FR258900, a novel glycogen phosphorylase inhibitor isolated from Fungus No. 138354: I. Taxonomy, fermentation, isolation and biological activities

Journal of Antibiotics

Volumn 58, Issue 8, 2005, Pages 497-502

  Furukawa, Shigetada ^a   Tsurumi, Yasuhisa ^a   Murakami, Kana ^a   Nakanishi, Tomoko ^a   Ohsumi, Keisuke ^a   Hashimoto, Michizane ^a   Nishikawa, Motoaki ^a   Takase, Shigehiro ^a   Nakayama, Osamu ^a   Hino, Motohiro ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Diabetes; Fungal metabolite; Glycogen phosphorylase inhibitor

Indexed keywords

2,3 BIS(4 HYDROXYCINNAMOYLOXY)GLUTARIC ACID; ANTIDIABETIC AGENT; FR 258900; GLYCOGEN PHOSPHORYLASE; GLYCOGEN SYNTHASE; GLYCOSYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOLOGICAL ACTIVITY; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DRUG DECOMPOSITION; DRUG ISOLATION; DRUG MECHANISM; DRUG POTENCY; DRUG PURIFICATION; DRUG SCREENING; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; FUNGAL STRAIN; GLYCOGEN SYNTHESIS; HYPERGLYCEMIA; IC 50; LIVER CELL; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PHYSICAL CHEMISTRY; POSTPRANDIAL STATE; PRIORITY JOURNAL; RAT; SOLVENT EXTRACTION; TAXONOMY;

FUNGI;

EID: 25144501079     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.1038/ja.2005.66     Document Type: Article

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