Binding of oxalyl derivatives of β-d-glucopyranosylamine to muscle glycogen phosphorylase b

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 11, 2006, Pages 3872-3882

  Hadjiloi, Theodoros ^a   Tiraidis, Costas ^a   Chrysina, Evangelia D ^a   Leonidas, Demetres D ^a   Oikonomakos, Nikos G ^a   Tsipos, Panagiotis ^b   Gimisis, Thanasis ^b  

^a INSTITUTE OF BIOLOGY   (Greece)

^b UNIVERSITY OF ATHENS   (Greece)

Author keywords

Glycogen phosphorylase; Inhibition; Oxalyl derivatives; Type 2 diabetes; X ray crystallography

Indexed keywords

ALPHA DEXTRO GLUCOSE 1 PHOSPHATE; ASPARTIC ACID; BETA DEXTRO GLUCOPYRANOSYLAMINE OXALYL DERIVATIVE; ENZYME INHIBITOR; GLUCOSE; GLYCOGEN PHOSPHORYLASE B; GLYCOGEN PHOSPHORYLASE B INHIBITOR; HISTIDINE; N ACETYL BETA DEXTRO GLUCOPYRANOSYLAMINE; NITROGEN DERIVATIVE; PHOSPHORIC ACID DERIVATIVE; UNCLASSIFIED DRUG; DRUG DERIVATIVE; GLUCOPYRANOSYLAMINE; GLUCOSAMINE; GLYCOGEN PHOSPHORYLASE; OXALIC ACID DERIVATIVE;

ARTICLE; BINDING AFFINITY; CATALYSIS; CHEMICAL INTERACTION; COMPETITIVE INHIBITION; COMPLEX FORMATION; CONCENTRATION RESPONSE; DRUG CONFORMATION; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SYNTHESIS; ENTROPY; ENZYME ACTIVE SITE; HYDROGEN BOND; INHIBITION KINETICS; PHARMACODYNAMICS; STRUCTURE ACTIVITY RELATION; ANIMAL; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DRUG ANTAGONISM; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE; RABBIT; STEREOISOMERISM; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ORYCTOLAGUS CUNICULUS;

ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; GLUCOSAMINE; GLYCOGEN PHOSPHORYLASE, MUSCLE FORM; MODELS, MOLECULAR; MOLECULAR CONFORMATION; OXALATES; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RABBITS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33747069442     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.01.045     Document Type: Article

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