Adenoviral Gene Vector Tethering to Nanoparticle Surfaces Results in Receptor-Independent Cell Entry and Increased Transgene Expression

Molecular Therapy

Volumn 14, Issue 3, 2006, Pages 382-391

  Chorny, Michael ^a   Fishbein, Ilia ^a   Alferiev, Ivan S ^a   Nyanguile, Origene ^a   Gaster, Richard ^a   Levy, Robert J ^a  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

adenovirus; biodegradable polymer; chemical surface activation; endocytosis; gene expression; nanoparticle adenovirus affinity complex; nanoparticle based gene delivery; viral gene transfer

Indexed keywords

ADENOVIRUS VECTOR; COXSACKIE VIRUS AND ADENOVIRUS RECEPTOR; GREEN FLUORESCENT PROTEIN; IMMUNOGLOBULIN G; INDUCIBLE NITRIC OXIDE SYNTHASE; NANOPARTICLE; POLYLACTIDE;

ANIMAL CELL; ARTERY MUSCLE; ARTICLE; BINDING AFFINITY; CELL CULTURE; CELL GROWTH; CELL TRANSPORT; CELL TYPE; COMPLEX FORMATION; CONTROLLED STUDY; CORRELATION FUNCTION; COVALENT BOND; DRUG MECHANISM; ENDOTHELIUM CELL; GENE EXPRESSION; GENE TRANSFER; GENETIC TRANSDUCTION; HYPOTHESIS; MOUSE; NANOPARTICLE BASED GENE DELIVERY SYSTEM; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PROTEIN DOMAIN; RAT; REPORTER GENE; SMOOTH MUSCLE FIBER; TRANSGENE; VIRAL GENE DELIVERY SYSTEM; VIRUS REPLICATION;

ADENOVIRIDAE; ANIMALS; ANTIBODIES; ARTERIES; CELL PROLIFERATION; CELLS, CULTURED; ENDOCYTOSIS; GENE EXPRESSION; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; IMMUNOGLOBULIN G; MYOCYTES, SMOOTH MUSCLE; NANOSTRUCTURES; NITRIC OXIDE SYNTHASE TYPE II; PHOTOCHEMISTRY; POLYAMINES; POLYESTERS; RATS; RECEPTORS, VIRUS; TRANSDUCTION, GENETIC; TRANSGENES;

ADENOVIRIDAE;

EID: 33746904005     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymthe.2006.03.023     Document Type: Article

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