CCR5 usage by CCL5 induces a selective leukocyte recruitment in human skin xenografts In vivo

Journal of Investigative Dermatology

Volumn 126, Issue 9, 2006, Pages 2057-2064

  De Nadaï, Patricia ^a   Chenivesse, Cécile ^a   Gilet, Jules ^a   Porte, Henri ^b   Vorng, Han ^a   Chang, Ying ^a,c   Walls, Andrew F ^d   Wallaert, Benoît ^a,b   Tonnel, André Bernard ^a,b   Tsicopoulos, Anne ^a,b   Zerwes, Hans Günter ^e  

^a INSTITUT PASTEUR DE LILLE   (France)

^b UNIV LILLE   (France)

^c JILIN UNIVERSITY   (China)

^d SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

^e NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BLOCKING ANTIBODY; CHEMOKINE RECEPTOR ANTAGONIST; CHEMOKINE RECEPTOR CCR5; GAMMA INTERFERON; INTERLEUKIN 4; INTERLEUKIN 5; MONOCLONAL ANTIBODY; RANTES;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EOSINOPHIL; EVALUATION; HUMAN; HUMAN CELL; HUMAN TISSUE; LEUKOCYTE TRANSFUSION; MACROPHAGE; MEMORY T LYMPHOCYTE; MONOCYTE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SCID MOUSE; TH1 CELL; XENOGRAFT;

EID: 33747360962     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/sj.jid.5700369     Document Type: Article

References (55)

