Species selectivity of a small molecule antagonist for the CCR1 chemokine receptor

European Journal of Pharmacology

Volumn 389, Issue 1, 2000, Pages 41-49

  Liang, Meina ^a   Rosser, Mary ^a   Ng, Howard P ^a,b   May, Karen ^a   Bauman, John G ^a   Islam, Imadul ^a   Ghannam, Ameen ^a   Kretschmer, Peter J ^a   Pu, Haifeng ^a   Dunning, Laura ^a   Snider, R Michael ^a   Morrissey, Michael M ^a   Hesselgesser, Joseph ^a   Perez, H Daniel ^a   Horuk, Richard ^a  

^a BAYER AG   (Germany)

^b Berlex Biosciences 94806 ^*  (United States)

Author keywords

CCR1; Molecule antagonist; Species selectivity

Indexed keywords

CALCIUM ION; CHEMOKINE RECEPTOR; FORMYLMETHIONYLLEUCYLPHENYLALANINE; LACTATE DEHYDROGENASE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; RECEPTOR BLOCKING AGENT;

ARTICLE; BINDING SITE; BIOCHEMISTRY; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL LINE; CELL VIABILITY; CONTROLLED STUDY; ENZYME RELEASE; HUMAN; HUMAN CELL; MARMOSET; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RABBIT; RECEPTOR BINDING; RECEPTOR BLOCKING; SPECIES DIFFERENCE;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CALCIUM; CALLITHRIX; CLONING, MOLECULAR; DNA, COMPLEMENTARY; HUMANS; MACROPHAGE INFLAMMATORY PROTEIN-1; MICE; MOLECULAR SEQUENCE DATA; NITRILES; PIPERAZINES; PIPERIDINES; RABBITS; RANTES; RECEPTORS, CHEMOKINE; SPECIES SPECIFICITY;

EID: 0034635406     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00863-8     Document Type: Article

References (27)

