Artocarpol A stimulation of superoxide anion generation in neutrophils involved the activation of PLC, PKC and p38 mitogen-activated PK signaling pathways

British Journal of Pharmacology

Volumn 145, Issue 4, 2005, Pages 460-468

  Kuan, Yu Hsiang ^a   Lin, Ruey Hseng ^a   Tsao, Lo Ti ^b   Lin, Chun Nan ^c   Wang, Jih Pyang ^b,d  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^b TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^c KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Artocarpol A; Intracellular free Ca 2+ concentration; Mitogen activated PK; Neutrophils; PKC; Superoxide anion

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; 1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ARTOCARPOL A; CALCIUM; CYTOCHALASIN B; DIMETHYL SULFOXIDE; FORMYLMETHIONYLLEUCYLPHENYLALANINE; INOSITOL 1,4,5 TRISPHOSPHATE; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PERTUSSIS TOXIN; PHENOL DERIVATIVE; PHOSPHOLIPASE C; PROTEIN KINASE C; PROTEIN P47; SUPEROXIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BREADFRUIT; CELL FREE SYSTEM; CONTROLLED STUDY; DRUG EFFECT; ENZYME PHOSPHORYLATION; ENZYME RELEASE; IC 50; IMMUNOBLOTTING; NEUTROPHIL; NONHUMAN; OXIDATIVE STRESS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ANIMALS; BUTADIENES; CALCIUM; CELL-FREE SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME INHIBITORS; ESTRENES; FLAVONOIDS; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; IMIDAZOLES; IMMUNOBLOTTING; INDOLES; MALEIMIDES; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; NEUTROPHILS; NITRILES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHOLIPASE C; PHOSPHORYLATION; PROTEIN KINASE C; PYRIDINES; PYRROLIDINONES; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SUPEROXIDES; TETRADECANOYLPHORBOL ACETATE;

EID: 22044450230     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706205     Document Type: Article

References (36)

