CCR3-Blocking antibody inhibits allergen-induced eosinophil recruitment in human skin xenografts from allergic patients

Laboratory Investigation

Volumn 82, Issue 7, 2002, Pages 929-939

  Sénéchal, Stephanie ^a   Fahy, Olivier ^a   Gentina, Thibaut ^a,c   Vorng, Han ^a   Capron, Monique ^a,b   Walls, Andrew F ^d   McEuen, Alan R ^d   Buckley, Mark G ^d   Hamid, Qutayba ^e   Wallaert, Benoît ^a,c   Tonnel, Andée Bernard ^a,c   Tsicopoulos, Anne ^a,c  

^a INSERM   (France)

^b INSTITUT PASTEUR DE LILLE   (France)

^c LILLE UNIVERSITY HOSPITAL   (France)

^d SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

^e MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR3; CHEMOKINE RECEPTOR CCR3 ANTIBODY; CYTOKINE; MESSENGER RNA; RECEPTOR ANTIBODY; UNCLASSIFIED DRUG;

ALLERGIC DISEASE; ALLERGY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ANTIGEN PRESENTING CELL; ANTIGEN SPECIFICITY; ARTICLE; AUTOTRANSPLANTATION; BASOPHIL; CELL MIGRATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE MODEL; EOSINOPHIL; EOSINOPHILIA; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPATHOLOGY; MONONUCLEAR CELL; MOUSE; NONHUMAN; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SCID MOUSE; SKIN GRAFT; SKIN MANIFESTATION; T LYMPHOCYTE ACTIVATION; TH2 CELL; XENOGRAFT;

ALLERGENS; ANIMALS; ANTIBODIES; EOSINOPHILS; HUMANS; HYPERSENSITIVITY; IN SITU HYBRIDIZATION; MICE; MICE, SCID; MITES; RECEPTORS, CHEMOKINE; SKIN TRANSPLANTATION;

EID: 0036314229     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.LAB.0000020417.13757.05     Document Type: Article

References (51)