1. Arunlakshana O., Schild H.O. Some quantitative uses of drug antagonists. Br. J. Pharmacol. 14:1959;48-58.
2. Baggiolini M. Chemokines and leukocyte traffic. Nature. 392:1998;565-568.
3. Barnes D.A., Tse J., Kaufhold M., Owen M., Hesselgesser J., Strieter R., Horuk R., Perez H.D. Polyclonal antibody directed against human RANTES ameliorates disease in the Lewis rat adjuvant-induced arthritis model. J. Clin. Invest. 101:1998;2910-2919.
4. Beinborn M., Lee Y.M., McBride E.W., Quinn S.M., Kopin A.S. A single amino acid of the cholecystokinin-B/gastrin receptor determines specificity for non-peptide antagonists. Nature. 362:1993;348-350.
5. Cotte N., Balestre M.N., Phalipou S., Hibert M., Manning M., Barberis C., Mouillac B. Identification of residues responsible for the selective binding of peptide antagonists and agonists in the V2 vasopressin receptor. J. Biol. Chem. 273:1998;29462-29468.
6. Dohlman H.G., Thorner J., Caron M.G., Lefkowitz R.J. Model systems for the study of seven transmembrane-segment receptors. Annu. Rev. Biochem. 60:1991;653-688.
7. Fong T.M., Yu H., Strader C.D. Molecular basis for the species selectivity of the neurokinin-1 receptor antagonists, CP-96,345 and RP67580. J. Biol. Chem. 267:1992;25668-25671.
8. Gao J.L., Kuhns D.B., Tiffany H.L., McDermott D., Li X., Francke U., Murphy P.M. Structure and functional expression of the human macrophage inflammatory protein 1α/RANTES receptor. J. Exp. Med. 177:1993;1421-1427.
9. Gao J.L., Murphy P.M. Cloning and differential tissue-specific expression of three mouse{beta} chemokine receptor-like genes, including the gene for a functional macrophage inflammatory protein-1{alpha} receptor. J. Biol. Chem. 270:1995;17494-17501.
10. Gether U., Johansen T.E., Snider R.M., Lowe J.A.D., Nakanishi S., Schwartz T.W. Different binding epitopes on the NK1 receptor for substance P and non-peptide antagonist. Nature. 362:1993;345-348.
11. Godiska R., Chantry D., Dietsch G.N., Gray P.W. Chemokine expression in murine experimental allergic encephalomyelitis. J. Neuroimmunol. 58:1995;167-176.
12. Hesselgesser J., Ng H.P., Liang M., Zheng W., May K., Bauman J.G., Monahan S., Islam I., Wei G.P., Ghannam A., Taub D.D., Rosser M., Snider R.M., Morrissey M.M., Perez H.D., Horuk R. Identification and characterization of small molecule functional antagonists of the CCR1 chemokine receptor. J. Biol. Chem. 273:1998;15687-15692.
13. Horn F., Weare J., Beukers M.W., Horsch S., Bairoch A., Chen W., Edvardsen O., Campagne F., Vriend G. G-protein coupled receptor DB: an information system for G protein-coupled receptors. Nucleic Acids Res. 26:1998;275-279.
14. Horuk R. Molecular properties of the chemokine receptor family. Trends Pharmacol. Sci. 15:1994;159-165.
15. Karpus W.J., Kennedy K.J. MIP-1alpha and MCP-1 differentially regulate acute and relapsing autoimmune encephalomyelitis as well as Th1/Th2 lymphocyte differentiation. J. Leukocyte Biol. 62:1997;681-687.
16. Karpus W.J., Lukacs N.W., McRae B.L., Strieter R.M., Kunkel S.L., Miller S.D. An important role for the chemokine macrophage inflammatory protein-1α in the pathogenesis of the T cell-mediated autoimmune disease, experimental autoimmune encephalomyelitis. J. Immunol. 155:1995;5003-5010.
17. Kong H., Raynor K., Yano H., Takeda J., Bell G.I., Reisine T. Agonists and antagonists bind to different domains of the cloned kappa opioid receptor. Proc. Natl. Acad. Sci. U.S.A. 91:1994;8042-8046.
18. Link R., Daunt D., Barsh G., Chruscinski A., Kobilka B. Cloning of two mouse genes encoding alpha 2-adrenergic receptor subtypes and identification of a single amino acid in the mouse alpha 2-C10 homolog responsible for an interspecies variation in antagonist binding. Mol. Pharmacol. 42:1992;16-27.
19. Luster A.D. Chemokineschemotactic cytokines that mediate inflammation. N. Engl. J. Med. 338:1998;436-445.
20. Mackay C.R. Chemokine receptors and T cell chemotaxis. J. Exp. Med. 184:1996;799-802.
21. Neote K., DiGregorio D., Mak J.Y., Horuk R., Schall T.J. Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor. Cell. 72:1993;415-425.
22. Pease J.E., Wang J., Ponath P.D., Murphy P.M. The N-terminal extracellular segments of the chemokine receptors, CCR1 and CCR3, are determinants for MIP-1alpha and eotaxin binding, respectively, but a second domain is essential for efficient receptor activation. J. Biol. Chem. 273:1998;19972-19976.
23. Perez H.D., Vilander L., Andrews W.H., Holmes R. Human formyl peptide receptor ligand binding domain(s). Studies using an improved mutagenesis/expression vector reveal a novel mechanism for the regulation of receptor occupancy. J. Biol. Chem. 269:1994;22485-22487.
24. Plater-Zyberk C., Hoogewerf A.J., Proudfoot A.E.I., Power C.A., Wells T.N.C. Effect of a CC chemokine receptor antagonist on collagen-induced arthritis in DBA/1 mice. Immunol. Lett. 57:1997;117-120.
25. Rathanaswami P., Hachicha M., Sadick M., Schall T.J., McColl S.R. Expression of the cytokine, RANTES, in human rheumatoid synovial fibroblasts. J. Biol. Chem. 268:1993;5834-5839.
26. Schall T. The chemokines. Thompson A. The Cytokine Handbook. 1994;419-460 Academic Press, San Diego.
27. Snowden N., Hajeer A., Thomson W., Ollier B. RANTES role in rheumatoid arthritis. Lancet. 343:1994;547-548.