1. AVDI, N.J., WINSTON, B.W., RUSSEL, M., YOUNG, S.K., JOHNSON, G.L. & WORTHEN, G.S. (1996). Activation of MEKK by formyl-methionyl-leucyl- phenylalanine in human neutrophils. Mapping pathways for mitogen-activated protein kinase activation. J. Biol. Chem., 271, 33598-33606.
2. BABIOR, B.M., LAMBETH, J.D. & NAUSEEF, W. (2002). The neutrophil NADPH oxidase. Arch. Biochem. Biophys., 379, 342-344.
3. BERRIDGE, M.J. (1987). Inositol trisphosphate and diacylglycerol: two interacting second messengers. Annu. Rev. Biochem., 56, 159-193.
4. 2+ release. FASEB J., 16, 1145-1150.
5. 2, PtdIns(3)P, and PKCδ in intracellular production of reactive oxygen species by the NADPH oxidase. Mol. Cell, 11, 35-47.
6. CASTAGNA, M., TAKAI, Y., KAIBUCHI, K., SANO, K., KIKKAWA, U. & NISHIZUKA, Y. (1982). Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters. J. Biol. Chem., 257, 7847-7851.
7. CHANG, L.C. & WANG, J.P. (1999). Examination of the signal transduction pathways leading to activation of extracellular signal-regulated kinase by formyl-methionyl-leucyl-phenylalanine in rat neutrophils. FEBS Lett., 454, 165-168.
8. CHUNG, M.I., KUO, H.H., YEN, M.H., LIN, C.N., YANG, S.Z., TSAO, L.T. & WANG, J.P. (2000). Artocarpol A, a novel constituent with potent anti-inflammatory effect, isolated from Artocarpus rigida. Helv. Chim. Acta, 83, 1200-1204.
9. CROSS, A.R. & JONES, O.T. (1986). The effect of the inhibitor diphenylene iodonium on the superoxide-generating system of neutrophils: specific labeling of a component polypeptide of the oxidase. Biochem. J., 237, 111-116.
10. CUENDA, A., ROUSE, J., DOZA, Y.N., MEIER, R., COHEN, P., GALLAGHER, T.F., YOUNG, P.R. & LEE, J.C. (1995). SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett., 364, 229-233.
11. DEKKER, L.V., LEITGES, M., ALTSCHULER, G., MISTRY, N., McDERMOTT, A., ROSE, J. & SEGAL, A.W. (2000). Protein kinase C-β contributes to NADPH oxidase activation in neutrophils. Biochem. J., 347, 285-289.
12. DELEO, F.R., ALLAN, L.A., APICELLA, M. & NAUSEEF, W.M. (1999). NADPH oxidase activation and assembly during phagocytosis. J. Immunol., 163, 6732-6740.
13. DERIJARD, B., RAINGEAUD, J., BARRETT, T., WU, I.H., HAN, J., ULEVITCH, R.J. & DAVIS, R.J. (1995). Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. Science, 267, 682-685.
14. DIETER, P. & SCHWENDE, H. (2000). Protein kinase C-α and -β play antagonistic roles in the differentiation process of THP-1 cells. Cell. Signal., 12, 297-302.
15. phox as determined by two-dimensional phosphopeptide mapping. Phosphorylation by protein kinase C, protein kinase A, and a mitogen-activated protein kinase. J. Biol. Chem., 271, 6374-6378.
16. FAVATA, M.F., HORIUCHI, K.Y., MANOS, E.J., DAULERIO, A.J., STRADLEY, D.A., FEESER, W.S., VAN DYK, D.E., PITTS, W.J., EARL, R.A., HOBBS, F., COPELAND, R.A., MAGOLDA, R.L., SCHERLE, P.A. & TRZASKOS, J.M. (1998). Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J. Biol. Chem., 273, 18623-18632.
17. phox of the neutrophil oxidase complex using the two-hybrid system. J. Biol. Chem., 270, 5695-5697.
18. HALE, K.K., TROLLINGER, D., RIHANEK, M. & MANTHEY, C.L. (1999). Differential expression and activation of p38 mitogen-activated protein kinase α, β, γ, and δ in inflammatory cell lineages. J. Immunol., 162, 4246-4252.
19. HSU, M.F., LU, M.C., TSAO, L.T., KUAN, Y.H., CHEN, C.C. & WANG, J.P. (2004). Mechanisms of the influence of magnolol on eicosanoid metabolism in neutrophils. Biochem. Pharmacol., 67, 831-840.
20. KORCHAK, H.M., ROSSI, M.W. & KILPATRICK, L.E. (1998). Selective role for β-protein kinase C in signaling for superoxide anion generation but not degranulation or adherence in differentiated HL60 cells. J. Biol. Chem., 273, 27292-27299.
21. KUROKI, M. & O'FLAHERTY, J.T. (1997). Differential effects of a mitogen-activated protein kinase kinase inhibitor on human neutrophil responses to chemotactic factors. Biochem. Biophys. Res. Commun., 232, 474-477.
22. LAL, A.S., CLIFTON, A.D., ROUSE, J., SEGAL, A.W. & COHEN, P. (1999). Activation of the neutrophil NADPH oxidase is inhibited by SB 203580, a specific inhibitor of SAPK2/p38. Biochem. Biophys. Res. Commun., 259, 465-470.
23. LAMBETH, J.D. (2000). Regulation of the phagocyte respiratory burst oxidase by protein interactions. Biochem. Mol. Biol. Int., 33, 427-439.
24. LI, Z., JIANG, H., XIE, W., ZHANG, Z., SMRCKA, A.V. & WU, D. (2000). Roles of PLC-β2 and -β3 and PI3Kγ in chemoattractant-mediated signal transduction. Science, 287, 1046-1049.
25. 2+ release. J. Biochem. (Tokyo), 122, 498-505.
26. phox, an NADPH oxidase component. J. Biol. Chem., 274, 36601-36608.
27. RHEE, S.G. (2001). Regulation of phosphoinositide-specific phospholipase C. Annu. Rev. Biochem., 70, 281-312.
28. SEGAL, A. W. & ABO, A. (1993). The biochemical basis of the NADPH oxidase of phagocytes. Trends Biochem. Sci., 18, 43-47.
29. SMITH, R.M. & CURNUTTE, J.T. (1991). Molecular basis of chronic granulomatous disease. Blood, 77, 673-686.
30. TAMURA, M., YOSHIDA, K. & KATAOKA, K. (1999). Guanosine 5′-O-(3-thiotriphosphate)-induced superoxide anion generation in permeabilized neutrophils requires protein kinase C and phospholipase C but not tyrosine kinase or phospholipase D. Arch. Biochem. Biophys., 361, 257-263.
31. 2+ influx through phospholipase C-independent mechanism in neutrophil activation. Naunyn-Schmiedeberg's Arch. Pharmacol., 353, 599-605.
32. WANG, J.P., RAUNG, S.L., KUO, Y.H. & TENG, C.M. (1995). Daphnoretin induced respiratory burst in rat neutrophils is, probably, mainly through protein kinase C activation. Eur. J. Pharmacol., 288, 341-348.
33. WANG, J.P., TSAO, L.T., RAUNG, S.L., HSU, M.F. & KUO, S.C. (1997a). Inhibition by HAJ11 of respiratory burst in neutrophils and the involvement of protein tyrosine phosphorylation and phospholipase D activation. Br. J. Pharmacol., 120, 79-87.
34. WANG, X.S., DIENER, K., MANTHEY, C.L., WANG, S., ROSENZWEIG, B., BRAY, J., DELANEY, J., COLE, C.N., CHAN-HUI, P.Y., MANTLO, N., LICHENSTEIN, H.S., ZUKOWSKI, M. & YAO, Z. (1997b). Molecular cloning and characterization of a novel p38 mitogen-activated protein kinase. J. Biol. Chem., 272, 23668-23674.
35. YAMAMORI, T., INANAMI, O., SUMIMOTO, H., AKASAKI, T., NAGAHATA, H. & KUWABARA, M. (2002). Relationship between p38 mitogen-activated protein kinase and small GTPase Rac for the activation of NADPH oxidase in bovine neutrophils. Biochem. Biophys. Res. Commun., 293, 1571-1578.
36. ZU, Y.L., QI, J., GILCHRIST, A., FERNANDEZ, G.A., VAZQUE-ABAD, D., KREUTZER, D.L., HUANG, C.K. & SHA'AFI, R.I. (1998). p38 mitogen-activated protein kinase activation is required for human neutrophil function triggered by TNF-α or FMLP stimulation. J. Immunol., 160, 1982-1989.