1. IL-4- and IL-5-positive T lymphocytes, eosinophils, and mast cells in allergen-induced late-phase cutaneous reactions in atopic subjects
2. CCR3 blockade as a new therapy for asthma
3. Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s
4. Aberrant in vivo T helper type cell response and impaired eosinophil recruitment in CC chemokine receptor 8 knockout mice
5. Experimental production and modulation of human cytotoxic dermatitis in human-murine chimeras
6. Human skin/SCID mouse chimeras as an in vivo model for human cutaneous mast cell hyperplasia
7. Induction of E-selectin-dependent leukocyte recruitment by mast cell degranulation in human skin grafts transplanted on SCID mice
8. Synergistic effect of diesel organic extracts and allergen Der p 1 on the release of chemokines by peripheral blood mononuclear cells from allergic subjects: Involvement of the map kinase pathway
9. In vitro and in vivo studies with purified recombinant human interleukin 5
10. An immuno-fluorescent method for specific staining of eosinophil granule major basic protein
11. + lymphocytes, activated eosinophils, and the magnitude of the allergen-induced late phase cutaneous reaction in man
12. Eosinophil activation and T lymphocyte infiltration in allergen-induced late phase skin reactions and classical delayed-type hypersensitivity
13. Macrophage-derived chemokine production by activated human T cells in vitro and in vivo: Preferential association with the production of type 2 cytokines
14. T-lymphocyte dependence of psoriatic pathology in human skin grafted to SCID mice
15. Depletion of eosinophils in mice through the use of antibodies specific for C-C chemokine receptor 3 (CCR3)
16. Localization of atrial natriuretic peptide mRNA in rat heart and human atrial appendage
17. Chemokine receptor usage by human eosinophils: The importance of CCR3 demonstrated using an antagonistic monoclonal antibody
18. The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4
19. Macrophagederived chemokine is a functional ligand for the CC chemokine receptor 4
20. Immunohisto-chemical detection of human basophils in late-phase skin reactions
21. Development of Pemphigus-Vulgads-Like lesions in severe combined immunodeficiency disease mice reconstituted with lymphocytes from patients
22. Thymus and activation-regulated chemokine in atopic dermatitis: Serum thymus and activation-regulated chemokine level is closely related with disease activity
23. Messenger RNA expression of the cytokine gene cluster, IL-3, IL-4, IL-5, and GM-CSF in allergen-induced late-phase reactions in atopic subjects
24. Increased expression of eotaxin in bronchoalveolar lavage and airways of asthmatics contributes to the chemotaxis of eosinophils to the site of inflammation
25. CC chemokine receptor (CCR)3/eotaxin is followed by CCR4/monocyte-derived chemokine in mediating pulmonary T helper lymphocyte type 2 recruitment after serial antigen challenge in vivo
26. Role of chemokines in asthmatic airway inflammation
27. Development and characterization of a monoclonal antibody specific for human basophils and the identification of a unique secretory product of basophil activation
28. Transfer of a functional human immune system to mice with severe combined immunodeficiency
29. Human T-cell-mediated destruction of allogeneic dermal microvessels in a severe combined immuno-deficient mouse
30. Severe combined immunodeficiency mouse and human psoriatic skin chimeras: Validation of a new animal model
31. T helper cell type 2 cytokine-mediated comitogenic responses and CCR3 expression during differentiation of human mast cells in vitro
32. Human delayed-type hypersensitivity reaction in a SCID mouse engrafted with human T cells and autologous skin
33. Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils
34. Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line
35. Tryptasechymase double-positive human mast cells express the eotaxin receptor CCR3 and are attracted by CCR3-binding chemokines
36. Cloning and characterization of the guinea pig eosinophil eotaxin receptor, C-C chemokine receptor-3: Blockade using a monoclonal antibody in vivo
37. Switch in chemokine receptor expression upon TCR stimulation reveals novel homing potential for recently activated T cells
38. Chemokines and chemokine receptors in T-cell priming and Th1/Th2- mediated responses
39. Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells
40. The role of chemokines in cutaneous allergic inflammation
41. Production of the novel C-C chemokine MCP-4 by airway cells and comparison of its biological activity to other C-C chemokines
42. Blockade of CD2-LFA-3 interactions protects human skin allografts in immunodeficient mouse/human chimeras
43. Chemokine-induced eosinophil recruitment: Evidence of a role for endogenous eotaxin in an in vivo allergy model in mouse skin
44. Kinetics of cell infiltration and cytokine mRNA expression after intradermal challenge with allergen and tuberculin in the same atopic individuals
45. Tuberculin-induced delayed-type hypersensitivity reaction in a model of hu-PBMC-SCID mice grafted with autologous skin
46. High expression of the chemokine receptor CCR3 in human blood basophils: Role in activation by eotaxin, MCP-4, and other chemokines
47. A Th2 chemokine, TARC, produced by keratinocytes may recruit CLA+CCR4+ lymphocytes into lesional atopic dermatitis skin
48. Human/severe combined immunodeficient mouse chimeras: An experimental in vivo model system to study the regulation of human endothelial cell-leukocyte adhesion molecules
49. Enhanced expression of eotaxin and CCR3 in atopic dermatitis
50. C-C chemokines in allergen-induced late-phase cutaneous responses in atopic subjects: Association of eotaxin with early 6-hour eosinophils, and of eotaxin-2 and monocyte chemoattractant protein-4 with the later 24-hour tissue eosinophilia, and relationship to basophils and other C- C chemokines (monocyte chemoattractant protein-3 and RANTES)
51. Enhanced expression of eotaxin and CCR3 mRNA and protein in atopic asthma: Association with airway hyperresponsiveness and predominant co-localization of eotaxin mRNA to bronchial epithelial and endothelial cells