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Volumn 6, Issue 1, 2002, Pages 106-112

Improved method of recombinant AAV2 delivery for systemic targeted gene therapy

Author keywords

Dependovirus; Drug carriers; Gene therapy; Microspheres; Vehicles

Indexed keywords

ALPHA 1 ANTITRYPSIN; BETA GALACTOSIDASE; CELL RECEPTOR; GREEN FLUORESCENT PROTEIN; HELICASE; HEPARAN SULFATE; MICROSPHERE; PROTEOGLYCAN; VIRUS VECTOR;

EID: 0036665607     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1006/mthe.2001.0636     Document Type: Article
Times cited : (173)

References (51)
  • 1
    • 0026525713 scopus 로고
    • Use of adeno-associated virus as a general transduction vector for mammalian cells
    • Muzyczka, N. (1992). Use of adeno-associated virus as a general transduction vector for mammalian cells. Curr. Top. Microbiol. Immunol. 158: 97-129.
    • (1992) Curr. Top. Microbiol. Immunol. , vol.158 , pp. 97-129
    • Muzyczka, N.1
  • 2
    • 0029151404 scopus 로고
    • Adeno-associated virus vectors for gene therapy
    • Flotte, T. R., and Carter, B. J. (1995). Adeno-associated virus vectors for gene therapy. Gene Ther. 2: 357-362.
    • (1995) Gene Ther. , vol.2 , pp. 357-362
    • Flotte, T.R.1    Carter, B.J.2
  • 3
    • 0034050904 scopus 로고    scopus 로고
    • Evidence for gene transfer and expression of factor IX in haemophilia B patients treated with an AAV vector
    • Kay, M. A., et al. (2000). Evidence for gene transfer and expression of factor IX in haemophilia B patients treated with an AAV vector. Nat. Genet. 24: 257-261.
    • (2000) Nat. Genet. , vol.24 , pp. 257-261
    • Kay, M.A.1
  • 4
    • 0029836780 scopus 로고    scopus 로고
    • Evaluation of the concentration and bioactivity of adenovirus vectors for gene therapy
    • Mittereder, N., March, K. L., and Trapnell, B. C. (1996). Evaluation of the concentration and bioactivity of adenovirus vectors for gene therapy. J. Virol. 70: 7498-7509.
    • (1996) J. Virol. , vol.70 , pp. 7498-7509
    • Mittereder, N.1    March, K.L.2    Trapnell, B.C.3
  • 5
    • 0033010884 scopus 로고    scopus 로고
    • Human fibroblast growth factor receptor 1 is a co-receptor for infection by adeno-associated virus 2
    • Qing, K., et al. (1999). Human fibroblast growth factor receptor 1 is a co-receptor for infection by adeno-associated virus 2. Nat. Med. 5: 71-77.
    • (1999) Nat. Med. , vol.5 , pp. 71-77
    • Qing, K.1
  • 6
    • 0031906147 scopus 로고    scopus 로고
    • Membrane-associated heparan sulfate proteoglycan is a receptor for adeno-associated virus type 2 virions
    • Summerford, C., and Samulski, R. J. (1998). Membrane-associated heparan sulfate proteoglycan is a receptor for adeno-associated virus type 2 virions. J. Virol. 72: 1438-1445.
    • (1998) J. Virol. , vol.72 , pp. 1438-1445
    • Summerford, C.1    Samulski, R.J.2
  • 7
    • 0032589751 scopus 로고    scopus 로고
    • αVβ5 integrin: A co-receptor for adeno-associated virus type 2 infection
    • Summerford, C., Bartlett, J. S., and Samulski, R. J. (1999). αVβ5 integrin: a co-receptor for adeno-associated virus type 2 infection. Nat. Med. 5: 78-82.
    • (1999) Nat. Med. , vol.5 , pp. 78-82
    • Summerford, C.1    Bartlett, J.S.2    Samulski, R.J.3
  • 8
    • 0033022953 scopus 로고    scopus 로고
    • Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield
    • Zolotukhin, S., et al. (1999). Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield. Gene Ther. 6: 973-985.
    • (1999) Gene Ther. , vol.6 , pp. 973-985
    • Zolotukhin, S.1
  • 9
    • 0030458783 scopus 로고    scopus 로고
    • A stable cell line carrying adenovirus-inducible rep and cap genes allows for infectivity titration of adeno-associated virus vectors
    • Clark, K. R., Voulgaropoulou, F., and Johnson, P. R. (1996). A stable cell line carrying adenovirus-inducible rep and cap genes allows for infectivity titration of adeno-associated virus vectors. Gene Ther. 3: 1124-1132.