1. Algood HM, Flynn JL (2004) CCR5-deficient mice control Mycobacterium tuberculosis infection despite increased pulmonary lymphocytic infiltration. J Immunol 173:3287-96
2. Amano H, Bickerstaff A, Orosz CG, Novick AC, Toma H, Fairchild RL (2005) Absence of recipient CCR5 promotes early and increased allospecific antibody responses to cardiac allografts. J Immunol 174:6499-508
3. Appay V, Rowland-Jones SL (2001) RANTES: a versatile and controversial chemokine. Trends Immunol 22:83-7
4. Beck LA, Dalke S, Leiferman KM, Bickel CA, Hamilton R, Rosen H et al. (1997) Cutaneous injection of RANTES causes eosinophil recruitment: comparison of nonallergic and allergic human subjects. J Immunol 159:2962-72
5. Berger EA, Murphy PM, Farber JM (1999) Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease. Annu Rev Immunol 17:657-700
6. Blanpain C, Buser R, Power CA, Edgerton M, Buchanan C, Mack M et al. (2001) A chimeric MIP-1alpha/RANTES protein demonstrates the use of different regions of the RANTES protein to bind and activate its receptors. J Leukocyte Biol 69:977-85
7. Blanpain C, Libert F, Vassart G, Parmentier M (2002) CCR5 and HIV infection. Receptors Channels 8:19-31
8. Bonecchi R, Bianchi G, Bordignon PP, D'Ambrosio D, Lang R, Borsatti A et al. (1998) Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. J Exp Med 187:129-34
9. Chen Z, Yu S, Bakhiet M, Winblad B, Zhu J (2003) The chemokine receptor CCR5 is not a necessary inflammatory mediator in kainic acid-induced hippocampal injury: evidence for a compensatory effect by increased CCR2 and CCR3. J Neurochem 86:61-8
10. Christofidou-Solomidou M, Albelda SM, Bennett FC, Murphy GF (1997a) Experimental production and modulation of human cytotoxic dermatitis in human-murine chimeras. Am J Pathol 150:631-9
11. Christofidou-Solomidou M, Longley BJ, Whitaker-Menezes D, Albelda SM, Murphy GF (1997b) Human skin/SCID mouse chimeras as an in vivo model for human cutaneous mast cell hyperplasia. J Invest Dermatol 109:102-7
12. Christofidou-Solomidou M, Murphy GF, Albelda SM (1996) Induction of E-selectin-dependent leukocyte recruitment by mast cell degranulation in human skin grafts transplanted on SCID mice. Am J Pathol 148:177-88
13. Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P (1995) Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells. Science 270:1811-5
14. D'Amico G, Frascaroli G, Bianchi G, Transidico P, Doni A, Vecchi A et al. (2000) Uncoupling of inflammatory chemokine receptors by IL-10: generation of functional decoys. Nat Immunol 1:387-91
15. Fahy O, Porte H, Senechal S, Vorng H, McEuen AR, Buckley MG et al. (2001) Chemokine-induced cutaneous inflammatory cell infiltration in a model of Hu-PBMC-SCID mice grafted with human skin. Am J Pathol 158:1053-63
16. Fahy O, Tsicopoulos A, Hammad H, Pestel J, Tonnel AB, Wallaert B (1999) Effects of diesel organic extracts on chemokine production by peripheral blood mononuclear cells. J Allergy Clin Immunol 103:1115-24
17. Field J, Marshall ACJ, Hertzog P, Wells TN, Alderuccio F, Toh BH (2003) Chemokine receptor CCR5 is not required for development of experimental autoimmune gastritis. Clin Immunol 109:238-47
18. Filley WV, Ackerman SJ, Gleich GJ (1981) An immunofluorescent method for specific staining of eosinophil granule major basic protein. J Immunol Methods 47:227-38
19. Gilhar A, David M, Ullmann Y, Berkutski T, Kalish RS (1997) T-lymphocyte dependence of psoriatic pathology in human psoriatic skin grafted to SCID mice. J Invest Dermatol 109:283-8
20. Hadida F, Vieillard V, Autran B, Clark-Lewis I, Baggiolini M, Debre P (1998) HIV-specific T cell cytotoxicity mediated by RANTES via the chemokine receptor CCR3. J Exp Med 188:609-14
21. He J, Chen Y, Farzan M, Choe H, Ohagen A, Gartner S et al. (1997) CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia. Nature 385:645-9
22. Hellier S, Frodsham AJ, Hennig BJ, Klenerman P, Knapp S, Ramaley P et al. (2003) Association of genetic variants of the chemokine receptor CCR5 and its ligands, RANTES and MCP-2, with outcome of HCV infection. Hepatology 38:1468-76
23. Juhasz I, Murphy GF, Yan HC, Herlyn M, Albelda SM (1993) Regulation of extracellular matrix proteins and integrin cell substratum adhesion receptors on epithelium during cutaneous human wound healing in vivo. Am J Pathol 143:1458-69
24. Lee B, Sharron M, Blanpain C, Doranz BJ, Vakili J, Setoh P et al. (1999) Epitope mapping of CCR5 reveals multiple conformational states and distinct but overlapping structures involved in chemokine and coreceptor function. J Biol Chem 274:9617-26
25. Liang M, Rosser M, Ng HP, May K, Bauman JG, Islam I et al. (2000) Species selectivity of a small molecule antagonist for the CCR1 chemokine receptor. Eur J Pharmacol 389:41-9
26. Lloyd CM, Delaney T, Nguyen T, Tian J, Martinez-A C, Coyle AJ et al. (2000) CC chemokine receptor (CCR)3/eotaxin is followed by CCR4/monocyte-derived chemokine in mediating pulmonary T helper lymphocyte type 2 recruitment after serial antigen challenge in vivo. J Exp Med 191:265-74
27. Luckow B, Joergensen J, Chilla S, Li JP, Henger A, Kiss E et al. (2004) Reduced intragraft mRNA expression of matrix metalloproteinases Mmp3, Mmp12, Mmp13 and Adam8, and diminished transplant arteriosclerosis in Ccr5-deficient mice. Eur J Immunol 34:2568-78
28. McEuen AR, Buckley MG, Compton SJ, Walls AF (1999) Development and characterization of a monoclonal antibody specific for human basophils and the identification of a unique secretory product of basophil activation. Lab Invest 79:27-38
