Absence of recipient CCR5 promotes early and increased allospecific antibody responses to cardiac allografts

Journal of Immunology

Volumn 174, Issue 10, 2005, Pages 6499-6508

  Amano, Hiroyuki ^a,c   Bickerstaff, Alice ^d   Orosz, Charles G ^d   Novick, Andrew C ^a   Toma, Hiroshi ^c   Fairchild, Robert L ^a,b  

^a LERNER RESEARCH INSTITUTE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^d THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CHEMOKINE RECEPTOR CCR5; COMPLEMENT COMPONENT C3D; GAMMA INTERFERON; INTERLEUKIN 4;

ALLOIMMUNITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; CARDIAC GRAFT REJECTION; COMPLEMENT DEPOSITION; CONTROLLED STUDY; HEART GRAFT; LYMPHOCYTE COUNT; LYMPHOCYTIC INFILTRATION; MACROPHAGE; MALE; MOUSE; NONHUMAN; PARENCHYMA; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 18644372263     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.174.10.6499     Document Type: Article

References (36)

1. Melter, M., A. Evxeni, M. E. Reinders, J. C. Fang, G. McMahon, P. Ganz, W. W. Hancock, and D. M. Briscoe. 2001. Expression of the chemokine receptor CXCR3 and its ligand IP-10 during human cardiac ailograft rejection. Circulation 104: 2558-2564.
2. Sederer, S., Y. Cui, F. Eitner, T. Goodpaster, K. L. Hudkins, M. Mack, J. P. Cartron, D. Schlondorff, and C. E. Alpers. 2001. Expression of chemokines and chemokine receptors during human renal transplant rejection. Am. J. Kidney Dis. 37: 518-531.
3. Zhao, D. X. M.. Y. Y. Hu, G. G. Miller, A. D. Luster, R. N. Mitchell, and P. Libby. 2002. Differential expression of the IFN-γ-inducible CXCR3-binding chemokines, and IFN-inducible protein 10, monokine induced by IFN, and IFN-inducible T cell α chemoattractant in human cardiac allografts: association with cardiac ailograft vasculopathy and acute rejection. J. Immunol. 169: 1556-1560.
4. Fahmy, N. M., M. H. Yamani, R. C. Starling, N. B. Ratliff, J. B. Young, P. M. McCarthy, J. Feng, A. C. Novick, and R. L. Fairchild. 2003. Chemokine and chemokine receptor gene expression indicates acute rejection of human cardiac transplants. Transplantation 15: 72-78.
5. Belperio, J. A., M. A. Burdick, M. P. Keane, Y. Y. Xue, J. P. Lynch, B. L. Daugherty, S. L. Kunkel, and R. M. Stricter. 2000. The role of the CC chemokine. RANTES, in acute lung allograft rejection. J. Immunol. 165: 461-472.
6. Gao, W., P. S. Topham, J. A. King, S. T. Smiley, V. Csizmadia, B. Lu, C. J. Gerard, and W. W. Hancock. 2000. Targeting of the chemokine receptor CCR1 suppresses development of acute and chronic cardiac allograft rejection. J. Clin. Invest. 105: 35-44.
7. Hancock, W. W., B. Lu, W. Goa, V. Csizmadia, K. Faia, J. A. King, S. T. Smiley, M. Ling, N. P. Gerard, and C. Gerard. 2000. Requirement of the chemokine receptor CXCR3 for acute allograft rejection. J. Exp. Med. 192: 1515-1520.
8. Hancock, W. W., W. Gao, V. Csizmadia, K. L. Faia, N. Shemmeri, and A. D. Luster. 2001. Donor-derived IP-10 initiates development of acute allograft rejection. J. Exp. Med. 193: 975-980.
9. Miura, M., K. Morita, H. Kobayashi, T. A. Hamilton, M. A. Burdick, R. M. Stricter, and R. L. Fairchild. 2001. Monokine induced by IFN-γ is a dominant factor directing T cells into murine cardiac allografts during acute rejection. J. Immunol. 167: 3494-3504.
10. Morita, K., M. Miura, D. R. Paolone. T. M. Engeman, A. Kapoor, D. G. Remick, and R. L. Fairchild. 2001. Early chemokine cascades in murine cardiac grafts regulate T cell recruitment and progression of acute allograft rejection. J. Immunol. 167: 2979-2984.
11. Gao, W., K. L. Faia, V. Csizmadia, S. T. Smiley, D. Soler, J. A. King, T. M. Danoff, and W. W. Hancock. 2001. Beneficial effects of targeting CCR5 in allograft recipients. Transplantation 72: 1199-1205.
12. Fischereder, M., B. Luckow, B. Hocher, R. P. Wuthrich. U. Rothenpieler, H. Schneeberger, U. Panzer, R. A. Stahl, I. A. Hauser, K. Budde, et al. 2001. CC chemokine receptor 5 and renal-transplant survival. Lancet 357: 1758-1761.
13. Bacon, K. B., B. A. Premack, P. Gardner, and T. J. Schall. 1995. Activation of dual T cell signaling pathways by the chemokine RANTES. Science 269: 1727-1730.
14. Taub, D. D., S. M. Turcovski-Corrales, M. L. Key, D. L. Longo, and W. J. Murphy. 1996. Chemokines and T lymphocyte activation. I. β chemokines costimulate human T lymphocyte activation in vitro. J. Immunol. 156: 2095-2103.
