Synthesis of adenoviral targeting molecules by intein-mediated protein ligation

Gene Therapy

Volumn 10, Issue 16, 2003, Pages 1362-1369

  Nyanguile, O ^a   Dancik, C ^a   Blakemore, J ^a   Mulgrew, K ^a   Kaleko, M ^a   Stevenson, S C ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Adenoviral targeting molecules; Apolipoprotein E; Coxsackie adenovirus receptor; Fibroblast growth factor; Folic acid; Intein mediated protein ligation

Indexed keywords

ADENOVIRUS VECTOR; APOLIPOPROTEIN E; BASIC FIBROBLAST GROWTH FACTOR; CAPSID PROTEIN; CELL RECEPTOR; CELL SURFACE RECEPTOR; FOLIC ACID; INTEIN; SYNTHETIC PEPTIDE; VIRUS PROTEIN;

CANCER THERAPY; CONTROLLED STUDY; COXSACKIE VIRUS; DRUG CONJUGATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; GENE TARGETING; HUMAN; HUMAN CELL; LIGAND BINDING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVIEW; STRUCTURE ANALYSIS; VIRAL GENE DELIVERY SYSTEM;

ADENOVIRIDAE; APOLIPOPROTEINS E; FIBROBLAST GROWTH FACTOR 2; FOLIC ACID; GENE THERAPY; GENETIC ENGINEERING; GENETIC VECTORS; HUMANS; LIGANDS; NEOPLASMS; PROTEIN BINDING; RECEPTORS, CELL SURFACE; TUMOR CELLS, CULTURED;

ADENOVIRIDAE; COXSACKIEVIRUS; RNA VIRUSES;

EID: 0042526048     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301989     Document Type: Article

References (49)