    • (1996) Gene Ther. , vol.3 , pp. 1124-1132
    • Clark, K.R.1    Voulgaropoulou, F.2    Johnson, P.R.3
  • 10
    • 0030451214 scopus 로고    scopus 로고
    • Gene delivery to skeletal muscle results in sustained expression and systemic delivery of a therapeutic protein
    • Kessler, P. D., et al. (1996). Gene delivery to skeletal muscle results in sustained expression and systemic delivery of a therapeutic protein. Proc. Natl. Acad. Sci. USA 93: 14082-14087.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 14082-14087
    • Kessler, P.D.1
  • 11
    • 13144305062 scopus 로고    scopus 로고
    • Sustained secretion of human α-1-antitrypsin from murine muscle transduced with adeno-associated virus vectors
    • Song, S., et al. (1998). Sustained secretion of human α-1-antitrypsin from murine muscle transduced with adeno-associated virus vectors. Proc. Natl. Acad. Sci. USA 95: 14384-14388.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 14384-14388
    • Song, S.1
  • 12
    • 0033759007 scopus 로고    scopus 로고
    • Inhibition of recombinant adeno-associated virus (rAAV) transduction by bronchial secretions from cystic fibrosis patients
    • Virella-Lowell, I., Poirier, A., Chesnut, K. A., Brantly, M., and Flotte, T. R. (2000). Inhibition of recombinant adeno-associated virus (rAAV) transduction by bronchial secretions from cystic fibrosis patients. Gene Ther. 7: 1783-1789.
    • (2000) Gene Ther. , vol.7 , pp. 1783-1789
    • Virella-Lowell, I.1    Poirier, A.2    Chesnut, K.A.3    Brantly, M.4    Flotte, T.R.5
  • 13
    • 0033998692 scopus 로고    scopus 로고
    • Infectious entry pathway of adeno-associated virus and adeno-associated virus vectors
    • Bartlett, J. S., Wilcher, R., and Samulski, R. J. (2000). Infectious entry pathway of adeno-associated virus and adeno-associated virus vectors. J. Virol. 74: 2777-2785.
    • (2000) J. Virol. , vol.74 , pp. 2777-2785
    • Bartlett, J.S.1    Wilcher, R.2    Samulski, R.J.3
  • 14
    • 0032737034 scopus 로고    scopus 로고
    • Dynamin is required for recombinant adeno-associated virus type 2 infection
    • Duan, D., et al. (1999). Dynamin is required for recombinant adeno-associated virus type 2 infection. J. Virol. 73: 10371-10376.
    • (1999) J. Virol. , vol.73 , pp. 10371-10376
    • Duan, D.1
  • 15
    • 0033987571 scopus 로고    scopus 로고
    • Impaired intracellular trafficking of adeno-associated virus type 2 vectors limits efficient transduction of murine fibroblasts
    • Hansen, J., Qing, K., Kwon, H. J., Mah, C., and Srivastava, A. (2000). Impaired intracellular trafficking of adeno-associated virus type 2 vectors limits efficient transduction of murine fibroblasts. J. Virol. 74: 992-996.
    • (2000) J. Virol. , vol.74 , pp. 992-996
    • Hansen, J.1    Qing, K.2    Kwon, H.J.3    Mah, C.4    Srivastava, A.5
  • 16
    • 0034759535 scopus 로고    scopus 로고
    • Infection of purified nuclei by adeno-associated virus 2
    • doi:10.1006/mthe.2001.0457
    • Hansen, J., Qing, K., and Srivastava, A. (2001). Infection of purified nuclei by adeno-associated virus 2. Mol. Ther. 4: 289-296, doi:10.1006/mthe.2001.0457.
    • (2001) Mol. Ther. , vol.4 , pp. 289-296
    • Hansen, J.1    Qing, K.2    Srivastava, A.3
  • 17
    • 0031691257 scopus 로고    scopus 로고
    • Circular intermediates of recombinant adeno-associated virus have defined structural characteristics responsible for long-term episomal persistence in muscle tissue
    • Duan, D., et al. (1998). Circular intermediates of recombinant adeno-associated virus have defined structural characteristics responsible for long-term episomal persistence in muscle tissue. J. Virol. 72: 8568-8577.