15. Karpus, W. J., N. W. Lukacs, K. J. Kennedy, W. S. Smith, S. D. Hurst, and T. A. Barrett. 1997. Differential CC chemokine-induced enhancement of T helper cell cytokine production. J. Immunol. 158: 4129-4136.
16. Corry, R. J., H. J. Winn, and P. S. Russell. 1973. Primarily vascularized allografts of hearts in mice. Transplantation 16: 343-350.
17. Osamura, R. Y., K. Watanabe, I. Tanaka, Y. Nakai, and H. Imura. 1981. Comparative immunohistochemical studies of γ-melanocyte stimulating hormone (γ-MSH) and adrenocorticotrophic hormone (ACTH) in the bovine and human pituitaries. Acta Endocrinol. 96: 458-463.
18. Benichou, G., A. Valujskikh, and P. S. Heeger. 1999. Contributions of direct and indirect alloreactivity during ailograft rejection in mice. J. Immunol. 162: 352-358.
19. Zhang, Q.-W., D. D. Kish, and R. L. Fairchild. 2003. Absence of allograft ICAM-1 attenuates alloantigen-specific T cell priming, but not primed T cell trafficking into the graft, to mediate acute rejection. J. Immunol. 170: 5530-5537.
20. Wasowska, B. A., Z. Qian, D. L. Cangellow, E. Behrens, K. Van Tran, J. Layton, F. Sanfilippo, and W. M. Baldwin. 2001. Passive transfer of alloantibodies restores acute cardiac rejection in IgKO mice. Transplantation 71: 727-736.
21. Mueller, A., and P. G. Strange. 2004. The chemokine receptor CCR5. Int. J. Biochem. Cell Biol. 36: 35-38.
22. Rossi, D., and A. Zlotnik. 2000. The biology of chemokines and their receptors. Annu. Rev. Immunol. 18: 217-242.
23. Campbell, J. J., and E. C. Butcher. 2000. Chemokines in tissue-specific and microenvironment-specific lymphocyte homing. Curr. Opin. Immunol. 12: 336-341.
24. 2 integrin affinity and mobility changes: differential regulation and roles in lymphocyte arrest under flow. Immunity 13: 759-769.
25. Laudanna, C., J. Y. Kim, G. Constantin, and E. C. Butcher. 2002. Rapid leukocyte integrin activation by chemokines. Immunol. Rev. 186: 37-46.
26. Koga, S., M. B. Auerbach, T. M. Engeman, A. C. Novick, H. Toma, and R. L. Fairchild. 1999. T cell infiltration into class II MHC-disparate allografts and acute rejection is dependent on the IFN-γ induced chemokine Mig. J. Immunol. 163: 4878-4885.
27. Abdi, R., R. N. Smith, L. Makhlouf, N. Najafian, A. D. Luster, H. Auchincloss, and M. H. Sayegh. 2002. The role of CC chemokine receptor 5 (CCR5) in islet allograft rejection. Diabetes 51: 2489-2495.
28. Zhang, Z., L. Kaptanoglu, Y. Tang, D. Ivancic, S. M. Rao, A. D. Luster, T. A. Barrelt, and J. Fryer. 2004. IP-10-induced recruitment of CXCR3 host T cells is required for small bowel allograft rejection. Gastroenterology 126: 809-818.
29. Kimata, H., A. Yoshida, C. Ishioka, M. Fujimoto, I. Lindley, and K. Furusho. 1996. RANTES and macrophage inflammatory protein 1α selectively enhance immunoglobulin (IgE) and IgG4 production by human B cells. J. Exp. Med. 183: 2397-2402.
30. Zhou, Y., T. Kurihara, R.-P. Ryseck, Y. Yang, C. Ryan, J. Loy, G. Warr, and R. Bravo. 1998. Impaired macrophage function and enhanced T cell-dependent immune response in mice lacking CCR5, the mouse homologue of the major HIV-1 coreceptor. J. Immunol. 160: 4018-4025.
31. Carvalho-Pinto, C., M. I. Garcia, L. Gomez, A. Ballesteros, A. Zaballos, J. M. Pflores, M. Mellado, J. M. Rodriguez-Frade, D. Balomenos, and C. Martinez-A. 2004. Leukocyte attraction through the CCR5 receptor controls progress form insulitis to diabetes in non-obese diabetic mice. Eur. J. Immunol. 34: 548-557.
32. Seagal, J., and D. Melamed. 2004, Contribution of αβ and γδ cells to the generation of primary immunoglobulin G-driven autoimmune response in immunoglobulin-μ-deficient/lpr mice. Immunology 112: 265-273.
33. Brandes, M., K. Willmann, A. B. Lang, K.-H. Nam, C. Jin, M. B. Brenner, C. T. Monta, and B. Moser. 2003. Flexible migration program regulates γδ T-cell involvement in humoral immunity. Blood 15: 3693-3701.
34. Piccotti, J. R., S. Y. Chan, R. E. Goodman, J. Magram, E. J. Eichwald, and D. K. Bishop. 1996. IL-12 antagonism induces T helper 2 responses, yet exacerbates cardiac allograft rejection: evidence against a dominant protective role for T helper 2 cytokines in alloimmunity. J. Immunol. 157: 1951-1957.
35. VanBuskirk, A. M., M. E. Wakely, and C. G. Orosz. 1996. Transfusion of polarized TH2-like cell populations into SCID mouse cardiac allograft recipients results in acute allograft rejection. Transplantation 62: 229-238.
36. + T cells. J. Immunol. 161: 5236-5244.