1. Bergelson JM et al. Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5. Science 1997; 275: 1320-1323.
2. Wickham TJ, Mathias P, Cheresh DA, Nemerow GR. Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment. Cell 1993; 73: 309-319.
3. Wickham TJ. Targeting adenovirus. Gene Therapy 2000; 7: 110-114.
4. Smith T et al. In vivo hepatic adenoviral gene delivery occurs independently of the coxsackievirus-adenovirus receptor. Mol Ther 2002; 5: 770-779.
5. Magnusson MK, Hong SS, Boulanger P, Lindholm L. Genetic retargeting of adenovirus: novel strategy employing 'deknobbing' of the fiber. J Virol 2001; 75: 7280-7289.
6. Krasnykh V et al. Characterization of an adenovirus vector containing a heterologous peptide epitope in the HI loop of the fiber knob. J Virol 1998; 72: 1844-1852.
7. Gonzalez R et al. Increased gene transfer in acute myeloid leukemic cells by an adenovirus vector containing a modified fiber protein. Gene Therapy 1999; 6: 314-320.
8. Michael SI, Hong JS, Curiel DT, Engler JA. Addition of a short peptide ligand to the adenovirus fiber protein. Gene Therapy 1995; 2: 660-668.
9. Hay CM et al. Enhanced gene transfer to rabbit jugular veins by an adenovirus containing a cyclic RGD motif in the HI loop of the fiber knob. J Vasc Res 2001; 38: 315-323.
10. Douglas JT et al. Targeted gene delivery by tropism-modified adenoviral vectors. Nat Biotechnol 1996; 14: 1574-1578.
11. Goldman CK et al. Targeted gene delivery to Kaposi's sarcoma cells via the fibroblast growth factor receptor. Cancer Res 1997; 57: 1447-1451.
12. Kim J et al. Targeting adenoviral vectors by using the extracellular domain of the coxsackie-adenovirus receptor: improved potency via trimerization. J Virol 2002; 76: 1892-1903.
13. Rogers BE et al. Enhanced in vivo gene delivery to human ovarian cancer xenografts utilizing a tropism-modified adenovirus vector. Tumor Targeting 1998; 3: 25-31.
14. Noren CJ, Wang J, Perler FB. Dissecting the chemistry of protein splicing and its applications. Angew Chem Int Ed Engl 2000; 39: 450-466.
15. Xu MQ, Evans Jr TC. Intein-mediated ligation and cyclization of expressed proteins. Methods 2001; 24: 257-277.
16. Severinov K, Muir TW. Expressed protein ligation, a novel method for studying protein-protein interactions in transcription. J Biol Chem 1998; 273: 16205-16209.
17. Evans Jr TC, Benner J, Xu MQ. Semisynthesis of cytotoxic proteins using a modified protein splicing element. Protein Sci 1998; 7: 2256-2264.
18. Xu R, Ayers B, Cowburn D, Muir TW. Chemical ligation of folded recombinant proteins: segmental isotopic labeling of domains for NMR studies. Proc Natl Acad Sci USA 1999; 96: 388-393.
19. Graham J, Cotton BA, Rong X, Muir TW. Insertion of a synthetic peptide into a recombinant protein framework: a protein biosensor. J Am Chem Soc 1999; 121: 1100-1101.
20. Tolbert TJ, Wong CH. Intein-mediated synthesis of proteins containing carbohydrates and other molecular probes. J Am Chem Soc 2000; 122: 5421-5428.
21. Dmitriev I et al. Ectodomain of coxsackievirus and adenovirus receptor genetically fused to epidermal growth factor mediates adenovirus targeting to epidermal growth factor receptor-positive cells. J Virol 2000; 74: 6875-6884.
22. Kashentseva EA, Seki T, Curiel DT, Dmitriev IP. Adenovirus targeting to c-erbB-2 oncoprotein by single-chain antibody fused to trimeric form of adenovirus receptor ectodomain. Cancer Res 2002; 62: 609-616.
23. Lortat-Jacob H, Chouin E, Cusack S, van Raaij MJ. Kinetic analysis of adenovirus fiber binding to its receptor reveals an avidity mechanism for trimeric receptor-ligand interactions. J Biol Chem 2001; 276: 9009-9015.
24. Freimuth P et al. Coxsackievirus and adenovirus receptor amino-terminal immunoglobulin V-related domain binds adenovirus type 2 and fiber knob from adenovirus type 12. J Virol 1999; 73: 1392-1398.
25. van Raaij MJ et al. Dimeric structure of the coxsackievirus and adenovirus receptor D1 domain at 1.7 A resolution. Structure Fold Des 2000; 8: 1147-1155.
26. Telenti A et al. The Mycobacterium xenopi GyrA protein splicing element: characterization of a minimal intein. J Bacteriol 1997; 179: 6378-6382.
27. Southworth MW et al. Purification of proteins fused to either the amino or carboxy terminus of the Mycobacterium xenopi gyrase A intein. Biotechniques 1999; 27: 110-114, 116, 118-120.
28. Dawson PE, Muir TW, Clark-Lewis I, Kent SB. Synthesis of proteins by native chemical ligation. Science 1994; 266: 776-779.
29. Dyer CA, Cistola DP, Parry GC, Curtiss LK. Structural features of synthetic peptides of apolipoprotein E that bind the LDL receptor. J Lipid Res 1995; 36: 80-88.
30. Stevenson SC et al. Human adenovirus serotypes 3 and 5 bind to two different cellular receptors via the fiber head domain. J Virol 1995; 69: 2850-2857.
31. Leamon CP, Pastan I, Low PS. Cytotoxicity of folate-Pseudomonas exotoxin conjugates toward tumor cells. Contribution of translocation domain. J Biol Chem 1993; 268: 24847-24854.
32. Rogers BE et al. Use of a novel cross-linking method to modify adenovirus tropism. Gene Therapy 1997; 4: 1387-1392.
33. Klagsbrun M, Baird A. A dual receptor system is required for basic fibroblast growth factor activity. Cell 1991; 67: 229-231.
34. Plotnikov AN, Schlessinger J, Hubbard SR, Mohammadi M. Structural basis for FGF receptor dimerization and activation. Cell 1999; 98: 641-650.
35. Wu H, Xu MQ, Liu XQ. Protein trans-splicing and functional mini-inteins of a cyanobacterial dnaB intein. Biochim Biophys Acta 1998; 1387: 422-432.
36. Kranz DM et al. Conjugates of folate and anti-T-cell-receptor antibodies specifically target folate-receptor-positive tumor cells for lysis. Proc Natl Acad Sci USA 1995; 92: 9057-9061.
37. Doukas J et al. Retargeted delivery of adenoviral vectors through fibroblast growth factor receptors involves unique cellular pathways. FASEB J 1999; 13: 1459-1466.
38. Delgado GEFaC. Drug targeting: strategies, principles and applications. In: Inc. HP (ed). Methods in Molecular Medicine. Totowa: NJ, 2000. pp 69-76.
39. Hong SS et al. Enhancement of adenovirus-mediated gene delivery by use of an oligopeptide with dual binding specificity. Hum Gene Ther 1999; 10: 2577-2586.
40. Barry MA, Dower WJ, Johnston SA. Toward cell-targeting gene therapy vectors: selection of cell-binding peptides from random peptide-presenting phage libraries. Nat Med 1996; 2: 299-305.
41. Pasqualini R, Ruoslahti E. Organ targeting in vivo using phage display peptide libraries. Nature 1996; 380: 364-366.
42. Trepel M, Grifman M, Weitzman MD, Pasqualini R. Molecular adaptors for vascular-targeted adenoviral gene delivery. Hum Gene Ther 2000; 11: 1971-1981.
43. Gu DL et al. Fibroblast growth factor 2 retargeted adenovirus has redirected cellular tropism: evidence for reduced toxicity and enhanced antitumor activity in mice. Cancer Res 1999; 59: 2608-2614.
44. Reynolds PN et al. A targetable, injectable adenoviral vector for selective gene delivery to pulmonary endothelium in vivo. Mol Ther 2000; 2: 562-578.
45. Evans Jr TC, Benner J, Xu MQ. The in vitro ligation of bacterially expressed proteins using an intein from Methanobacterium thermoautotrophicum. J Biol Chem 1999; 274: 3923-3926.
46. Gorziglia MI et al. Elimination of both E1 and E2 from adenovir-us vectors further improves prospects for in vivo human gene therapy. J Virol 1996; 70: 4173-4178.
47. Mittereder N, March KL, Trapnell BC. Evaluation of the concentration and bioactivity of adenovirus vectors for gene therapy. J Virol 1996; 70: 7498-7509.
48. Henry LJ et al. Characterization of the knob domain of the adenovirus type 5 fiber protein expressed in Escherichia coli. J Virol 1994; 68: 5239-5246.
49. Dyer CA, Curtiss LK. A synthetic peptide mimic of plasma apolipoprotein E that binds the LDL receptor. J Biol Chem 1991; 266: 22803-22806.