    • (1998) J. Virol. , vol.72 , pp. 8568-8577
    • Duan, D.1
  • 18
    • 0033567129 scopus 로고    scopus 로고
    • Structural analysis of adeno-associated virus transduction circular intermediates
    • doi:10.1006/viro.1999.9821
    • Duan, D., Yan, Z., Yue, Y., and Engelhardt, J. F. (1999). Structural analysis of adeno-associated virus transduction circular intermediates. Virology 261: 8-14, doi:10.1006/viro.1999.9821.
    • (1999) Virology , vol.261 , pp. 8-14
    • Duan, D.1    Yan, Z.2    Yue, Y.3    Engelhardt, J.F.4
  • 19
    • 0033023881 scopus 로고    scopus 로고
    • Structure of adeno-associated virus vector DNA following transduction of the skeletal muscle
    • Vincent-Lacaze, N., et al. (1999). Structure of adeno-associated virus vector DNA following transduction of the skeletal muscle. J. Virol. 73: 1949-1955.
    • (1999) J. Virol. , vol.73 , pp. 1949-1955
    • Vincent-Lacaze, N.1
  • 20
    • 0032862285 scopus 로고    scopus 로고
    • Concatamerization of adeno-associated virus circular genomes occurs through intermolecular recombination
    • Yang, J., et al. (1999). Concatamerization of adeno-associated virus circular genomes occurs through intermolecular recombination. J. Virol. 73: 9468-9477.
    • (1999) J. Virol. , vol.73 , pp. 9468-9477
    • Yang, J.1
  • 21
    • 0034030443 scopus 로고    scopus 로고
    • Nonrandom transduction of recombinant adeno-associated virus vectors in mouse hepatocytes in vivo: Cell cycling does not influence hepatocyte transduction
    • Miao, C. H., et al. (2000). Nonrandom transduction of recombinant adeno-associated virus vectors in mouse hepatocytes in vivo: cell cycling does not influence hepatocyte transduction. J. Virol. 74: 3793-3803.
    • (2000) J. Virol. , vol.74 , pp. 3793-3803
    • Miao, C.H.1
  • 22
    • 0028577595 scopus 로고
    • Adeno-associated virus vectors preferentially transduce cells in S phase
    • Russell, D. W., Miller, A. D., and Alexander, I. E. (1994). Adeno-associated virus vectors preferentially transduce cells in S phase. Proc. Natl. Acad. Sci. USA 91: 8915-8919.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 8915-8919
    • Russell, D.W.1    Miller, A.D.2    Alexander, I.E.3
  • 23
    • 0029923638 scopus 로고    scopus 로고
    • Second-strand synthesis is a rate-limiting step for efficient transduction by recombinant adeno-associated virus vectors
    • Ferrari, F. K., Samulski, T., Shenk, T., and Samulski, R. J. (1996). Second-strand synthesis is a rate-limiting step for efficient transduction by recombinant adeno-associated virus vectors. J. Virol. 70: 3227-3234.
    • (1996) J. Virol. , vol.70 , pp. 3227-3234
    • Ferrari, F.K.1    Samulski, T.2    Shenk, T.3    Samulski, R.J.4
  • 24
    • 0029655894 scopus 로고    scopus 로고
    • Transduction with recombinant adeno-associated virus for gene therapy is limited by leading-strand synthesis
    • Fisher, K. J., et al. (1996). Transduction with recombinant adeno-associated virus for gene therapy is limited by leading-strand synthesis. J. Virol. 70: 520-532.
    • (1996) J. Virol. , vol.70 , pp. 520-532
    • Fisher, K.J.1
  • 25
    • 0030931601 scopus 로고    scopus 로고
    • Role of tyrosine phosphorylation of a cellular protein in adeno-associated virus 2-mediated transgene expression
    • Qing, K., et al. (1997). Role of tyrosine phosphorylation of a cellular protein in adeno-associated virus 2-mediated transgene expression. Proc. Natl. Acad. Sci. USA 94: 10879-10884.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 10879-10884
    • Qing, K.1
  • 27
    • 0033588890 scopus 로고    scopus 로고
    • Enhanced expression of transgenes from adeno-associated virus vectors with the woodchuck hepatitus virus posttranscriptional regulatory element: Implications for gene therapy
    • Loeb, J. E., Cordier, W. S., Harris, M. E., Weitzman, M. D., and Hope, T. J. (1999). Enhanced expression of transgenes from adeno-associated virus vectors with the woodchuck hepatitus virus posttranscriptional regulatory element: implications for gene therapy. Hum. Gene Ther. 10: 2295-2305.