29. Mueller A, Strange PG (2004) The chemokine receptor, CCR5. Int J Biochem Cell Biol 36:35-8
30. Murphy PM (2001) Viral exploitation and subversion of the immune system through chemokine mimicry. Nat Immunol 2:116-22
31. Murray AG, Petzelbauer P, Hughes CC, Costa J, Askenase P, Pober JS (1994) Human T-cell-mediated destruction of allogeneic dermal microvessels in a severe combined immunodeficient mouse. Proc Natl Acad Sci USA 91:9146-50
32. Nickoloff BJ, Kunkel SL, Burdick M, Strieter RM (1995) Severe combined immunodeficiency mouse and human psoriatic skin chimeras. Validation of a new animal model. Am J Pathol 146:580-8
33. Oki M, Ohtani H, Kinouchi Y, Sato E, Nakamura S, Matsumoto T et al. (2005) Accumulation of CCR5+ T cells around RANTES+ granulomas in Crohn's disease: a pivotal site of Th1-shifted immune response? Lab Invest 85:137-45
34. Oliveira SH, Lira S, Martinez-A C, Wiekowski M, Sullivan L, Lukacs NW (2002) Increased responsiveness of murine eosinophils to MIP-1beta (CCL4) and TCA-3 (CCL1) is mediated by their specific receptors, CCR5 and CCR8. J Leukocyte Biol 71:1019-25
35. Oravecz T, Pall M, Roderiquez G, Gorrell MD, Ditto M, Nguyen NY et al. (1997) Regulation of the receptor specificity and function of the chemokine RANTES (regulated on activation, normal T cell expressed and secreted) by dipeptidyl peptidase IV (CD26)-mediated cleavage. J Exp Med 186:1865-72
36. Panzer U, Reinking RR, Steinmetz OM, Zahner G, Sudbeck U, Fehr S et al. (2004) CXCR3 and CCR5 positive T-cell recruitment in acute human renal allograft rejection. Transplantation 78:1341-50
37. Petzelbauer P, Groger M, Kunstfeld R, Petzelbauer E, Wolff K (1996) Human delayed-type hypersensitivity reaction in a SCID mouse engrafted with human T cells and autologous skin. J Invest Dermatol 107:576-81
38. Proudfoot AE (2002) Chemokine receptors: multifaceted therapeutic targets. Nat Rev Immunol 2:106-15
39. Proudfoot AE, Handel TM, Johnson Z, Lau EK, LiWang P, Clark-Lewis I et al. (2003) Glycosaminoglycan binding and oligomerization are essential for the in vivo activity of certain chemokines. Proc Natl Acad Sci USA 100:1885-90
40. Sallusto F, Mackay CR, Lanzavecchia A (1997) Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells. Science 277:2005-7
41. Schall TJ (1991) Biology of the RANTES/SIS cytokine family. Cytokine 3:165-83
42. Schall TJ, Bacon K, Toy KJ, Goeddel DV (1990) Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES. Nature 347:669-71
43. Schuh JM, Blease K, Hogaboam CM (2002) The role of CC chemokine receptor 5 (CCR5) and RANTES/CCL5 during chronic fungal asthma in mice. FASEB J 16:228-30
44. Senechal S, Fahy O, Gentina T, Vorng H, Capron M, Walls AF et al. (2002) CCR3-blocking antibody inhibits allergen-induced eosinophil recruitment in human skin xenografts from allergic patients. Lab Invest 82:929-39
45. Sultan P, Schechner JS, McNiff JM, Hochman PS, Hughes CC, Lorber MI et al. (1997) Blockade of CD2-LFA-3 interactions protects human skin allografts in immunodeficient mouse/human chimeras. Nat Biotechnol 15:759-62
46. Suzuki N, Nakajima A, Yoshino S, Matsushima K, Yagita H, Okumura K (1999) Selective accumulation of CCR5+ T lymphocytes into inflamed joints of rheumatoid arthritis. Int Immunol 11:553-9
47. Tsicopoulos A, Hamid Q, Haczku A, Jacobson MR, Durham SR, North J et al. (1994) Kinetics of cell infiltration and cytokine messenger RNA expression after intradermal challenge with allergen and tuberculin in the same atopic individuals. J Allergy Clin Immunol 94:764-72
48. Tsicopoulos A, Janin A, Akoum H, Lamblin C, Vorng H, Hamid Q et al. (2000) Cytokine profile in minor salivary glands from patients with bronchial asthma. J Allergy Clin Immunol 106:687-96
49. Tsicopoulos A, Pestel J, Fahy O, Vorng H, Vandenbusche F, Porte H et al. (1998) Tuberculin-induced delayed-type hypersensitivity reaction in a model of hu-PBMC-SCID mice grafted with autologous skin. Am J Pathol 152:1681-8
50. Weber C, Belge KU, von Hundelshausen P, Draude G, Steppich B, Mack M et al. (2000) Differential chemokine receptor expression and function in human monocyte subpopulations. J Leukocyte Biol 67:699-704
51. Yan HC, Juhasz I, Pilewski J, Murphy GF, Herlyn M, Albelda SM (1993) Human/severe combined immunodeficient mouse chimeras. An experimental in vivo model system to study the regulation of human endothelial cell-leukocyte adhesion molecules. J Clin Invest 91:986-996
52. Ying S, Meng Q, Zeibecoglou K, Robinson DS, Macfarlane A, Humbert M et al. (1999) Eosinophil chemotactic chemokines (eotaxin, eotaxin-2, RANTES, monocyte chemoattractant protein-3 (MCP-3), and MCP-4), and C-C chemokine receptor 3 expression in bronchial biopsies from atopic and nonatopic (intrinsic) asthmatics. J Immunol 163:6321-6329
53. Zang YC, Samanta AK, Halder JB, Hong J, Tejada-Simon MV, Rivera VM et al. (2000) Aberrant T cell migration toward RANTES and MIP-1 alpha in patients with multiple sclerosis. Overexpression of chemokine receptor CCR5. Brain 123(Part 9):1874-82
54. Zhong MX, Kuziel WA, Pamer EG, Serbina NV (2004) Chemokine receptor 5 is dispensable for innate and adaptive immune responses to Listeria monocytogenes infection. Infect Immun 72:1057-64
55. Zhou Y, Huang D, Farver C, Hoffman GS (2003) Relative importance of CCR5 and antineutrophil cytoplasmic antibodies in patients with Wegener's granulomatosis. J Rheumatol 30:1541-7