.4
  • 33
    • 0039619868 scopus 로고    scopus 로고
    • Identification of tyrosine phosphatases that dephosphorylate the insulin receptor. A brute force approach based on "substrate-trapping" mutants
    • Wälchli S, Curchod M-L, Gobert RP, Arkinstall S, and van Huijsduijnen RH (2000) Identification of tyrosine phosphatases that dephosphorylate the insulin receptor. A brute force approach based on "substrate-trapping" mutants. J Biol Chem 275:9792-9796.
    • (2000) J Biol Chem , vol.275 , pp. 9792-9796
    • Wälchli, S.1    Curchod, M.-L.2    Gobert, R.P.3    Arkinstall, S.4    Van Huijsduijnen, R.H.5
  • 34
    • 0030957863 scopus 로고    scopus 로고
    • Impairment of phosphatidylinositol signaling in acetylshikonin-treated neutrophils
    • Wang JP and Kuo SC (1997) Impairment of phosphatidylinositol signaling in acetylshikonin-treated neutrophils. Biochem Pharmacol 53:1173-1177.
    • (1997) Biochem Pharmacol , vol.53 , pp. 1173-1177
    • Wang, J.P.1    Kuo, S.C.2
  • 35
    • 0030949165 scopus 로고    scopus 로고
    • Investigation of the inhibition by acetylshikonin of the respiratory burst in rat neutrophils
    • Wang JP, Tsao LT, Raung SL, Hsu MF, and Kuo SC (1997) Investigation of the inhibition by acetylshikonin of the respiratory burst in rat neutrophils. Br J Pharmacol 121:409-416.
    • (1997) Br J Pharmacol , vol.121 , pp. 409-416
    • Wang, J.P.1    Tsao, L.T.2    Raung, S.L.3    Hsu, M.F.4    Kuo, S.C.5
  • 36
    • 0028227732 scopus 로고
    • Suicide inactivation of human prostatic acid phosphatase and a phosphotyrosine phosphatase
    • Wang Q, Dechert U, Jirik F, and Withers SG (1994) Suicide inactivation of human prostatic acid phosphatase and a phosphotyrosine phosphatase. Biochem Biophys Res Commun 200:577-583.
    • (1994) Biochem Biophys Res Commun , vol.200 , pp. 577-583
    • Wang, Q.1    Dechert, U.2    Jirik, F.3    Withers, S.G.4
  • 37
    • 0032497832 scopus 로고    scopus 로고
    • Structure and function of phosphoinositide 3-kinases
    • Wymann MP and Pirola L (1998) Structure and function of phosphoinositide 3-kinases. Biochim Biophys Acta 1436:127-150.
    • (1998) Biochim Biophys Acta , vol.1436 , pp. 127-150
    • Wymann, M.P.1    Pirola, L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.