    • (1999) Hum. Gene Ther. , vol.10 , pp. 2295-2305
    • Loeb, J.E.1    Cordier, W.S.2    Harris, M.E.3    Weitzman, M.D.4    Hope, T.J.5
  • 28
    • 0034572459 scopus 로고    scopus 로고
    • Several log increase in therapeutic transgene delivery by distinct adeno-associated viral serotype vectors
    • doi:10.1006/mthe.2000.0219
    • Chao, H., et al. (2000). Several log increase in therapeutic transgene delivery by distinct adeno-associated viral serotype vectors. Mol. Ther. 2: 619-623, doi:10.1006/mthe.2000.0219.
    • (2000) Mol. Ther. , vol.2 , pp. 619-623
    • Chao, H.1
  • 29
    • 0034724209 scopus 로고    scopus 로고
    • Recombinant adeno-associated virus type 2, 4, and 5 vectors: Transduction of variant cell types and regions in the mammalian central nervous system
    • Davidson, B. L., et al. (2000). Recombinant adeno-associated virus type 2, 4, and 5 vectors: transduction of variant cell types and regions in the mammalian central nervous system. Proc. Natl. Acad. Sci. USA 97: 3428-3432.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 3428-3432
    • Davidson, B.L.1
  • 30
    • 0034957168 scopus 로고    scopus 로고
    • Adeno-associated virus serotype 4 (AAV4) and AAV5 both require sialic acid binding for hemagglutination and efficient transduction but differ in sialic acid linkage specificity
    • Kaludov, N., Brown, K. E., Walters, R. W., Zabner, J., and Chiorini, J. A. (2001). Adeno-associated virus serotype 4 (AAV4) and AAV5 both require sialic acid binding for hemagglutination and efficient transduction but differ in sialic acid linkage specificity. J. Virol. 75: 6884-6893.
    • (2001) J. Virol. , vol.75 , pp. 6884-6893
    • Kaludov, N.1    Brown, K.E.2    Walters, R.W.3    Zabner, J.4    Chiorini, J.A.5
  • 31
    • 0032870158 scopus 로고    scopus 로고
    • Genetic capsid modifications allow efficient re-targeting of adeno-associated virus type 2
    • Girod, A., et al. (1999). Genetic capsid modifications allow efficient re-targeting of adeno-associated virus type 2. Nat. Med. 5: 1052-1056.
    • (1999) Nat. Med. , vol.5 , pp. 1052-1056
    • Girod, A.1
  • 32
    • 0033590138 scopus 로고    scopus 로고
    • Insertional mutagenesis of AAV2 capsid and the production of recombinant virus
    • doi:10.1006/viro.1999.0036
    • Rabinowitz, J. E., Xiao, W., and Samulski, R. J. (1999). Insertional mutagenesis of AAV2 capsid and the production of recombinant virus. Virology 265: 274-285, doi:10.1006/viro.1999.0036.
    • (1999) Virology , vol.265 , pp. 274-285
    • Rabinowitz, J.E.1    Xiao, W.2    Samulski, R.J.3
  • 33
    • 0034814413 scopus 로고    scopus 로고
    • Insertional mutagenesis of the adeno-associated virus type 2 (aav2) capsid gene and generation of aav2 vectors targeted to alternative cell-surface receptors
    • Shi, W., Arnold, G. S., and Bartlett, J. S. (2001). Insertional mutagenesis of the adeno-associated virus type 2 (aav2) capsid gene and generation of aav2 vectors targeted to alternative cell-surface receptors. Hum. Gene Ther. 12: 1697-1711.
    • (2001) Hum. Gene Ther. , vol.12 , pp. 1697-1711
    • Shi, W.1    Arnold, G.S.2    Bartlett, J.S.3
  • 34
    • 0033851104 scopus 로고    scopus 로고
    • Mutational analysis of the adeno-associated virus type 2 (AAV2) capsid gene and construction of AAV2 vectors with altered tropism
    • Wu, P., et al. (2000). Mutational analysis of the adeno-associated virus type 2 (AAV2) capsid gene and construction of AAV2 vectors with altered tropism. J. Virol. 74: 8635-8647.
    • (2000) J. Virol. , vol.74 , pp. 8635-8647
    • Wu, P.1
  • 35
    • 0029883821 scopus 로고    scopus 로고
    • Effects of γ irradiation on the transduction of dividing and nondividing cells in brain and muscle of rats by adeno-associated virus vectors
    • Alexander, I. E., Russell, D. W., Spence, A. M., and Miller, A. D. (1996). Effects of γ irradiation on the transduction of dividing and nondividing cells in brain and muscle of rats by adeno-associated virus vectors. Hum. Gene Ther. 7: 841-850.
    • (1996) Hum. Gene Ther. , vol.7 , pp. 841-850
    • Alexander, I.E.1    Russell, D.W.2    Spence, A.M.3    Miller, A.D.4
  • 36
    • 0031775223 scopus 로고    scopus 로고
    • Adeno-associated virus type 2-mediated gene transfer: Role of epidermal growth factor receptor protein tyrosine kinase in transgene expression
    • Mah, C., et al. (1998). Adeno-associated virus type 2-mediated gene transfer: role of epidermal growth factor receptor protein tyrosine kinase in transgene expression. J. Virol. 72: 9835-9843.
    • (1998) J. Virol. , vol.72 , pp. 9835-9843
    • Mah, C.1
  • 37
    • 0029047860 scopus 로고
    • DNA synthesis and topoisomerase inhibitors increase transduction by adeno-associated virus vectors
    • Russell, D. W., Alexander, I. E., and Miller, A. D. (1995). DNA synthesis and topoisomerase inhibitors increase transduction by adeno-associated virus vectors. Proc. Natl. Acad. Sci. USA 92: 5719-5723.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 5719-5723
    • Russell, D.W.1    Alexander, I.E.2    Miller, A.D.3
  • 38
    • 0032819125 scopus 로고    scopus 로고
    • Cellular redox state alters recombinant adeno-associated virus transduction through tyrosine phosphatase pathways
    • Sanlioglu, S., and Engelhardt, J. F. (1999). Cellular redox state alters recombinant adeno-associated virus transduction through tyrosine phosphatase pathways. Gene Ther. 6: 1427-1437.
    • (1999) Gene Ther. , vol.6 , pp. 1427-1437
    • Sanlioglu, S.1    Engelhardt, J.F.2
  • 39
    • 0033739544 scopus 로고    scopus 로고
    • Comparison of octreotide acetate LAR and lanreotide SR in patients with acromegaly
    • Chanson, P., et al. (2000). Comparison of octreotide acetate LAR and lanreotide SR in patients with acromegaly. Clin. Endocrinol. (Oxf.) 53: 577-586.
    • (2000) Clin. Endocrinol. (Oxf.) , vol.53 , pp. 577-586
    • Chanson, P.1
  • 40
    • 0024518881 scopus 로고
    • Employment of magnet-susceptible microparticles for the targeting of drugs
    • Kharkevich, D. A., Alyautdin, R. N., and Filippov, V. I. (1989). Employment of magnet-susceptible microparticles for the targeting of drugs. J. Pharm. Pharmacol. 41: 286-288.
    • (1989) J. Pharm. Pharmacol. , vol.41 , pp. 286-288
    • Kharkevich, D.A.1    Alyautdin, R.N.2    Filippov, V.I.3
  • 41
    • 0036149049 scopus 로고    scopus 로고
    • Chemoembolization of oral and oropharyngeal cancer using a high-dose cisplatin crystal suspension and degradable starch microspheres
    • Kovacs, A. F., and Turowski, B. (2002). Chemoembolization of oral and oropharyngeal cancer using a high-dose cisplatin crystal suspension and degradable starch microspheres. Oral Oncol. 38: 87-95.
    • (2002) Oral Oncol. , vol.38 , pp. 87-95
    • Kovacs, A.F.1    Turowski, B.2
  • 42
    • 0033956526 scopus 로고    scopus 로고
    • Biomaterials in drug delivery and tissue engineering: One laboratory's experience
    • Langer, R. (2000). Biomaterials in drug delivery and tissue engineering: one laboratory's experience. Acc. Chem. Res. 33: 94-101.
    • (2000) Acc. Chem. Res. , vol.33 , pp. 94-101
    • Langer, R.1
  • 43
    • 0023220240 scopus 로고
    • Treatment of a syngeneic rat tumor with magnetically responsive albumin microspheres labeled with doxorubicin or protein A
    • Rettenmaier, M. A., et al. (1987). Treatment of a syngeneic rat tumor with magnetically responsive albumin microspheres labeled with doxorubicin or protein A. Gynecol. Oncol. 27: 34-43.
    • (1987) Gynecol. Oncol. , vol.27 , pp. 34-43
    • Rettenmaier, M.A.1
  • 45
    • 0032841235 scopus 로고    scopus 로고
    • Local and distant transfection of mdx muscle fibers with dystrophin and LacZ genes delivered in vivo by synthetic microspheres
    • Baranov, A., et al. (1999). Local and distant transfection of mdx muscle fibers with dystrophin and LacZ genes delivered in vivo by synthetic microspheres. Gene Ther. 6: 1406-1414.
    • (1999) Gene Ther. , vol.6 , pp. 1406-1414
    • Baranov, A.1
  • 46
    • 0034984451 scopus 로고    scopus 로고
    • Efficient naked plasmid cotransfection of lung grafts by extended lung/plasmid exposure time
    • D'Ovidio, F., Daddi, N., Suda, T., Grapperhaus, K., and Patterson, A. G. (2001). Efficient naked plasmid cotransfection of lung grafts by extended lung/plasmid exposure time. Ann. Thorac. Surg. 71: 1817-1823.
    • (2001) Ann. Thorac. Surg. , vol.71 , pp. 1817-1823
    • D'Ovidio, F.1    Daddi, N.2    Suda, T.3    Grapperhaus, K.4    Patterson, A.G.5
  • 47
    • 0034920631 scopus 로고    scopus 로고
    • mdx/mdx mice through systemic administration of plasmid DNA
    • doi:10.1006/mthe.2001.0419
    • mdx/mdx mice through systemic administration of plasmid DNA. Mol. Ther. 4: 45-51, doi:10.1006/mthe.2001.0419.
    • (2001) Mol. Ther. , vol.4 , pp. 45-51
    • Liu, F.1    Nishikawa, M.2    Clemens, P.R.3    Huang, L.4
  • 48
    • 0028989346 scopus 로고
    • Pharmacokinetics of adenoviral vector-mediated gene delivery to vascular smooth muscle cells: Modulation by poloxamer 407 and implications for cardiovascular gene therapy
    • March, K. L., Madison, J. E., and Trapnell, B. C. (1995). Pharmacokinetics of adenoviral vector-mediated gene delivery to vascular smooth muscle cells: modulation by poloxamer 407 and implications for cardiovascular gene therapy. Hum. Gene Ther. 6: 41-53.
    • (1995) Hum. Gene Ther. , vol.6 , pp. 41-53
    • March, K.L.1    Madison, J.E.2    Trapnell, B.C.3
  • 49
    • 0034986080 scopus 로고    scopus 로고
    • Use of perfluorochemical liquid allows earlier detection of gene expression and use of less vector in normal lung and enhances gene expression in acutely injured lung
    • doi:10.1006/mthe.2001.0321
    • Weiss, D. J., Bonneau, L., and Liggitt, D. (2001). Use of perfluorochemical liquid allows earlier detection of gene expression and use of less vector in normal lung and enhances gene expression in acutely injured lung. Mol. Ther. 3: 734-745, doi:10.1006/mthe.2001.0321.
    • (2001) Mol. Ther. , vol.3 , pp. 734-745
    • Weiss, D.J.1    Bonneau, L.2    Liggitt, D.3
  • 50
    • 0032051603 scopus 로고    scopus 로고
    • Neuron-specific transduction in the rat septohippocampal or nigrostriatal pathway by recombinant adeno-associated virus vectors
    • doi:10.1006/exnr.1997.6736
    • Klein, R. L., et al. (1998). Neuron-specific transduction in the rat septohippocampal or nigrostriatal pathway by recombinant adeno-associated virus vectors. Exp. Neurol. 150: 183-194, doi:10.1006/exnr.1997.6736.
    • (1998) Exp. Neurol. , vol.150 , pp. 183-194
    • Klein, R.L.1
  • 51
    • 0034828903 scopus 로고    scopus 로고
    • Stable therapeutic serum levels of human α-1antitrypsin (AAT) after portal vein injection of recombinant adeno-associated virus (rAAV) vectors
    • Song, S., et al. (2001). Stable therapeutic serum levels of human α-1antitrypsin (AAT) after portal vein injection of recombinant adeno-associated virus (rAAV) vectors. Gene Ther. 8:
    • (2001) Gene Ther. , vol.8 , pp. 1299-1306
    • Song, S.1


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